Polyamine analogue induction of the p53-p21(WAF1/CIP1)-Rb pathway and G1 Ar in human melanoma cells

Cancer Research

Volumn 59, Issue 6, 1999, Pages 1278-1286

  Kramer, Debora L ^a   Vujcic, Slavoljub ^a   Diegelman, Paula ^a   Alderfer, James ^b   Miller, John T ^a   Black, Jennifer D ^a   Bergeron, Raymond J ^c   Porter, Carl W ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; N1,N11 DIETHYLNORSPERMINE; POLYAMINE; PROTEIN P21; PROTEIN P53; PUTRESCINE; RETINOBLASTOMA PROTEIN; SPERMIDINE; SPERMINE DERIVATIVE;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; CONTROLLED STUDY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; G1 PHASE; HUMANS; KINETICS; MELANOMA; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; SPERMINE; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033559550     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Luk, G. D., and Baylin, S. B. Omithine decarboxylase as a biologic marker in familial colonic polyposis. N. Engl. J. Med., 331: 80-83, 1984.
2. Kingsnorth, A. N., Lumdsen, A. B., and Wallace, H. M. Polyamines in colorectal cancer. Br. J. Surg., 71: 791-794, 1984.
3. Porter, C. W., Herrera-Ornelas, L., Pera, P., Petrelli, N. F., and Mittelman, A. Polyamine biosynthetic activity in normal and neoplastic human colorectal tissues. Cancer (Phila.), 60: 1275-1281, 1987.
4. 1. J. Cell. Physiol., 94: 161-170, 1978.
5. Scedenfeld, J., Block, A. L., Komar, K. A., and Naujokas, M. F. Altered cell cycle phase distribution in cultured human carcinoma cells particularly depleted of polyamines by treatment with difluoromethylomithine. Cancer Res., 46: 47-53, 1986.
6. Koza, R. A., and Herbst, E. J. Deficiencies in DNA replication and cell cycle progression inn polyamine-depleted HeLa cells. Biochem. J., 281: 87-93, 1992.
7. Bergeron, C. J., Basu, H. S., Marton, L. J., Deen, D. F., Pellarin, M., and Feuerstein, B. G. Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival and cell cycle progression in two human brain tumor cell lines. Cancer Chemother. Pharmacol., 36: 411-417, 1995.
8. Muller, R., Mumberg, D., and Lucibello, F. C. Signals and genes in the control of cell-cycle progression. Biochim. Biophys. Acta. 1155: 151-179, 1993.
9. Gallo, K. C., Koza, J., and Herbst, E. J. Polyamines and HeLa cell replication. Biochem. J., 238: 37-42, 1986.
10. 2 phase progression by polyamine synthesis inhibitors. Exp. Cell Res., 111: 461-464, 1978.
11. 2 phases of polyamine-dependent (arginine-deficient) CHO cell. Mol. Cell. Biol., 4: 915-922, 1984.
12. Fredlund, J. O., and Oredsson, S. M. Impairment of DNA replication within one cell cycle after seeding of cells in the presence of a polyamine-biosynthesis inhibitor. Eur. J. Biochem., 137: 539-544, 1996.
13. Pojhanpelto, P., Nordling, S., and Knuutila. S. Flow cytometric analysis of the cell cycle in polyamine-depleted cells. Cytometry, 16: 331-338, 1994.
14. Kahana, C., and Nathans, D. Isolation of cloned cDNA encoding mammalian ornithine decarboxylase. Proc. Natl. Acad. Sci. USA, 81: 3645-3649, 1984.
15. Kaczmarek, L., Calabretta, B., Ferrari, S., and Riel, J. K. Cell cycle dependent expression of human omithine decarboxylase. J. Cell. Physiol., 132: 545-551, 1987.
16. 1 to S phase transition. J. Cell. Physiol., 93: 81-87, 1977.
17. Bello-Fernandez, C., Packham, G., and Cleveland, J. L. The ornithine decarboxylase gene is a transcriptional target of c-myc. Proc. Natl. Acad. Sci. USA. 90: 7804-7808, 1993.
18. Wagner, A. J., Meyers, C. Laimins, L. A., and Hay, N. c-Myc induces the expression and activity of ornithine decarboxylase. Cell Growth Differ., 4: 879-883, 1993.
19. Peña, A., Reddy, C. D., Wu, S., Hickok, N., Reddy, E. P., Yumet, G., Soprano, D. R., and Soprano, K. J. Regulation of human ornithine decarboxylase expression by the c-Myc/Max protein complex. J. Biol. Chem., 268: 27277-27285, 1993.
20. Thomas, T., and Thomas, T. J. Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells. Cancer Res., 54: 1077-1084, 1994.
21. Celano, P., Baylin, S. B., Giardiello, F. M., Nelkin, B. D., and Casero, R. A., Jr. Effect of polyamine depletion on c-myc expression in human colon carcinoma cells. J. Biol. Chem., 263: 5491-5494, 1988.
22. 11-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels. J. Cell. Physiol., 174: 380-386, 1998.
23. Porter, C. W., and Bergeron, R. J. Enzyme regulation as an approach to interference with polyamine biosynthesis: an alternative to enzyme inhibition. In: G. Weber (ed.), Advances in Enzyme Regulation, Vol. 27, pp. 57-79. New York: Pergamon Press, 1988.
24. 1-acetyltransferase activity and growth inhibition in human melanoma cell lines. Cancer Res., 51: 3715-3720, 1991.
25. 12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells. J. Biol. Chem., 264: 11744-11749, 1989.
26. Kramer, D. L. Fogel-Petrovic, M., Miller, J., Diegelman, P., McManis, J. S., Bergeron, R. J., and Porter, C. W. Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells. Cancer Res., 57: 5521-5527, 1997.
27. Kramer, D. L., Vujcic, S., Diegelman, P., White, C., Black, J. D., and Porter, C. W. Polyamine analogue-mediated cell cycle responses in human melanoma cells involved the p53, p21, Rb regulatory pathway. Biochem. Soc. Trans., 26: 609-614, 1998.
28. Bergeron, R. J., Feng, Y., Weimar, W. R., McManis, J. S., Dimova, H., Porter, C., Raisler, B., and Phanstiel, O. A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics. J. Med. Chem., 40: 1475-1494, 1997.
29. Bolkenius, F. N., Bey, P., and Seiler, N. Specific inhibition of polyamine oxidase in vivo is a method for the elucidation of its physiological role. Biochim. Biophys. Acta. 838: 69-76, 1985.
30. O'Connor, P. M., Jackman, J., Bae, I., Myers, T. G., Fan, S., Mutoh, M., Scudiero, D. A., Monks, A., Sausville, E. A., Weinstein, J. N., Friend, S., Fornace, A. J., and Kohn, K. W. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with growth-inhibitory potency of 123 anticancer agents. Cancer Res., 57: 4285-4300, 1997.
31. Kramer, D. L., Mett, H., Regenass, U., Diegelman, P., and Porter, C. W. Stable amplification of the S-adenosyltnethionine gene in Chinese hamster ovary cells. J. Biol. Them., 270: 2124-2132, 1995.
32. Krishan, A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol., 66: 188-193, 1975.
33. Blankenberg, F. G., Storrs, R. W., Naumovski, L., Goralski, T., and Spielman, D. Detection of apoptotic cell death by proton nuclear magnetic resonance spectroscopy. Blood, 87: 1951-1956, 1996.
34. Blankenberg, F. G., Katsikis, P. D., Storrs, R. W., Beaulieu, C., Spielman, D., Chen, J. Y., Naumovski, L., and Tait, J. F. Quantitative analysis of apoptotic cell death using proton nuclear magnetic resonance spectroscopy. Blood, 89: 3778-3786, 1997.
35. 1-acetyltransferase activity by novel spermine analogs. Mol. Pharmacol., 52: 69-74, 1997.
36. 11-diethylnorspermine. Biochemistry, 35: 14436-14444, 1996.
37. El-Deiry, W. S., Tokino, T., Velculescu, V., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1 a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
38. Ishioka, C., Englert, C., Winge, P., Yan, Y. X., Engelstein, M., and Friend, S. H. Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo. Oncogene. 10: 1485-1492, 1995.
39. 1 arrest. Cancer Res., 58: 396-401, 1998.
40. cipi, Nature (Lond.), 375: 159-161, 1995.
41. 1 restriction point. Crit. Rev. Oncog., 7: 127-142, 1996.
42. Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chernova, O. B., and Stark, G. R. The p53 network. J. Biol. Chem., 273: 1-4, 1998.
43. Pisha, E., Pezzuto, J. M., Rauth, S., and Das Guptak, T. K. Melanoma cell cycle perturbations by betulinic acid. Proc. Am. Assoc. Cancer Res., 39: 68, 1998.
44. Levine, A. J. p53. the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
45. Kastan, M. B., Onyekwere, O., Sidransky, D. Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
46. 1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. USA, 92: 8493-8497, 1995.
47. 1/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol., 18: 629-643, 1998.
48. WAF1/CIP1 expression by p53-independent pathways. Oncogene, 12: 1557-1564, 1996.
49. Macloed, K. F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinsler, K., Vogelstein, B., and Jacks, T. p53-dependent and independent expression of p21 during cell cycle growth, differentiation and DNA damage. Genes Dev., 9: 935-944, 1995.
50. kip1 and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells. J. Biol. Chem., 272: 9424-9435, 1997.
51. 1 arrest induced by rNTP depletion in the absence of detectable DNA damage. Genes Dev., 10: 934-947, 1996.
52. Feuerstein, B., Pattabiraman, N. P., and Marton, L. J. Molecular mechanics of the interactions of spermine with DNA: DNA bending as a result of ligand binding. Nucleic Acids Res., 18: 1271-1282, 1990.
53. 5dC). Proc. Natl. Acad. Sci. USA, 78: 1619-1623, 1981.
54. Vertino, P. M., Bergeron, R. J., Cavanaugh, P. F., Jr., and Porter, C. W. Structural determinants of spermidine DNA interactions. Biopolymers, 26: 691-703, 1984.
55. Basu, H. S., Pellarin, M., Feuerstein, B. G., Shirahata, A., Samejima, K., Deen, D. F., and Marton, L. J. Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15,-triazaonadecane (BE-4-4-4-4), with DNA and effects on growth, survival, and polyamine levels in seven human brain tumor cell lines. Cancer Res., 53: 3948-3955, 1993.
56. Russo, T., Zambrano, N., Esposilo, F., Ammadenola, R., Cimino, F., Fiscella, M., Jackman, J., O'Connor, P. M., and Anderson, C. W. A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J. Biol. Chem., 270: 29386-29391, 1995.
57. Ha, H. C., Woster, P. M., Yager, J. D., and Casero, R. A., Jr. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. USA, 94: 11557-11562, 1997.
58. 1 arrest in human cancer cells. Cancer Res., 55: 5187-5190, 1995.
59. Waldman, T., Lengauer, D., Kinzler, K. W., and Vogelstein, B. Uncoupling of S-phase and mitosis induced by anticancer drugs in cells lacking p21. Nature (Lond.), 371: 713-716, 1996.
60. Polyak, K., Waldman, T., He, T. C., Kinzler, K. W., and Vogelstein, B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev., 10: 1945-1952, 1996.
61. Wang, J., and Walsh, K. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science (Washington DC), 273: 359-361, 1996.
62. cip1/waf1 protects against p53-mediated apoptosis of human melanoma cells. Oncogene. 14: 929-935, 1997.
63. 1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues. Cancer Res., 49: 3829-3833, 1989.
64. 12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes. Anticancer Res., 12: 1083-1090, 1992.
65. 2 as a DNA fragmentating agent in the alkaline elulion interstrand crosslinking and DNA-protein crosslinking assays. Anal. Biochem., 168: 88-93, 1988.
66. Dini, L., Coppola, S., Ruzittu, M. T., and Ghibelli, L. Multiple pathways for apoptotic nuclear fragmentation. Exp. Cell Res., 223: 340-347, 1996.
67. Chen, Q., and Ames, B. N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast. Proc. Natl. Acad. Sci. USA, 91: 4130-4134, 1994.
68. Mizzen, C. A., and Allis, C. D. Linking histone acetylation to transcriptional regulation. Cell. Mol. Life Sci., 54: 6-20, 1998.
69. Gu, W., and Roeder, R. G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90: 595-606, 1997.