The extracellular matrix and ciliary signaling

Current Opinion in Cell Biology

Volumn 24, Issue 5, 2012, Pages 652-661

  Seeger Nukpezah, Tamina ^a   Golemis, Erica A ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN;

CELL ADHESION; CILIARY MOTILITY; EUKARYOTIC FLAGELLUM; EXTRACELLULAR MATRIX; FOCAL ADHESION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CILIA; EXTRACELLULAR MATRIX; HUMANS; MEMBRANE PROTEINS; POLYCYSTIC KIDNEY DISEASES; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 84867851891     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2012.06.002     Document Type: Review

References (112)

1. Marcet B., Chevalier B., Luxardi G., Coraux C., Zaragosi L.E., Cibois M., Robbe-Sermesant K., Jolly T., Cardinaud B., Moreilhon C., et al. Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway. Nat Cell Biol 2011, 13:693-699.
2. Lee L. Mechanisms of mammalian ciliary motility: insights from primary ciliary dyskinesia genetics. Gene 2011, 473:57-66.
3. Kim S., Tsiokas L. Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle 2011, 10:2683-2690.
4. Avasthi P., Marshall W.F. Stages of ciliogenesis and regulation of ciliary length. Differentiation 2012, 83:S30-S42.
5. Harris P.C., Torres V.E. Polycystic kidney disease. Annu Rev Med 2009, 60:321-337.
6. Plotnikova O.V., Golemis E.A., Pugacheva E.N. Cell cycle-dependent ciliogenesis and cancer. Cancer Res 2008, 68:2058-2061.
7. Ishikawa H., Marshall W.F. Ciliogenesis: building the cell's antenna. Nat Rev Mol Cell Biol 2011, 12:222-234.
8. Wu J., Du H., Wang X., Mei C., Sieck G.C., Qian Q. Characterization of primary cilia in human airway smooth muscle cells. Chest 2009, 136:561-570.
9. McGlashan S.R., Cluett E.C., Jensen C.G., Poole C.A. Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters. Dev Dyn 2008, 237:2013-2020.
10. McGlashan S.R., Jensen C.G., Poole C.A. Localization of extracellular matrix receptors on the chondrocyte primary cilium. J Histochem Cytochem 2006, 54:1005-1014.
11. Ascenzi M.G., Lenox M., Farnum C. Analysis of the orientation of primary cilia in growth plate cartilage: a mathematical method based on multiphoton microscopical images. J Struct Biol 2007, 158:293-306.
12. Donnelly E., Ascenzi M.G., Farnum C. Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon. J Orthop Res 2010, 28:77-82.
13. Tsiokas L. Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Renal Physiol 2009, 297:F1-F9.
14. Chapin H.C., Caplan M.J. The cell biology of polycystic kidney disease. J Cell Biol 2010, 191:701-710.
15. Qian F., Wei W., Germino G., Oberhauser A. The nanomechanics of polycystin-1 extracellular region. J Biol Chem 2005, 280:40723-40730.
16. Drummond I.A. Polycystins, focal adhesions and extracellular matrix interactions. Biochim Biophys Acta 2011, 1812:1322-1326.
17. Mangos S., Lam P.Y., Zhao A., Liu Y., Mudumana S., Vasilyev A., Liu A., Drummond I.A. The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Models Mech 2010, 3:354-365.
18. Ingham P.W., Nakano Y., Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011, 12:393-406.
19. Schneider L., Cammer M., Lehman J., Nielsen S.K., Guerra C.F., Veland I.R., Stock C., Hoffmann E.K., Yoder B.K., Schwab A., et al. Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem 2010, 25:279-292.
20. Schneider L., Stock C.M., Dieterich P., Jensen B.H., Pedersen L.B., Satir P., Schwab A., Christensen S.T., Pedersen S.F. The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium. J Cell Biol 2009, 185:163-176.
21. Praetorius H.A., Praetorius J., Nielsen S., Frokiaer J., Spring K.R. Beta1-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signaling. Am J Physiol Renal Physiol 2004, 287:F969-F978.
22. Ezratty E.J., Stokes N., Chai S., Shah A.S., Williams S.E., Fuchs E. A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 2011, 145:1129-1141.
23. Benzing T., Gerke P., Hopker K., Hildebrandt F., Kim E., Walz G. Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. Proc Natl Acad Sci USA 2001, 98:9784-9789.
24. Delous M., Hellman N.E., Gaude H.M., Silbermann F., Le Bivic A., Salomon R., Antignac C., Saunier S. Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6. Hum Mol Genet 2009, 18:4711-4723.
25. Liebau M.C., Hopker K., Muller R.U., Schmedding I., Zank S., Schairer B., Fabretti F., Hohne M., Bartram M.P., Dafinger C., et al. Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem 2011, 286:14237-14245.
26. Donaldson J.C., Dempsey P.J., Reddy S., Bouton A.H., Coffey R.J., Hanks S.K. Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res 2000, 256:168-178.
27. Mollet G., Silbermann F., Delous M., Salomon R., Antignac C., Saunier S. Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes. Hum Mol Genet 2005, 14:645-656.
28. Simons M., Gloy J., Ganner A., Bullerkotte A., Bashkurov M., Kronig C., Schermer B., Benzing T., Cabello O.A., Jenny A., et al. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 2005, 37:537-543.
29. Dzamba B.J., Jakab K.R., Marsden M., Schwartz M.A., DeSimone D.W. Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization. Dev Cell 2009, 16:421-432.
30. Garcia-Gonzalo F.R., Corbit K.C., Sirerol-Piquer M.S., Ramaswami G., Otto E.A., Noriega T.R., Seol A.D., Robinson J.F., Bennett C.L., Josifova D.J., et al. A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nat Genet 2011, 43:776-784.
31. Sang L., Miller J.J., Corbit K.C., Giles R.H., Brauer M.J., Otto E.A., Baye L.M., Wen X., Scales S.J., Kwong M., et al. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 2011, 145:513-528.
32. Wolf M.T., Hildebrandt F. Nephronophthisis. Pediatr Nephrol 2011, 26:181-194.
33. Salomon R., Saunier S., Niaudet P. Nephronophthisis. Pediatr Nephrol 2009, 24:2333-2344.
34. Attanasio M., Uhlenhaut N.H., Sousa V.H., O'Toole J.F., Otto E., Anlag K., Klugmann C., Treier A.C., Helou J., Sayer J.A., et al. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat Genet 2007, 39:1018-1024.
35. Pugacheva E.N., Jablonski S.A., Hartman T.R., Henske E.P., Golemis E.A. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 2007, 129:1351-1363.
36. Tobin J.L., Di Franco M., Eichers E., May-Simera H., Garcia M., Yan J., Quinlan R., Justice M.J., Hennekam R.C., Briscoe J., et al. Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Proc Natl Acad Sci USA 2008, 105:6714-6719.
37. Vasilyev A., Liu Y., Mudumana S., Mangos S., Lam P.Y., Majumdar A., Zhao J., Poon K.L., Kondrychyn I., Korzh V., et al. Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol 2009, 7:e9.
38. Guirao B., Meunier A., Mortaud S., Aguilar A., Corsi J.M., Strehl L., Hirota Y., Desoeuvre A., Boutin C., Han Y.G., et al. Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat Cell Biol 2010, 12:341-350.
39. Lee J.E., Gleeson J.G. Cilia in the nervous system: linking cilia function and neurodevelopmental disorders. Curr Opin Neurol 2011, 24:98-105.
40. Sawamoto K., Wichterle H., Gonzalez-Perez O., Cholfin J.A., Yamada M., Spassky N., Murcia N.S., Garcia-Verdugo J.M., Marin O., Rubenstein J.L., et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 2006, 311:629-632.
41. Muhammad H., Rais Y., Miosge N., Ornan E.M. The primary cilium as a dual sensor of mechanochemical signals in chondrocytes. Cell Mol Life Sci 2012, 69:2101-2107.
42. Jensen C.G., Poole C.A., McGlashan S.R., Marko M., Issa Z.I., Vujcich K.V., Bowser S.S. Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ. Cell Biol Int 2004, 28:101-110.
43. Farnum C.E., Wilsman N.J. Orientation of primary cilia of articular chondrocytes in three-dimensional space. Anat Rec 2011, 294:533-549.
44. Wann A.K., Zuo N., Haycraft C.J., Jensen C.G., Poole C.A., McGlashan S.R., Knight M.M. Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes. FASEB J 2012, 26:1663-1671.
45. McGlashan S.R., Haycraft C.J., Jensen C.G., Yoder B.K., Poole C.A. Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris. Matrix Biol 2007, 26:234-246.
46. Zhang Q., Murcia N.S., Chittenden L.R., Richards W.G., Michaud E.J., Woychik R.P., Yoder B.K. Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn 2003, 227:78-90.
47. Song B., Haycraft C.J., Seo H.S., Yoder B.K., Serra R. Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol 2007, 305:202-216.
48. Kaushik A.P., Martin J.A., Zhang Q., Sheffield V.C., Morcuende J.A. Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet-Biedl syndrome mutant mice. J Orthop Res 2009, 27:1093-1099.
49. Chang C.F., Ramaswamy G., Serra R. Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis. Osteoarthritis Cartilage 2012, 20:152-161.
50. Gardner K., Arnoczky S.P., Lavagnino M. Effect of in vitro stress-deprivation and cyclic loading on the length of tendon cell cilia in situ. J Orthop Res 2011, 29:582-587.
51. Kwon R.Y., Temiyasathit S., Tummala P., Quah C.C., Jacobs C.R. Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J 2010, 24:2859-2868.
52. Malone A.M., Anderson C.T., Tummala P., Kwon R.Y., Johnston T.R., Stearns T., Jacobs C.R. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci USA 2007, 104:13325-13330.
53. Hoey D.A., Kelly D.J., Jacobs C.R. A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun 2011, 412:182-187.
54. Gao J., DeRouen M.C., Chen C.H., Nguyen M., Nguyen N.T., Ido H., Harada K., Sekiguchi K., Morgan B.A., Miner J.H., et al. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 2008, 22:2111-2124.
55. DeRouen M.C., Zhen H., Tan S.H., Williams S., Marinkovich M.P., Oro A.E. Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol 2010, 10:112.
56. McDermott K.M., Liu B.Y., Tlsty T.D., Pazour G.J. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol 2010, 20:731-737.
57. Bergmann C., Fliegauf M., Bruchle N.O., Frank V., Olbrich H., Kirschner J., Schermer B., Schmedding I., Kispert A., Kranzlin B., et al. Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet 2008, 82:959-970.
58. Gallagher A.R., Esquivel E.L., Briere T.S., Tian X., Mitobe M., Menezes L.F., Markowitz G.S., Jain D., Onuchic L.F., Somlo S. Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1. Am J Pathol 2008, 172:417-429.
59. Norman J. Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD). Biochim Biophys Acta 2011, 1812:1327-1336.
60. Stroope A., Radtke B., Huang B., Masyuk T., Torres V., Ritman E., LaRusso N. Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease. Am J Pathol 2010, 176:1282-1291.
61. Togawa H., Nakanishi K., Mukaiyama H., Hama T., Shima Y., Sako M., Miyajima M., Nozu K., Nishii K., Nagao S., et al. Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease. Am J Physiol Renal Physiol 2011, 300:F511-F520.
62. Arts H.H., Bongers E.M., Mans D.A., van Beersum S.E., Oud M.M., Bolat E., Spruijt L., Cornelissen E.A., Schuurs-Hoeijmakers J.H., de Leeuw N., et al. C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome. J Med Genet 2011, 48:390-395.
63. Natoli T.A., Gareski T.C., Dackowski W.R., Smith L., Bukanov N.O., Russo R.J., Husson H., Matthews D., Piepenhagen P., Ibraghimov-Beskrovnaya O. Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures. Am J Physiol Renal Physiol 2008, 294:F73-F83.
64. Streets A.J., Wagner B.E., Harris P.C., Ward C.J., Ong A.C. Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells. J Cell Sci 2009, 122:1410-1417.
65. Joly D., Morel V., Hummel A., Ruello A., Nusbaum P., Patey N., Noel L.H., Rousselle P., Knebelmann B. Beta4 integrin and laminin 5 are aberrantly expressed in polycystic kidney disease: role in increased cell adhesion and migration. Am J Pathol 2003, 163:1791-1800.
66. Klingel R., Ramadori G., Schuppan D., Knittel T., Meyer zum Buschenfelde K.H., Kohler H. Coexpression of extracellular matrix glycoproteins undulin and tenascin in human autosomal dominant polycystic kidney disease. Nephron 1993, 65:111-118.
67. Nakamura T., Ushiyama C., Suzuki S., Ebihara I., Shimada N., Koide H. Elevation of serum levels of metalloproteinase-1, tissue inhibitor of metalloproteinase-1 and type IV collagen, and plasma levels of metalloproteinase-9 in polycystic kidney disease. Am J Nephrol 2000, 20:32-36.
68. Battini L., Fedorova E., Macip S., Li X., Wilson P.D., Gusella G.L. Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance. J Am Soc Nephrol 2006, 17:3049-3058.
69. Egorova A.D., Khedoe P.P., Goumans M.J., Yoder B.K., Nauli S.M., ten Dijke P., Poelmann R.E., Hierck B.P. Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Circ Res 2011, 108:1093-1101.
70. van Adelsberg J. Murine polycystic kidney epithelial cell lines have increased integrin-mediated adhesion to collagen. Am J Physiol 1994, 267:F1082-F1093.
71. Boucher C.A., Ward H.H., Case R.L., Thurston K.S., Li X., Needham A., Romero E., Hyink D., Qamar S., Roitbak T., et al. Receptor protein tyrosine phosphatases are novel components of a polycystin complex. Biochim Biophys Acta 2011, 1812:1225-1238.
72. Huan Y., van Adelsberg J. Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest 1999, 104:1459-1468.
73. Geng L., Burrow C.R., Li H.P., Wilson P.D. Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation. Biochim Biophys Acta 2000, 1535:21-35.
74. Kaletta T., Van der Craen M., Van Geel A., Dewulf N., Bogaert T., Branden M., King K.V., Buechner M., Barstead R., Hyink D., et al. Towards understanding the polycystins. Nephron Exp Nephrol 2003, 93:e9-e17.
75. Li H.P., Geng L., Burrow C.R., Wilson P.D. Identification of phosphorylation sites in the PKD1-encoded protein C-terminal domain. Biochem Biophys Res Commun 1999, 259:356-363.
76. Wilson P.D., Geng L., Li X., Burrow C.R. The PKD1 gene product, " polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia. Lab Invest 1999, 79:1311-1323.
77. Woods A.J., White D.P., Caswell P.T., Norman J.C. PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions. EMBO J 2004, 23:2531-2543.
78. Cano D.A., Sekine S., Hebrok M. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 2006, 131:1856-1869.
79. Jonassen J.A., Sanagustin J., Baker S.P., Pazour G.J. Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol 2012, 23:641-651.
80. Jonassen J.A., San Agustin J., Follit J.A., Pazour G.J. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 2008, 183:377-384.
81. Lin F., Hiesberger T., Cordes K., Sinclair A.M., Goldstein L.S., Somlo S., Igarashi P. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 2003, 100:5286-5291.
82. Shannon M.B., Patton B.L., Harvey S.J., Miner J.H. A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease. J Am Soc Nephrol 2006, 17:1913-1922.
83. Condac E., Silasi-Mansat R., Kosanke S., Schoeb T., Towner R., Lupu F., Cummings R.D., Hinsdale M.E. Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci USA 2007, 104:9416-9421.
84. Joly D., Berissi S., Bertrand A., Strehl L., Patey N., Knebelmann B. Laminin 5 regulates polycystic kidney cell proliferation and cyst formation. J Biol Chem 2006, 281:29181-29189.
85. Shields M.A., Dangi-Garimella S., Redig A.J., Munshi H.G. Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression. Biochem J 2012, 441:541-552.
86. Jun J.I., Lau L.F. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 2011, 10:945-963.
87. Abrass C.K., Berfield A.K. Phenotypic modulation of rat glomerular visceral epithelial cells by culture substratum. J Am Soc Nephrol 1995, 5:1591-1599.
88. Tissir F., Qu Y., Montcouquiol M., Zhou L., Komatsu K., Shi D., Fujimori T., Labeau J., Tyteca D., Courtoy P., et al. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci 2010, 13:700-707.
89. Rondanino C., Poland P.A., Kinlough C.L., Li H., Rbaibi Y., Myerburg M.M., Al-bataineh M.M., Kashlan O.B., Pastor-Soler N.M., Hallows K.R., et al. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol 2011, 301:F622-F633.
90. Pan J., You Y., Huang T., Brody S.L. RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J Cell Sci 2007, 120:1868-1876.
91. Pitaval A., Tseng Q., Bornens M., Thery M. Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells. J Cell Biol 2010, 191:303-312.
92. Adams M., Simms R.J., Abdelhamed Z., Dawe H.R., Szymanska K., Logan C.V., Wheway G., Pitt E., Gull K., Knowles M.A., et al. A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet 2012, 21:1272-1286.
93. Kim J., Lee J.E., Heynen-Genel S., Suyama E., Ono K., Lee K., Ideker T., Aza-Blanc P., Gleeson J.G. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 2010, 464:1048-1051.
94. Bershteyn M., Atwood S.X., Woo W.M., Li M., Oro A.E. MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell 2010, 19:270-283.
95. Tikhmyanova N., Golemis E.A. NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. PLoS ONE 2011, 6:e22102.
96. Fashena S.J., Einarson M.B., O'Neill G.M., Patriotis C., Golemis E.A. Dissection of HEF1-dependent functions in motility and transcriptional regulation. J Cell Sci 2002, 115:99-111.
97. Tikhmyanova N., Little J.L., Golemis E.A. CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci 2010, 67:1025-1048.
98. Plotnikova O.V., Nikonova A.S., Loskutov Y.V., Kozyulina P.Y., Pugacheva E.N., Golemis E.A. Calmodulin activation of Aurora-A (AURKA) is required during ciliary disassembly and in mitosis. Mol Biol Cell 2012, [Epub ahead of print].
99. Plotnikova O.V., Pugacheva E.N., Golemis E.A. Aurora A kinase activity influences calcium signaling in kidney cells. J Cell Biol 2011, 193:1021-1032.
100. Plotnikova O.V., Pugacheva E.N., Dunbrack R.L., Golemis E.A. Rapid calcium-dependent activation of Aurora-A kinase. Nat Commun 2010, 1:64.
101. Thoma C.R., Frew I.J., Hoerner C.R., Montani M., Moch H., Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol 2007, 9:588-595.
102. Kuehn E.W., Walz G., Benzing T. Von Hippel-Lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res 2007, 67:4537-4540.
103. Xu J., Li H., Wang B., Xu Y., Yang J., Zhang X., Harten S.K., Shukla D., Maxwell P.H., Pei D., et al. VHL inactivation induces HEF1 and Aurora kinase A. J Am Soc Nephrol 2010, 21:2041-2046.
104. Zhou Q., Pardo A., Konigshoff M., Eickelberg O., Budinger G.R., Thavarajah K., Gottardi C.J., Jones J., Varga J., Selman M., et al. Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J 2011, 25:3032-3044.
105. Schietke R.E., Hackenbeck T., Tran M., Gunther R., Klanke B., Warnecke C.L., Knaup K.X., Shukla D., Rosenberger C., Koesters R., et al. Renal tubular HIF-2alpha expression requires VHL inactivation and causes fibrosis and cysts. PLoS ONE 2012, 7:e31034.
106. Gomez Garcia E.B., Knoers N.V. Gardner's syndrome (familial adenomatous polyposis): a cilia-related disorder. Lancet Oncol 2009, 10:727-735.
107. Siemens J., Lillo C., Dumont R.A., Reynolds A., Williams D.S., Gillespie P.G., Muller U. Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature 2004, 428:950-955.
108. Sollner C., Rauch G.J., Siemens J., Geisler R., Schuster S.C., Muller U., Nicolson T. Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells. Nature 2004, 428:955-959.
109. Dawe H.R., Adams M., Wheway G., Szymanska K., Logan C.V., Noegel A.A., Gull K., Johnson C.A. Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci 2009, 122:2716-2726.
110. Lu C.J., Du H., Wu J., Jansen D.A., Jordan K.L., Xu N., Sieck G.C., Qian Q. Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells. Kidney Blood Press Res 2008, 31:171-184.
111. Luyten A., Su X., Gondela S., Chen Y., Rompani S., Takakura A., Zhou J. Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol 2010, 21:1521-1532.
112. Shao Y.Y., Wang L., Welter J.F., Ballock R.T. Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone 2012, 50:79-84.