Differential Effects of Selective Cyclooxygenase-2 Inhibitors on Endothelial Function in Salt-Induced Hypertension

Circulation

Volumn 108, Issue 19, 2003, Pages 2308-2311

  Hermann, Matthias ^a   Camici, Giovanni ^a   Fratton, Aisha ^a   Hurlimann, David ^b   Tanner, Felix C ^a   Hellermann, Jens P ^a   Fiedler, Martin ^b   Thiery, Joachim ^b   Neidhart, Michel ^a   Gay, Renate E ^a   Gay, Steffen ^a   Lüscher, Thomas F ^a   Ruschitzka, Frank ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b University Hospital Zürich ^*

Author keywords

Drugs, antiinflammatory; Endothelium; Hypertension; Nitric oxide; Stress

Indexed keywords

ACETYLCHOLINE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; ISOPROSTANE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; ROFECOXIB; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HIGH SODIUM INTAKE; HYPERTENSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RAT STRAIN; VASCULAR RING; VASOCONSTRICTION;

ACETYLCHOLINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DINOPROST; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; F2-ISOPROSTANES; HYPERTENSION; INTERLEUKIN-1; ISOENZYMES; LACTONES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RATS; RATS, INBRED DAHL; SAFETY; SODIUM CHLORIDE, DIETARY; SULFONAMIDES; SULFONES; VASODILATION;

EID: 10744225128     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000101683.30157.0B     Document Type: Article

References (19)

1. McAdam BF, Catella-Lawson F, Mardini IA, et al. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA. 1999;96:272-277.
2. Pitt B, Pepine C, Willerson JT. Cyclooxygenase-2 inhibition and cardiovascular events. Circulation. 2002;106:167-169.
3. Strand V, Hochberg MC. The risk of cardiovascular thrombotic events with selective cyclooxygenase-2 inhibitors. Arthritis Rheum. 2002;47:349-355.
4. Ray WA, Stein CM, Daugherty JR, et al. COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. Lancet. 2002;360:1071-1073.
5. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001;104:191-196.
6. Schonbeck U, Sukhova GK, Graber P, et al. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol. 1999;155:1281-1291.
7. Taddei S, Virdis A, Ghiadoni L, et al. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 1998;97:2222-2229.
8. Kitahara M, Eitner F, Ostendorf T, et al. Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis. J Am Soc Nephrol. 2002;13:1261-1270.
9. Ruschitzka F, Quaschning T, Noll G, et al. Endothelin 1 type A receptor antagonism prevents vascular dysfunction and hypertension induced by 11β-hydroxysteroid dehydrogenase inhibition: role of nitric oxide. Circulation. 2001;103:3129-3135.
10. Chenevard R, Hurlimann D, Bechir M, et al. Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation. 2003;107:405-409.
11. de Jager W, te Velthuis H, Prakken BJ, et al. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol. 2003;10:133-139.
12. Loscalzo J. Nitric oxide and vascular disease. N Engl J Med. 1995;333:251-253.
13. Somers MJ, Mavromatis K, Galis ZS, et al. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation. 2000;101:1722-1728.
14. Armstead WM. Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation. Anesthesiology. 2003;98:1378-1383.
15. Courtois E, Marques M, Barrientos A, et al. Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2. J Am Soc Nephrol. 2003;14:1464-1470.
16. 2 in superoxide-dismutase-induced enhancement of endothelium-dependent relaxation in rabbit mesenteric resistance artery. Br J Pharmacol. 2003;139:444-456.
17. Widlansky ME, Price DT, Gokce N, et al. Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension. 2003;42:310-315.
18. Loughrey JP, Laffey JG, Moore BJ, et al. Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism. Crit Care Med. 2003;31:910-915.
19. Bradbury DA, Newton R, Zhu YM, et al. Effect of bradykinin, TGF-β1, IL-1β, and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells. Am J Physiol. 2002;283:L717-L725.