Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition

Circulation Research

Volumn 108, Issue 9, 2011, Pages 1093-1101

  Egorova, Anastasia D ^a   Khedoe, Padmini P S J ^a   Goumans, Marie José T H ^a   Yoder, Bradley K ^b   Nauli, Surya M ^c   Ten Dijke, Peter ^a   Poelmann, Robert E ^a   Hierck, Beerend P ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

cilia; EndoMT; endothelial cells; Klf4; shear stress; Tg737orpk orpk; Tgf Alk5

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CD31 ANTIGEN; KRUPPEL LIKE FACTOR 4; NCAD PROTEIN; PAIL PROTEIN; SMAD2 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EUKARYOTIC FLAGELLUM; GENE MUTATION; HEART; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; CELL DIFFERENTIATION; CILIA; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MECHANOTRANSDUCTION, CELLULAR; MESODERM; MICE; MICE, MUTANT STRAINS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN; STRESS, MECHANICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 79955583104     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.231860     Document Type: Article

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