Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice

Neuroscience Letters

Volumn 433, Issue 2, 2008, Pages 82-86

  Erbayat Altay, Ebru ^a   Yamada, Kelvin A ^a   Wong, Michael ^a   Thio, Liu Lin ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Absence seizure; Anticonvulsant; Clonic tonic seizure; Ketogenic diet; Myoclonic seizure; Video EEG

Indexed keywords

ION CHANNEL; LEPTIN; PENTETRAZOLE;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ELECTROENCEPHALOGRAM; IN VIVO STUDY; MALE; MOUSE; MOUSE STRAIN; MYOCLONUS SEIZURE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; SEIZURE; TONIC CLONIC SEIZURE; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; LEPTIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; PENTYLENETETRAZOLE; REACTION TIME; SEIZURES; SEVERITY OF ILLNESS INDEX;

EID: 39649116909     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.12.051     Document Type: Article

References (20)

1. Ahima R.S., Bjorbaek C., Osei S., and Flier J.S. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140 (1999) 2755-2762
2. Andre V., Pineau N., Motte J.E., Marescaux C., and Nehlig A. Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-Fos immunohistochemical study. Eur. J. Neurosci. 10 (1998) 2094-2106
3. Ayyildiz M., Yildirim M., Agar E., and Baltaci A.K. The effect of leptin on penicillin-induced epileptiform activity in rats. Brain Res. Bull. 68 (2006) 374-378
4. Banks W.A. The many lives of leptin. Peptides 25 (2004) 331-338
5. Durakoglugil M., Irving A.J., and Harvey J. Leptin induces a novel form of NMDA receptor-dependent long-term depression. J. Neurochem. 95 (2005) 396-405
6. Erbayat-Altay E., Yamada K., Wong M., and Thio L.L. Increased severity of pentylenetetrazol-induced seizures in leptin deficient ob/ob mice. Epilepsia 47 (2006) 303 S4
7. Indrayan A., and Sarmukaddam S.B. Inference from means. Medical Biostatistics (2001), CRC Press Taylor & Francis Group, Boca Raton, FL pp. 393-452
8. Kinzig K.P., Scott K.A., Hyun J., Bi S., and Moran T.H. Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet. Obes. Res. 13 (2005) 1672-1682
9. Matochik J.A., London E.D., Yildiz B.O., Ozata M., Caglayan S., Depaoli A.M., Wong M.L., and Licinio J. Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J. Clin. Endocrinol. Metab. 90 (2005) 2851-2854
10. McColl C.D., Horne M.K., Finkelstein D.I., Wong J.Y., Berkovic S.F., and Drago J. Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the α4 subunit of the neuronal nicotinic receptor. Neuropharmacology 44 (2003) 234-243
11. O'Malley D., Irving A.J., and Harvey J. Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels. FASEB J. 19 (2005) 1917-1919
12. Shanley L.J., Irving A.J., and Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J. Neurosci. 21 (2001) RC186
13. Shanley L.J., O'Malley D., Irving A.J., Ashford M.L., and Harvey J. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. J. Physiol. 545 (2002) 933-944
14. A receptor: a critical role for metabotropic glutamate receptor 4 (mGluR4). J. Neurosci. 20 (2000) 6218-6224
15. + channels in hypothalamic neurons of lean, but not obese rats. Nat. Neurosci. 3 (2000) 757-758
16. Steppan C.M., and Swick A.G. A role for leptin in brain development. Biochem. Biophys. Res. Commun. 256 (1999) 600-602
17. Thio L.L., Erbayat-Altay E., Rensing N., and Yamada K.A. Leptin contributes to slower weight gain in juvenile rodents on a ketogenic diet. Pediatr. Res. 60 (2006) 413-417
18. Wong M., Wozniak D.F., and Yamada K.A. An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects. Exp. Neurol. 183 (2003) 87-99
19. Xu L., Rensing N., Yang X.F., Zhang H.X., Thio L.L., Rothman S.M., Weisenfeld A.E., Wong M., and Yamada K.A. Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J. Clin. Invest. 118 (2008) 272-280
20. Yonekawa W.D., Kupferberg H.J., and Woodbury D.M. Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice. J. Pharmacol. Exp. Ther. 214 (1980) 589-593