Pharmacological characterization of AM1710, a putative cannabinoid CB 2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects

Pharmacology Biochemistry and Behavior

Volumn 98, Issue 4, 2011, Pages 493-502

  Rahn, Elizabeth J ^a   Thakur, Ganesh A ^b   Wood, Jodi Anne T ^b   Zvonok, Alexander M ^b   Makriyannis, Alexandros ^b   Hohmann, Andrea G ^a,c  

^a UNIVERSITY OF GEORGIA   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

Antinociception; Cannabinoid; CB2; Pain; Tetrad

Indexed keywords

3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; [3 (1',1' DIMETHYLHEPTYL) 1 HYDROXY 9 METHOXY 6H BENZO[C]CHROMENE 6 ONE]; AM 1710; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; ATAXIA; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG MEGADOSE; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYPOTHERMIA; LOCOMOTION; LOW DRUG DOSE; MALE; MECHANICAL STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECTUM TEMPERATURE; TAIL FLICK TEST; TEMPERATURE SENSITIVITY; TOXICITY TESTING;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; BLOOD-BRAIN BARRIER; BORNANES; CANNABINOIDS; CENTRAL NERVOUS SYSTEM; CHROMONES; HEK293 CELLS; HUMANS; MALE; MICE; PAIN THRESHOLD; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECOMBINANT PROTEINS;

EID: 79952988955     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.02.024     Document Type: Article

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