Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors

European Journal of Pharmacology

Volumn 571, Issue 2-3, 2007, Pages 129-137

  Smith, Paul A ^a   Selley, Dana E ^a   Sim Selley, Laura J ^a   Welch, Sandra P ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cannabinoid; GTP S; Morphine; Paw pressure test; Tolerance

Indexed keywords

DRONABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG DOSE ESCALATION; DRUG TOLERANCE; MALE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRESSURE; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMALS; BENZOXAZINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; DRUG TOLERANCE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; MORPHOLINES; NAPHTHALENES; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTORS, OPIOID, MU; SPINAL CORD; SULFUR RADIOISOTOPES; TETRAHYDROCANNABINOL; TIME FACTORS;

EID: 34548483418     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.001     Document Type: Article

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