Interferon γ induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells

Journal of Clinical Investigation

Volumn 99, Issue 5, 1997, Pages 1057-1063

  Asano, Koichiro ^a   Nakamura, Hidetoshi ^a   Lilly, Craig M ^a   Klagsbrun, Michael ^b,c   Drazen, Jeffrey M ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Keio Medical School   (Japan)

Author keywords

amphiregulin; epithelium; heparin binding EGF like growth factor; prostaglandin E2; transforming growth factor

Indexed keywords

AMPHIREGULIN; ARACHIDONIC ACID; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; NEUTRALIZING ANTIBODY; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; RNA; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; BRONCHUS MUCOSA; CANCER CELL CULTURE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INDUCTION; EPITHELIUM CELL; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORTHERN BLOTTING; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN;

EID: 0030960506     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119233     Document Type: Article

References (28)

1. Jacoby, D.B. 1995. Mediator functions of epithelial cells. In Asthma and Rhinitis. W.W. Busse and S.T. Holgate, editors. Blackwell Scientific Publications, Boston. 573-583.
2. 2 production. Br. J. Pharmacol. 95:300-308.
3. Bitterman, P.B., M.D. Wewers, S.I. Rennard, S. Adelberg, and R.G. Crystal. 1986. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J. Clin. Invest. 77:700-708.
4. Hu, Z.-Q., K. Asano, H. Seki, and T. Shimamura. 1995. An essential role of prostaglandin E on mouse mast cell induction. J. Immunol. 155:2134-2142.
5. Phipps, R.P., S.H. Stein, and R.P. Roper. 1991. A new view of prostaglandin E regulation of the immune response. Immunol. Today. 12:349-352.
6. 2. J. Exp. Med. 180:2365-2370.
7. Mitchell, J.A., P. Akarasereenont, C. Thiemermann, R.J. Flower, and J.R. Vane. 1994. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA. 90:11693-11697.
8. Asano, K., C.M. Lilly, and J.M. Drazen. 1997. Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells. Am. J. Physiol. 271:L126-L131.
9. O'Banion, M.K., V.D. Winn, and D.A. Young. 1992. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. USA. 89:4888-4892.
10. Jones, D.A., D.P. Carlton, T.M. McIntyre, G.A. Zimmerman, and S.M. Prescott. 1993. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration in response to cytokines. J. Biol. Chem. 268: 9049-9054.
11. 2 mRNA in lung fibroblasts and endothelial cells in culture. Biochem. Biophys. Res. Commun. 197: 1465-1474.
12. RistimŠki, A., S. Garfinkel, J. Wessendorf, T. Maciag, and T. Hla. 1994. Induction of cyclooxygenase-2 by interleukin-1α. Evidence for post-transcriptional regulation. J. Biol. Chem. 269:11769-11775.
13. Crofford, L.J., R.L. Wilder, A.P. RistimŠki, H. Sano, E.F. Remmers, H.P. Epps, and T. Hla. 1994. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1β, phorbol ester, and corticosteroids. J. Clin. Invest. 93:1095-1101.
14. Brum-Fernandes, A.J., S. Laporte, M. Heroux, M. Lora, C. Patry, H.-A. Menard, R. Dumais, and R. Leduc. 1994. Expression of prostaglandin endoperoxide synthase-1 and prostaglandin endoperoxide synthase-2 in human osteoblasts. Biochem. Biophys. Res. Commun. 198:955-960.
15. Mitchell, J.A., M.G. Belvisi, P. Akarasereenont, R.A. Robbins, O.J. Kwon, J. Croxtall, P.J. Barnes, and J.R. Vane. 1994. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br. J. Pharmacol. 113:1008-1014.
16. Asano, K., C.B.E. Chee, B. Gaston, C.M. Lilly, C. Gerard, J.M. Drazen, and J.S. Stamler. 1994. Constitutive and inducible nitric oxide synthase gene expression and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA. 91:10089-10093.
17. DuBois, R.N., J. Awad, J. Morrow, L.J. Roberts II, and P.R. Bishop. 1994. Regulation of eicosanoid and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. J. Clin. Invest. 93:493-498.
18. Valyi-Nagy, I., P.J. Jansen, S.M. Albelda, and U. Rodeck. 1992. Cytokine-induced expression of transforming growth factor-α and the epidermal growth factor receptor in neonatal skin explants. J. Invest. Dermatol. 99:350-356.
19. Hamburger, A.W., and G.D. Pinnamneni. 1991. Increased epidermal growth factor gene expression by γ-interferon in a human breast carcinoma cell line. Br. J. Cancer. 64:64-68.
20. Hamasaki, Y., J. Kitzler, R. Hardman, P. Nettesheim, and T.E. Eling. 1993. Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. Arch. Biochem. Biophys. 304:226-234.
21. Look, D.C., S.R. Rapp, B.T. Keller, and M.J. Holtzman. 1992. Selective induction of intercellular adhesion molecule-1 by interferon-γ in human airway epithelial cells. Am. J. Physiol. 263:L79-L87.
22. Look, D.C., M.R. Pelletier, and M.J. Holtzman. 1994. Selective interaction of a subset of interferon-γ response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells. J. Biol. Chem. 269:8952-8958.
23. Tazawa, R., X.-M. Xu, K.K. Wu, and L.-H. Wang. 1994. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem. Biophys. Res. Commun. 203:190-199.
24. Sirois, J., and J.S. Richards. 1993. Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. J. Biol. Chem. 268:21931-21938.
25. Xie, W., and H.R. Herschman. 1995. v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J. Biol. Chem. 270:27622-27628.
26. Higashiyama, S., J.A. Abraham, and M. Klagsbrun. 1993. Heparin-binding EGF-like growth factor stimulation of smooth-muscle cell migration: dependance on interactions with cell surface heparan sulfate. J. Cell Biol. 122:933-940.
27. Madtes, D.K. H.K. Busby, T.P. Strandjord, and J.G. Clark. 1994. Expression of transforming growth factor-α and epidermal growth factor receptor is increased following bleomycin-induced lung injury in rats. Am. J. Respir. Cell Mol. Biol. 11:540-551.
28. Vane, J.R., J.A. Mitchell, I. Appleton, A. Tomlinson, D. Bishop-Bailey, J. Croxtall, and D.A. Willoughby. 1994. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA. 91:2046-2050.