Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 91-104

  Anavi Goffer, Sharon ^a,d   Baillie, Gemma ^a   Irving, Andrew J ^b   Gertsch, Jürg ^c   Greig, Iain R ^a   Pertwee, Roger G ^a   Ross, Ruth A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF BERN   (Switzerland)

^d ARIEL UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOIDS; CANNABIS SATIVA; HIGH THROUGHPUT SYSTEMS; MITOGEN ACTIVATED PROTEIN KINASE; POTENT INHIBITOR; RECEPTOR ANTAGONISTS; RECEPTOR LIGANDS; RIMONABANT; SIGNALING PATHWAYS;

HEMP; LIGANDS; PHOSPHORYLATION;

SIGNALING;

1 (2,3 DICHLOROBENZOYL) 5 METHOXY 2 METHYL 3 (2 MORPHOLINOETHYL)INDOLE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABIDIVARIN; CANNABIGEROVARIN; CANNABINOID; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CANNABIS DERIVATIVE; DELTA 9 TETRAHYDROCANNABIVARIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; GLYCEROPHOSPHOLIPID; LEVO ALPHA LYSOPHOSPHATIDYLINOSITOL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RIMONABANT; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; NEUROPATHIC PAIN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ANALGESICS; CANNABINOIDS; CANNABIS; HEK293 CELLS; HUMANS; LIGANDS; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEURALGIA; PHOSPHOPROTEINS; PHOSPHORYLATION; PIPERIDINES; PLANT EXTRACTS; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; RECEPTORS, G-PROTEIN-COUPLED; TETRAHYDROCANNABINOL;

CANNABIS SATIVA;

EID: 84855272776     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.296020     Document Type: Article

References (62)

1. Staton, P. C., Hatcher, J. P., Walker, D. J., Morrison, A. D., Shapland, E. M., Hughes, J. P., Chong, E., Mander, P. K., Green, P. J., Billinton, A., Fulley- love, M., Lancaster, H. C., Smith, J. C., Bailey, L. T., Wise, A., Brown, A. J., Richardson, J. C., and Chessell, I. P. (2008) Pain 139, 225-236
2. Whyte, L. S., Ryberg, E., Sims, N. A., Ridge, S. A., Mackie, K., Greasley, P. J., Ross, R. A., and Rogers, M. J. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 16511-16516
3. Ford, L. A., Roelofs, A. J., Anavi-Goffer, S., Mowat, L., Simpson, D. G., Irving, A. J., Rogers, M. J., Rajnicek, A. M., and Ross, R. A. (2010) Br. J. Pharmacol. 160, 762-771
4. Henstridge, C. M., Balenga, N. A., Ford, L. A., Ross, R. A., Waldhoer, M., and Irving, A. J. (2009) FASEB J. 23, 183-193
5. Kapur, A., Zhao, P., Sharir, H., Bai, Y., Caron, M. G., Barak, L. S., and Abood, M. E. (2009) J. Biol. Chem. 284, 29817-29827
6. Lauckner, J. E., Jensen, J. B., Chen, H. Y., Lu, H. C., Hille, B., and Mackie, K. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 2699-2704
7. Oka, S., Nakajima, K., Yamashita, A., Kishimoto, S., and Sugiura, T. (2007) Biochem. Biophys. Res. Commun. 362, 928-934
8. Piñeiro, R., Maffucci, T., and Falasca, M. (2011) Oncogene 30, 142-152
9. Waldeck-Weiermair, M., Zoratti, C., Osibow, K., Balenga, N., Goessnitzer, E., Waldhoer, M., Malli, R., and Graier, W. F. (2008) J. Cell Sci. 121, 1704-1717
10. Bondarenko, A., Waldeck-Weiermair, M., Naghdi, S., Poteser, M., Malli, R., and Graier, W. F. (2010) Br. J. Pharmacol. 161, 308-320
11. Andradas, C., Caffarel, M. M., Pérez-Gómez, E., Salazar, M., Lorente, M., Velasco, G., Guzmán, M., and Sánchez, C. (2011) Oncogene 30, 245-252
12. Sutphen, R., Xu, Y., Wilbanks, G. D., Fiorica, J., Grendys, E. C., Jr., LaPolla, J. P., Arango, H., Hoffman, M. S., Martino, M., Wakeley, K., Griffin, D., Blanco, R. W., Cantor, A. B., Xiao, Y. J., and Krischer, J. P. (2004) Cancer Epidemiol. Biomarkers Prev. 13, 1185-1191
13. Henstridge, C. M., Balenga, N. A., Schroder, R., Kargl, J. K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J. L., Kostenis, E., Waldhoer, M., and Irving, A. J. (2010) Br. J. Pharmacol. 160, 604-614
14. Yin, H., Chu, A., Li, W., Wang, B., Shelton, F., Otero, F., Nguyen, D. G., Caldwell, J. S., and Chen, Y. A. (2009) J. Biol. Chem. 284, 12328-12338
15. Ryberg, E., Larsson, N., Sjögren, S., Hjorth, S., Hermansson, N. O., Leonova, J., Elebring, T., Nilsson, K., Drmota, T., and Greasley, P. J. (2007) Br. J. Pharmacol. 152, 1092-1101
16. Hatzivassiliou, G., Song, K., Yen, I., Brandhuber, B. J., Anderson, D. J., Alvarado, R., Ludlam, M. J., Stokoe, D., Gloor, S. L., Vigers, G., Morales, T., Aliagas, I., Liu, B., Sideris, S., Hoeflich, K. P., Jaiswal, B. S., Seshagiri, S., Koeppen, H., Belvin, M., Friedman, L. S., and Malek, S. (2010) Nature 464, 431-435
17. Pietr, M., Kozela, E., Levy, R., Rimmerman, N., Lin, Y. H., Stella, N., Vogel, Z., and Juknat, A. (2009) FEBS Lett. 583, 2071-2076
18. Oka, S., Kimura, S., Toshida, T., Ota, R., Yamashita, A., and Sugiura, T. (2010) J. Biochem. 147, 671-678
19. Beltramo, M. (2009) Mini. Rev. Med. Chem. 9, 11-25
20. Li, H. F., Chen, Y., Rao, S. S., Chen, X. M., Liu, H. C., Qin, J. H., Tang, W. F., Yue-Wang Zhou, X., and Lu, T. (2010) Curr. Med. Chem. 17, 1618-1634
21. Lin, Y. W., Chuang, S. M., and Yang, J. L. (2003) J. Biol. Chem. 278, 21534-21541
22. Adwanikar, H., Karim, F., and Gereau, R. W., 4th (2004) Pain 111, 125-135
23. Ji, R. R., Befort, K., Brenner, G. J., and Woolf, C. J. (2002) J. Neurosci. 22, 478-485
24. Atwood, B. K., and Mackie, K. (2010) Br. J. Pharmacol. 160, 467-479
25. Gertsch, J., Leonti, M., Raduner, S., Racz, I., Chen, J. Z., Xie, X. Q., Altmann, K. H., Karsak, M., and Zimmer, A. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 9099-9104
26. Marcu, J. P., Christian, R. T., Lau, D., Zielinski, A. J., Horowitz, M. P., Lee, J., Pakdel, A., Allison, J., Limbad, C., Moore, D. H., Yount, G. L., Desprez, P. Y., and McAllister, S. D. (2010) Mol. Cancer Ther. 9, 180-189
27. McAllister, S. D., Christian, R. T., Horowitz, M. P., Garcia, A., and Desprez, P. Y. (2007) Mol. Cancer Ther. 6, 2921-2927
28. Shepherd, C., Puzanov, I., and Sosman, J. A. (2010) Curr. Oncol. Rep. 12, 146-152
29. Tsai, J., Lee, J. T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N. K., Sproesser, K., Li, L., Smalley, K. S., Fong, D., Zhu, Y. L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S. H., Schlessinger, J., Zhang, K. Y., West, B. L., Powell, B., Habets, G., Zhang, C., Ibrahim, P. N., Hirth, P., Artis, D. R., Herlyn, M., and Bollag, G. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 3041-3046
30. Osmond, R. I., Das, S., and Crouch, M. F. (2010) Anal. Biochem. 403, 94-101
31. Shih, H. H., Zhang, S., Cao, W., Hahn, A., Wang, J., Paulsen, J. E., and Harnish, D. C. (2009) Am. J. Physiol. Heart Circ. Physiol. 296, H1643-H1650
32. Mazella, J., Pétrault, O., Lucas, G., Deval, E., Béraud-Dufour, S., Gandin, C., El-Yacoubi, M., Widmann, C., Guyon, A., Chevet, E., Taouji, S., Conductier, G., Corinus, A., Coppola, T., Gobbi, G., Nahon, J. L., Heurteaux, C., and Borsotto, M. (2010) PLoS Biol. 8, e1000355
33. Uehara, Y., Mochizuki, M., Matsuno, K., Haino, T., and Asai, A. (2009) Biochem. Biophys. Res. Commun. 380, 627-631
34. Wigle, T. J., Herold, J. M., Senisterra, G. A., Vedadi, M., Kireev, D. B., Arrowsmith, C. H., Frye, S. V., and Janzen, W. P. (2010) J. Biomol. Screen. 15, 62-71
35. Xu, Z., Nagashima, K., Sun, D., Rush, T., Northrup, A., Andersen, J. N., Kariv, I., and Bobkova, E. V. (2009) J. Biomol. Screen. 14, 1257-1262
36. Chu, C. T., Levinthal, D. J., Kulich, S. M., Chalovich, E. M., and DeFranco, D. B. (2004) Eur. J. Biochem. 271, 2060-2066
37. Szydlowska, K., Gozdz, A., Dabrowski, M., Zawadzka, M., and Kaminska, B. (2010) J. Neurochem. 113, 904-918
38. Kim, E. K., and Choi, E. J. (2010) Biochim. Biophys. Acta 1802, 396-405
39. Boutros, T., Chevet, E., and Metrakos, P. (2008) Pharmacol. Rev. 60, 261-310
40. May, L. T., Leach, K., Sexton, P. M., and Christopoulos, A. (2007) Annu. Rev. Pharmacol. Toxicol. 47, 1-51
41. Valant, C., Sexton, P. M., and Christopoulos, A. (2009) Mol. Interv. 9, 125-135
42. Price, M. R., Baillie, G. L., Thomas, A., Stevenson, L. A., Easson, M., Goodwin, R., McLean, A., McIntosh, L., Goodwin, G., Walker, G., Westwood, P., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R. G., and Ross, R. A. (2005) Mol. Pharmacol. 68, 1484-1495
43. Milligan, G., Stoddart, L. A., and Smith, N. J. (2009) Br. J. Pharmacol. 158, 146-153
44. Padwal, R. S., and Majumdar, S. R. (2007) Lancet 369, 71-77
45. Scheen, A. J., Finer, N., Hollander, P., Jensen, M. D., and Van Gaal, L. F. (2006) Lancet 368, 1660-1672
46. Comelli, F., Bettoni, I., Colombo, A., Fumagalli, P., Giagnoni, G., and Costa, B. (2010) Eur. J. Pharmacol. 637, 62-69
47. Costa, B., Trovato, A. E., Colleoni, M., Giagnoni, G., Zarini, E., and Croci, T. (2005) Pain 116, 52-61
48. Jafari, M. R., Golmohammadi, S., Ghiasvand, F., Zarrindast, M. R., and Djahanguiri, B. (2007) Behav. Pharmacol. 18, 691-697
49. Elmes, S. J., Jhaveri, M. D., Smart, D., Kendall, D. A., and Chapman, V. (2004) Eur. J. Neurosci. 20, 2311-2320
50. Schuelert, N., Zhang, C., Mogg, A. J., Broad, L. M., Hepburn, D. L., Nisenbaum, E. S., Johnson, M. P., and McDougall, J. J. (2010) Osteoarthritis Cartilage 18, 1536-1543
51. Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V., and Mechoulam, R. (2009) Trends Pharmacol. Sci. 30, 515-527
52. Pertwee, R. G. (2008) Br. J. Pharmacol. 153, 199-215
53. Ishiguro, H., Onaivi, E. S., Horiuchi, Y., Imai, K., Komaki, G., Ishikawa, T., Suzuki, M., Watanabe, Y., Ando, T., Higuchi, S., and Arinami, T. (2011) Synapse 65, 103-108
54. Riedel, G., Fadda, P., McKillop-Smith, S., Pertwee, R. G., Platt, B., and Robinson, L. (2009) Br. J. Pharmacol. 156, 1154-1166
55. Aragona, M., Onesti, E., Tomassini, V., Conte, A., Gupta, S., Gilio, F., Pantano, P., Pozzilli, C., and Inghilleri, M. (2009) Clin. Neuropharmacol. 32, 41-47
56. Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., and Fallon, M. T. (2010) J. Pain Symptom Manage 39, 167-179
57. Ramer, R., Merkord, J., Rohde, H., and Hinz, B. (2010) Biochem. Pharmacol. 79, 955-966
58. De Petrocellis, L., Vellani, V., Schiano-Moriello, A., Marini, P., Magherini, P. C., Orlando, P., and Di Marzo, V. (2008) J. Pharmacol. Exp. Ther. 325, 1007-1015
59. Ligresti, A., Moriello, A. S., Starowicz, K., Matias, I., Pisanti, S., De Petrocellis, L., Laezza, C., Portella, G., Bifulco, M., and Di Marzo, V. (2006) J. Pharmacol. Exp. Ther. 318, 1375-1387
60. Klein, R. M., Spofford, L. S., Abel, E. V., Ortiz, A., and Aplin, A. E. (2008) Mol. Biol. Cell 19, 498-508
61. Pritchard, C. A., Hayes, L., Wojnowski, L., Zimmer, A., Marais, R. M., and Norman, J. C. (2004) Mol. Cell. Biol. 24, 5937-5952
62. Kotsikorou, E., Madrigal, K. E., Hurst, D. P., Sharir, H., Lynch, D. L., Heynen-Genel, S., Milan, L. B., Chung, T. D., Seltzman, H. H., Bai, Y., Caron, M. G., Barak, L., Abood, M. E., and Reggio, P. H. (2011) Biochemistry 50, 5633-5647