Overview: Combating diabetic nephropathy

Journal of the American Society of Nephrology

Volumn 14, Issue 5, 2003, Pages 1355-1357

  Ziyadeh, Fuad N ^a   Sharma, Kumar ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA;

CYTOTOXICITY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; GLUCOSE HOMEOSTASIS; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0037407935     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000065608.37756.58     Document Type: Review

References (16)

1. Steffes MW, Bilous RW, Sutherland DER, Mauer SM: Cell and matrix components of the glomerular mesangium in type I diabetes mellitus. Diabetes 41: 679-684, 1992
2. Lane PH, Steffes MW, Fioretto P, Mauer SM: Renal interstitial expansion in insulin-dependent diabetes mellitus. Kidney Int 43: 661-667, 1993
3. Ziyadeh FN, Sharma K, Ericksen M, Wolf G: Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. J Clin Invest 93: 536-542, 1994
4. Sharma K, Ziyadeh FN: Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 44: 1139-1146, 1995
5. Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, Brownlee M: Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Spl glycosylation. Proc Natl Acad Sci USA 97: 12222-12226, 2000
6. Riser BL, Cortes P, Zhao X, Bernstein J, Dumier F, Narins RG: Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat. J Clin Invest 90: 1932-1943, 1992
7. Ziyadeh FN, Hoffman BB, Han DC. Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long-term prevention of renal insufficiency, excess matrix gene expression and glomerular mesangial matrix expression by treatment with monoclonal anti-TGF-β antibody in db/db diabetic mice. Proc Nat Acad Sci USA 97: 8015-8020, 2000
8. Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN: Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem Biophys Res Commun 300: 16-22, 2003
9. Sharma K, Ziyadeh FN, Alzahabi B, McGowan TA, Kapoor S, Kurnik BRC, Kurnik PB, Weisberg LS: Increased renal production of transforming growth factor-beta 1 in patients with type II diabetes. Diabetes 46: 854-859, 1997
10. Huang C, Kim Y, Caramori ML, Fish AJ, Rich SS, Miller ME, Russell GB, Mauer M: Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes. Diabetes 51: 3577-3581, 2002
11. Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001
12. Mogyorosi A, Ziyadeh FN: GLUT1 and TGF-beta: The link between hyperglycaemia and diabetic nephropathy: Nephrol Dial Transplant 14: 2827-2829, 1999
13. Kelly DJ, Zhang Y, Hepper C, Gow RM, Jaworski K, Kemp BE, Wilkinson-Berka JL, Gilbert RE: Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes 52: 512-518, 2003
14. Cohen MP, Ziyadeh FN, Hong SW, Shearman CW, Hud E, Lautenslager GT, Iglesias-de la Cruz MC, Chen S: Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta 1. Kidney Int 61: 2025-32, 2002
15. Chaturvedi N, Schalkwijk CG, Abrahamian H, Fuller JH, Stehouwer CD: Circulating and urinary transforming growth factor beta 1, Amadori albumin, and complications of type 1 diabetes: The EURODIAB prospective complications study. Diabetes Care 25: 2320-2327, 2002
16. Vlassara H: Protein glycation in the kidney. Kidney Int 49: 1795-1804, 1996