메뉴 건너뛰기




Volumn 21, Issue 4, 2012, Pages

Clinical implications of biological markers in pancreatic ductal adenocarcinoma

Author keywords

Cancer biology; Neoplastic molecular markers; Pancreatic cancer; Pancreatic surgery

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; BRCA2 PROTEIN; CAVEOLIN 1; CETUXIMAB; CHEMOKINE RECEPTOR CXCR4; CISPLATIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DJ 1 PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; EPIDERMAL GROWTH FACTOR RECEPTOR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; ERLOTINIB; GEMCITABINE; HEAT SHOCK PROTEIN 27; K RAS PROTEIN; MATRIX METALLOPROTEINASE; MESOTHELIN; MUCIN 1; OXALIPLATIN; PROSTATE STEM CELL ANTIGEN; PROTEIN P53; SALIRASIB; SCATTER FACTOR RECEPTOR; SMAD4 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TRASTUZUMAB; UNINDEXED DRUG; VASCULOTROPIN;

EID: 84867849103     PISSN: 09607404     EISSN: 18793320     Source Type: Journal    
DOI: 10.1016/j.suronc.2012.07.004     Document Type: Review
Times cited : (16)

References (126)
  • 1
    • 0035020633 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions
    • R.H. Hruban, N.V. Adsay, J. Albores-Saavedra, C. Compton, E.S. Garrett, and S.N. Goodman Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions Am J Surg Pathol 25 2001 579 586
    • (2001) Am J Surg Pathol , vol.25 , pp. 579-586
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3    Compton, C.4    Garrett, E.S.5    Goodman, S.N.6
  • 2
    • 0032985541 scopus 로고    scopus 로고
    • Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database
    • S.F. Sener, A. Fremgen, H.R. Menck, and D.P. Winchester Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database J Am Coll Surg 189 1999 1 7
    • (1999) J Am Coll Surg , vol.189 , pp. 1-7
    • Sener, S.F.1    Fremgen, A.2    Menck, H.R.3    Winchester, D.P.4
  • 4
    • 78650507860 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia - Can we detect early pancreatic cancer?
    • B. Haugk Pancreatic intraepithelial neoplasia - can we detect early pancreatic cancer? Histopathology 57 2010 503 514
    • (2010) Histopathology , vol.57 , pp. 503-514
    • Haugk, B.1
  • 6
    • 57449106363 scopus 로고    scopus 로고
    • Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma
    • D. Antonello, S. Gobbo, V. Corbo, B. Sipos, N.R. Lemoine, and A. Scarpa Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma Pancreatology 9 2009 25 33
    • (2009) Pancreatology , vol.9 , pp. 25-33
    • Antonello, D.1    Gobbo, S.2    Corbo, V.3    Sipos, B.4    Lemoine, N.R.5    Scarpa, A.6
  • 8
    • 0035184956 scopus 로고    scopus 로고
    • Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications
    • C.J. Magee, W. Greenhalf, N. Howes, P. Ghaneh, and J.P. Neoptolemos Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications Surg Oncol 10 2001 1 23
    • (2001) Surg Oncol , vol.10 , pp. 1-23
    • Magee, C.J.1    Greenhalf, W.2    Howes, N.3    Ghaneh, P.4    Neoptolemos, J.P.5
  • 9
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, and G.B. Morin Extension of life-span by introduction of telomerase into normal human cells Science 279 1998 349 352
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3    Holt, S.E.4    Chiu, C.P.5    Morin, G.B.6
  • 10
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • C.B. Harley, A.B. Futcher, and C.W. Greider Telomeres shorten during ageing of human fibroblasts Nature 345 1990 458 460
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 11
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, and P.L. Ho Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3    Harley, C.B.4    West, M.D.5    Ho, P.L.6
  • 13
    • 48749095772 scopus 로고    scopus 로고
    • Role of menin in the regulation of telomerase activity in normal and cancer cells
    • M. Hashimoto, S. Kyo, X. Hua, S.L. Weinrich, W.H. Andrews, and J. Lingner Role of menin in the regulation of telomerase activity in normal and cancer cells Int J Oncol 33 2008 333 340
    • (2008) Int J Oncol , vol.33 , pp. 333-340
    • Hashimoto, M.1    Kyo, S.2    Hua, X.3    Weinrich, S.L.4    Andrews, W.H.5    Lingner, J.6
  • 14
    • 0033932489 scopus 로고    scopus 로고
    • Role of telomerase in normal and cancer cells
    • M. Meyerson Role of telomerase in normal and cancer cells J Clin Oncol 18 2000 2626 2634
    • (2000) J Clin Oncol , vol.18 , pp. 2626-2634
    • Meyerson, M.1
  • 15
    • 0000839280 scopus 로고    scopus 로고
    • Telomere dysfunction provokes regional amplification and deletion in cancer genomes
    • R.C. O'Hagan, S. Chang, R.S. Maser, R. Mohan, S.E. Artandi, and L. Chin Telomere dysfunction provokes regional amplification and deletion in cancer genomes Cancer Cell 2 2002 149 155
    • (2002) Cancer Cell , vol.2 , pp. 149-155
    • O'Hagan, R.C.1    Chang, S.2    Maser, R.S.3    Mohan, R.4    Artandi, S.E.5    Chin, L.6
  • 16
    • 38149109033 scopus 로고    scopus 로고
    • Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas
    • [discussion 28-9]
    • Y. Hashimoto, Y. Murakami, K. Uemura, Y. Hayashidani, T. Sudo, and H. Ohge Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas J Gastrointest Surg 12 2008 17 28 [discussion 28-9]
    • (2008) J Gastrointest Surg , vol.12 , pp. 17-28
    • Hashimoto, Y.1    Murakami, Y.2    Uemura, K.3    Hayashidani, Y.4    Sudo, T.5    Ohge, H.6
  • 17
    • 37249043127 scopus 로고    scopus 로고
    • Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer
    • Y. Hashimoto, Y. Murakami, K. Uemura, Y. Hayashidani, T. Sudo, and H. Ohge Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer Surgery 143 2008 113 125
    • (2008) Surgery , vol.143 , pp. 113-125
    • Hashimoto, Y.1    Murakami, Y.2    Uemura, K.3    Hayashidani, Y.4    Sudo, T.5    Ohge, H.6
  • 18
    • 67651100673 scopus 로고    scopus 로고
    • Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy
    • A. Nakashima, Y. Murakami, K. Uemura, Y. Hayashidani, T. Sudo, and Y. Hashimoto Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy Pancreas 38 2009 527 533
    • (2009) Pancreas , vol.38 , pp. 527-533
    • Nakashima, A.1    Murakami, Y.2    Uemura, K.3    Hayashidani, Y.4    Sudo, T.5    Hashimoto, Y.6
  • 19
    • 0037183673 scopus 로고    scopus 로고
    • Differential diagnosis between chronic pancreatitis and pancreatic cancer: Value of the detection of KRAS2 mutations in circulating DNA
    • F. Maire, S. Micard, P. Hammel, H. Voitot, P. Lévy, and P.H. Cugnenc Differential diagnosis between chronic pancreatitis and pancreatic cancer: value of the detection of KRAS2 mutations in circulating DNA Br J Cancer 87 2002 551 554
    • (2002) Br J Cancer , vol.87 , pp. 551-554
    • Maire, F.1    Micard, S.2    Hammel, P.3    Voitot, H.4    Lévy, P.5    Cugnenc, P.H.6
  • 20
    • 0141425732 scopus 로고    scopus 로고
    • BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: Potential therapeutic targets
    • E.S. Calhoun, J.B. Jones, R. Ashfaq, V. Adsay, S.J. Baker, and V. Valentine BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets Am J Pathol 163 2003 1255 1260
    • (2003) Am J Pathol , vol.163 , pp. 1255-1260
    • Calhoun, E.S.1    Jones, J.B.2    Ashfaq, R.3    Adsay, V.4    Baker, S.J.5    Valentine, V.6
  • 22
    • 77953916705 scopus 로고    scopus 로고
    • K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
    • H. Chen, H. Tu, Z.Q. Meng, Z. Chen, P. Wang, and L.M. Liu K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer Eur J Surg Oncol 36 2010 657 662
    • (2010) Eur J Surg Oncol , vol.36 , pp. 657-662
    • Chen, H.1    Tu, H.2    Meng, Z.Q.3    Chen, Z.4    Wang, P.5    Liu, L.M.6
  • 23
    • 77954108548 scopus 로고    scopus 로고
    • Single-pattern convergence of K-ras mutation correlates with surgical indication of intraductal papillary mucinous neoplasms
    • O. Mizuno, H. Kawamoto, N. Yamamoto, S. Horiguchi, K. Tsutsumi, and M. Fujii Single-pattern convergence of K-ras mutation correlates with surgical indication of intraductal papillary mucinous neoplasms Pancreas 39 2010 617 621
    • (2010) Pancreas , vol.39 , pp. 617-621
    • Mizuno, O.1    Kawamoto, H.2    Yamamoto, N.3    Horiguchi, S.4    Tsutsumi, K.5    Fujii, M.6
  • 24
    • 80052316938 scopus 로고    scopus 로고
    • KRAS mutation in metastatic pancreatic ductal adenocarcinoma: Results of a multicenter phase II study evaluating efficacy of cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line therapy
    • F. Kullmann, A. Hartmann, R. Stöhr, H. Messmann, M.M. Dollinger, and J. Trojan KRAS mutation in metastatic pancreatic ductal adenocarcinoma: results of a multicenter phase II study evaluating efficacy of cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line therapy Oncology 81 1 2011 3 8
    • (2011) Oncology , vol.81 , Issue.1 , pp. 3-8
    • Kullmann, F.1    Hartmann, A.2    Stöhr, R.3    Messmann, H.4    Dollinger, M.M.5    Trojan, J.6
  • 25
    • 84875534210 scopus 로고    scopus 로고
    • Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer
    • D. Laheru, P. Shah, and N.V. Rajeshkumar Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer Invest New Drugs 2012 May 1
    • (2012) Invest New Drugs
    • Laheru, D.1    Shah, P.2    Rajeshkumar, N.V.3
  • 26
    • 78650743475 scopus 로고    scopus 로고
    • Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras
    • S. Weden, M. Klemp, I.P. Gladhaug, M. Moller, J.A. Eriksen, and G. Gaudernack Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras Int J Cancer 128 5 2011 Mar 1 1120 1128
    • (2011) Int J Cancer , vol.128 , Issue.5 , pp. 1120-1128
    • Weden, S.1    Klemp, M.2    Gladhaug, I.P.3    Moller, M.4    Eriksen, J.A.5    Gaudernack, G.6
  • 27
  • 28
    • 0037352493 scopus 로고    scopus 로고
    • Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma
    • A.G. de Nooij-van Dalen, G.A. van Dongen, S.J. Smeets, E.J. Nieuwenhuis, M. Stigter-van Walsum, and G.B. Snow Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma Int J Cancer 103 2003 768 774
    • (2003) Int J Cancer , vol.103 , pp. 768-774
    • De Nooij-Van Dalen, A.G.1    Van Dongen, G.A.2    Smeets, S.J.3    Nieuwenhuis, E.J.4    Stigter-Van Walsum, M.5    Snow, G.B.6
  • 29
    • 0036928732 scopus 로고    scopus 로고
    • Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells
    • C.P. Tran, C. Lin, and J. Yamashiro Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells Mol Cancer Res 1 2002 113 121
    • (2002) Mol Cancer Res , vol.1 , pp. 113-121
    • Tran, C.P.1    Lin, C.2    Yamashiro, J.3
  • 30
    • 44349178008 scopus 로고    scopus 로고
    • Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
    • H. Sakamoto, K. Yoshimura, N. Saeki, H. Katai, T. Shimoda, and Y. Matsuno Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer Nat Genet 40 2008 730 740
    • (2008) Nat Genet , vol.40 , pp. 730-740
    • Sakamoto, H.1    Yoshimura, K.2    Saeki, N.3    Katai, H.4    Shimoda, T.5    Matsuno, Y.6
  • 31
    • 77954748206 scopus 로고    scopus 로고
    • Prostate stem cell antigen: A Jekyll and Hyde molecule?
    • N. Saeki, J. Gu, and T. Yoshida Prostate stem cell antigen: a Jekyll and Hyde molecule? Clin Cancer Res 16 2010 3533 3538
    • (2010) Clin Cancer Res , vol.16 , pp. 3533-3538
    • Saeki, N.1    Gu, J.2    Yoshida, T.3
  • 32
    • 0035674996 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
    • P. Argani, C. Iacobuzio-Donahue, B. Ryu, C. Rosty, M. Goggins, and R.E. Wilentz Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE) Clin Cancer Res 7 2001 3862 3868
    • (2001) Clin Cancer Res , vol.7 , pp. 3862-3868
    • Argani, P.1    Iacobuzio-Donahue, C.2    Ryu, B.3    Rosty, C.4    Goggins, M.5    Wilentz, R.E.6
  • 33
    • 0042316739 scopus 로고    scopus 로고
    • Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: Mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases
    • D.M. McCarthy, A. Maitra, P. Argani, A.E. Rader, D.O. Faigel, and N.T. Van Heek Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases Appl Immunohistochem Mol Morphol 11 2003 238 243
    • (2003) Appl Immunohistochem Mol Morphol , vol.11 , pp. 238-243
    • McCarthy, D.M.1    Maitra, A.2    Argani, P.3    Rader, A.E.4    Faigel, D.O.5    Van Heek, N.T.6
  • 34
    • 0035360275 scopus 로고    scopus 로고
    • Discovery of new markers of cancer through serial analysis of gene expression: Prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
    • P. Argani, C. Rosty, R.E. Reiter, R.E. Wilentz, S.R. Murugesan, and S.D. Leach Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma Cancer Res 61 2001 4320 4324
    • (2001) Cancer Res , vol.61 , pp. 4320-4324
    • Argani, P.1    Rosty, C.2    Reiter, R.E.3    Wilentz, R.E.4    Murugesan, S.R.5    Leach, S.D.6
  • 35
    • 0036098611 scopus 로고    scopus 로고
    • Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas
    • B. Terris, E. Blaveri, T. Crnogorac-Jurcevic, M. Jones, E. Missiaglia, and P. Ruszniewski Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas Am J Pathol 160 2002 1745 1754
    • (2002) Am J Pathol , vol.160 , pp. 1745-1754
    • Terris, B.1    Blaveri, E.2    Crnogorac-Jurcevic, T.3    Jones, M.4    Missiaglia, E.5    Ruszniewski, P.6
  • 36
    • 20044392145 scopus 로고    scopus 로고
    • Gene overexpression in pancreatic adenocarcinoma: Diagnostic and therapeutic implications
    • J.A. Rodriguez, M. Li, Q. Yao, C. Chen, and W.E. Fisher Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications World J Surg 29 2005 297 305
    • (2005) World J Surg , vol.29 , pp. 297-305
    • Rodriguez, J.A.1    Li, M.2    Yao, Q.3    Chen, C.4    Fisher, W.E.5
  • 37
    • 79551602512 scopus 로고    scopus 로고
    • Poly(A) RT-PCR measurement of diagnostic genes in pancreatic juice in pancreatic cancer
    • M. Oliveira-Cunha, R.J. Byers, and A.K. Siriwardena Poly(A) RT-PCR measurement of diagnostic genes in pancreatic juice in pancreatic cancer Br J Cancer 104 2011 514 519
    • (2011) Br J Cancer , vol.104 , pp. 514-519
    • Oliveira-Cunha, M.1    Byers, R.J.2    Siriwardena, A.K.3
  • 38
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • C. Caldas, S.A. Hahn, L.T. daCosta, M.S. Redston, M. Schutte, and A.B. Seymour Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma Nat Genet 8 1994 27 32
    • (1994) Nat Genet , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Dacosta, L.T.3    Redston, M.S.4    Schutte, M.5    Seymour, A.B.6
  • 39
    • 16944367477 scopus 로고    scopus 로고
    • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
    • M. Schutte, R.H. Hruban, J. Geradts, R. Maynard, W. Hilgers, and S.K. Rabindran Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas Cancer Res 57 1997 3126 3130
    • (1997) Cancer Res , vol.57 , pp. 3126-3130
    • Schutte, M.1    Hruban, R.H.2    Geradts, J.3    Maynard, R.4    Hilgers, W.5    Rabindran, S.K.6
  • 40
    • 0032541623 scopus 로고    scopus 로고
    • Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
    • A.A. Russo, L. Tong, J.O. Lee, P.D. Jeffrey, and N.P. Pavletich Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a Nature 395 1998 237 243
    • (1998) Nature , vol.395 , pp. 237-243
    • Russo, A.A.1    Tong, L.2    Lee, J.O.3    Jeffrey, P.D.4    Pavletich, N.P.5
  • 41
    • 0344301900 scopus 로고    scopus 로고
    • Role of the p16 tumor suppressor gene in cancer
    • W.H. Liggett Jr., and D. Sidransky Role of the p16 tumor suppressor gene in cancer J Clin Oncol 16 1998 1197 1206
    • (1998) J Clin Oncol , vol.16 , pp. 1197-1206
    • Liggett, Jr.W.H.1    Sidransky, D.2
  • 42
    • 0029612231 scopus 로고
    • A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
    • W.R. Sellers, J.W. Rodgers, and W.G. Kaelin Jr. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites Proc Natl Acad Sci U S A 92 1995 11544 11548
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11544-11548
    • Sellers, W.R.1    Rodgers, J.W.2    Kaelin, Jr.W.G.3
  • 43
    • 0034697655 scopus 로고    scopus 로고
    • Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations
    • A.M. Goldstein, J.P. Struewing, A. Chidambaram, M.C. Fraser, and M.A. Tucker Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations J Natl Cancer Inst 92 2000 1006 1010
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1006-1010
    • Goldstein, A.M.1    Struewing, J.P.2    Chidambaram, A.3    Fraser, M.C.4    Tucker, M.A.5
  • 44
    • 0036143702 scopus 로고    scopus 로고
    • Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: The familial atypical mole melanoma-pancreatic carcinoma syndrome
    • H.T. Lynch, R.E. Brand, D. Hogg, C.A. Deters, R.M. Fusaro, and J.F. Lynch Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome Cancer 94 2002 84 96
    • (2002) Cancer , vol.94 , pp. 84-96
    • Lynch, H.T.1    Brand, R.E.2    Hogg, D.3    Deters, C.A.4    Fusaro, R.M.5    Lynch, J.F.6
  • 45
    • 79959837073 scopus 로고    scopus 로고
    • Major molecular markers in pancreatic ductal adenocarcinoma and their roles in screening, diagnosis, prognosis, and treatment
    • P. Singh, R. Srinivasan, and J.D. Wig Major molecular markers in pancreatic ductal adenocarcinoma and their roles in screening, diagnosis, prognosis, and treatment Pancreas 40 2011 644 652
    • (2011) Pancreas , vol.40 , pp. 644-652
    • Singh, P.1    Srinivasan, R.2    Wig, J.D.3
  • 46
    • 24644494649 scopus 로고    scopus 로고
    • Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer
    • J. Jeong, Y.N. Park, J.S. Park, D.S. Yoon, H.S. Chi, and B.R. Kim Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer Yonsei Med J 46 2005 519 525
    • (2005) Yonsei Med J , vol.46 , pp. 519-525
    • Jeong, J.1    Park, Y.N.2    Park, J.S.3    Yoon, D.S.4    Chi, H.S.5    Kim, B.R.6
  • 47
    • 78449285473 scopus 로고    scopus 로고
    • Expression of p16(INK4A) but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma
    • D.T. Chang, C.H. Chapman, J.A. Norton, B. Visser, G.A. Fisher, and P. Kunz Expression of p16(INK4A) but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma Cancer 116 2010 5179 5187
    • (2010) Cancer , vol.116 , pp. 5179-5187
    • Chang, D.T.1    Chapman, C.H.2    Norton, J.A.3    Visser, B.4    Fisher, G.A.5    Kunz, P.6
  • 48
    • 84355162005 scopus 로고    scopus 로고
    • Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm
    • G.M. Sclabas, J.G. Barton, T.C. Smyrk, D.A. Barrett, S. Khan, and M.L. Kendrick Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm J Am Coll Surg 214 2012 27 32
    • (2012) J Am Coll Surg , vol.214 , pp. 27-32
    • Sclabas, G.M.1    Barton, J.G.2    Smyrk, T.C.3    Barrett, D.A.4    Khan, S.5    Kendrick, M.L.6
  • 49
    • 24744434192 scopus 로고    scopus 로고
    • MUC1 as a target antigen for cancer immunotherapy
    • B. Acres, and J.M. Limacher MUC1 as a target antigen for cancer immunotherapy Expert Rev Vaccines 4 2005 493 502
    • (2005) Expert Rev Vaccines , vol.4 , pp. 493-502
    • Acres, B.1    Limacher, J.M.2
  • 50
    • 79953061206 scopus 로고    scopus 로고
    • MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition
    • G.M. Sclabas, J.G. Barton, T.C. Smyrk, D.A. Barrett, S. Khan, and M.L. Kendrick MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition Oncogene 30 2011 1449 1459
    • (2011) Oncogene , vol.30 , pp. 1449-1459
    • Sclabas, G.M.1    Barton, J.G.2    Smyrk, T.C.3    Barrett, D.A.4    Khan, S.5    Kendrick, M.L.6
  • 51
    • 51549099068 scopus 로고    scopus 로고
    • MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma
    • T.L. Tinder, D.B. Subramani, G.D. Basu, J.M. Bradley, J. Schettini, and A. Million MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma J Immunol 181 2008 3116 3125
    • (2008) J Immunol , vol.181 , pp. 3116-3125
    • Tinder, T.L.1    Subramani, D.B.2    Basu, G.D.3    Bradley, J.M.4    Schettini, J.5    Million, A.6
  • 52
    • 45949110882 scopus 로고    scopus 로고
    • Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma
    • A. Westgaard, S. Tafjord, I.N. Farstad, M. Cvancarova, T.J. Eide, and O. Mathisen Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma BMC Cancer 8 2008 170
    • (2008) BMC Cancer , vol.8 , pp. 170
    • Westgaard, A.1    Tafjord, S.2    Farstad, I.N.3    Cvancarova, M.4    Eide, T.J.5    Mathisen, O.6
  • 53
    • 60349092235 scopus 로고    scopus 로고
    • Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours
    • A. Westgaard, A.R. Schjolberg, M. Cvancarova, T.J. Eide, O.P. Clausen, and I.P. Gladhaug Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours Histopathology 54 2009 337 347
    • (2009) Histopathology , vol.54 , pp. 337-347
    • Westgaard, A.1    Schjolberg, A.R.2    Cvancarova, M.3    Eide, T.J.4    Clausen, O.P.5    Gladhaug, I.P.6
  • 54
    • 79959891751 scopus 로고    scopus 로고
    • Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis
    • D.M. Besmer, J.M. Curry, L.D. Roy, T.L. Tinder, M. Sahraei, and J. Schettini Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis Cancer Res 71 2011 4432 4442
    • (2011) Cancer Res , vol.71 , pp. 4432-4442
    • Besmer, D.M.1    Curry, J.M.2    Roy, L.D.3    Tinder, T.L.4    Sahraei, M.5    Schettini, J.6
  • 55
    • 40549097760 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes
    • H. Kondo, S. Hazama, T. Kawaoka, S. Yoshino, S. Yoshida, and K. Tokuno Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes Anticancer Res 28 1B 2008 Jan-Feb 379 387
    • (2008) Anticancer Res , vol.28 , Issue.1 B , pp. 379-387
    • Kondo, H.1    Hazama, S.2    Kawaoka, T.3    Yoshino, S.4    Yoshida, S.5    Tokuno, K.6
  • 57
    • 0030969478 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis
    • S. Gansauge, F. Gansauge, M. Ramadani, H. Stobbe, B. Rau, and N. Harada Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis Cancer Res 57 1997 1634 1637
    • (1997) Cancer Res , vol.57 , pp. 1634-1637
    • Gansauge, S.1    Gansauge, F.2    Ramadani, M.3    Stobbe, H.4    Rau, B.5    Harada, N.6
  • 58
    • 0031812131 scopus 로고    scopus 로고
    • Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival
    • M. Kornmann, T. Ishiwata, J. Itakura, P. Tangvoranuntakul, H.G. Beger, and M. Korc Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival Oncology 55 1998 363 369
    • (1998) Oncology , vol.55 , pp. 363-369
    • Kornmann, M.1    Ishiwata, T.2    Itakura, J.3    Tangvoranuntakul, P.4    Beger, H.G.5    Korc, M.6
  • 59
    • 0034693635 scopus 로고    scopus 로고
    • K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma
    • A. Kawesha, P. Ghaneh, A. Andren-Sandberg, D. Ograed, R. Skar, and S. Dawiskiba K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma Int J Cancer 89 2000 469 474
    • (2000) Int J Cancer , vol.89 , pp. 469-474
    • Kawesha, A.1    Ghaneh, P.2    Andren-Sandberg, A.3    Ograed, D.4    Skar, R.5    Dawiskiba, S.6
  • 60
    • 0035918538 scopus 로고    scopus 로고
    • Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer
    • Q. Qiao, M. Ramadani, S. Gansauge, F. Gansauge, G. Leder, and H.G. Beger Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer Int J Cancer 95 2001 194 197
    • (2001) Int J Cancer , vol.95 , pp. 194-197
    • Qiao, Q.1    Ramadani, M.2    Gansauge, S.3    Gansauge, F.4    Leder, G.5    Beger, H.G.6
  • 61
    • 0031717905 scopus 로고    scopus 로고
    • Tumor-suppressor p53: Implications for tumor development and prognosis
    • D.G. Kirsch, and M.B. Kastan Tumor-suppressor p53: implications for tumor development and prognosis J Clin Oncol 16 1998 3158 3168
    • (1998) J Clin Oncol , vol.16 , pp. 3158-3168
    • Kirsch, D.G.1    Kastan, M.B.2
  • 62
    • 0028308492 scopus 로고
    • P53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
    • M.S. Redston, C. Caldas, A.B. Seymour, R.H. Hruban, L. da Costa, and C.J. Yeo p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions Cancer Res 54 1994 3025 3033
    • (1994) Cancer Res , vol.54 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3    Hruban, R.H.4    Da Costa, L.5    Yeo, C.J.6
  • 63
    • 84866746447 scopus 로고    scopus 로고
    • Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only
    • N.A. Ottenhof, F.H. Morsink, F. Ten Kate, C.J. van Noorden, and G.J. Offerhaus Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only Cell Oncol (Dordr) 35 2012 119 126
    • (2012) Cell Oncol (Dordr) , vol.35 , pp. 119-126
    • Ottenhof, N.A.1    Morsink, F.H.2    Ten Kate, F.3    Van Noorden, C.J.4    Offerhaus, G.J.5
  • 64
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • C.H. Heldin, K. Miyazono, and P. ten Dijke TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature 390 1997 465 471
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 65
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • J. Massague, S.W. Blain, and R.S. Lo TGFbeta signaling in growth control, cancer, and heritable disorders Cell 103 2000 295 309
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 67
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • C.A. Iacobuzio-Donahue, B. Fu, S. Yachida, M. Luo, H. Abe, and C.M. Henderson DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer J Clin Oncol 27 2009 1806 1813
    • (2009) J Clin Oncol , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3    Luo, M.4    Abe, H.5    Henderson, C.M.6
  • 68
    • 80051613675 scopus 로고    scopus 로고
    • Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: Correlation of Smad4(Dpc4) immunostaining with pattern of disease progression
    • [Epub 2011 Jun 27]
    • C.H. Crane, G.R. Varadhachary, J.S. Yordy, G.A. Staerkel, M.M. Javle, and H. Safran Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression J Clin Oncol 29 22 2011 Aug 1 3037 3043 [Epub 2011 Jun 27]
    • (2011) J Clin Oncol , vol.29 , Issue.22 , pp. 3037-3043
    • Crane, C.H.1    Varadhachary, G.R.2    Yordy, J.S.3    Staerkel, G.A.4    Javle, M.M.5    Safran, H.6
  • 69
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • J.C. Wang DNA topoisomerases Annu Rev Biochem 65 1996 635 692
    • (1996) Annu Rev Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 70
    • 33750615735 scopus 로고    scopus 로고
    • Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes - Molecular basis for combination chemotherapy in cancer
    • T.A. Jarvinen, and E.T. Liu Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes - molecular basis for combination chemotherapy in cancer Curr Cancer Drug Targets 6 2006 579 602
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 579-602
    • Jarvinen, T.A.1    Liu, E.T.2
  • 71
    • 0043145754 scopus 로고    scopus 로고
    • Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer
    • T.A. Jarvinen, M. Tanner, M. Barlund, A. Borg, and J. Isola Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer Genes Chromosomes Cancer 26 1999 142 150
    • (1999) Genes Chromosomes Cancer , vol.26 , pp. 142-150
    • Jarvinen, T.A.1    Tanner, M.2    Barlund, M.3    Borg, A.4    Isola, J.5
  • 72
    • 11244321759 scopus 로고    scopus 로고
    • A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: Use of immunolabeling and multicolor FISH for potential patient screening andtreatment
    • D.E. Hansel, R. Ashfaq, A. Rahman, D. Wanzer, C.J. Yeo, and R.E. Wilentz A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening andtreatment Am J Clin Pathol 123 2005 28 35
    • (2005) Am J Clin Pathol , vol.123 , pp. 28-35
    • Hansel, D.E.1    Ashfaq, R.2    Rahman, A.3    Wanzer, D.4    Yeo, C.J.5    Wilentz, R.E.6
  • 74
    • 78249247414 scopus 로고    scopus 로고
    • Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer
    • F. Skoulidis, L.D. Cassidy, V. Pisupati, J.G. Jonasson, H. Bjarnason, and J.E. Eyfjord Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer Cancer Cell 18 2010 499 509
    • (2010) Cancer Cell , vol.18 , pp. 499-509
    • Skoulidis, F.1    Cassidy, L.D.2    Pisupati, V.3    Jonasson, J.G.4    Bjarnason, H.5    Eyfjord, J.E.6
  • 75
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • A.R. Venkitaraman Cancer susceptibility and the functions of BRCA1 and BRCA2 Cell 108 2002 171 182
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 76
    • 0029680501 scopus 로고    scopus 로고
    • A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals
    • D.B. Berman, J. Costalas, D.C. Schultz, G. Grana, M. Daly, and A.K. Godwin A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals Cancer Res 56 1996 3409 3414
    • (1996) Cancer Res , vol.56 , pp. 3409-3414
    • Berman, D.B.1    Costalas, J.2    Schultz, D.C.3    Grana, G.4    Daly, M.5    Godwin, A.K.6
  • 79
    • 0030069718 scopus 로고    scopus 로고
    • Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers
    • K. Chang, and I. Pastan Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers Proc Natl Acad Sci U S A 93 1996 136 140
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 136-140
    • Chang, K.1    Pastan, I.2
  • 80
    • 0142169984 scopus 로고    scopus 로고
    • Application of mesothelin immunostaining in tumor diagnosis
    • N.G. Ordonez Application of mesothelin immunostaining in tumor diagnosis Am J Surg Pathol 27 11 2003 1418 1428
    • (2003) Am J Surg Pathol , vol.27 , Issue.11 , pp. 1418-1428
    • Ordonez, N.G.1
  • 81
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation
    • E. Lutz, C.J. Yeo, and K.D. Lillemoe A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation Ann Surg 253 2 2011 Feb 328 335
    • (2011) Ann Surg , vol.253 , Issue.2 , pp. 328-335
    • Lutz, E.1    Yeo, C.J.2    Lillemoe, K.D.3
  • 82
    • 78650339895 scopus 로고    scopus 로고
    • Phase i clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers
    • R. Hassan, S.J. Cohen, M. Phillips, I. Pastan, E. Sharon, and R.J. Kelly Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers Clin Cancer Res 16 24 2010 Dec 15 6132 6138
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 6132-6138
    • Hassan, R.1    Cohen, S.J.2    Phillips, M.3    Pastan, I.4    Sharon, E.5    Kelly, R.J.6
  • 83
    • 11144226727 scopus 로고    scopus 로고
    • The Caveolin genes: From cell biology to medicine
    • T.M. Williams, and M.P. Lisanti The Caveolin genes: from cell biology to medicine Ann Med 36 2004 584 595
    • (2004) Ann Med , vol.36 , pp. 584-595
    • Williams, T.M.1    Lisanti, M.P.2
  • 84
    • 67749094835 scopus 로고    scopus 로고
    • Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma
    • C.P. Tanase, S. Dima, M. Mihai, E. Raducan, M.I. Nicolescu, and L. Albulescu Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma J Mol Histol 40 2009 23 29
    • (2009) J Mol Histol , vol.40 , pp. 23-29
    • Tanase, C.P.1    Dima, S.2    Mihai, M.3    Raducan, E.4    Nicolescu, M.I.5    Albulescu, L.6
  • 86
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • J.R. Mackey, R.S. Mani, M. Selner, D. Mowles, J.D. Young, and J.A. Belt Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines Cancer Res 58 1998 4349 4357
    • (1998) Cancer Res , vol.58 , pp. 4349-4357
    • MacKey, J.R.1    Mani, R.S.2    Selner, M.3    Mowles, D.4    Young, J.D.5    Belt, J.A.6
  • 87
    • 74949112149 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
    • T. Okazaki, M. Javle, M. Tanaka, J.L. Abbruzzese, and D. Li Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity Clin Cancer Res 16 2010 320 329
    • (2010) Clin Cancer Res , vol.16 , pp. 320-329
    • Okazaki, T.1    Javle, M.2    Tanaka, M.3    Abbruzzese, J.L.4    Li, D.5
  • 88
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • J.J. Farrell, H. Elsaleh, M. Garcia, R. Lai, A. Ammar, and W.F. Regine Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer Gastroenterology 136 1 2009 Jan 187 195
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 187-195
    • Farrell, J.J.1    Elsaleh, H.2    Garcia, M.3    Lai, R.4    Ammar, A.5    Regine, W.F.6
  • 89
    • 0037010076 scopus 로고    scopus 로고
    • Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia
    • C.L. Arteaga Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia Semin Oncol 29 2002 3 9
    • (2002) Semin Oncol , vol.29 , pp. 3-9
    • Arteaga, C.L.1
  • 90
    • 33744725273 scopus 로고    scopus 로고
    • Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
    • H. Immervoll, D. Hoem, K. Kugarajh, S.J. Steine, and A. Molven Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes Virchows Arch 448 2006 788 796
    • (2006) Virchows Arch , vol.448 , pp. 788-796
    • Immervoll, H.1    Hoem, D.2    Kugarajh, K.3    Steine, S.J.4    Molven, A.5
  • 91
    • 37549027274 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: A randomised, multicentre, phase II trial
    • S. Cascinu, R. Berardi, R. Labianca, S. Siena, A. Falcone, and E. Aitini Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomised, multicentre, phase II trial Lancet Oncol 9 1 2008 Jan 39 44
    • (2008) Lancet Oncol , vol.9 , Issue.1 , pp. 39-44
    • Cascinu, S.1    Berardi, R.2    Labianca, R.3    Siena, S.4    Falcone, A.5    Aitini, E.6
  • 92
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • P.A. Philip, J. Benedetti, C.L. Corless, R. Wong, E.M. O'Reilly, and P.J. Flynn Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205 J Clin Oncol 28 22 2010 Aug 1 3605 3610
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3    Wong, R.4    O'Reilly, E.M.5    Flynn, P.J.6
  • 93
    • 79952095727 scopus 로고    scopus 로고
    • Phase II study of erlotinib plus gemcitabine in Japanese patients with unresectable pancreatic cancer
    • T. Okusaka, J. Furuse, A. Funakoshi, T. Ioka, K. Yamao, and S. Ohkawa Phase II study of erlotinib plus gemcitabine in Japanese patients with unresectable pancreatic cancer Cancer Sci 102 2 2011 Feb 425 431
    • (2011) Cancer Sci , vol.102 , Issue.2 , pp. 425-431
    • Okusaka, T.1    Furuse, J.2    Funakoshi, A.3    Ioka, T.4    Yamao, K.5    Ohkawa, S.6
  • 94
    • 78651099803 scopus 로고    scopus 로고
    • Phase II study of a fixed dose-rate infusion of gemcitabine associated with erlotinib in advanced pancreatic cancer
    • J. Feliu, P. Borrega, A. León, L. López-Gómez, M. López, and J. Castro Phase II study of a fixed dose-rate infusion of gemcitabine associated with erlotinib in advanced pancreatic cancer Cancer Chemother Pharmacol 67 1 2011 Jan 215 221
    • (2011) Cancer Chemother Pharmacol , vol.67 , Issue.1 , pp. 215-221
    • Feliu, J.1    Borrega, P.2    León, A.3    López-Gómez, L.4    López, M.5    Castro, J.6
  • 95
    • 79955873823 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancer
    • P.Q. Bao, R.K. Ramanathan, A. Krasinkas, N. Bahary, B.C. Lembersky, and D.L. Bartlett Phase II study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancer Ann Surg Oncol 18 4 2011 Apr 1122 1129
    • (2011) Ann Surg Oncol , vol.18 , Issue.4 , pp. 1122-1129
    • Bao, P.Q.1    Ramanathan, R.K.2    Krasinkas, A.3    Bahary, N.4    Lembersky, B.C.5    Bartlett, D.L.6
  • 96
    • 79959836604 scopus 로고    scopus 로고
    • Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer
    • N.N. Rahbari, T. Schmidt, C.S. Falk, U. Hinz, M. Herber, and U. Bork Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer BMC Cancer 11 2011 286
    • (2011) BMC Cancer , vol.11 , pp. 286
    • Rahbari, N.N.1    Schmidt, T.2    Falk, C.S.3    Hinz, U.4    Herber, M.5    Bork, U.6
  • 97
    • 79958287140 scopus 로고    scopus 로고
    • Plasma concentrations of angiogenetic factors and angiogenetic inhibitors in patients with ductal pancreatic neoplasms. A pilot study
    • R. Pezzilli, D. Fabbri, M.M. Corsi, A. Imbrogno, A. Barassi, and A.M. Morselli-Labate Plasma concentrations of angiogenetic factors and angiogenetic inhibitors in patients with ductal pancreatic neoplasms. A pilot study Clin Chem Lab Med 49 2011 1047 1051
    • (2011) Clin Chem Lab Med , vol.49 , pp. 1047-1051
    • Pezzilli, R.1    Fabbri, D.2    Corsi, M.M.3    Imbrogno, A.4    Barassi, A.5    Morselli-Labate, A.M.6
  • 98
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the cancer and leukemia group B (CALGB 80303)
    • H.L. Kindler, D. Niedzwiecki, D. Hollis, S. Sutherland, D. Schrag, and H. Hurwitz Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the cancer and leukemia group B (CALGB 80303) J Clin Oncol 28 22 2010 Aug 1 3617 3622
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3    Sutherland, S.4    Schrag, D.5    Hurwitz, H.6
  • 99
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • H.L. Kindler, G. Friberg, D.A. Singh, G. Locker, S. Nattam, and M. Kozloff Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer J Clin Oncol 23 31 2005 Nov 1 8033 8040
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3    Locker, G.4    Nattam, S.5    Kozloff, M.6
  • 100
    • 79955641985 scopus 로고    scopus 로고
    • Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma
    • G.H. Zhu, C. Huang, Z.J. Qiu, J. Liu, Z.H. Zhang, and N. Zhao Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma Dig Dis Sci 56 2011 1090 1098
    • (2011) Dig Dis Sci , vol.56 , pp. 1090-1098
    • Zhu, G.H.1    Huang, C.2    Qiu, Z.J.3    Liu, J.4    Zhang, Z.H.5    Zhao, N.6
  • 101
    • 34247111871 scopus 로고    scopus 로고
    • Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer
    • A. Juuti, J. Lundin, S. Nordling, J. Louhimo, and C. Haglund Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer Oncology 71 2006 61 68
    • (2006) Oncology , vol.71 , pp. 61-68
    • Juuti, A.1    Lundin, J.2    Nordling, S.3    Louhimo, J.4    Haglund, C.5
  • 102
    • 45949100633 scopus 로고    scopus 로고
    • The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters
    • G. Giannopoulos, K. Pavlakis, A. Parasi, N. Kavatzas, D. Tiniakos, and A. Karakosta The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters Anticancer Res 28 2008 1875 1881
    • (2008) Anticancer Res , vol.28 , pp. 1875-1881
    • Giannopoulos, G.1    Pavlakis, K.2    Parasi, A.3    Kavatzas, N.4    Tiniakos, D.5    Karakosta, A.6
  • 103
    • 48349083700 scopus 로고    scopus 로고
    • Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas
    • U. Tamahashi, J. Kumagai, T. Takizawa, M. Sekine, and Y. Eishi Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas Virchows Arch 453 2008 79 87
    • (2008) Virchows Arch , vol.453 , pp. 79-87
    • Tamahashi, U.1    Kumagai, J.2    Takizawa, T.3    Sekine, M.4    Eishi, Y.5
  • 105
    • 33746345881 scopus 로고    scopus 로고
    • Intraductal papillary mucinous neoplasms of the pancreas: An analysis of protein expression and clinical features
    • N. Nishikawa, Y. Kimura, K. Okita, H. Zembutsu, T. Furuhata, and T. Katsuramaki Intraductal papillary mucinous neoplasms of the pancreas: an analysis of protein expression and clinical features J Hepatobiliary Pancreat Surg 13 2006 327 335
    • (2006) J Hepatobiliary Pancreat Surg , vol.13 , pp. 327-335
    • Nishikawa, N.1    Kimura, Y.2    Okita, K.3    Zembutsu, H.4    Furuhata, T.5    Katsuramaki, T.6
  • 106
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • A. Fukuda, S.C. Wang, J.P. Morris 4th, A.E. Folias, A. Liou, and G.E. Kim Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression Cancer Cell. 19 4 2011 441 455
    • (2011) Cancer Cell. , vol.19 , Issue.4 , pp. 441-455
    • Fukuda, A.1    Wang, S.C.2    Morris, J.P.3    Folias, A.E.4    Liou, A.5    Kim, G.E.6
  • 107
    • 51349092847 scopus 로고    scopus 로고
    • Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    • M. Tian, Y.Z. Cui, G.H. Song, M.J. Zong, X.Y. Zhou, and Y. Chen Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients BMC Cancer 8 2008 241
    • (2008) BMC Cancer , vol.8 , pp. 241
    • Tian, M.1    Cui, Y.Z.2    Song, G.H.3    Zong, M.J.4    Zhou, X.Y.5    Chen, Y.6
  • 108
    • 0033818476 scopus 로고    scopus 로고
    • Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression
    • T. Koshiba, R. Hosotani, Y. Miyamoto, J. Ida, S. Tsuji, and S. Nakajima Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression Clin Cancer Res 6 2000 3530 3535
    • (2000) Clin Cancer Res , vol.6 , pp. 3530-3535
    • Koshiba, T.1    Hosotani, R.2    Miyamoto, Y.3    Ida, J.4    Tsuji, S.5    Nakajima, S.6
  • 109
    • 1242316269 scopus 로고    scopus 로고
    • Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas
    • N. Sato, N. Fukushima, A. Maitra, C.A. Iacobuzio-Donahue, N.T. van Heek, and J.L. Cameron Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas Am J Pathol 164 2004 903 914
    • (2004) Am J Pathol , vol.164 , pp. 903-914
    • Sato, N.1    Fukushima, N.2    Maitra, A.3    Iacobuzio-Donahue, C.A.4    Van Heek, N.T.5    Cameron, J.L.6
  • 110
    • 71849118588 scopus 로고    scopus 로고
    • Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma
    • T. Welsch, S. Keleg, F. Bergmann, L. Degrate, S. Bauer, and J. Schmidt Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma Clin Exp Metastasis 26 2009 701 711
    • (2009) Clin Exp Metastasis , vol.26 , pp. 701-711
    • Welsch, T.1    Keleg, S.2    Bergmann, F.3    Degrate, L.4    Bauer, S.5    Schmidt, J.6
  • 111
    • 39049141776 scopus 로고    scopus 로고
    • The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation
    • Z. Wang, Y. Hao, and A.W. Lowe The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation Cancer Res 68 2 2008 Jan 15 492 497
    • (2008) Cancer Res , vol.68 , Issue.2 , pp. 492-497
    • Wang, Z.1    Hao, Y.2    Lowe, A.W.3
  • 112
    • 77953440843 scopus 로고    scopus 로고
    • Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia
    • R. Chen, S. Pan, X. Duan, B.H. Nelson, R.A. Sahota, and S. de Rham Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia Mol Cancer 9 2010 Jun 15 149
    • (2010) Mol Cancer , vol.9 , pp. 149
    • Chen, R.1    Pan, S.2    Duan, X.3    Nelson, B.H.4    Sahota, R.A.5    De Rham, S.6
  • 113
    • 84863259132 scopus 로고    scopus 로고
    • DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA
    • X. He, Z. Zheng, J. Li, Q. Ben, Q. Ben, J. Liu, and J. Zhang DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA Carcinogenesis 33 3 2012 Mar 555 562
    • (2012) Carcinogenesis , vol.33 , Issue.3 , pp. 555-562
    • He, X.1    Zheng, Z.2    Li, J.3    Ben, Q.4    Ben, Q.5    Liu, J.6    Zhang, J.7
  • 114
    • 79952691516 scopus 로고    scopus 로고
    • Serum DJ-1 as a diagnostic marker and prognostic factor for pancreatic cancer
    • X.Y. He, B.Y. Liu, W.Y. Yao, X.J. Zhao, Z. Zheng, and J.F. Li Serum DJ-1 as a diagnostic marker and prognostic factor for pancreatic cancer J Dig Dis 12 2 2011 Apr 131 137
    • (2011) J Dig Dis , vol.12 , Issue.2 , pp. 131-137
    • He, X.Y.1    Liu, B.Y.2    Yao, W.Y.3    Zhao, X.J.4    Zheng, Z.5    Li, J.F.6
  • 115
    • 70350474677 scopus 로고    scopus 로고
    • Heat shock protein 27 phosphorylation: Kinases, phosphatases, functions and pathology
    • S. Kostenko, and U. Moens Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology Cell Mol Life Sci 66 20 2009 Oct 3289 3307
    • (2009) Cell Mol Life Sci , vol.66 , Issue.20 , pp. 3289-3307
    • Kostenko, S.1    Moens, U.2
  • 116
    • 34147220062 scopus 로고    scopus 로고
    • Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker
    • C. Melle, G. Ernst, N. Escher, D. Hartmann, B. Schimmel, and A. Bleul Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker Clin Chem 53 4 2007 Apr 629 635
    • (2007) Clin Chem , vol.53 , Issue.4 , pp. 629-635
    • Melle, C.1    Ernst, G.2    Escher, N.3    Hartmann, D.4    Schimmel, B.5    Bleul, A.6
  • 117
    • 33845974916 scopus 로고    scopus 로고
    • Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis
    • R. Chen, S. Pan, K. Cooke, K.W. Moyes, M.P. Bronner, and D.R. Goodlett Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis Pancreas 34 1 2007 Jan 70 79
    • (2007) Pancreas , vol.34 , Issue.1 , pp. 70-79
    • Chen, R.1    Pan, S.2    Cooke, K.3    Moyes, K.W.4    Bronner, M.P.5    Goodlett, D.R.6
  • 118
    • 77954656531 scopus 로고    scopus 로고
    • Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer
    • S. Takano, K. Sogawa, H. Yoshitomi, T. Shida, K. Mogushi, and F. Kimura Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer Br J Cancer 103 2 2010 Jul 13 223 231
    • (2010) Br J Cancer , vol.103 , Issue.2 , pp. 223-231
    • Takano, S.1    Sogawa, K.2    Yoshitomi, H.3    Shida, T.4    Mogushi, K.5    Kimura, F.6
  • 119
    • 28344457829 scopus 로고    scopus 로고
    • Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: Results of a comparative study
    • [discussion 771-3]
    • C. Bassi, M. Falconi, E. Molinari, R. Salvia, G. Butturini, and N. Sartori Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study Ann Surg 242 2005 767 771 [discussion 771-3]
    • (2005) Ann Surg , vol.242 , pp. 767-771
    • Bassi, C.1    Falconi, M.2    Molinari, E.3    Salvia, R.4    Butturini, G.5    Sartori, N.6
  • 120
    • 38049103003 scopus 로고    scopus 로고
    • Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: A large, population-based analysis
    • M.B. Slidell, D.C. Chang, J.L. Cameron, C. Wolfgang, J.M. Herman, and R.D. Schulick Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis Ann Surg Oncol 15 2008 165 174
    • (2008) Ann Surg Oncol , vol.15 , pp. 165-174
    • Slidell, M.B.1    Chang, D.C.2    Cameron, J.L.3    Wolfgang, C.4    Herman, J.M.5    Schulick, R.D.6
  • 121
    • 77956310443 scopus 로고    scopus 로고
    • Impact of tumor grade on prognosis in pancreatic cancer: Should we include grade in AJCC staging?
    • N. Wasif, C.Y. Ko, J. Farrell, Z. Wainberg, O.J. Hines, and H. Reber Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging? Ann Surg Oncol 17 2010 2312 2320
    • (2010) Ann Surg Oncol , vol.17 , pp. 2312-2320
    • Wasif, N.1    Ko, C.Y.2    Farrell, J.3    Wainberg, Z.4    Hines, O.J.5    Reber, H.6
  • 122
    • 33644511725 scopus 로고    scopus 로고
    • Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial
    • C. Bassi, D.D. Stocken, A. Olah, H. Friess, J. Buckels, and H. Hickey Influence of surgical resection and post-operative complications on survival following adjuvant treatment for pancreatic cancer in the ESPAC-1 randomized controlled trial Dig Surg 22 2005 353 363
    • (2005) Dig Surg , vol.22 , pp. 353-363
    • Bassi, C.1    Stocken, D.D.2    Olah, A.3    Friess, H.4    Buckels, J.5    Hickey, H.6
  • 123
    • 33947668471 scopus 로고    scopus 로고
    • Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer
    • K.S. Goonetilleke, and A.K. Siriwardena Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer Eur J Surg Oncol 33 2007 266 270
    • (2007) Eur J Surg Oncol , vol.33 , pp. 266-270
    • Goonetilleke, K.S.1    Siriwardena, A.K.2
  • 124
    • 0025307965 scopus 로고
    • The clinical utility of the CA 19-9 tumor-associated antigen
    • W. Steinberg The clinical utility of the CA 19-9 tumor-associated antigen Am J Gastroenterol 85 1990 350 355
    • (1990) Am J Gastroenterol , vol.85 , pp. 350-355
    • Steinberg, W.1
  • 125
    • 84857606982 scopus 로고    scopus 로고
    • New strategies and designs in pancreatic cancer research: Consensus guidelines report from a European expert panel
    • J.L. Van Laethem, C. Verslype, J.L. Iovanna, P. Michl, T. Conroy, and C. Louvet New strategies and designs in pancreatic cancer research: consensus guidelines report from a European expert panel Ann Oncol 23 3 2012 Mar 570 576
    • (2012) Ann Oncol , vol.23 , Issue.3 , pp. 570-576
    • Van Laethem, J.L.1    Verslype, C.2    Iovanna, J.L.3    Michl, P.4    Conroy, T.5    Louvet, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.