Determinants of leptin gene expression in fat depots of lean mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 282, Issue 1 51-1, 2002, Pages

  Zhang, Yiying ^a   Guo, Kai Ying ^a   Diaz, Patricia A ^a   Heo, Moonseong ^a   Leibel, Rudolph L ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Glucocorticoid receptor; Insulin receptor; Tumor necrosis factor

Indexed keywords

GLUCOCORTICOID RECEPTOR; INSULIN RECEPTOR; LEPTIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; GENE EXPRESSION; LEAN BODY WEIGHT; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0036084221     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00392.2001     Document Type: Article

References (59)

1. Human fat cell sizing-a quick, simple method
2. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects
3. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors
4. Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes
5. Insulin responsiveness of diaphragm tissue and adipose cellularity in mice selected for rapid growth
6. Effects of parabiosis of obese with diabetes and normal mice
7. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
8. Adipocyte insulin resistance: Effects of aging, obesity, exercise, and food restriction
9. Effects of stopping training on size and response to insulin of fat cells in female rats
10. A simple method to determine fat cell size and number in four mammalian species
11. Effects of cell size and animal age on glucose metabolism in pig adipose tissue
12. Adipose tissue regeneration following lipectomy
13. Noncompensation of adipose mass in partially lipectomized mice and rats
14. Clinical review 94: What's in a name? In search of leptin's physiologic role
15. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
16. Alteration in membrane lipid order and composition in metabolically hyperactive fatty rat adipocytes
17. Regulation of leptin production in cultured mature white adipocytes
18. The effects of lesions in the hypothalamus in parabiotic rats
19. Adipose cellularity in relation to human obesity
20. Insulin responsiveness in non-fa/fa and fa/fa Zucker rats: Effects of adipocyte size
21. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
22. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α
23. Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans
24. The role of depot fat in the hypothalamic control of food intake in the rats
25. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro
26. Regulation of leptin by steroid hormones in rat adipose tissue
27. Regulation by cytokines of leptin expression in human bone marrow adipocytes
28. Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes
29. Expression of ob gene in adipose cells. Regulation by insulin
30. Leptin gene expression increases with age independent of increasing adiposity in rats
31. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
32. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L 1 adipocytes
33. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
34. Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue
35. Effects of tumor necrosis factor-α on leptin secretion and gene expression: Relationship to changes of glucose metabolism in isolated rat adipocytes
36. Differential binding of dexamethasone to ammonium sulfate precipitates of human adipose tissue cytosols
37. Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution
38. Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3T3-L 1 adipocytes
39. Adipose tissue-derived tumor necrosis factor activity correlates with fat cell size but not insulin action in aging rats
40. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes
41. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats
42. Characterization of regional and gender differences in glucocorticoid receptors and lipoprotein lipase activity in human adipose tissue
43. Plasma leptin responses to fasting in Pima Indians
44. Effects of gender, body composition, and menopause on plasma concentrations of leptin
45. Leptin expression in adipose tissue from obese humans: Depot-specific regulation by insulin and dexamethasone
46. Physiological insulinemia acutely modulates plasma leptin
47. Transient increase in obese gene expression after food intake or insulin administration
48. Effects of hyperinsulinaemia and hypoglycaemia on circulating leptin levels in healthy lean males
49. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
50. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
51. Protein kinase C mediates tumor necrosis factor-α-induced inhibition of obese gene expression and leptin secretion in brown adipocytes
52. Leptin secretion from subcutaneous and visceral adipose tissue in women
53. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
54. Leptin production in adipocytes from morbidly obese subjects: Stimulation by dexamethasone, inhibition with troglitazone, and influence of gender
55. The role of insulin as a satiety factor in the central nervous system
56. Insulin binding and action in adipocytes in vitro in relation to insulin action in vivo in young and middle-aged subjects
57. Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups
58. The leptin receptor mediates apparent autocrine regulation of leptin gene expression
59. Differential expression of ob mRNA in rat adipose tissues in response to insulin