Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis

Peptides

Volumn 32, Issue 8, 2011, Pages 1567-1574

  Otvos Jr , Laszlo ^a,b   Shao, Wen Hai ^c   Vanniasinghe, Anne S ^d   Amon, Michael A ^e   Holub, Marianna Csilla ^f   Kovalszky, Ilona ^g   Wade, John D ^h   Doll, Michelle ^c   Cohen, Philip L ^c   Manolios, Nicholas ^d   Surmacz, Eva ^b,i  

^a Temple University   (United States)

^b Peptherx Inc   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d University of Sydney   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f SEMMELWEIS UNIVERSITY   (Hungary)

^g SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^h UNIVERSITY OF MELBOURNE   (Australia)

ⁱ TEMPLE UNIVERSITY   (United States)

Author keywords

Adjuvant induced arthritis; Antagonist; Inflammation; K BxN serum arthritis; Leptin; NF B pathway; Peptides

Indexed keywords

ALLO ACA; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTIN; LEPTIN RECEPTOR; METHOTREXATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LEPTIN; LEUKOCYTES, MONONUCLEAR; MICE; MICE, TRANSGENIC; OLIGOPEPTIDES; RATS; RECEPTORS, LEPTIN;

ANIMALIA; MUS; RATTUS;

EID: 80051551943     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.06.015     Document Type: Article

References (67)

1. Y. Alamanos, and A.A. Drosos Epidemiology of adult rheumatoid arthritis Autoimmun Rev 4 2005 130 136 (Pubitemid 40488741)
2. H.J. Anders, M. Rihl, A. Heufelder, O. Loch, and M. Schattenkirchner Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis Metabolism 48 1999 745 748 (Pubitemid 29277646)
3. M. Barbier, C. Cherbut, A.C. Aube, H.M. Blottiere, and J.P. Galmiche Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats Gut 43 1998 183 790
4. A.M. Bendele Animal models of rheumatoid arthritis J Musculoskelet Neuron Interact 1 2001 377 385
5. C. Bjorbaek, S. Uotani, B. da Silva, and J.S. Flier Divergent signaling capacities of the long and short isoforms of the leptin receptor J Biol Chem 272 1997 32686 32695 (Pubitemid 28011961)
6. C. Bjorbaek, R.M. Buchholz, S.M. Davis, S.H. Bates, D.D. Pierroz, and H. Gu Divergent roles of SHP-2 in ERK activation by leptin receptors J Biol Chem 276 2001 4747 4755
7. M. Bokarewa, D. Bokarew, O. Hultgren, and A. Tarkowski Leptin consumption in the inflamed joints of patients with rheumatoid arthritis Ann Rheum Dis 62 2003 952 956 (Pubitemid 37159493)
8. B. Canavan, R.O. Salem, S. Schurgin, P. Koutkia, I. Lipinska, and M. Laposata Effects of physiological leptin administration on markers of inflammation, platelet activation and platelet aggregation during caloric deprivation J Clin Endocrinol Metab 90 2005 5779 5795
9. B. Cakir, A. Bozkurt, F. Ercan, and B.C. Yegen The anti-inflammatory effect of leptin on experimental colitis: involvement of endogenous glucocorticoids Peptides 25 2004 95 104 (Pubitemid 38304946)
10. J.L. Chan, S.J. Moschos, J. Bullen, K. Heist, X. Li, and Y.-B. Kim Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-α receptor levels in humans with relative leptin deficiency J Clin Endocrinol Metab 90 2005 1625 1631 (Pubitemid 40464029)
11. M. Fazeli, H. Zarkesh-Esfahani, Z. Wu, M. Maamra, M. Bidlingmaier, and A.G. Pockley Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation J Immunol Methods 312 2006 190 200 (Pubitemid 44209011)
12. U. Feige, A. Schulmeister, J. Mollenhauer, K. Brune, and H. Bang A constitutive 65 kDa chondrocyte protein as a target antigen in adjuvant arthritis in Lewis rats Autoimmunity 17 1994 233 239 (Pubitemid 24218312)
13. R. Fleischmann Safety and efficacy of disease-modifying anti-rheumatic agents: focus on the benefits and risks of etanercept Drug Saf 25 2002 173 197 (Pubitemid 34492938)
14. C. Garofalo, D. Sisci, and E. Surmacz Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells Clin Cancer Res 10 2004 6466 6475 (Pubitemid 39346542)
15. C. Garofalo, and E. Surmacz Leptin and cancer J Cell Physiol 207 2006 12 22
16. R.R. Gonzalez, and P.C. Leavis A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells Endocrine 21 2003 185 195 (Pubitemid 36936361)
17. R.R. Gonzalez-Perez, Y. Xu, S. Guo, A. Watters, W. Zhou, and S.J. Leibovich Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFκB/HIF-1α activation Cell Signal 22 2010 1350 1362
18. E. Goyenechea, D. Parra, A.B. Crujeiras, I. Abete, and J.A. Martinez A nutrigenomic inflammation-related PBMC-based approach to predict the weight-loss regain in obese subjects Ann Nutr Metab 54 2009 43 51
19. M. Granado, T. Priego, A.I. Martin, A. Villanua, and A. Lopez-Calderon Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats Am J Physiol Metab 288 2005 E486 E492
20. M. Granado, A.I. Martin, E. Castillero, and A. Lopez-Calderon Cyclooxigenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation Eur J Pharmacol 17 2009 97 103
21. R. Gunaydin, T. Kaya, A. Atay, N. Olmez, A. Hur, and M. Koseoglu Serum leptin levels in rheumatoid arthritis and relationships with disease activity South Med J 99 2006 1078 1083 (Pubitemid 44631238)
22. F. Haugen, and C.A. Devon Activation of nuclear factor κB by high molecular weight and globular adiponectin Endocrinology 148 2007 5478 5486 (Pubitemid 350012628)
23. M.S. Hickey, J.A. Houmard, R.V. Considine, G.L. Tyndall, J.B. Midgette, and K.E. Gavigan Gender-dependent effects of exercise training on serum leptin levels in humans Am J Physiol 274 1997 E562 E566
24. S. Hizmetli, M. Kisa, N. Gokalp, and M.Z. Bakici Are plasma and synovial fluid levels correlated with disease activity in rheumatoid arthritis? Rheumatol Int 27 2007 335 338 (Pubitemid 46122275)
25. O.H. Hultgren, and A. Tarkowski Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon administration Arthritis Res 3 2001 389 394 (Pubitemid 33080820)
26. J. Jurcovicova, K. Svik, S. Scsukopva, K. Bauerova, J. Rovensky, and M. Stancikova Methotrexate treatment ameliorated testicular suppression and anorexia related leptin reduction in rats with adjuvant arthritis Rheumatol Int 29 2009 1187 1191
27. I. Kovalszky, E. Surmacz, L. Scolaro, M. Cassone, A. Sztodola, and J. Olah Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models Diabetes Obes Metab 12 2010 393 402
28. D. Kyburz, and M. Corr The KRN mouse model of inflammatory arthritis Springer Semin Immunopathol 25 2003 79 90 (Pubitemid 37000040)
29. D.M. Lee, D.S. Friend, M.F. Gurish, C. Benoist, D. Mathis, and M.B. Brenner Mast cells; a cellular link between autoantibodies and inflammatory arthritis Science 297 2002 1689 1692 (Pubitemid 35000781)
30. S. Loffreda, S.Q. Yang, H.Z. Lin, C.L. Karp, M.L. Brengman, and D.J. Wang Leptin regulates proinflammatory immune responses FASEB J 12 1998 57 65 (Pubitemid 28060271)
31. N. Manolios, S. Collier, J. Tailor, J. Pollard, L.C. Harrison, and V. Bender T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease Nat Med 3 1997 84 88 (Pubitemid 27019147)
32. C.S. Mantzoros The role of leptin in human obesity and disease: a review of current evidence Ann Intern Med 130 1999 671 680 (Pubitemid 29196202)
33. A.I. Martin, E. Catillero, M. Granado, M. Lopez-Menduina, M.A. Villanua, and A. Lopez-Calderon Adipose tissue in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis J Endocrinol 197 2008 111 119 (Pubitemid 351566930)
34. G. Matarese, V. Sanna, R.I. Lechler, N. Sarvetnik, S. Fontana, and S. Zappacosta Leptin accelerates autoimmune diabetes in female NOD mice Diabetes 51 2002 1356 1361 (Pubitemid 34826599)
35. I. Matsumoto, A. Staub, C. Benoist, and D. Mathis Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme Science 286 1999 1732 1735 (Pubitemid 129515879)
36. V. Miskolci, J. Rollins, H.Y. Vu, C.C. Ghosh, D. Davidson, and I. Vancurova NFκB is persistently activated in continuously stimulated human neutrophils Mol Med 13 2007 134 142 (Pubitemid 46944955)
37. P.A. Monach, D. Mathis, and C. Benoist The K/BxN arthritis model Curr Protoc Immunol S81 2008 15.22.1-12
38. A.D. Mooradian, and J.M. Chehade Serum leptin response to endogenous hyperinsulinemia in aging rats Mech Ageing Dev 115 2000 101 106 (Pubitemid 30347440)
39. P. Nair, K. Radford, A. Fanat, L.J. Janssen, M. Peters-Golden, and P.G. Cox The effects of leptin on airway smooth muscle responses Am J Respir Cell Mol Biol 39 2008 475 481
40. L. Niv-Spector, D. Gonen-Berger, I. Gourdou, E. Biener, E.E. Gussakovsky, and Y. Benomar Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists Biochem J 391 2005 221 230 (Pubitemid 41532418)
41. P.B. Noto, G. Abbadessa, M. Cassone, G.D. Mateo, A. Agelan, and J.D. Wade Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo Protein Sci 17 2008 1249 1255 (Pubitemid 351930922)
42. E. Ostorhazi, M.C. Holub, F. Rozgonyi, F. Harmos, M. Cassone, and J.D. Wade The broad spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved Int J Antimicrob Agents 37 2011 480 484
43. M. Otero, R. Lago, R. Gomez, F. Lago, C. Dieguez, and J.J. Gomez-Reino Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis Ann Rheum Dis 65 2006 1198 1201 (Pubitemid 44277396)
44. L. Otvos Jr., M. Terrasi, S. Cascio, M. Cassone, G. Abbadessa, and F. di Pascali Development of a pharmacologically improved peptide agonist of the leptin receptor Biochim Biophys Acta 1783 2008 1745 1754
45. L. Otvos Jr., I. Kovalszky, L. Scolaro, A. Sztodola, J. Olah, and M. Cassone Peptide-based receptor antagonists for cancer treatment and appetite regulation Biopolymers 96 2011 117 125
46. L. Otvos Jr., I. Kovalszky, M. Riolfi, R. Ferla, J. Olah, and A. Sztodola Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer Eur J Cancer 47 2011 1578 1584
47. M.A. Panagoulias, Z. Dervilli, V. Zolota, P. Spadidea, M. Rodi, and F.P. Panitsas Expression patterns of leptin receptor (OB-R) isoforms and direct in vitro effects of recombinant leptin on OB-R, leptin expression and cytokine secretion by human hematopoietic malignant cells Cytokine 48 2009 203 211
48. E. Papathanassoglou, K. El-Haschimi, X.C. Li, G. Matarese, T. Strom, and C. Mantzoros Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice J Immunol 176 2006 7745 7752 (Pubitemid 43849075)
49. F. Peelman, H. Iserentant, A.S. De Smet, J. Vandekerckhove, L. Zabeau, and J. Tavernier Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex J Biol Chem 281 2006 15496 15504 (Pubitemid 43855142)
50. C. Popa, M.G. Netea, T.R. Radstake, P.L. van Riel, P. Barrera, and J.W. van der Meer Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis Ann Rheum Dis 64 2005 1195 1198 (Pubitemid 41113356)
51. D.P. Rose, E.M. Gilhooly, and D.W. Nixon Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin Int J Oncol 21 2002 1285 1292
52. J. Santos-Alvarez, R. Goberna, and V. Sanchez-Margalet Human leptin stimulates proliferation and activation of human circulating monocytes Cell Immunol 194 1999 6 11 (Pubitemid 29283971)
53. J.-P. Segain, R. de la Bletiere, A. Bourreille, V. Leray, N. Gervois, and C. Rosales Butyrate inhibits inflammatory responses through NFκB inhibition: implication for Crohn's disease Gut 47 2000 397 403
54. A. Stofkova Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity Endocr Regul 43 2009 157 168
55. E. Suresh Recent advances in rheumatoid arthritis Postgrad Med J 86 2010 243 250
56. G. Sweeney Leptin signalling Cell Signal 14 2002 655 663 (Pubitemid 34518619)
57. L.A. Tartaglia The leptin receptor J Biol Chem 272 1997 6093 6096 (Pubitemid 27118072)
58. C.J. Tobon, P. Youinou, and A. Saraux The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis Autoimmun Rev 35 2010 10 14
59. A. Tokarczyk-Knapik, M. Nowicki, and J. Wyroslak The relation between plasma leptin concentration and body fat mass in patients with rheumatoid arthritis Pol Arch Med Wewn 108 2002 761 767
60. T. Tomimatsu, M. Yamaguchi, T. Murakami, K. Ogura, M. Sakata, and N. Mitsuda Increase of mouse leptin production by adipose tissue after midpregnancy: gestational profile of serum leptin concentration Biochem Biophys Res Commun 240 1997 213 215 (Pubitemid 27503777)
61. P.C. Tsiotra, V. Pappa, A. Koukourava, T. Economopoulos, C. Tsigos, and S.A. Raptos Expression of leptin receptors in mononuclear cells from myelodusplastic syndromes and acute myeloid leukemias Acta Haematol 114 2005 71 77 (Pubitemid 41160933)
62. A.G.M. Van de Langerijt, P.L.E.M. van Lent, A.R.M.M. Hermus, C.G.J. Sweep, A.R. Cools, and W.B. van de Berg Susceptibility to adjuvant arthritis: relative importance of adrenal activity and bacterial flora Clin Exp Immunol 97 1994 33 38 (Pubitemid 24244051)
63. R.R. Wing, M.K. Sinha, R.V. Considine, W. Lang, and J.F. Caro Relationship between weight loss maintenance and changes in serum leptin levels Horm Metab Res 28 1996 698 703 (Pubitemid 27057919)
64. M. Wauters, R.V. Considine, and L.F. Van Gaal Human leptin: from an adipocyte hormone to an endocrine mediator Eur J Endocrinol 143 2000 293 311
65. E. Xiao, L. Xia-Zhang, N.R. Vulleimoz, M. Ferin, and S.L. Werdlaw Leptin modules inflammatory cytokine and neuroendocrine responses to endotoxin in the primate Endocrinology 144 2003 4350 4353 (Pubitemid 37204834)
66. M.J. Yeom, H.C. Lee, G.H. Kim, I. Shim, H.J. Lee, and D.H. Hahm Therapeutic effects of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat Biol Pharm Bull 26 2003 1472 1477 (Pubitemid 41685402)
67. H. Zarkesh-Esfahani, G. Pockley, R.A. Metcalfe, M. Bidlingmaier, Z. Wu, and A. Ajami High-dose leptin activates human leukocytes via receptor expression on monocytes J Immunol 167 2001 4593 4599 (Pubitemid 32954339)