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Volumn 116, Issue 22, 2010, Pages 5179-5187

Expression of p16INK4A but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma

Author keywords

cyclin dependent kinase inhibitor; p16; pancreas cancer; tissue microarray

Indexed keywords

CARBONATE DEHYDRATASE IX; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DIHYDROFOLATE REDUCTASE; DNA; K RAS PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

EID: 78449285473     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.25481     Document Type: Article
Times cited : (15)

References (46)
  • 2
    • 25444471804 scopus 로고    scopus 로고
    • Ductal neoplasia of the pancreas: Nosologic, clinicopathologic, and biologic aspects
    • Adsay NV, Basturk O, Cheng JD, Andea AA., Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects. Semin Radiat Oncol. 2005; 15: 254-264.
    • (2005) Semin Radiat Oncol. , vol.15 , pp. 254-264
    • Adsay, N.V.1    Basturk, O.2    Cheng, J.D.3    Andea, A.A.4
  • 4
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown JM, Giaccia AJ., The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 1998: 1408-1416.
    • (1998) Cancer Res. , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 5
    • 16244367619 scopus 로고    scopus 로고
    • Tumor deprivation of oxygen and tumor suppressor gene function
    • Yun Z, Giaccia AJ., Tumor deprivation of oxygen and tumor suppressor gene function. Methods Mol Biol. 2003: 485-504.
    • (2003) Methods Mol Biol. , pp. 485-504
    • Yun, Z.1    Giaccia, A.J.2
  • 6
    • 34547225129 scopus 로고    scopus 로고
    • Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
    • Cairns RA., Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2007; 104: 9445-9450.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , pp. 9445-9450
    • Cairns, R.A.1
  • 7
    • 0030465080 scopus 로고    scopus 로고
    • Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas
    • et al.;: .
    • Brizel DM, Scully SP, Harrelson JM, et al. Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res. 1996; 56: 5347-5350.
    • (1996) Cancer Res. , vol.56 , pp. 5347-5350
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3
  • 8
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • et al.;: .
    • Fyles A, Milosevic M, Hedley D, et al. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol. 2002; 20: 680-687.
    • (2002) J Clin Oncol. , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3
  • 9
    • 3042719231 scopus 로고    scopus 로고
    • Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer
    • Nordsmark M, Overgaard J., Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer. Acta Oncol. 2004; 43: 396-403.
    • (2004) Acta Oncol. , vol.43 , pp. 396-403
    • Nordsmark, M.1    Overgaard, J.2
  • 10
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel M, Vaupel P., Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 2001; 93: 266-276.
    • (2001) J Natl Cancer Inst. , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 12
    • 33645079888 scopus 로고    scopus 로고
    • An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    • et al.;: .
    • Le QT, Chen E, Salim A, et al. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res. 2006; 12: 1507-1514.
    • (2006) Clin Cancer Res. , vol.12 , pp. 1507-1514
    • Le, Q.T.1    Chen, E.2    Salim, A.3
  • 13
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P., Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996; 56: 4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 15
    • 34547842084 scopus 로고    scopus 로고
    • Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas
    • et al.;: .
    • Le QT, Kong C, Lavori PW, et al. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2007; 69: 167-175.
    • (2007) Int J Radiat Oncol Biol Phys. , vol.69 , pp. 167-175
    • Le, Q.T.1    Kong, C.2    Lavori, P.W.3
  • 16
    • 0031594279 scopus 로고    scopus 로고
    • Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer
    • Naka T, Kobayashi M, Ashida K, Toyota N, Kaneko T, Kaibara N., Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer. Int J Oncol. 1998; 12: 1111-1116.
    • (1998) Int J Oncol. , vol.12 , pp. 1111-1116
    • Naka, T.1    Kobayashi, M.2    Ashida, K.3    Toyota, N.4    Kaneko, T.5    Kaibara, N.6
  • 18
    • 0035480005 scopus 로고    scopus 로고
    • Tissue microarrays (TMAs) for high-throughput molecular pathology research
    • Nocito A, Kononen J, Kallioniemi OP, Sauter G., Tissue microarrays (TMAs) for high-throughput molecular pathology research. Int J Cancer. 2001; 94: 1-5.
    • (2001) Int J Cancer. , vol.94 , pp. 1-5
    • Nocito, A.1    Kononen, J.2    Kallioniemi, O.P.3    Sauter, G.4
  • 19
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • et al.;: .
    • Swinson DE, Jones JL, Richardson D, et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol. 2003; 21: 473-482.
    • (2003) J Clin Oncol. , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3
  • 20
    • 57449117769 scopus 로고    scopus 로고
    • Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma
    • et al.;: .
    • Cui Y, Tian M, Zong M, et al. Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. Pancreatology. 2009; 9: 89-98.
    • (2009) Pancreatology. , vol.9 , pp. 89-98
    • Cui, Y.1    Tian, M.2    Zong, M.3
  • 21
    • 61449224742 scopus 로고    scopus 로고
    • Proteomic profiling in pancreatic cancer with and without lymph node metastasis
    • et al.;: .
    • Cui Y, Wu J, Zong M, et al. Proteomic profiling in pancreatic cancer with and without lymph node metastasis. Int J Cancer. 2009; 124: 1614-1621.
    • (2009) Int J Cancer. , vol.124 , pp. 1614-1621
    • Cui, Y.1    Wu, J.2    Zong, M.3
  • 22
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • et al.;: .
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008; 359: 1757-1765.
    • (2008) N Engl J Med. , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 23
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • et al.;: .
    • Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003; 349: 247-257.
    • (2003) N Engl J Med. , vol.349 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 24
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • et al.;: .
    • Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet. 1994; 8: 27-32.
    • (1994) Nat Genet. , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3
  • 27
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • et al.;: .
    • Aguirre AJ, Bardeesy N, Sinha M, et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003; 17: 3112-3126.
    • (2003) Genes Dev. , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3
  • 28
    • 33645824724 scopus 로고    scopus 로고
    • Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
    • et al.;: .
    • Bardeesy N, Aguirre AJ, Chu GC, et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006; 103: 5947-5952.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , pp. 5947-5952
    • Bardeesy, N.1    Aguirre, A.J.2    Chu, G.C.3
  • 29
    • 0032532379 scopus 로고    scopus 로고
    • Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
    • et al.;: .
    • Wilentz RE, Geradts J, Maynard R, et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res. 1998; 58: 4740-4744.
    • (1998) Cancer Res. , vol.58 , pp. 4740-4744
    • Wilentz, R.E.1    Geradts, J.2    Maynard, R.3
  • 30
    • 0034075153 scopus 로고    scopus 로고
    • Hypermethylation of multiple genes in pancreatic adenocarcinoma
    • et al.;: .
    • Ueki T, Toyota M, Sohn T, et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res. 2000; 60: 1835-1839.
    • (2000) Cancer Res. , vol.60 , pp. 1835-1839
    • Ueki, T.1    Toyota, M.2    Sohn, T.3
  • 31
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • et al.;: .
    • Rozenblum E, Schutte M, Goggins M, et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 1997; 57: 1731-1734.
    • (1997) Cancer Res. , vol.57 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 32
    • 16944367477 scopus 로고    scopus 로고
    • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
    • et al.;: .
    • Schutte M, Hruban RH, Geradts J, et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997; 57: 3126-3130.
    • (1997) Cancer Res. , vol.57 , pp. 3126-3130
    • Schutte, M.1    Hruban, R.H.2    Geradts, J.3
  • 33
    • 0034153642 scopus 로고    scopus 로고
    • INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of 4 commercial antibodies
    • INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of 4 commercial antibodies. Appl Immunohistochem Mol Morphol. 2000; 8: 71-79.
    • (2000) Appl Immunohistochem Mol Morphol. , vol.8 , pp. 71-79
    • Geradts, J.1    Hruban, R.H.2    Schutte, M.3    Kern, S.E.4    Maynard, R.5
  • 35
    • 0037079027 scopus 로고    scopus 로고
    • Cyclin e and survival in patients with breast cancer
    • et al.;: .
    • Keyomarsi K, Tucker SL, Buchholz TA, et al. Cyclin E and survival in patients with breast cancer. N Engl J Med. 2002; 347: 1566-1575.
    • (2002) N Engl J Med. , vol.347 , pp. 1566-1575
    • Keyomarsi, K.1    Tucker, S.L.2    Buchholz, T.A.3
  • 36
    • 33750504838 scopus 로고    scopus 로고
    • Cyclin e expression and outcome in pancreatic ductal adenocarcinoma
    • et al.;: .
    • Skalicky DA, Kench JG, Segara D, et al. Cyclin E expression and outcome in pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2006; 15: 1941-1947.
    • (2006) Cancer Epidemiol Biomarkers Prev. , vol.15 , pp. 1941-1947
    • Skalicky, D.A.1    Kench, J.G.2    Segara, D.3
  • 37
    • 0034693635 scopus 로고    scopus 로고
    • K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma
    • et al.;: .
    • Kawesha A, Ghaneh P, Andren-Sandberg A, et al. K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma. Int J Cancer. 2000; 89: 469-474.
    • (2000) Int J Cancer. , vol.89 , pp. 469-474
    • Kawesha, A.1    Ghaneh, P.2    Andren-Sandberg, A.3
  • 38
    • 0036894028 scopus 로고    scopus 로고
    • DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma
    • et al.;: .
    • Biankin AV, Morey AL, Lee CS, et al. DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. J Clin Oncol. 2002; 20: 4531-4542.
    • (2002) J Clin Oncol. , vol.20 , pp. 4531-4542
    • Biankin, A.V.1    Morey, A.L.2    Lee, C.S.3
  • 39
    • 0030795157 scopus 로고    scopus 로고
    • Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
    • et al.;: .
    • Hu YX, Watanabe H, Ohtsubo K, et al. Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin Cancer Res. 1997; 3: 1473-1477.
    • (1997) Clin Cancer Res. , vol.3 , pp. 1473-1477
    • Hu, Y.X.1    Watanabe, H.2    Ohtsubo, K.3
  • 41
    • 24644494649 scopus 로고    scopus 로고
    • Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer
    • Jeong J, Park YN, Park JS, Yoon DS, Chi HS, Kim BR., Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer. Yonsei Med J. 2005; 46: 519-525.
    • (2005) Yonsei Med J. , vol.46 , pp. 519-525
    • Jeong, J.1    Park, Y.N.2    Park, J.S.3    Yoon, D.S.4    Chi, H.S.5    Kim, B.R.6
  • 42
    • 67650081077 scopus 로고    scopus 로고
    • Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer
    • et al.;: .
    • Salek C, Minarikova P, Benesova L, et al. Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer. Anticancer Res. 2009; 29: 1803-1810.
    • (2009) Anticancer Res. , vol.29 , pp. 1803-1810
    • Salek, C.1    Minarikova, P.2    Benesova, L.3
  • 43
    • 68049115773 scopus 로고    scopus 로고
    • SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    • et al.;: .
    • Blackford A, Serrano OK, Wolfgang CL, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009; 15: 4674-4679.
    • (2009) Clin Cancer Res. , vol.15 , pp. 4674-4679
    • Blackford, A.1    Serrano, O.K.2    Wolfgang, C.L.3
  • 44
    • 0038293080 scopus 로고    scopus 로고
    • Prognostic significance of tumor oxygenation in humans
    • Evans SM, Koch CJ., Prognostic significance of tumor oxygenation in humans. Cancer Lett. 2003; 195: 1-16.
    • (2003) Cancer Lett. , vol.195 , pp. 1-16
    • Evans, S.M.1    Koch, C.J.2
  • 45
    • 51649091688 scopus 로고    scopus 로고
    • Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: Potential role of PARP inhibitors in cancer treatment
    • Peralta-Leal A, Rodriguez MI, Oliver FJ., Poly(ADP-ribose)polymerase-1 (PARP-1) in carcinogenesis: potential role of PARP inhibitors in cancer treatment. Clin Transl Oncol. 2008; 10: 318-323.
    • (2008) Clin Transl Oncol. , vol.10 , pp. 318-323
    • Peralta-Leal, A.1    Rodriguez, M.I.2    Oliver, F.J.3
  • 46
    • 76149107145 scopus 로고    scopus 로고
    • Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer
    • Comen EA, Robson M., Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer. Oncology (Williston Park). 2010; 24: 55-62.
    • (2010) Oncology (Williston Park). , vol.24 , pp. 55-62
    • Comen, E.A.1    Robson, M.2


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