Leptin as a mediator between obesity and cardiac dysfunction;Leptyna jako hormon ła̧cza̧cy otyłoś ć z dysfunkcja̧ miȩśnia sercowego

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 66, Issue , 2012, Pages 267-274

  Karbowska, Joanna ^a   Kochan, Zdzisław ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Cardiac remodelling; Heart failure; Heart rate; Hypertrophy; Leptin; Obesity

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; CARDIOVASCULAR DISEASE; CORONARY ARTERY DISEASE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HEART MUSCLE CELL; HEART RATE; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; METABOLISM; OBESITY; PHYSIOLOGY; REVIEW; WEIGHT REDUCTION;

ADIPOSE TISSUE; CARDIOVASCULAR DISEASES; CORONARY ARTERY DISEASE; HEART RATE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LEPTIN; MYOCARDIUM; MYOCYTES, CARDIAC; OBESITY; VENTRICULAR REMODELING; WEIGHT LOSS;

EID: 84867960397     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.997817     Document Type: Review

References (50)

1. Abe Y., Ono K., Kawamura T., Wada H., Kita T., Shimatsu A., Hasegawa K.: Leptin induces elongation of cardiac myocyte and causes eccentric left ventricular dilatation with compensation. Am. J. Physiol. Heart. Circ. Physiol., 2007;292:H2387-H2396
2. Abel E. D., Litwin S. E., Sweeney G.: Cardiac remodeling in obesity. Physiol. Rev., 2008;88:389-419
3. Akasaka Y., Tsunoda M., Ogata T., Ide T., Murakami K.: Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. Biochim. Biophys. Acta, 2010;1801:1115-1122
4. Atkinson L. L., Fischer M. A., Lopaschuk G. D.: Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J. Biol. Chem., 2002;277:29424-29430
5. Bjorbaek C., Uotani S., da Silva B., Flier J. S.: Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem., 1997;272:32686-32695
6. Considine R. V., Sinha M. K., Heiman M. L., Kriauciunas A., Stephens T. W., Nyce M. R., Ohannesian J. P., Marco C. C., McKee L. J., Bauer T. L., Caro J. F.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med., 1996;334:292-295
7. Correia M. L., Morgan D. A., Sivitz W. I., Mark A. L., Haynes W. G.: Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension, 2001;37:936-942
8. Elmquist J. K., Bjorbaek C., Ahima R. S., Flier J. S., Saper C. B.: Distributions of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol., 1998;395:535-547
9. Fedak P. W., Verma S., Weisel R. D., Li R. K.: Cardiac remodeling and failure. From molecules to man (Part II). Cardiovasc. Pathol., 2005;14:49-60
10. Fei H., Okano H. J., Li C., Lee G. H., Zhao C., Darnell R., Friedman J. M.: Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. USA, 1997;94:7001-7005
11. Friedman J. M., Halaas J. L.: Leptin and the regulation of body weight in mammals. Nature, 1998;395:763-770
12. Gogga P., Karbowska J., Meissner W., Kochan Z.: Rola leptyny w regulacji metabolizmu lipidów i wȩglowodanów. Postȩpy Hig. Med. Dośw., 2011;65:255-262
13. Guzman-Ruiz R., Somoza B., Gil-Ortega M., Merino B., Cano V., Attane C., Castan-Laurell I., Valet P., Fernandez-Alfonso M. S., Ruiz-Gayo M.: Sensitivity of cardiac carnitine palmitoyltransferase to malonyl-CoA is regulated by leptin: similarities with a model of endogenous hyperleptinemia. Endocrinology, 2010;151:1010-1018
14. Illiano G., Naviglio S., Pagano M., Spina A., Chiosi E., Barbieri M., Paolisso G.: Leptin affects adenylate cyclase activity in H9c2 cardiac cell line: effects of short-and long-term exposure. Am. J. Hypertens., 2002;15:638-643
15. Jaffer I., Riederer M., Shah P., Peters P., Quehenberger F., Wood A., Scharnagl H., Marz W., Kostner K. M., Kostner G. M.: Expression of fat mobilizing genes in human epicardial adipose tissue. Atherosclerosis, 2012;220:122-127
16. Keung W., Cadete V. J., Palaniyappan A., Jablonski A., Fischer M., Lopaschuk G. D.: Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet. J. Cardiovasc. Pharmacol., 2011;57:103-113
17. King K. L., Okere I. C., Sharma N., Dyck J. R., Reszko A. E., McElfresh T. A., Kerner J., Chandler M. P., Lopaschuk G. D., Stanley W. C.: Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power. Am. J. Physiol. Heart Circ. Physiol., 2005;289:H1033-H1037
18. Kochan Z., Karbowska J.: Wydzielnicza funkcja tkanki tłuszczowej. Postȩpy Biochem., 2004;50:256-271
19. Kochan Z., Karbowska J., Swierczynski J.: The effects of weight cycling on serum leptin levels and lipogenic enzyme activities in adipose tissue. J. Physiol. Pharmacol., 2006;57(Suppl.6):115-127
20. Kopelman P.: Health risks associated with overweight and obesity. Obes. Rev., 2007;8(Suppl.1):13-17
21. Li Y. Y., Feldman A. M., Sun Y., McTiernan C. F.: Differential expression of tissue inhibitors of metalloproteinases in the failing human heart. Circulation, 1998;98:1728-1734
22. Lohse M. J., Engelhardt S., Eschenhagen T.: What is the role of β-adrenergic signaling in heart failure? Circ. Res., 2003;93:896-906
23. Lonnqvist F., Arner P., Nordfors L., Schalling M.: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat. Med., 1995;1:950-953
24. Madani S., De Girolamo S., Munoz D. M., Li R. K., Sweeney G.: Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc. Res., 2006;69:716-725
25. Maffei M., Halaas J., Ravussin E., Pratley R. E., Lee G. H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., Friedman J. M.: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med., 1995;1:1155-1161
26. Masuzaki H., Ogawa Y., Isse N., Satoh N., Okazaki T., Shigemoto M., Mori K., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., Nakao K.: Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes, 1995;44:855-858
27. Narkiewicz K., Somers V. K., Mos L., Kato M., Accurso V., Palatini P.: An independent relationship between plasma leptin and heart rate in untreated patients with essential hypertension. J. Hypertens., 1999;17:245-249
28. Palanivel R., Eguchi M., Shuralyova I., Coe I., Sweeney G.: Distinct effects of short-and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes. Metabolism, 2006;55:1067-1075
29. Paolisso G., Tagliamonte M. R., Galderisi M., Zito G. A., Petrocelli A., Carella C., de Divitiis O., Varricchio M.: Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension, 1999;34:1047-1052
30. Perego L., Pizzocri P., Corradi D., Maisano F., Paganelli M., Fiorina P., Barbieri M., Morabito A., Paolisso G., Folli F., Pontiroli A. E.: Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J. Clin. Endocrinol. Metab., 2005;90:4087-4093
31. Pratley R. E., Ren K., Milner M. R., Sell S. M.: Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans. Mol. Genet. Metab., 2000;70:19-26
32. Purdham D. M., Rajapurohitam V., Zeidan A., Huang C., Gross G. J., Karmazyn M.: A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart. Am. J. Physiol. Heart. Circ. Physiol., 2008;295:H441-H446
33. Purdham D. M., Zou M. X., Rajapurohitam V., Karmazyn M.: Rat heart is a site of leptin production and action. Am. J. Physiol. Heart. Circ. Physiol., 2004;287:H2877-H2884
34. Rajapurohitam V., Gan X. T., Kirshenbaum L. A., Karmazyn M.: The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ. Res., 2003;93:277-279
35. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., Auwerx J.: Transient increase in obese gene expression after food intake or insulin administration. Nature, 1995;377:527-529
36. Schram K., De Girolamo S., Madani S., Munoz D., Thong F., Sweeney G.: Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes. Cell. Mol. Biol. Lett., 2010;15:551-563
37. Schram K., Wong M. M., Palanivel R., No E. K., Dixon I. M., Sweeney G.: Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts. J. Mol. Cell. Cardiol., 2008;44:874-881
38. Schulze P. C., Kratzsch J., Linke A., Schoene N., Adams V., Gielen S., Erbs S., Moebius-Winkler S., Schuler G.: Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur. J. Heart Fail., 2003;5:33-40
39. Sharma V., Mustafa S., Patel N., Wambolt R., Allard M. F., McNeill J. H.: Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism. Eur. J. Pharmacol., 2009;617:113-117
40. Shek E. W., Brands M. W., Hall J. E.: Chronic leptin infusion increases arterial pressure. Hypertension, 1998;31:409-414
41. Slieker L. J., Sloop K. W., Surface P. L., Kriauciunas A., La Quier F., Manetta J., Bue-Valleskey J., Stephens T. W.: Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem., 1996;271:5301-5304
42. Soderberg S., Colquhoun D., Keech A., Yallop J., Barnes E. H., Pollicino C., Simes J., Tonkin A. M., Nestel P.; LIPID Study Investigators: Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study. Int. J. Obes., 2009;33:123-130
43. Tajmir P., Ceddia R. B., Li R. K., Coe I. R., Sweeney G.: Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase-and phosphatidylinositol 3-kinase-dependent signaling pathways. Endocrinology, 2004;145:1550-1555
44. Toda C., Shiuchi T., Lee S., Yamato-Esaki M., Fujino Y., Suzuki A., Okamoto S., Minokoshi Y.: Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes, 2009;58:2757-2765
45. Wallace A. M., Mcmahon A. D., Packard C. J., Kelly A., Shepherd J., Gaw A., Sattar N.: Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation, 2001;104:3052-3056
46. Winnicki M., Phillips B. G., Accurso V., Van De Borne P., Shamsuzzaman A., Patil K., Narkiewicz K., Somers V. K.: Independent association between plasma leptin levels and heart rate in heart transplant recipients. Circulation, 2001;104:384-386
47. Xu F. P., Chen M. S., Wang Y. Z., Yi Q., Lin S. B., Chen A. F., Luo J. D.: Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation, 2004;110:1269-1275
48. Yang G., Ge H., Boucher A., Yu X., Li C.: Modulation of direct leptin signaling by soluble leptin receptor. Mol. Endocrinol., 2004;18:1354-1362
49. Zabeau L., Defeau D., Van der Heyden J., Iserentant H., Vandekerckhove J., Tavernier J.: Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay. Mol. Endocrinol., 2004;18:150-161
50. Zhang Y., Guo K. Y., Diaz P. A., Heo M., Leibel R. L.: Determinants of leptin gene expression in fat depots of lean mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002;282:R226-R234