메뉴 건너뛰기




Volumn 322, Issue 3, 2007, Pages 913-922

Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; CASPASE 3; DOPAMINE; PROTEIN KINASE C DELTA; ROTTLERIN; SMALL INTERFERING RNA; TYROSINE 3 MONOOXYGENASE;

EID: 34548101125     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.124669     Document Type: Article
Times cited : (124)

References (42)
  • 1
    • 0036956424 scopus 로고    scopus 로고
    • Protein kinase C-epsilon (PKC-epsilon): Its unique structure and function
    • Akita Y (2002) Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. J Biochem 132:847-852.
    • (2002) J Biochem , vol.132 , pp. 847-852
    • Akita, Y.1
  • 2
    • 0036523088 scopus 로고    scopus 로고
    • Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl
    • Anantharam V, Kitazawa M, Wagner J, Kaul S, and Kanthasamy AG (2002) Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 22:1738-1751.
    • (2002) J Neurosci , vol.22 , pp. 1738-1751
    • Anantharam, V.1    Kitazawa, M.2    Wagner, J.3    Kaul, S.4    Kanthasamy, A.G.5
  • 3
    • 0037248032 scopus 로고    scopus 로고
    • Perspectives on reperfusion-induced damage in rodent models of experimental focal ischemia and role of gamma-protein kinase C
    • Aronowski J and Labiche LA (2003) Perspectives on reperfusion-induced damage in rodent models of experimental focal ischemia and role of gamma-protein kinase C. ILAR J 44:105-109.
    • (2003) ILAR J , vol.44 , pp. 105-109
    • Aronowski, J.1    Labiche, L.A.2
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 34249340482 scopus 로고    scopus 로고
    • Kinase signaling pathways: Potential therapeutic targets in Parkinson's disease
    • Burke RE (2007) Kinase signaling pathways: potential therapeutic targets in Parkinson's disease. Future Neurol 2:39-49.
    • (2007) Future Neurol , vol.2 , pp. 39-49
    • Burke, R.E.1
  • 6
    • 33646765383 scopus 로고    scopus 로고
    • Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death
    • Choi BH, Hur EM, Lee JH, Jun DJ, and Kim KT (2006) Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J Cell Sci 119:1329- 1340.
    • (2006) J Cell Sci , vol.119 , pp. 1329-1340
    • Choi, B.H.1    Hur, E.M.2    Lee, J.H.3    Jun, D.J.4    Kim, K.T.5
  • 7
    • 34147177574 scopus 로고    scopus 로고
    • Clinical research. Testing a novel strategy against Parkinson's disease
    • Couzin J (2007) Clinical research. Testing a novel strategy against Parkinson's disease. Science 315:1778.
    • (2007) Science , vol.315 , pp. 1778
    • Couzin, J.1
  • 8
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, and Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 11
    • 0026079238 scopus 로고
    • Dopamine synthesis precedes dopamine uptake in embryonic rat mesencephalic neurons
    • Fiszman ML, Zuddas A, Masana MI, Barker JL, and di Porzio U (1991) Dopamine synthesis precedes dopamine uptake in embryonic rat mesencephalic neurons. J Neurochem 56:392-399.
    • (1991) J Neurochem , vol.56 , pp. 392-399
    • Fiszman, M.L.1    Zuddas, A.2    Masana, M.I.3    Barker, J.L.4    di Porzio, U.5
  • 12
    • 2442636348 scopus 로고    scopus 로고
    • Biomedicine. Parkinson's-divergent causes, convergent mechanisms
    • Greenamyre JT and Hastings TG (2004) Biomedicine. Parkinson's-divergent causes, convergent mechanisms. Science 304:1120-1122.
    • (2004) Science , vol.304 , pp. 1120-1122
    • Greenamyre, J.T.1    Hastings, T.G.2
  • 14
    • 2442638936 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Iwashita A, Yamazaki S, Mihara K, Hattori K, Yamamoto H, Ishida J, Matsuoka N, and Mutoh S (2004) Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Pharmacol Exp Ther 309:1067-1078.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1067-1078
    • Iwashita, A.1    Yamazaki, S.2    Mihara, K.3    Hattori, K.4    Yamamoto, H.5    Ishida, J.6    Matsuoka, N.7    Mutoh, S.8
  • 15
    • 0142200985 scopus 로고    scopus 로고
    • Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis
    • Kanthasamy AG, Kitazawa M, Kanthasamy A, and Anantharam V (2003) Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxid Redox Signal 5:609-620.
    • (2003) Antioxid Redox Signal , vol.5 , pp. 609-620
    • Kanthasamy, A.G.1    Kitazawa, M.2    Kanthasamy, A.3    Anantharam, V.4
  • 16
    • 23344444562 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells
    • Kaul S, Anantharam V, Yang Y, Choi CJ, Kanthasamy A, and Kanthasamy AG (2005) Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. J Biol Chem 280:28721-28730.
    • (2005) J Biol Chem , vol.280 , pp. 28721-28730
    • Kaul, S.1    Anantharam, V.2    Yang, Y.3    Choi, C.J.4    Kanthasamy, A.5    Kanthasamy, A.G.6
  • 17
    • 0141705340 scopus 로고    scopus 로고
    • Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: Relevance to oxidative stress in dopaminergic degeneration
    • Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, and Kanthasamy AG (2003) Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. Eur J Neurosci 18:1387-1401.
    • (2003) Eur J Neurosci , vol.18 , pp. 1387-1401
    • Kaul, S.1    Kanthasamy, A.2    Kitazawa, M.3    Anantharam, V.4    Kanthasamy, A.G.5
  • 19
    • 0035581423 scopus 로고    scopus 로고
    • Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells
    • Kitazawa M, Anantharam V, and Kanthasamy AG (2001) Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radic Biol Med 31:1473-1485.
    • (2001) Free Radic Biol Med , vol.31 , pp. 1473-1485
    • Kitazawa, M.1    Anantharam, V.2    Kanthasamy, A.G.3
  • 20
    • 0038433325 scopus 로고    scopus 로고
    • Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: Relevance to oxidative stress and dopaminergic degeneration
    • Kitazawa M, Anantharam V, and Kanthasamy AG (2003) Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 119:945-964.
    • (2003) Neuroscience , vol.119 , pp. 945-964
    • Kitazawa, M.1    Anantharam, V.2    Kanthasamy, A.G.3
  • 21
    • 2942542719 scopus 로고    scopus 로고
    • Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: Protective effect of mitochondrial anti-apoptotic protein Bcl-2
    • Kitazawa M, Anantharam V, Kanthasamy A, and Kanthasamy AG (2004) Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology 25:589-598.
    • (2004) Neurotoxicology , vol.25 , pp. 589-598
    • Kitazawa, M.1    Anantharam, V.2    Kanthasamy, A.3    Kanthasamy, A.G.4
  • 23
    • 15744405993 scopus 로고    scopus 로고
    • Synuclein, dopamine and oxidative stress: Co-conspirators in Parkinson's disease
    • Maguire-Zeiss KA, Short DW, and Federoff HJ (2005) Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease. Brain Res Mol Brain Res 134:18-23.
    • (2005) Brain Res Mol Brain Res , vol.134 , pp. 18-23
    • Maguire-Zeiss, K.A.1    Short, D.W.2    Federoff, H.J.3
  • 25
    • 0036719861 scopus 로고    scopus 로고
    • Neuroprotection by propargylamines in Parkinson's disease: Suppression of apoptosis and induction of prosurvival genes
    • Maruyama W, Akao Y, Carrillo MC, Kitani K, Youdium MB, and Naoi M (2002) Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes. Neurotoxicol Teratol 24:675-682.
    • (2002) Neurotoxicol Teratol , vol.24 , pp. 675-682
    • Maruyama, W.1    Akao, Y.2    Carrillo, M.C.3    Kitani, K.4    Youdium, M.B.5    Naoi, M.6
  • 27
    • 33645894705 scopus 로고    scopus 로고
    • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
    • National Institute of Neurological Disorders and Stroke
    • National Institute of Neurological Disorders and Stroke (2006) A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology 66:664-671.
    • (2006) Neurology , vol.66 , pp. 664-671
  • 28
    • 33646886368 scopus 로고    scopus 로고
    • Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in the rat striatum
    • Obata T (2006) Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in the rat striatum. Eur J Pharmacol 539:34-38.
    • (2006) Eur J Pharmacol , vol.539 , pp. 34-38
    • Obata, T.1
  • 31
    • 0036856263 scopus 로고    scopus 로고
    • Protein kinase C gamma (PKC gamma): Function of neuron specific isotype
    • Saito N and Shirai Y (2002) Protein kinase C gamma (PKC gamma): function of neuron specific isotype. J Biochem 132:683-687.
    • (2002) J Biochem , vol.132 , pp. 683-687
    • Saito, N.1    Shirai, Y.2
  • 32
    • 0033385554 scopus 로고    scopus 로고
    • Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets
    • Samokhin GP, Jirousek MR, Ways DK, and Henriksen RA (1999) Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets. Eur J Pharmacol 386:297-303.
    • (1999) Eur J Pharmacol , vol.386 , pp. 297-303
    • Samokhin, G.P.1    Jirousek, M.R.2    Ways, D.K.3    Henriksen, R.A.4
  • 33
    • 0033029823 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
    • Saporito MS, Brown EM, Miller MS, and Carswell S (1999) CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J Pharmacol Exp Ther 288:421-427.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 421-427
    • Saporito, M.S.1    Brown, E.M.2    Miller, M.S.3    Carswell, S.4
  • 34
    • 33746048422 scopus 로고    scopus 로고
    • Clinical trials of coenzyme Q10 in neurological disorders
    • Shults CW and Haas R (2005) Clinical trials of coenzyme Q10 in neurological disorders. Biofactors 25:117-126.
    • (2005) Biofactors , vol.25 , pp. 117-126
    • Shults, C.W.1    Haas, R.2
  • 35
    • 33749506023 scopus 로고    scopus 로고
    • A Neurodegenerative diseases: Mechanisms and therapies
    • Smith MA, Perry G, Zhu X, and Haoudi (2006) A Neurodegenerative diseases: mechanisms and therapies. J Biomed Biotechnol 2006:47539.
    • (2006) J Biomed Biotechnol , vol.2006 , pp. 47539
    • Smith, M.A.1    Perry, G.2    Zhu, X.3    Haoudi4
  • 36
    • 0035851112 scopus 로고    scopus 로고
    • Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cδ tyrosine phosphorylation
    • Soltoff SP (2001) Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cδ tyrosine phosphorylation. J Biol Chem 276:37986-37992.
    • (2001) J Biol Chem , vol.276 , pp. 37986-37992
    • Soltoff, S.P.1
  • 37
    • 0035002174 scopus 로고    scopus 로고
    • Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
    • Tarnopolsky MA and Beal MF (2001) Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann Neurol 49:561-574.
    • (2001) Ann Neurol , vol.49 , pp. 561-574
    • Tarnopolsky, M.A.1    Beal, M.F.2
  • 38
  • 39
    • 34548074815 scopus 로고
    • Oral contraptive-part III. Further observations on the antifertility effect of rottlerin
    • Varma DR, Sareen KN, Roy AK, and Gujral ML (1959) Oral contraptive-part III. Further observations on the antifertility effect of rottlerin. Indian J Physiol Pharmacol 3:168-172.
    • (1959) Indian J Physiol Pharmacol , vol.3 , pp. 168-172
    • Varma, D.R.1    Sareen, K.N.2    Roy, A.K.3    Gujral, M.L.4
  • 41
    • 1642362529 scopus 로고    scopus 로고
    • Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPPδ-induced dopaminergic degeneration
    • Yang Y, Kaul S, Zhang D, Anantharam V, and Kanthasamy AG (2004) Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPPδ-induced dopaminergic degeneration. Mol Cell Neurosci 25:406-421.
    • (2004) Mol Cell Neurosci , vol.25 , pp. 406-421
    • Yang, Y.1    Kaul, S.2    Zhang, D.3    Anantharam, V.4    Kanthasamy, A.G.5
  • 42
    • 2242473920 scopus 로고    scopus 로고
    • Activation of SAPK/JNK signaling by protein kinase Cδ in response to DNA damage
    • Yoshida K, Miki Y, and Kufe D (2002) Activation of SAPK/JNK signaling by protein kinase Cδ in response to DNA damage. J Biol Chem 277:48372-48378.
    • (2002) J Biol Chem , vol.277 , pp. 48372-48378
    • Yoshida, K.1    Miki, Y.2    Kufe, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.