-
1
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497 (1975). Nobel prize-winning work describing the method to produce hybridoma cells to produce antibodies of a desired specificity.
-
(1975)
Nature
, vol.256
, Issue.5517
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
2
-
-
0020083756
-
A monoclonal antibody (b72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations
-
Nuti M, Teramoto YA, Mariani-Costantini R, Hand PH, Colcher D, Schlom J. A monoclonal antibody (b72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations. Int. J. Cancer 29(5), 539-555 (1982).
-
(1982)
Int. J. Cancer
, vol.29
, Issue.5
, pp. 539-555
-
-
Nuti, M.1
Teramoto, Y.A.2
Mariani-Costantini, R.3
Hand, P.H.4
Colcher, D.5
Schlom, J.6
-
3
-
-
0022195244
-
Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas
-
Sekine H, Ohno T, Kufe DW. Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas. J. Immunol. 135(5), 3610-3615 (1985).
-
(1985)
J. Immunol.
, vol.135
, Issue.5
, pp. 3610-3615
-
-
Sekine, H.1
Ohno, T.2
Kufe, D.W.3
-
4
-
-
0024588431
-
Purification and biochemical characterisation of a novel breast carcinoma associated mucin-like glycoprotein defined by antibody 3e1.2
-
Stacker SA, Tjandra JJ, Xing PX, Walker ID, Thompson CH, McKenzie IF. Purification and biochemical characterisation of a novel breast carcinoma associated mucin-like glycoprotein defined by antibody 3e1.2. Br. J. Cancer 59(4), 544-553 (1989).
-
(1989)
Br. J. Cancer
, vol.59
, Issue.4
, pp. 544-553
-
-
Stacker, S.A.1
Tjandra, J.J.2
Xing, P.X.3
Walker, I.D.4
Thompson, C.H.5
McKenzie, I.F.6
-
5
-
-
0024551170
-
Production and characterization of monoclonal antibodies identifying breast tumor-associated antigens
-
Keydar I, Chou CS, Hareuveni M et al. Production and characterization of monoclonal antibodies identifying breast tumor-associated antigens. Proc. Natl Acad. Sci. USA 86(4), 1362-1366 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, Issue.4
, pp. 1362-1366
-
-
Keydar, I.1
Chou, C.S.2
Hareuveni, M.3
-
6
-
-
0023617395
-
Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin
-
Burchell J, Gendler S, Taylor-Papadimitriou J et al. Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res. 47(20), 5476-5482 (1987). Demonstrated that a monoclonal antibody produced to human milk mucin, stripped of its sugar side chains, shows specificity for the form of MUC1 produced by breast cancer cells.
-
(1987)
Cancer Res.
, vol.47
, Issue.20
, pp. 5476-5482
-
-
Burchell, J.1
Gendler, S.2
Taylor-Papadimitriou, J.3
-
7
-
-
0023161838
-
Molecular characterization of a mucin-type antigen associated with human pancreatic cancer. The du-pan-2 antigen
-
Lan MS, Khorrami A, Kaufman B, Metzgar RS. Molecular characterization of a mucin-type antigen associated with human pancreatic cancer. The du-pan-2 antigen. J. Biol. Chem. 262(26), 12863-12870 (1987).
-
(1987)
J. Biol. Chem.
, vol.262
, Issue.26
, pp. 12863-12870
-
-
Lan, M.S.1
Khorrami, A.2
Kaufman, B.3
Metzgar, R.S.4
-
8
-
-
0024353046
-
A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas
-
Girling A, Bartkova J, Burchell J, Gendler S, Gillett C, Taylor-Papadimitriou J. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int. J. Cancer 43(6), 1072-1076 (1989).
-
(1989)
Int. J. Cancer
, vol.43
, Issue.6
, pp. 1072-1076
-
-
Girling, A.1
Bartkova, J.2
Burchell, J.3
Gendler, S.4
Gillett, C.5
Taylor-Papadimitriou, J.6
-
9
-
-
0031457133
-
Antibody and T-cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein
-
Karanikas V, Hwang LA, Pearson J et al. Antibody and T-cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J. Clin. Invest. 100(11), 2783-2792 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, Issue.11
, pp. 2783-2792
-
-
Karanikas, V.1
Hwang, L.A.2
Pearson, J.3
-
10
-
-
0025029969
-
Cloning and sequencing of a human pancreatic tumor mucin cDNA
-
Lan MS, Batra SK, Qi WN, Metzgar RS, Hollingsworth MA. Cloning and sequencing of a human pancreatic tumor mucin cDNA. J. Biol. Chem. 265(25), 15294-15299 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, Issue.25
, pp. 15294-15299
-
-
Lan, M.S.1
Batra, S.K.2
Qi, W.N.3
Metzgar, R.S.4
Hollingsworth, M.A.5
-
11
-
-
0023741252
-
A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats
-
Gendler S, Taylor-Papadimitriou J, Duhig T, Rothbard J, Burchell J. A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol. Chem. 263(26), 12820-12823 (1998).
-
(1998)
J. Biol. Chem.
, vol.263
, Issue.26
, pp. 12820-12823
-
-
Gendler, S.1
Taylor-Papadimitriou, J.2
Duhig, T.3
Rothbard, J.4
Burchell, J.5
-
12
-
-
0025029968
-
Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin
-
Gendler SJ, Lancaster CA, Taylor-Papadimitriou J et al. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J. Biol. Chem. 265(25), 15286-152893 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, Issue.25
, pp. 15286-152893
-
-
Gendler, S.J.1
Lancaster, C.A.2
Taylor-Papadimitriou, J.3
-
13
-
-
0345824723
-
Differential regulation of membrane-associated mucins in the human ocular surface epithelium
-
Hori Y, Spurr-Michaud S, Russo CL, Argueso P, Gipson IK. Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest. Ophthalmol. Vis. Sci. 45(1), 114-122(2004).
-
(2004)
Invest. Ophthalmol. Vis. Sci.
, vol.45
, Issue.1
, pp. 114-122
-
-
Hori, Y.1
Spurr-Michaud, S.2
Russo, C.L.3
Argueso, P.4
Gipson, I.K.5
-
14
-
-
0028963144
-
Is episialin/mucl involved in breast cancer progression?
-
Hilkens J, Vos HL, Wesseling J et al. Is episialin/mucl involved in breast cancer progression? Cancer Lett. 90(1), 27-33 (1995).
-
(1995)
Cancer Lett.
, vol.90
, Issue.1
, pp. 27-33
-
-
Hilkens, J.1
Vos, H.L.2
Wesseling, J.3
-
15
-
-
9144251970
-
Gene expression profiling identifies clinically relevant subtypes of prostate cancer
-
Lapointe J, Li C, Higgins JP et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc. Natl Acad. Sci. USA 101(3), 811-816 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.3
, pp. 811-816
-
-
Lapointe, J.1
Li, C.2
Higgins, J.P.3
-
16
-
-
0042941382
-
Contribution of the muc1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line
-
Kohlgraf KG, Gawron AJ, Higashi M et al. Contribution of the muc1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Cancer Res. 63(16), 5011-5020 (2003).
-
(2003)
Cancer Res.
, vol.63
, Issue.16
, pp. 5011-5020
-
-
Kohlgraf, K.G.1
Gawron, A.J.2
Higashi, M.3
-
17
-
-
0036283597
-
Non-glycosylated tandem repeats of muc1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ecm) in vitro: Potential role in metastasis
-
Ciborowski P, Finn OJ. Non-glycosylated tandem repeats of muc1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ecm) in vitro: potential role in metastasis Clin. Exp. Metastasis 19(4), 339-345 (2002).
-
(2002)
Clin. Exp. Metastasis
, vol.19
, Issue.4
, pp. 339-345
-
-
Ciborowski, P.1
Finn, O.J.2
-
18
-
-
0033761311
-
Enhancement of metastatic properties of pancreatic cancer cells by muc1 gene encoding an anti-adhesion molecule
-
Satoh S, Hinoda Y, Hayashi T, Burdick MD, Imai K, Hollingsworth MA. Enhancement of metastatic properties of pancreatic cancer cells by muc1 gene encoding an anti-adhesion molecule. Int. J. Cancer 88(8), 507-508 (2000).
-
(2000)
Int. J. Cancer
, vol.88
, Issue.8
, pp. 507-508
-
-
Satoh, S.1
Hinoda, Y.2
Hayashi, T.3
Burdick, M.D.4
Imai, K.5
Hollingsworth, M.A.6
-
19
-
-
0034650187
-
Immunohistochemical study of MUC1 mucin in premalignant oral lesions and oral squamous cell carcinoma: Association with disease progression, mode of invasion, and lymph node metastasis
-
Nitta T, Sugihara K, Tsuyama S, Murata F. Immunohistochemical study of MUC1 mucin in premalignant oral lesions and oral squamous cell carcinoma: association with disease progression, mode of invasion, and lymph node metastasis. Cancer 88(2), 245-254 (2000).
-
(2000)
Cancer
, vol.88
, Issue.2
, pp. 245-254
-
-
Nitta, T.1
Sugihara, K.2
Tsuyama, S.3
Murata, F.4
-
20
-
-
0043210682
-
Role of MUC1 and MUC5ac expressions as prognostic indicators in gastric carcinomas
-
Wang JY, Chang CT, Hsieh JS et al. Role of MUC1 and MUC5ac expressions as prognostic indicators in gastric carcinomas. J. Surg. Oncol. 83(4), 253-260 (2003).
-
(2003)
J. Surg. Oncol.
, vol.83
, Issue.4
, pp. 253-260
-
-
Wang, J.Y.1
Chang, C.T.2
Hsieh, J.S.3
-
21
-
-
0032897021
-
Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients
-
Fujita K, Denda K, Yamamoto M, Matsumoto T, Fujime M, Irimura T. Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients. Br. J. Cancer 80(1-2), 301-308 (1999).
-
(1999)
Br. J. Cancer
, vol.80
, Issue.1-2
, pp. 301-308
-
-
Fujita, K.1
Denda, K.2
Yamamoto, M.3
Matsumoto, T.4
Fujime, M.5
Irimura, T.6
-
22
-
-
0032934218
-
MUC1 mucin mRNA expression in stage I lung adenocarcinoma and its association with early recurrence
-
Ohgami A, Tsuda T, Osaki T et al. MUC1 mucin mRNA expression in stage I lung adenocarcinoma and its association with early recurrence. Ann. Thorac Surg. 67(3), 810-814 (1999).
-
(1999)
Ann. Thorac Surg.
, vol.67
, Issue.3
, pp. 810-814
-
-
Ohgami, A.1
Tsuda, T.2
Osaki, T.3
-
23
-
-
0033091727
-
Prognostic values of MUC-1 molecule expressing cytokine receptor-like epitope and DF3 in patients with gastric carcinoma
-
Nakagawa K, Akagi J, Takai E et al. Prognostic values of MUC-1 molecule expressing cytokine receptor-like epitope and DF3 in patients with gastric carcinoma Int. J. Oncol. 14(3), 425-435 (1999).
-
(1999)
Int. J. Oncol.
, vol.14
, Issue.3
, pp. 425-435
-
-
Nakagawa, K.1
Akagi, J.2
Takai, E.3
-
24
-
-
0028957721
-
Prognostic significance of MUC1 epithelial mucin expression in breast cancer
-
McGuckin MEA. Prognostic significance of MUC1 epithelial mucin expression in breast cancer. Human Pathol. 26(4), 432-439 (1995).
-
(1995)
Human Pathol.
, vol.26
, Issue.4
, pp. 432-439
-
-
McGuckin, M.E.A.1
-
25
-
-
0028031619
-
MUC1 mucin expression as a marker of progression and metastasis in human colorectal carcinoma
-
Nakamori S, Ota DM, Cleary KR, Shirotani K, Itimura T. MUC1 mucin expression as a marker of progression and metastasis in human colorectal carcinoma. Gastroenterolgy 106(2), 353-361 (1994).
-
(1994)
Gastroenterolgy
, vol.106
, Issue.2
, pp. 353-361
-
-
Nakamori, S.1
Ota, D.M.2
Cleary, K.R.3
Shirotani, K.4
Itimura, T.5
-
26
-
-
15644365913
-
MUC1(episialin) expression in non-small cell lung cancer is independant of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients
-
Guddo F, Giatromanolaki A, Koukourakis MI et al. MUC1(episialin) expression in non-small cell lung cancer is independant of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients. J. Clin. Pathol. 54(9), 667-671 (1998).
-
(1998)
J. Clin. Pathol.
, vol.54
, Issue.9
, pp. 667-671
-
-
Guddo, F.1
Giatromanolaki, A.2
Koukourakis, M.I.3
-
27
-
-
0032754226
-
MUC1 expression in prostate carcinoma: Correlation with grade and stage
-
Kirschenbaum A, Itzkowitz SH, Wang JP, Yao S, Eliashvili M, Levine AC. MUC1 expression in prostate carcinoma: correlation with grade and stage. Mol. Urol. 3(3), 163-168 (1999).
-
(1999)
Mol. Urol.
, vol.3
, Issue.3
, pp. 163-168
-
-
Kirschenbaum, A.1
Itzkowitz, S.H.2
Wang, J.P.3
Yao, S.4
Eliashvili, M.5
Levine, A.C.6
-
28
-
-
0035370711
-
The importance of MUC1 cellular localization in patients with breast carcinoma: An immunohistologic study of 71 patients and review of the literature
-
Rahn JJ, Dabbagh L, Pasdar M, Hugh JC. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer 94(11), 1973-1982(2001).
-
(2001)
Cancer
, vol.94
, Issue.11
, pp. 1973-1982
-
-
Rahn, J.J.1
Dabbagh, L.2
Pasdar, M.3
Hugh, J.C.4
-
29
-
-
1842627662
-
Is MUC1 polymorphism associated with female infertility?
-
Goulart LR, Vieira GS, Martelli L, Inacio J, Goulart IM, Franco JG Jr. Is MUC1 polymorphism associated with female infertility? Reprod. Biomed. Online 8(4), 477-482 (2004).
-
(2004)
Reprod. Biomed. Online
, vol.8
, Issue.4
, pp. 477-482
-
-
Goulart, L.R.1
Vieira, G.S.2
Martelli, L.3
Inacio, J.4
Goulart, I.M.5
Franco Jr., J.G.6
-
30
-
-
0027234998
-
Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: Effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene
-
Ding L, Lalani EN, Reddish M et al. Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene. Cancer Immunol. Immunother. 36(1), 9-17 (1993).
-
(1993)
Cancer Immunol. Immunother.
, vol.36
, Issue.1
, pp. 9-17
-
-
Ding, L.1
Lalani, E.N.2
Reddish, M.3
-
31
-
-
0032892403
-
Isolation of MUC1-primed B lymphocytes from tumor-draining lymph nodes by immunomagnetic beads
-
Petrarca C, Casalino B, von Mensdorff-Pouilly S et al. Isolation of MUC1-primed B lymphocytes from tumor-draining lymph nodes by immunomagnetic beads. Cancer Immunol. Immunother. 47(5), 272-277 (1999).
-
(1999)
Cancer Immunol. Immunother.
, vol.47
, Issue.5
, pp. 272-277
-
-
Petrarca, C.1
Casalino, B.2
Von Mensdorff-Pouilly, S.3
-
32
-
-
17344392248
-
Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin
-
von Mensdorff-Pouilly S, Verstraeten AA, Kenemans P et al. Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin. J. Clin. Oncol. 18(3), 574-583 (2000).
-
(2000)
J. Clin. Oncol.
, vol.18
, Issue.3
, pp. 574-583
-
-
Von Mensdorff-Pouilly, S.1
Verstraeten, A.A.2
Kenemans, P.3
-
33
-
-
0028235908
-
Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients
-
Kotera Y, Fontenot JD, Pecher G, Metzgar RS, Finn OJ. Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 54(11), 2856-2860 (1994).
-
(1994)
Cancer Res.
, vol.54
, Issue.11
, pp. 2856-2860
-
-
Kotera, Y.1
Fontenot, J.D.2
Pecher, G.3
Metzgar, R.S.4
Finn, O.J.5
-
34
-
-
0027942214
-
Murine immune response to cells transfected with human MUC1: Immunization with cellular and synthetic antigens
-
Apostolopoulos V, Xing PX, McKenzie IF. Murine immune response to cells transfected with human MUC1: immunization with cellular and synthetic antigens. Cancer Res. 54(19), 5186-5193 (1994).
-
(1994)
Cancer Res.
, vol.54
, Issue.19
, pp. 5186-5193
-
-
Apostolopoulos, V.1
Xing, P.X.2
McKenzie, I.F.3
-
35
-
-
0002353838
-
Immunotherapy of breast cancer using a recombinant Vaccinia virus expressing the human MUC1 and IL2
-
Bizouarne P. Immunotherapy of breast cancer using a recombinant Vaccinia virus expressing the human MUC1 and IL2. Breast Cancer Advances Biol. Ther. 303-308 (1996).
-
(1996)
Breast Cancer Advances Biol. Ther.
, pp. 303-308
-
-
Bizouarne, P.1
-
36
-
-
0028822120
-
Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses
-
Apostolopoulos V, Pietersz GA, Loveland BE, Sandrin MS, McKenzie IF. Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses. Proc. Natl Acad. Sci. USA 92(22), 10128-10132 (1995). Describes a strategy to target antigens to major antigen-presenting cells. Antigen-presenting cells have developed receptors that bind the sugar mannan, which is most often found on yeasts. This group has shown that coupling mannan to a protein antigen (GST-MUC1 [variable number tandem repeat] fusion protein) enables the generation of strong MUC1-specific cytotoxic T-lymphocytes (CTLs) responses in mice at low doses and with no adjuvant. Moreover, whether a Th1 or Th2 response is generated can be manipulated by how the mannan is attached to the glutathione S-transferase protein.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, Issue.22
, pp. 10128-10132
-
-
Apostolopoulos, V.1
Pietersz, G.A.2
Loveland, B.E.3
Sandrin, M.S.4
McKenzie, I.F.5
-
37
-
-
0030862319
-
Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells
-
Gong J, Chen L, Chen D et al. Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells. Gene Ther. 4(10), 1023-1028 (1997).
-
(1997)
Gene Ther.
, vol.4
, Issue.10
, pp. 1023-1028
-
-
Gong, J.1
Chen, L.2
Chen, D.3
-
38
-
-
0345166825
-
A glycopeptide in complex with MHC class I uses the GalNac residue as an anchor
-
Apostolopoulos V, Yuriev E, Ramsland PA et al. A glycopeptide in complex with MHC class I uses the GalNac residue as an anchor. Proc. Natl Acad. Sci. USA 100(25), 15029-15034 (2003). Traditional immunology would predict that antigenic peptides, as presented by the major histocompatibility complex (MHC)-1, are samples of proteins produced in the cell, which are taken prior to passage through the Golgi apparatus and thus, are not glycosylated. Therefore, proposed potential CTLs epitopes were derived from lists of possible peptides taken from the protein sequence. This demonstration that the alternate antigen-presenting pathway can result in MHC-1 presentation of glycosylated peptides makes CTLs immunology much more complex.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.25
, pp. 15029-15034
-
-
Apostolopoulos, V.1
Yuriev, E.2
Ramsland, P.A.3
-
39
-
-
0030857022
-
Specificities of anti-sialyl-tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes
-
Reddish MA, Jackson L, Koganty RR, Qiu D, Hong W, Longenecker BM. Specificities of anti-sialyl-tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes. Glycoconj. J. 14(5), 549-560 (1997).
-
(1997)
Glycoconj. J.
, vol.14
, Issue.5
, pp. 549-560
-
-
Reddish, M.A.1
Jackson, L.2
Koganty, R.R.3
Qiu, D.4
Hong, W.5
Longenecker, B.M.6
-
40
-
-
0028318850
-
Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes
-
Haurum JS, Arsequell G, Lellouch AC et al. Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J. Exp. Med. 180(2), 739-744 (1994). Traditional immunology would predict that antigenic peptides, as presented by the MHC-1, are samples of proteins produced in the cell, which are taken prior to passage through the Golgi apparatus and thus, are not glycosylated. Therefore, proposed potential CTLs epitopes were derived from lists of possible peptides taken from the protein sequence. This demonstration that the alternate antigen-presenting pathway can result in MHC-1 presentation of glycosylated peptides makes CTLs immunology much more complex.
-
(1994)
J. Exp. Med.
, vol.180
, Issue.2
, pp. 739-744
-
-
Haurum, J.S.1
Arsequell, G.2
Lellouch, A.C.3
-
41
-
-
0024454148
-
Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T-cells
-
+, cytotoxic T-cells recognize antigenic peptides as presented in the context of the MHC-I. This group describes a population of T-cells from a pancreatic cancer patient, which recognizes MUC1 independantly of MHC-I. This is very important for potential MUC1-targeted cancer immunotherapy, since many tumor cells have decreased levels of MHC-I.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, Issue.18
, pp. 7159-7163
-
-
Barnd, D.L.1
Lan, M.S.2
Metzgar, R.S.3
Finn, O.J.4
-
42
-
-
0027156780
-
+ human cytotoxic T-lymphocytes
-
+ human cytotoxic T-lymphocytes. J. Immunol. 150(4), 1437645 (1993).
-
(1993)
J. Immunol.
, vol.150
, Issue.4
, pp. 1437645
-
-
Maccario, R.1
Revello, M.G.2
Comoli, P.3
Montagna, D.4
Locatelli, F.5
Gerna, G.6
-
43
-
-
0032534061
-
HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner
-
Sciammas R, Bluestone JA. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. J. Immunol. 161(10), 5187-5192 (1998).
-
(1998)
J. Immunol.
, vol.161
, Issue.10
, pp. 5187-5192
-
-
Sciammas, R.1
Bluestone, J.A.2
-
44
-
-
0842282557
-
+CD56-natural killer T-cells specific for MUC1 mucin
-
+CD56- natural killer T-cells specific for MUC1 mucin. Cancer Res. 64(3), 1171-1180 (2004)
-
(2004)
Cancer Res.
, vol.64
, Issue.3
, pp. 1171-1180
-
-
Wajchman, H.J.1
Pierce, C.W.2
Varma, V.A.3
Issa, M.M.4
Petros, J.5
Dombrowski, K.E.6
-
45
-
-
0031297362
-
Induction of HLA-A2-restricted controls to the mucin 1 human breast cancer antigen
-
Apostolopoulos V, Karanikas V, Haurum JS, McKenzie IF. Induction of HLA-A2-restricted controls to the mucin 1 human breast cancer antigen. J. Immunol. 59(11), 5211-5218 (1997).
-
(1997)
J. Immunol.
, vol.59
, Issue.11
, pp. 5211-5218
-
-
Apostolopoulos, V.1
Karanikas, V.2
Haurum, J.S.3
McKenzie, I.F.4
-
46
-
-
0033564363
-
Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies
-
Brossart P, Heinrich KS, Stuhler G et al. Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. Blood 93(12), 4309-4317 (1999).
-
(1999)
Blood
, vol.93
, Issue.12
, pp. 4309-4317
-
-
Brossart, P.1
Heinrich, K.S.2
Stuhler, G.3
-
48
-
-
0036146275
-
Analysis of endogenous peptides bound by soluble MHC class I molecules: A novel approach for identifying tumor-specific antigens
-
Barnea E, Beer I, Patoka R et al. Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens. Eur. J. Immunol. 32(1), 213-22 (2002).
-
(2002)
Eur. J. Immunol.
, vol.32
, Issue.1
, pp. 213-222
-
-
Barnea, E.1
Beer, I.2
Patoka, R.3
-
49
-
-
0035254940
-
Identification of three non-VNTR MUC1-derived HLA-A*0201-restricted T-cell epitopes that induce protective anti-tumor immunity in HLA-A2/k(b)-transgenic mice
-
Heukamp LC, van der Burg SH, Drijfhout JW, Melief CJ, Taylor-Papadimitriou J, Offringa R. Identification of three non-VNTR MUC1-derived HLA-A*0201-restricted T-cell epitopes that induce protective anti-tumor immunity in HLA-A2/k(b)-transgenic mice. Int. J. Cancer 91(3), 385-392 (2001).
-
(2001)
Int. J. Cancer
, vol.91
, Issue.3
, pp. 385-392
-
-
Heukamp, L.C.1
Van Der Burg, S.H.2
Drijfhout, J.W.3
Melief, C.J.4
Taylor-Papadimitriou, J.5
Offringa, R.6
-
50
-
-
0033986154
-
-/- × β2 microglobulin (β2m) null mice transgenic for a chimeric HLA-A2.1/Db-β2 microglobulin single chain
-
-/- × β2 microglobulin (β2m) null mice transgenic for a chimeric HLA-A2.1/Db-β2 microglobulin single chain. Int. J. Cancer 85(3), 391-397 (2000).
-
(2000)
Int. J. Cancer
, vol.85
, Issue.3
, pp. 391-397
-
-
Carmon, L.1
El-Shami, K.M.2
Paz, A.3
-
51
-
-
0025728909
-
Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (ta3-ha)
-
Fung PY, Longenecker BM. Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (ta3-ha). Cancer Res. 51(4), 1170-1176 (1991). First demonstration that mucins, such as MUC1, have a complex interaction with the immune system.
-
(1991)
Cancer Res.
, vol.51
, Issue.4
, pp. 1170-1176
-
-
Fung, P.Y.1
Longenecker, B.M.2
-
52
-
-
0031914321
-
Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
-
Agrawal B, Krantz MJ, Reddish MA, Longenecker BM. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nature Med 4(1), 43-49 (1998).
-
(1998)
Nature Med
, vol.4
, Issue.1
, pp. 43-49
-
-
Agrawal, B.1
Krantz, M.J.2
Reddish, M.A.3
Longenecker, B.M.4
-
53
-
-
17644401665
-
MUC1 mucin-mediated regulation of human T-cells
-
Agrawal B, Longenecker BM. MUC1 mucin-mediated regulation of human T-cells. Int. Immunol. 17(4), 391-399 (2005).
-
(2005)
Int. Immunol.
, vol.17
, Issue.4
, pp. 391-399
-
-
Agrawal, B.1
Longenecker, B.M.2
-
54
-
-
0032925109
-
Lack of evidence for an immunosuppressive role for MUC1
-
Paul S, Bizouarne N, Paul A et al. Lack of evidence for an immunosuppressive role for MUC1. Cancer Immunol. Immunother. 48(1), 22-28 (1999).
-
(1999)
Cancer Immunol. Immunother.
, vol.48
, Issue.1
, pp. 22-28
-
-
Paul, S.1
Bizouarne, N.2
Paul, A.3
-
55
-
-
0034194173
-
The epidielial mucin, MUC1, is expressed on resting T-lymphocytes and can function as a negative regulator of T-cell activation
-
Chang JF, Zhao HL, Phillips J, Greenburg G. The epidielial mucin, MUC1, is expressed on resting T-lymphocytes and can function as a negative regulator of T-cell activation. Cell Immunol. 201(2), 83-88 (2000).
-
(2000)
Cell Immunol.
, vol.201
, Issue.2
, pp. 83-88
-
-
Chang, J.F.1
Zhao, H.L.2
Phillips, J.3
Greenburg, G.4
-
56
-
-
0037278398
-
Regulated expression of MUC1 epithelial antigen in erythropoiesis
-
Rughetti A, Biffoni M, Pierelli L et al. Regulated expression of MUC1 epithelial antigen in erythropoiesis. Br. J. Haematol. 120(2), 344-352 (2003).
-
(2003)
Br. J. Haematol.
, vol.120
, Issue.2
, pp. 344-352
-
-
Rughetti, A.1
Biffoni, M.2
Pierelli, L.3
-
57
-
-
11144354528
-
Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by cho-k1 cells in protein-free medium
-
Link T, Backstrom M, Graham R et al. Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by cho-k1 cells in protein-free medium. J. Biotechnol. 110(1), 51-62 (2004).
-
(2004)
J. Biotechnol.
, vol.110
, Issue.1
, pp. 51-62
-
-
Link, T.1
Backstrom, M.2
Graham, R.3
-
58
-
-
0029951136
-
Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice
-
Zhang S, Graeber LA, Helling F et al. Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice. Cancer Res. 56(14), 3315-3319 (1996).
-
(1996)
Cancer Res.
, vol.56
, Issue.14
, pp. 3315-3319
-
-
Zhang, S.1
Graeber, L.A.2
Helling, F.3
-
59
-
-
0035339389
-
Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection
-
Soares MM, Mehta V, Finn OJ. Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J. Immunol. 166(11), 6555-6563 (2001).
-
(2001)
J. Immunol.
, vol.166
, Issue.11
, pp. 6555-6563
-
-
Soares, M.M.1
Mehta, V.2
Finn, O.J.3
-
61
-
-
0028846909
-
Structure of a tumor-associated antigen containing a tandemly repeated immunodominant epitope
-
Fontenot JD, Mariappan S V, Catasti P, Domenech N, Finn OJ, Gupta G. Structure of a tumor-associated antigen containing a tandemly repeated immunodominant epitope. J. Biomol. Struct. Dyn 13(2), 245-260 (1995).
-
(1995)
J. Biomol. Struct. Dyn.
, vol.13
, Issue.2
, pp. 245-260
-
-
Fontenot, J.D.1
Mariappan, S.V.2
Catasti, P.3
Domenech, N.4
Finn, O.J.5
Gupta, G.6
-
62
-
-
13144268565
-
Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells
-
Gong J, Chen D, Kashiwaba M et al. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc. Natl Acad. Sci. USA 95(11), 6279-6283 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, Issue.11
, pp. 6279-6283
-
-
Gong, J.1
Chen, D.2
Kashiwaba, M.3
-
63
-
-
0035181956
-
Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice
-
Tanaka Y, Koido S, Chen D, Gendler SJ, Kufe D, Gong J. Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice. Clin. Immunol. 101(2), 192-200(2001). Demonstrates that the dendritic cell antigen presentation system can be manipulated to present whole tumor cells. Furthermore, established MUC1 expressing tumors could be eliminated from mice by immunotherapy with these dendritic cell hybrid cells, which express the MUC1 antigen.
-
(2001)
Clin. Immunol.
, vol.101
, Issue.2
, pp. 192-200
-
-
Tanaka, Y.1
Koido, S.2
Chen, D.3
Gendler, S.J.4
Kufe, D.5
Gong, J.6
-
64
-
-
0029918564
-
Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B-cells
-
Pecher G, Finn OJ. Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B-cells. Proc. Natl. Acad. Sci. USA 93(4), 1699-1704 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, Issue.4
, pp. 1699-1704
-
-
Pecher, G.1
Finn, O.J.2
-
65
-
-
0027411456
-
A Heterologous protection against influenza by injection of DNA encoding a viral protein
-
Ulmer JB, Donnelly JJ, Parker SE et al. A Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259(5102), 1745-1749 (1993).
-
(1993)
Science
, vol.259
, Issue.5102
, pp. 1745-1749
-
-
Ulmer, J.B.1
Donnelly, J.J.2
Parker, S.E.3
-
66
-
-
0028060149
-
Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses
-
Raz E, Carson DA, Parker SE et al. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl Acad. Sci. USA 91(20), 9519-9523 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, Issue.20
, pp. 9519-9523
-
-
Raz, E.1
Carson, D.A.2
Parker, S.E.3
-
67
-
-
0029916313
-
Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumor cells
-
Graham RA, Burchell JM, Beverley P, Taylor-Papadimitriou J. Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumor cells. Int. J. Cancer 65(5), 664-670 (1996).
-
(1996)
Int. J. Cancer
, vol.65
, Issue.5
, pp. 664-670
-
-
Graham, R.A.1
Burchell, J.M.2
Beverley, P.3
Taylor-Papadimitriou, J.4
-
68
-
-
0025604608
-
Vaccination against tumor cells expressing breast cancer epithelial tumor antigen
-
Hareuveni M, Gautier C, Kieny MP, Wreschner D, Chambon P, Lathe R. Vaccination against tumor cells expressing breast cancer epithelial tumor antigen. Proc. Natl Acad. Sci. USA 87(23), 9498-9502 (1990). Shows that the MUC1 antigen can be expressed in a vaccinia virus vector and can be used in an immunotherapy setting to eliminate MUC1-transfected tumors from rats.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, Issue.23
, pp. 9498-9502
-
-
Hareuveni, M.1
Gautier, C.2
Kieny, M.P.3
Wreschner, D.4
Chambon, P.5
Lathe, R.6
-
69
-
-
0022405424
-
Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype
-
Buller RM, Smith GL, Cremer K, Notkins AL, Moss B. Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype. Nature 317(6040), 813-815 (1985).
-
(1985)
Nature
, vol.317
, Issue.6040
, pp. 813-815
-
-
Buller, R.M.1
Smith, G.L.2
Cremer, K.3
Notkins, A.L.4
Moss, B.5
-
70
-
-
0027489489
-
Recombinant vaccinia mucin vector: In vitro analysis of expression of tumor-associated epitopes for antibody and human cytotoxic T-cell recognition
-
Bu D, Domenech N, Lewis J, Taylor-Papadimitriou J, Finn OJ. Recombinant vaccinia mucin vector: in vitro analysis of expression of tumor-associated epitopes for antibody and human cytotoxic T-cell recognition. J. Immunother. 14(2), 127-135 (1993).
-
(1993)
J. Immunother.
, vol.14
, Issue.2
, pp. 127-135
-
-
Bu, D.1
Domenech, N.2
Lewis, J.3
Taylor-Papadimitriou, J.4
Finn, O.J.5
-
71
-
-
0027438199
-
Vaccinia virus MUC1 immunization of mice: Immune response and protection against the growth of murine tumors bearing the MUC1 antigen
-
Acres RB, Hareuveni M, Balloul JM, Kieny MP. Vaccinia virus MUC1 immunization of mice: immune response and protection against the growth of murine tumors bearing the MUC1 antigen. J. Immunother. 14(2), 136-143 (1993).
-
(1993)
J. Immunother.
, vol.14
, Issue.2
, pp. 136-143
-
-
Acres, R.B.1
Hareuveni, M.2
Balloul, J.M.3
Kieny, M.P.4
-
72
-
-
0031451498
-
Therapeutic antitumor response after immunization with an admixture of recombinant vaccinia viruses expressing a modified MUC1 gene and the murine T-cell costimulatory molecule b7
-
Akagi J, Hodge JW, McLaughlin JP et al. Therapeutic antitumor response after immunization with an admixture of recombinant vaccinia viruses expressing a modified MUC1 gene and the murine T-cell costimulatory molecule b7. J. Immunother. 20(1), 38-47 (1997).
-
(1997)
J. Immunother.
, vol.20
, Issue.1
, pp. 38-47
-
-
Akagi, J.1
Hodge, J.W.2
McLaughlin, J.P.3
-
73
-
-
0033989671
-
MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines
-
Acres B, Apostolopoulos V, Balloul JM et al. MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines. Cancer Immunol. Immunother. 48(10), 588-594 (2000).
-
(2000)
Cancer Immunol. Immunother.
, vol.48
, Issue.10
, pp. 588-594
-
-
Acres, B.1
Apostolopoulos, V.2
Balloul, J.M.3
-
74
-
-
5144233489
-
Gene-based vaccines and immunotherapeutics
-
Liu M, Acres B, Balloul JM et al. Gene-based vaccines and immunotherapeutics. Proc. Natl Acad. Sci. USA 101(Suppl. 2), 14567-14571 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.SUPPL. 2
, pp. 14567-14571
-
-
Liu, M.1
Acres, B.2
Balloul, J.M.3
-
75
-
-
0034856787
-
Adenovirus-mediated MUC1 gene transduction into blood derived dendritic cels
-
Maruyama K. Adenovirus-mediated MUC1 gene transduction into blood derived dendritic cels. J. Immunother. 24(4), 345-353 (2001).
-
(2001)
J. Immunother.
, vol.24
, Issue.4
, pp. 345-353
-
-
Maruyama, K.1
-
76
-
-
0034766337
-
Transduction of human dendritic cells with a recombinant modified vaccinia ankara virus encoding MUC1 and IL-2
-
Trevor KT, Hersh EM, Brailey J, Balloul JM, Acres B. Transduction of human dendritic cells with a recombinant modified vaccinia ankara virus encoding MUC1 and IL-2. Cancer Immunol. Immunother. 50(8), 397-407 (2001).
-
(2001)
Cancer Immunol. Immunother.
, vol.50
, Issue.8
, pp. 397-407
-
-
Trevor, K.T.1
Hersh, E.M.2
Brailey, J.3
Balloul, J.M.4
Acres, B.5
-
77
-
-
0028889356
-
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the df3/MUC1 promoter
-
Chen L, Chen D, Manome Y, Dong Y, Fine HA, Kufe DW. Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the df3/MUC1 promoter. J. Clin. Invest. 96(6), 2775-8272 (1995).
-
(1995)
J. Clin. Invest.
, vol.96
, Issue.6
, pp. 2775-8272
-
-
Chen, L.1
Chen, D.2
Manome, Y.3
Dong, Y.4
Fine, H.A.5
Kufe, D.W.6
-
78
-
-
0025834851
-
Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells
-
Jerome KR, Barnd DL, Bendt KM et al. Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res. 51(11), 2908-2916 (1991).
-
(1991)
Cancer Res.
, vol.51
, Issue.11
, pp. 2908-2916
-
-
Jerome, K.R.1
Barnd, D.L.2
Bendt, K.M.3
-
79
-
-
0027234878
-
Cytotoxic T-cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides
-
Ioannides CG, Fisk B, Jerome KR et al. Cytotoxic T-cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides. J. Immunol. 151(7), 3693-3703 (1993).
-
(1993)
J. Immunol.
, vol.151
, Issue.7
, pp. 3693-3703
-
-
Ioannides, C.G.1
Fisk, B.2
Jerome, K.R.3
-
80
-
-
0029787977
-
Enhancing the effect of theratope stn-klh cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cydophosphamide
-
MacLean GD, Miles DW, Rubens RD, Reddish MA, Longenecker BM. Enhancing the effect of theratope stn-klh cancer vaccine in patients with metastatic breast cancer by pretreatment with low-dose intravenous cydophosphamide. J. Immunother. Emphasis Tumor Immunol. 19(4), 309-316 (1996). Demonstration in a clinical trial setting that immune responses to a cancer-associated vaccine can be enhanced by pretreatment with a low dose of cydophosphamide.
-
(1996)
J. Immunother. Emphasis Tumor Immunol.
, vol.19
, Issue.4
, pp. 309-316
-
-
MacLean, G.D.1
Miles, D.W.2
Rubens, R.D.3
Reddish, M.A.4
Longenecker, B.M.5
-
81
-
-
0030000007
-
A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma
-
Goydos JS, Elder E, Whiteside TL, Finn OJ, Lotze MT. A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J. Surg. Res. 63(1), 298-304 (1996).
-
(1996)
J. Surg. Res.
, vol.63
, Issue.1
, pp. 298-304
-
-
Goydos, J.S.1
Elder, E.2
Whiteside, T.L.3
Finn, O.J.4
Lotze, M.T.5
-
82
-
-
19944433959
-
Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with sb-as2 adjuvant in resected and locally advanced pancreatic cancer
-
Ramanathan RK, Lee KM, McKolanis J et al. Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with sb-as2 adjuvant in resected and locally advanced pancreatic cancer. Cancer Immunol. Immunother. 54(3), 254-264 (2005).
-
(2005)
Cancer Immunol. Immunother.
, vol.54
, Issue.3
, pp. 254-264
-
-
Ramanathan, R.K.1
Lee, K.M.2
McKolanis, J.3
-
83
-
-
0034071575
-
Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus qs-21
-
Gilewski T, Adluri S, Ragupathi G et al. Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus qs-21. Clin. Cancer Res. 6(5), 1693-1701 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, Issue.5
, pp. 1693-1701
-
-
Gilewski, T.1
Adluri, S.2
Ragupathi, G.3
-
84
-
-
0031457133
-
Antibody and T-cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein
-
Karanikas V, Hwang LA, Pearson J et al. Antibody and T-cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J. Clin. Invest. 100(11), 2783-2792 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, Issue.11
, pp. 2783-2792
-
-
Karanikas, V.1
Hwang, L.A.2
Pearson, J.3
-
85
-
-
0034331218
-
Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
-
Brossart P, Wirths S, Stuhler G, Reichardt VL, Kanz L, Brugger W. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 96(9), 3102-3108 (2000). Clinical testing of a vaccine involving both dendritic cells and MUC1 peptides, which had been shown to be recognized by MUC1-specific, patient CTLs.
-
(2000)
Blood
, vol.96
, Issue.9
, pp. 3102-3108
-
-
Brossart, P.1
Wirths, S.2
Stuhler, G.3
Reichardt, V.L.4
Kanz, L.5
Brugger, W.6
-
86
-
-
0027180537
-
Assembly of vaccinia virus: Role of the intermediate compartment between the endoplasmic reticulum and the golgi stacks
-
Sodeik B, Doms RW, Ericsson M et al. Assembly of vaccinia virus: role of the intermediate compartment between the endoplasmic reticulum and the golgi stacks. J. Cell Biol. 121(3), 521-541 (1993).
-
(1993)
J. Cell Biol.
, vol.121
, Issue.3
, pp. 521-541
-
-
Sodeik, B.1
Doms, R.W.2
Ericsson, M.3
-
87
-
-
0348013088
-
O-linked glycans control glycoprotein processing by antigen-presenting cells: A biochemical approach to the molecular aspects of MUC1 processing by dendritic cells
-
Hanisch FG, Schwientek T, Von Bergwelt-Baildon MS, Schultze JL, Finn O. O-linked glycans control glycoprotein processing by antigen-presenting cells: a biochemical approach to the molecular aspects of MUC1 processing by dendritic cells. Eur. J. Immunol. 33(12), 3242-3254 (2003).
-
(2003)
Eur. J. Immunol.
, vol.33
, Issue.12
, pp. 3242-3254
-
-
Hanisch, F.G.1
Schwientek, T.2
Von Bergwelt-Baildon, M.S.3
Schultze, J.L.4
Finn, O.5
-
88
-
-
0030035046
-
Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma
-
Lai P, Rabinowich H, Crowley-Nowick PA et al. Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma. Clin. Cancer Res. 2(1), 161-173 (1996).
-
(1996)
Clin. Cancer Res.
, vol.2
, Issue.1
, pp. 161-173
-
-
Lai, P.1
Rabinowich, H.2
Crowley-Nowick, P.A.3
-
89
-
-
0033852076
-
Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer
-
Scholl SM, Balloul JM, Le Goc G et al. Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer. J. Immunother. 23(5), 570-580 (2000).
-
(2000)
J. Immunother.
, vol.23
, Issue.5
, pp. 570-580
-
-
Scholl, S.M.1
Balloul, J.M.2
Le Goc, G.3
-
90
-
-
4143077460
-
Metastatic breast tumor regression following treatment by a gene-modified vaccinia virus expressing MUC1 and IL-2
-
Scholl S, Squiban P, Bizouarne N et al. Metastatic breast tumor regression following treatment by a gene-modified vaccinia virus expressing MUC1 and IL-2. J. Biomed Biotechnol. 3, 194-201 (2003). Patients with metastatic breast cancer were immunized several times with a highly attenuated vaccinia virus (MVA) engineered to express both MUC1 and interleukin-2. Two partial responses were observed. One patient with several liver metastases had shrinkage of tumors such that they could be removed surgically. More than 5 years later, the patient is alive and tumor free.
-
(2003)
J. Biomed. Biotechnol.
, vol.3
, pp. 194-201
-
-
Scholl, S.1
Squiban, P.2
Bizouarne, N.3
-
91
-
-
4344713204
-
Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer
-
Pantuck AJ, van Ophoven A, Gitlitz BJ et al. Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer. J. Immunother. 27(3), 240-253 (2004).
-
(2004)
J. Immunother.
, vol.27
, Issue.3
, pp. 240-253
-
-
Pantuck, A.J.1
Van Ophoven, A.2
Gitlitz, B.J.3
-
92
-
-
0742324611
-
Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer
-
Rochlitz C , Figlin R, Squiban P et al. Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer. J. Gene Med. 5(8), 690-699 (2003).
-
(2003)
J. Gene Med.
, vol.5
, Issue.8
, pp. 690-699
-
-
Rochlitz, C.1
Figlin, R.2
Squiban, P.3
-
93
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T-lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
Phan GQ, Yang JC, Sherry RM et al. Cancer regression and autoimmunity induced by cytotoxic T-lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl Acad. Sci. USA 100(14), 8372-8377 (2003). Strategy to immunize cancer patients with a melanoma antigen, which is also a self antigen, in the context of efforts to inhibit immune tolerance to the self antigen, by blocking CTL antigen-4. Clinical responses were observed, but so were manifestations of autoimmunity. This demonstrates that continued efforts to manipulate the immune response, as well as immune regulation, will eventually result in successful cancer immunotherapy.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.14
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
-
94
-
-
9144268394
-
Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy
-
Moniaux N, Andrianifahanana M, Brand RE, Batra SK. Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. Br. J. Cancer 91(9), 1633-1638 (2004).
-
(2004)
Br. J. Cancer
, vol.91
, Issue.9
, pp. 1633-1638
-
-
Moniaux, N.1
Andrianifahanana, M.2
Brand, R.E.3
Batra, S.K.4
-
95
-
-
0037011127
-
Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: Processing of tumor antigen MUC1 glycopeptides for presentation to major histocompatibility complex class II-restricted T-cells
-
Vlad AM, Muller S, Cudic M et al. Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: processing of tumor antigen MUC1 glycopeptides for presentation to major histocompatibility complex class II-restricted T-cells. J. Exp. Med. 196(11), 1435-1446 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, Issue.11
, pp. 1435-1446
-
-
Vlad, A.M.1
Muller, S.2
Cudic, M.3
-
96
-
-
1542283702
-
Designer glycopeptides for cytotoxic T-cell-based elimination of carcinomas
-
Xu Y, Gendler SJ, Franco A. Designer glycopeptides for cytotoxic T-cell-based elimination of carcinomas. J. Exp. Med. 199(5), 707-716 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, Issue.5
, pp. 707-716
-
-
Xu, Y.1
Gendler, S.J.2
Franco, A.3
-
97
-
-
13544262683
-
Dendritic cells induce MUC1 expression and polarization on human T-cells by an IL-7-dependent mechanism
-
Vasir B, Avigan D, Wu Z et al. Dendritic cells induce MUC1 expression and polarization on human T-cells by an IL-7-dependent mechanism. J. Immunol. 174(4), 2376-2386 (2005).
-
(2005)
J. Immunol.
, vol.174
, Issue.4
, pp. 2376-2386
-
-
Vasir, B.1
Avigan, D.2
Wu, Z.3
-
98
-
-
0037238785
-
Form and pattern of MUC1 expression on T-cells activated in vivo or in vitro suggests a function in T-cell migration
-
Correa I, Plunkett T, Vlad A et al. Form and pattern of MUC1 expression on T-cells activated in vivo or in vitro suggests a function in T-cell migration. Immunology 108(1), 32-41 (2003).
-
(2003)
Immunology
, vol.108
, Issue.1
, pp. 32-41
-
-
Correa, I.1
Plunkett, T.2
Vlad, A.3
-
99
-
-
0028031619
-
MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma
-
Nakamori S, Ota DM, Cleary KR, Shirotani K, Irimura T. MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 106(2), 353-361 (1994).
-
(1994)
Gastroenterology
, vol.106
, Issue.2
, pp. 353-361
-
-
Nakamori, S.1
Ota, D.M.2
Cleary, K.R.3
Shirotani, K.4
Irimura, T.5
-
100
-
-
15644365913
-
MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients
-
Guddo F, Giatromanolaki A, Koukourakis MI et al. MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients. J Clin. Pathol. 51(9), 667-671 (1998).
-
(1998)
J. Clin. Pathol.
, vol.51
, Issue.9
, pp. 667-671
-
-
Guddo, F.1
Giatromanolaki, A.2
Koukourakis, M.I.3
-
101
-
-
0033949959
-
Cytotoxic T lymphocytes from humans with adenocarcinomas stimulated by native MUC1 mucin and a mucin peptide mutated at a glycosylation site
-
Wright SE, Kilinski L, Talib S et al. Cytotoxic T lymphocytes from humans with adenocarcinomas stimulated by native MUC1 mucin and a mucin peptide mutated at a glycosylation site. J. Immunother. 1, 2-10 (2000).
-
(2000)
J. Immunother.
, vol.1
, pp. 2-10
-
-
Wright, S.E.1
Kilinski, L.2
Talib, S.3
-
102
-
-
0034666716
-
Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice
-
Lees CJ, Apostolopoulos V, Acres B et al. Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice. Vaccine 19(2-3), 158-162 (2000).
-
(2000)
Vaccine
, vol.19
, Issue.2-3
, pp. 158-162
-
-
Lees, C.J.1
Apostolopoulos, V.2
Acres, B.3
-
103
-
-
0037031255
-
Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions
-
Grinstead JS, Koganty RR, Krantz MJ, Longenecker BM, Campbell AP. Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions. Biochemistry 41(31), 9946-9961 (2002).
-
(2002)
Biochemistry
, vol.41
, Issue.31
, pp. 9946-9961
-
-
Grinstead, J.S.1
Koganty, R.R.2
Krantz, M.J.3
Longenecker, B.M.4
Campbell, A.P.5
-
104
-
-
0035126975
-
Mannan mucin-1 peptide immunization: Influence of cyclophosphamide and the route of injection
-
Karanikas V, Thynne G, Mitchell P et al. Mannan mucin-1 peptide immunization: influence of cyclophosphamide and the route of injection. J. Immunother. 24(2), 172-183 (2001).
-
(2001)
J. Immunother.
, vol.24
, Issue.2
, pp. 172-183
-
-
Karanikas, V.1
Thynne, G.2
Mitchell, P.3
-
105
-
-
0029035766
-
Phase I study of synthetic MUC1 peptides in breast cancer
-
Xing PX, Michael M, Apostolopoulos V et al. Phase I study of synthetic MUC1 peptides in breast cancer. Internl J. Oncol. 6, 1283-1289 (1995).
-
(1995)
Internl. J. Oncol.
, vol.6
, pp. 1283-1289
-
-
Xing, P.X.1
Michael, M.2
Apostolopoulos, V.3
-
106
-
-
8344258397
-
Mucin-1 is expressed on dendritic cells, both in vitro and in vivo
-
Cloosen S, Thio M, Vanclee A et al. Mucin-1 is expressed on dendritic cells, both in vitro and in vivo. Int. Immunol. 16(11), 1561-1571 (2004).
-
(2004)
Int. Immunol.
, vol.16
, Issue.11
, pp. 1561-1571
-
-
Cloosen, S.1
Thio, M.2
Vanclee, A.3
-
107
-
-
0036826802
-
MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells
-
Wykes M, MacDonald KP, Tran M et al. MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. J. Leukoc Biol. 72(4), 692-701 (2002).
-
(2002)
J. Leukoc Biol.
, vol.72
, Issue.4
, pp. 692-701
-
-
Wykes, M.1
MacDonald, K.P.2
Tran, M.3
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