Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism

European Journal of Pharmacology

Volumn 617, Issue 1-3, 2009, Pages 113-117

  Sharma, Vijay ^a   Mustafa, Sally ^a   Patel, Natasha ^a   Wambolt, Richard ^b   Allard, Michael F ^b   McNeill, John H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

Author keywords

Fatty acid oxidation; Heart; Leptin; Nitric oxide; p38 MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRIC OXIDE; NITRITE; PYRUVIC ACID; STAT3 PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE; FATTY ACID OXIDATION; HEART FUNCTION; HEART PERFUSION; ISOLATED HEART; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; FATTY ACIDS; GLUCOSE; HEART; LACTIC ACID; LEPTIN; MALE; MITOCHONDRIA; MYOCARDIUM; NITRATES; NITRIC OXIDE; NITRITES; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; STAT3 TRANSCRIPTION FACTOR;

EID: 68549088696     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.037     Document Type: Article

References (18)

1. Allard M.F., Schonekess B.O., Henning S.L., English D.R., and Lopaschuk G.D. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am. J. Physiol. 267 (1994) H742-750
2. Allard M.F., Parsons H.L., Saeedi R., Wambolt R.B., and Brownsey R. AMPK and metabolic adaptation by the heart to pressure overload. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H140-148
3. Almeida A., Moncada S., and Bolanos J.P. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat. Cell Biol. 6 (2004) 45-51
4. Atkinson L.L., Fischer M.A., and Lopaschuk G.D. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J. Biol. Chem. 277 (2002) 29424-29430
5. Barr R., and Lopaschuk G. Measurements of energy metabolism in the isolated heart. In: McNeill J.H. (Ed). Measurement of Cardiac Function (1997), CRC Press, Boca Raton, Fl
6. Bielawska A.E., Shapiro J.P., Jiang L., Melkonyan H.S., Piot C., Wolfe C.L., Tomei L.D., Hannun Y.A., and Umansky S.R. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am. J. Pathol. 151 (1997) 1257-1263
7. Brown N.F. Expression, purification and reconstitution of rat liver carnitine palmitoyltransferase I. In: Selinsky B.S. (Ed). Membrane Protein Protocols: Expression, Purification and Characterisation vol. 228 (2003), Humana Press Inc., Totowa, NJ
8. Flier J.S. Clinical review 94: what's in a name? In search of leptin's physiologic role. J. Clin. Endocrinol. Metab. 83 (1998) 1407-1413
9. Kim S.O., Xu Y., Katz S., and Pelech S. Cyclic GMP-dependent and -independent regulation of MAP kinases by sodium nitroprusside in isolated cardiomyocytes. Biochim. Biophys. Acta 1496 (2000) 277-284
10. Lydell C.P., Chan A., Wambolt R.B., Sambandam N., Parsons H., Bondy G.P., Rodrigues B., Popov K.M., Harris R.A., Brownsey R.W., and Allard M.F. Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts. Cardiovasc. Res. 53 (2002) 841-851
11. Nickola M.W., Wold L.E., Colligan P.B., Wang G.J., Samson W.K., and Ren J. Leptin attenuates cardiac contraction in rat ventricular myocytes. Role of NO. Hypertension 36 (2000) 501-505
12. Palanivel R., Eguchi M., Shuralyova I., Coe I., and Sweeney G. Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes. Metabolism 55 (2006) 1067-1075
13. Rabkin S.W., Klassen S.S., and Tsang M.Y. Sodium nitroprusside activates p38 mitogen activated protein kinase through a cGMP/PKG independent mechanism. Life Sci. 81 (2007) 640-646
14. Ren J. Leptin and hyperleptinemia - from friend to foe for cardiovascular function. J. Endocrinol. 181 (2004) 1-10
15. Saeedi R., Parsons H.L., Wambolt R.B., Paulson K., Sharma V., Dyck J.R., Brownsey R.W., and Allard M.F. Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms. Am. J. Physiol. Heart Circ. Physiol. 294 (2008) H2497-2506
16. Severson D.L. Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes. Can. J. Physiol. Pharmacol. 82 (2004) 813-823
17. Tong H., Chen W., London R.E., Murphy E., and Steenbergen C. Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by phosphatidylinositol 3-kinase. J. Biol. Chem. 275 (2000) 11981-11986
18. Wold L.E., Relling D.P., Duan J., Norby F.L., and Ren J. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway. Hypertension 39 (2002) 69-74