Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Ligabue, Alessio ^a,b   Marverti, Gaetano ^c   Liebl, Ursula ^a,b   Myllykallio, Hannu ^a,b  

^a INSERM   (France)

^b LABORATOIRE D OPTIQUE ET BIOSCIENCES   (France)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DEOXYURIDINE PHOSPHATE; FLUOROURACIL; MESSENGER RNA; METHYLENETETRAHYDROFOLIC ACID; N1,N11 DIETHYLNORSPERMINE; THYMIDYLATE SYNTHASE;

ARTICLE; CANCER CELL CULTURE; CATALYSIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OVARY CANCER; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UPREGULATION;

BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; FLUOROURACIL; HUMANS; IMMUNOPRECIPITATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDYLATE SYNTHASE; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84867304928     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047318     Document Type: Article

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