Selective COX-2 inhibitors and human inflammatory bowel disease

Alimentary Pharmacology and Therapeutics

Volumn 13, Issue 8, 1999, Pages 1115-1117

  McCartney, S A ^a   Mitchell, J A ^b   Fairclough, P D ^a   Farthing, M J G ^a   Warner, T D ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; 6 OXOPROSTAGLANDIN F1 ALPHA; ANTIBIOTIC AGENT; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTANOID; THROMBOXANE A2;

ARTICLE; COLON BIOPSY; COLON MUCOSA; COLONOSCOPY; CROHN DISEASE; CULTURE MEDIUM; ENTERITIS; FETAL CALF SERUM; GASTROINTESTINAL DISEASE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; ULCERATIVE COLITIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLITIS, ULCERATIVE; CROHN DISEASE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; INDANS; INDOMETHACIN; INFLAMMATORY BOWEL DISEASES; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS;

EID: 0032853471     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00585.x     Document Type: Article

References (6)

1. 1 Evans JM, McMahon AD, Murray FE, McDevitt DG, MacDonald TM. Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease. Gut 1997; 40: 619-22.
2. 2 Singer II, Kawka DW, Schloemann S, Tessner T, Riehl T, Stenson WF. Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Gastroenterology 1998; 115: 297-306.
3. 3 Reuter BK, Asfaha S, Buret A, Sharkey KA, Wallace JL. Exacerbation of inflammation-associated colonie injury in rat through inhibition of cyclooxygenase-2. J Clin Invest 1996; 98: 2076-85.
4. 4 Chan CC, Boyce S, Brideau C, et al. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach J Pharmacol Exp Ther 1995; 274: 1531-7.
5. 5 Champion GD, Feng PH, Azuma T, et al. NSAID-induced gastrointestinal damage. Epidemiology, risk and prevention, with an evaluation of the role of misoprostol. An Asia-Pacific perspective and consensus Drugs 1997; 53: 6-19.
6. 6 Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J. Pharmacological and biochemical demonstration of the role of COX-2 in inflammation and pain. Proc Natl Acad Sci USA 1994; 91: 12013-7.