Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 1, 1999, Pages 272-277

  Mcadam, B F ^a,b   Catella Lawson, F ^a   Mardini, I A ^a   Kapoor, S ^a   Lawson, J A ^a   Fitzgerald, G A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Celecoxib; Ibuprofen; Monocytes; Platelets; Prostaglandins

Indexed keywords

11 OXOTHROMBOXANE B2; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; CELECOXIB; COLLAGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; THROMBOXANE A2; THROMBOXANE B2;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION INHIBITION; URINARY EXCRETION;

6-KETOPROSTAGLANDIN F1 ALPHA; ADULT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; EPOPROSTENOL; FEMALE; HUMANS; IBUPROFEN; ISOENZYMES; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MONOCYTES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SULFONAMIDES; THROMBOXANE B2;

EID: 0033524421     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.1.272     Document Type: Article

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