-
1
-
-
0141737573
-
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
-
Ducy P., et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000, 100:197-207.
-
(2000)
Cell
, vol.100
, pp. 197-207
-
-
Ducy, P.1
-
2
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell 2001, 104:531-543.
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
3
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
-
4
-
-
2442654859
-
Identification and expression cloning of a leptin receptor OB-R
-
Tartaglia L.A., et al. Identification and expression cloning of a leptin receptor OB-R. Cell 1995, 83:1263-1271.
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
-
5
-
-
0036847619
-
Leptin regulates bone formation via the sympathetic nervous system
-
Takeda S., et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002, 111:305-317.
-
(2002)
Cell
, vol.111
, pp. 305-317
-
-
Takeda, S.1
-
6
-
-
15844384047
-
Leptin regulation of bone resorption by the sympathetic nervous system and CART
-
Elefteriou F., et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005, 434:514-520.
-
(2005)
Nature
, vol.434
, pp. 514-520
-
-
Elefteriou, F.1
-
7
-
-
0037118285
-
High bone density due to a mutation in LDL-receptor-related protein 5
-
Boyden L.M., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 2002, 346:1513-1521.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1513-1521
-
-
Boyden, L.M.1
-
8
-
-
33751538595
-
Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation
-
Huising M.O., et al. Increased leptin expression in common Carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation. Endocrinology 2006, 147:5786-5797.
-
(2006)
Endocrinology
, vol.147
, pp. 5786-5797
-
-
Huising, M.O.1
-
9
-
-
78049518505
-
The central regulation of bone mass, the first link between bone remodeling and energy metabolism
-
Karsenty G., Oury F. The central regulation of bone mass, the first link between bone remodeling and energy metabolism. J. Clin. Endocrinol. Metab. 2010, 95:4795-4801.
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 4795-4801
-
-
Karsenty, G.1
Oury, F.2
-
10
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K., et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998, 392:398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
-
11
-
-
0030273540
-
Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm
-
Lee K., et al. Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm. Mech. Dev. 1996, 59:153-164.
-
(1996)
Mech. Dev.
, vol.59
, pp. 153-164
-
-
Lee, K.1
-
12
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A., et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 1998, 18:213-215.
-
(1998)
Nat. Genet.
, vol.18
, pp. 213-215
-
-
Strobel, A.1
-
13
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague C.T., et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997, 387:903-908.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
-
14
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
-
Chen H., et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996, 84:491-495.
-
(1996)
Cell
, vol.84
, pp. 491-495
-
-
Chen, H.1
-
15
-
-
34248227278
-
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
-
Bjornholm M., et al. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J. Clin. Invest. 2007, 117:1354-1360.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1354-1360
-
-
Bjornholm, M.1
-
16
-
-
58149498221
-
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo
-
Shi Y., et al. Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:20529-20533.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 20529-20533
-
-
Shi, Y.1
-
17
-
-
0031010408
-
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
-
Fei H., et al. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:7001-7005.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 7001-7005
-
-
Fei, H.1
-
18
-
-
0033944070
-
Leptin regulation of neuroendocrine systems
-
Ahima R.S., et al. Leptin regulation of neuroendocrine systems. Front. Neuroendocrinol. 2000, 21:263-307.
-
(2000)
Front. Neuroendocrinol.
, vol.21
, pp. 263-307
-
-
Ahima, R.S.1
-
19
-
-
84990756135
-
Hypothalamic lesions and adipocity in the rat
-
Hetherington A.W., Ranson S.W. Hypothalamic lesions and adipocity in the rat. Anat. Rec. 1940, 78:149.
-
(1940)
Anat. Rec.
, vol.78
, pp. 149
-
-
Hetherington, A.W.1
Ranson, S.W.2
-
20
-
-
84981834057
-
The relation of various hypothalamic lesions to adiposity in the rat
-
Hetherington A.W., Ranson S.W. The relation of various hypothalamic lesions to adiposity in the rat. J. Comp. Neurol. 1942, 76:475-499.
-
(1942)
J. Comp. Neurol.
, vol.76
, pp. 475-499
-
-
Hetherington, A.W.1
Ranson, S.W.2
-
21
-
-
0000833791
-
Mechanisms of the development of obesity in animals with hypothalamic lesions
-
Brobeck J.R. Mechanisms of the development of obesity in animals with hypothalamic lesions. Physiol. Rev. 1946, 26:541-559.
-
(1946)
Physiol. Rev.
, vol.26
, pp. 541-559
-
-
Brobeck, J.R.1
-
22
-
-
84964125510
-
Localization of a feeding center in the hypothalamus of the rat
-
Anand B.K., Brobeck J.R. Localization of a feeding center in the hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 1951, 77:323-324.
-
(1951)
Proc. Soc. Exp. Biol. Med.
, vol.77
, pp. 323-324
-
-
Anand, B.K.1
Brobeck, J.R.2
-
23
-
-
0014668762
-
Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
-
Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969, 164:719-721.
-
(1969)
Science
, vol.164
, pp. 719-721
-
-
Olney, J.W.1
-
24
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
Halaas J.L., et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:8878-8883.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 8878-8883
-
-
Halaas, J.L.1
-
25
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N., et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42:983-991.
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
-
26
-
-
69449083603
-
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
-
Yadav V.K., et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 2009, 138:976-989.
-
(2009)
Cell
, vol.138
, pp. 976-989
-
-
Yadav, V.K.1
-
27
-
-
34347262073
-
Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men
-
Haney E.M., et al. Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch. Intern. Med. 2007, 167:1246-1251.
-
(2007)
Arch. Intern. Med.
, vol.167
, pp. 1246-1251
-
-
Haney, E.M.1
-
28
-
-
0032213967
-
Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa
-
Kaye W., et al. Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa. Biol. Psychiatry 1998, 44:825-838.
-
(1998)
Biol. Psychiatry
, vol.44
, pp. 825-838
-
-
Kaye, W.1
-
29
-
-
52549085920
-
Osteoporosis after combined use of a neuroleptic and antidepressants
-
Laekeman G., et al. Osteoporosis after combined use of a neuroleptic and antidepressants. Pharm. World Sci. 2008, 30:613-616.
-
(2008)
Pharm. World Sci.
, vol.30
, pp. 613-616
-
-
Laekeman, G.1
-
30
-
-
33846440508
-
Effect of selective serotonin reuptake inhibitors on the risk of fracture
-
Richards J.B., et al. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch. Intern. Med. 2007, 167:188-194.
-
(2007)
Arch. Intern. Med.
, vol.167
, pp. 188-194
-
-
Richards, J.B.1
-
31
-
-
54449089554
-
Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures
-
Ziere G., et al. Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. J. Clin. Psychopharmacol. 2008, 28:411-417.
-
(2008)
J. Clin. Psychopharmacol.
, vol.28
, pp. 411-417
-
-
Ziere, G.1
-
32
-
-
0029362878
-
Serotonin receptors. Genetic insights into serotonin function
-
Heath M.J., Hen R. Serotonin receptors. Genetic insights into serotonin function. Curr. Biol. 1995, 5:997-999.
-
(1995)
Curr. Biol.
, vol.5
, pp. 997-999
-
-
Heath, M.J.1
Hen, R.2
-
33
-
-
0037414862
-
Synthesis of serotonin by a second tryptophan hydroxylase isoform
-
Walther D.J., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003, 299:76.
-
(2003)
Science
, vol.299
, pp. 76
-
-
Walther, D.J.1
-
34
-
-
0026474532
-
Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology
-
Mann J.J., et al. Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology. Biol. Psychiatry 1992, 32:243-257.
-
(1992)
Biol. Psychiatry
, vol.32
, pp. 243-257
-
-
Mann, J.J.1
-
35
-
-
77958523915
-
CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons
-
Oury F., et al. CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 2010, 24:2330-2342.
-
(2010)
Genes Dev.
, vol.24
, pp. 2330-2342
-
-
Oury, F.1
-
36
-
-
78651495664
-
Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications
-
Yadav V.K., et al. Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J. Exp. Med. 2011, 208:41-52.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 41-52
-
-
Yadav, V.K.1
-
37
-
-
0021846661
-
Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat
-
Dourish C.T., et al. Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacol. (Berl.) 1985, 86:197-204.
-
(1985)
Psychopharmacol. (Berl.)
, vol.86
, pp. 197-204
-
-
Dourish, C.T.1
-
38
-
-
0024244472
-
Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats
-
Gilbert F., et al. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology 1988, 13:471-478.
-
(1988)
Psychoneuroendocrinology
, vol.13
, pp. 471-478
-
-
Gilbert, F.1
-
39
-
-
0023721864
-
MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake
-
Neill J.C., Cooper S.J. MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake. Eur. J. Pharmacol. 1988, 151:329-332.
-
(1988)
Eur. J. Pharmacol.
, vol.151
, pp. 329-332
-
-
Neill, J.C.1
Cooper, S.J.2
-
40
-
-
0026613774
-
Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys
-
Moreau J.L., et al. Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys. Brain Res. Bull. 1992, 29:901-904.
-
(1992)
Brain Res. Bull.
, vol.29
, pp. 901-904
-
-
Moreau, J.L.1
-
41
-
-
0031721271
-
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
-
Nonogaki K., et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 1998, 4:1152-1156.
-
(1998)
Nat. Med.
, vol.4
, pp. 1152-1156
-
-
Nonogaki, K.1
-
42
-
-
44349100977
-
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms
-
Srinivasan S., et al. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008, 7:533-544.
-
(2008)
Cell Metab.
, vol.7
, pp. 533-544
-
-
Srinivasan, S.1
-
43
-
-
0030218856
-
Metergoline antagonizes fluoxetine-induced suppression of food intake but not changes in the behavioural satiety sequence
-
Halford J.C., Blundell J.E. Metergoline antagonizes fluoxetine-induced suppression of food intake but not changes in the behavioural satiety sequence. Pharmacol. Biochem. Behav. 1996, 54:745-751.
-
(1996)
Pharmacol. Biochem. Behav.
, vol.54
, pp. 745-751
-
-
Halford, J.C.1
Blundell, J.E.2
-
44
-
-
0031596722
-
Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats
-
Lee M.D., et al. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacol. (Berl.) 1998, 136:304-307.
-
(1998)
Psychopharmacol. (Berl.)
, vol.136
, pp. 304-307
-
-
Lee, M.D.1
-
45
-
-
0023678368
-
Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors
-
Kennett G.A., Curzon G. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. Psychopharmacol. (Berl.) 1988, 96:93-100.
-
(1988)
Psychopharmacol. (Berl.)
, vol.96
, pp. 93-100
-
-
Kennett, G.A.1
Curzon, G.2
-
46
-
-
0028298214
-
An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats
-
Kitchener S.J., Dourish C.T. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacol. (Berl) 1994, 113:369-377.
-
(1994)
Psychopharmacol. (Berl)
, vol.113
, pp. 369-377
-
-
Kitchener, S.J.1
Dourish, C.T.2
-
47
-
-
0030903068
-
RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist
-
Bonhaus D.W., et al. RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology 1997, 36:621-629.
-
(1997)
Neuropharmacology
, vol.36
, pp. 621-629
-
-
Bonhaus, D.W.1
-
48
-
-
77950858037
-
Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content
-
Fernandez-Galaz M.C. Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content. Brain Res. 2010, 1329:194-202.
-
(2010)
Brain Res.
, vol.1329
, pp. 194-202
-
-
Fernandez-Galaz, M.C.1
-
49
-
-
0842308719
-
The role of leptin-STAT3 signaling in neuroendocrine function: an integrative perspective
-
Bates S.H., Myers M.G. The role of leptin-STAT3 signaling in neuroendocrine function: an integrative perspective. J. Mol. Med. 2004, 82:12-20.
-
(2004)
J. Mol. Med.
, vol.82
, pp. 12-20
-
-
Bates, S.H.1
Myers, M.G.2
-
50
-
-
0028931604
-
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
-
Stahl N., et al. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 1995, 267:1349-1353.
-
(1995)
Science
, vol.267
, pp. 1349-1353
-
-
Stahl, N.1
-
51
-
-
0031040793
-
Leptin receptor (OB-R) signaling Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization
-
White D.W., et al. Leptin receptor (OB-R) signaling Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J. Biol. Chem. 1997, 272:4065-4071.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4065-4071
-
-
White, D.W.1
-
52
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks A.S., et al. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 2000, 275:14563-14572.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
|