Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB1 receptors: A keratinocyte-dependent effect

Archives of Dermatological Research

Volumn 303, Issue 3, 2011, Pages 201-210

  Magina, Sofia ^a,b,c   Esteves Pinto, Carina ^a   Moura, Eduardo ^a,b   Serrão, Maria Paula ^a   Moura, Daniel ^a   Petrosino, Stefania ^d   Di Marzo, Vincenzo ^d   Vieira Coelho, Maria Augusta ^a,b  

^a University of Porto   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c Consiglio Nazionale Delle Ricerche ^*  (Portugal)

^d CNR   (Italy)

Author keywords

Cannabinoids; Co culture; Melanin; Melanoma; Ultraviolet radiation

Indexed keywords

ARACHIDONYL 2 CHLOROETHYLAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; MELANIN; UNCLASSIFIED DRUG;

ARTICLE; COCULTURE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KERATINOCYTE; MELANOGENESIS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; ULTRAVIOLET B RADIATION;

ARACHIDONIC ACIDS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DOWN-REGULATION; ENDOCANNABINOIDS; HUMANS; KERATINOCYTES; MELANINS; MELANOCYTES; PARACRINE COMMUNICATION; PIGMENTATION DISORDERS; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; SKIN; ULTRAVIOLET RAYS;

EID: 79955877874     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-011-1126-z     Document Type: Article

References (22)

1. Berdyshev EV, Schmid PC, Dong Z, Schmid HH (2000) Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P? cells. Biochem J 346(Pt 2):369-374 (Pubitemid 30148122)
2. Biro T, Toth BI, Hasko G, Paus R, Pacher P (2009) The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci 30:411-420
3. Blazquez C, Carracedo A, Barrado L, Real PJ, Fernandez-Luna JL, Velasco G, Malumbres M, Guzman M (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J 20:2633-2635
4. Di Marzo V (2008) Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 7:438-455
5. Duval C, Regnier M, Schmidt R (2001) Distinct melanogenic response of human melanocytes in mono-culture, in co-culture with keratinocytes and in reconstructed epidermis, to UV exposure. Pigment Cell Res 14:348-355 (Pubitemid 32956360)
6. Gilsbach R, Brede M, Beetz N, Moura E, Muthig V, Gerstner C, Barreto F, Neubauer S, Vieira-Coelho MA, Hein L (2007) Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovasc Res 75:728-737 (Pubitemid 47238738)
7. Karsak M, Gaffal E, Date R, Wang-Eckhardt L, Rehnelt J, Petrosino S, Starowicz K, Steuder R, Schlicker E, Cravatt B, Mechoulam R, Buettner R, Werner S, Di Marzo V, Tuting T, Zimmer A (2007) Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 316:1494-1497 (Pubitemid 46906619)
8. Leonti M, Casu L, Raduner S, Cottiglia F, Floris C, Altmann KH, Gertsch J (2010) Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol 79:1815-1826
9. Maccarrone M, Di Rienzo M, Battista N, Gasperi V, Guerrieri P, Rossi A, Finazzi-Agro A (2003) The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. J Biol Chem 278:33896-33903 (Pubitemid 37553223)
10. Moura E, Afonso J, Serrao MP, Vieira-Coelho MA (2009) Effect of clonidine on tyrosine hydroxylase activity in the adrenal medulla and brain of spontaneously hypertensive rats. Basic Clin Pharmacol Toxicol 104:113-121
11. Oka S, Wakui J, Gokoh M, Kishimoto S, Sugiura T (2006) Suppression by WIN55212-2, a cannabinoid receptor agonist, of inflammatory reactions in mouse ear: interference with the actions of an endogenous ligand, 2- arachidonoylglycerol. Eur J Pharmacol 538:154-162
12. Paradisi A, Pasquariello N, Barcaroli D, Maccarrone M (2008) Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner. J Biol Chem 283:6005-6012
13. Park HY, Kosmadaki M, Yaar M, Gilchrest BA (2009) Cellular mechanisms regulating human melanogenesis. Cell Mol Life Sci 66:1493-1506
14. Pertwee RG (2005) Pharmacological actions of cannabinoids. Handb Exp Pharmacol 168:1-51
15. Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tuting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V (2009) Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy 698-711
16. Potsch L, Emmerich P, Skopp G (2002) Preliminary approach to elucidate the role of pigment as a binding site for drugs and chemicals in anagen hairs: pigments as carriers for 3H-haloperidol in HaCaT/Sk-Mel-1 co-cultures. Int J Legal Med 116:12-16 (Pubitemid 36055841)
17. Rad HH, Yamashita T, Jin HY, Hirosaki K, Wakamatsu K, Ito S, Jimbow K (2004) Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. Exp Cell Res 298:317-328 (Pubitemid 38950851)
18. Schallreuter KU (2007) Advances in melanocyte basic science research. Dermatol Clin 25(vii):283-291
19. Springer M, Engelhart K, Biesalski HK (2003) Effects of 3-isobutyl-1-methylxanthine and kojic acid on cocultures and skin equivalents composed of HaCaT cells and human melanocytes. Arch Dermatol Res 295:88-91
20. Stander S, Schmelz M, Metze D, Luger T, Rukwied R (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci 38:177-188 (Pubitemid 40779571)
21. Sugimoto K, Nishimura T, Nomura K, Kuriki T (2004) Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. Biol Pharm Bull 27:510-514 (Pubitemid 41701835)
22. Zheng D, Bode AM, Zhao Q, Cho YY, Zhu F, Ma WY, Dong Z (2008) The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 68:3992-3998