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Volumn 117, Issue 2, 2010, Pages 202-210

Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines

Author keywords

Cisplatin; Folate cycle inhibitors; Polyamine analogues; Quinoxalines; SSAT

Indexed keywords

CISPLATIN; DIETHYLDERIVATIVE OF NORSPERMINE; FLUOROURACIL; FOLIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; N1,N12 BISETHYLSPERMINE; NORSPERMINE; POLYAMINE DERIVATIVE; QUINOXALINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SPERMIDINE SPERMINE N1 ACETYLTRANSFERASE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 77950189269     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.11.030     Document Type: Article
Times cited : (20)

References (55)
  • 2
    • 3543147160 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and 5-fluorouracil/leucovorin combination in epithelial ovarian carcinoma relapsing within 2 years of platinum-based therapy
    • Sundar S., Symonds R.P., Decatris M.P., Kumar D.M., Osman A., Vasanthan S., et al. Phase II trial of oxaliplatin and 5-fluorouracil/leucovorin combination in epithelial ovarian carcinoma relapsing within 2 years of platinum-based therapy. Gynecol. Oncol. 94 (2004) 502-508
    • (2004) Gynecol. Oncol. , vol.94 , pp. 502-508
    • Sundar, S.1    Symonds, R.P.2    Decatris, M.P.3    Kumar, D.M.4    Osman, A.5    Vasanthan, S.6
  • 3
    • 0035116969 scopus 로고    scopus 로고
    • Prospective phase II trial of irinotecan, 5-fluorouacil, and leucovorin in combination as salvage therapy for advanced colorectal cancer
    • Gil-Delgado M.A., Guinet F., Castaing D., Adam R., Coeffic D., Durrani A.K., et al. Prospective phase II trial of irinotecan, 5-fluorouacil, and leucovorin in combination as salvage therapy for advanced colorectal cancer. Am. J. Clin. Oncol. 24 (2001) 101-105
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 101-105
    • Gil-Delgado, M.A.1    Guinet, F.2    Castaing, D.3    Adam, R.4    Coeffic, D.5    Durrani, A.K.6
  • 5
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5fluorouracil
    • Parker W.B., and Cheng Y.C. Metabolism and mechanism of action of 5fluorouracil. Pharmacol. Ther. 48 (1990) 381-395
    • (1990) Pharmacol. Ther. , vol.48 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 7
    • 1542787541 scopus 로고    scopus 로고
    • Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2
    • Zhang W., Ramdas L., Shen W., Song S.W., Hu L., and Hamilton S.R. Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. Cancer Biol. Ther. 2 (2003) 572-578
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 572-578
    • Zhang, W.1    Ramdas, L.2    Shen, W.3    Song, S.W.4    Hu, L.5    Hamilton, S.R.6
  • 8
    • 0043136753 scopus 로고    scopus 로고
    • Identification of 5-fluorouracil inducible target genes using cDNA microarray profiling
    • Maxwell P.J., Longley D.B., Latif T., Boyer J., Allen W., Lynch M., et al. Identification of 5-fluorouracil inducible target genes using cDNA microarray profiling. Cancer Res. 63 (2003) 4602-4606
    • (2003) Cancer Res. , vol.63 , pp. 4602-4606
    • Maxwell, P.J.1    Longley, D.B.2    Latif, T.3    Boyer, J.4    Allen, W.5    Lynch, M.6
  • 9
    • 1642327569 scopus 로고    scopus 로고
    • Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil,oxaliplatin, and irinotecan
    • Boyer J., McLean E.G., Aroori S., Wilson P., McCulla A., Carey P.D., et al. Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil,oxaliplatin, and irinotecan. Clin. Cancer Res. 10 (2004) 2158-2167
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2158-2167
    • Boyer, J.1    McLean, E.G.2    Aroori, S.3    Wilson, P.4    McCulla, A.5    Carey, P.D.6
  • 10
    • 0024393065 scopus 로고
    • Polyamine depletion is associated with altered chromatin structure in HeLa cells
    • Snyder R.D. Polyamine depletion is associated with altered chromatin structure in HeLa cells. Biochem. J. 260 (1989) 697-704
    • (1989) Biochem. J. , vol.260 , pp. 697-704
    • Snyder, R.D.1
  • 11
    • 67449146884 scopus 로고    scopus 로고
    • Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells
    • Marverti G., Ligabue A., Paglietti G., Corona P., Piras S., Vitale G., et al. Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells. Eur. J. Pharmacol. 615 (2009) 17-26
    • (2009) Eur. J. Pharmacol. , vol.615 , pp. 17-26
    • Marverti, G.1    Ligabue, A.2    Paglietti, G.3    Corona, P.4    Piras, S.5    Vitale, G.6
  • 12
    • 0034036384 scopus 로고    scopus 로고
    • Preclinical perspectives on platinum resistance
    • Kelland L.R. Preclinical perspectives on platinum resistance. Drugs 59 (2000) 1-8
    • (2000) Drugs , vol.59 , pp. 1-8
    • Kelland, L.R.1
  • 14
    • 0023750017 scopus 로고
    • Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian carcinoma cells
    • Masuda H., Ozols R.F., Lai G., Fojo A., Rothembert M., and Hamilton T.C. Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian carcinoma cells. Cancer Res. 48 (1988) 5713-5716
    • (1988) Cancer Res. , vol.48 , pp. 5713-5716
    • Masuda, H.1    Ozols, R.F.2    Lai, G.3    Fojo, A.4    Rothembert, M.5    Hamilton, T.C.6
  • 15
    • 0037398881 scopus 로고    scopus 로고
    • Polyamines and their role in human disease: an introduction
    • Wallace H.M. Polyamines and their role in human disease: an introduction. Biochem. Soc. Trans. 31 (2003) 354-355
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 354-355
    • Wallace, H.M.1
  • 16
    • 0346118938 scopus 로고    scopus 로고
    • Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites
    • Subhi A.L., Diegelman P., Porter C.W., Tang B., Lu Z.J., Markham G.D., et al. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J. Biol. Chem. 278 (2003) 49868-49873
    • (2003) J. Biol. Chem. , vol.278 , pp. 49868-49873
    • Subhi, A.L.1    Diegelman, P.2    Porter, C.W.3    Tang, B.4    Lu, Z.J.5    Markham, G.D.6
  • 18
    • 0035882159 scopus 로고    scopus 로고
    • Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation
    • Coleman C.S., and Pegg A.E. Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. Biochem. J. 358 (2001) 137-145
    • (2001) Biochem. J. , vol.358 , pp. 137-145
    • Coleman, C.S.1    Pegg, A.E.2
  • 19
    • 0028189807 scopus 로고
    • Aldehyde dehydrogenase and cytotoxicity of purified bovine serumam ine oxidase and spermine in Chinese hamster ovary cells
    • Averill-Bates D.A., Agostinelli E., Przybytkowski E., and Mondovi B. Aldehyde dehydrogenase and cytotoxicity of purified bovine serumam ine oxidase and spermine in Chinese hamster ovary cells. Biochem. Cell Biol. 72 (1994) 36-42
    • (1994) Biochem. Cell Biol. , vol.72 , pp. 36-42
    • Averill-Bates, D.A.1    Agostinelli, E.2    Przybytkowski, E.3    Mondovi, B.4
  • 20
    • 0001547001 scopus 로고    scopus 로고
    • The role of polyamine catabolism in polyamine analogue-induced programmed cell death
    • Ha H.C., Woster P.M., Yager J.D., and Casero Jr. R.A. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 11557-11562
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 11557-11562
    • Ha, H.C.1    Woster, P.M.2    Yager, J.D.3    Casero Jr., R.A.4
  • 21
    • 0035418231 scopus 로고    scopus 로고
    • Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells
    • Chen Y., Kramer D.L., Diegelman P., Vujcic S., and Porter C.W. Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res. 61 (2001) 6437-6444
    • (2001) Cancer Res. , vol.61 , pp. 6437-6444
    • Chen, Y.1    Kramer, D.L.2    Diegelman, P.3    Vujcic, S.4    Porter, C.W.5
  • 22
    • 13544265296 scopus 로고    scopus 로고
    • Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells
    • Choi W., Gerner E.W., Ramdas L., Dupart J., Carew J., Proctor L., et al. Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. J. Biol. Chem. 280 (2005) 3295-3304
    • (2005) J. Biol. Chem. , vol.280 , pp. 3295-3304
    • Choi, W.1    Gerner, E.W.2    Ramdas, L.3    Dupart, J.4    Carew, J.5    Proctor, L.6
  • 23
    • 33846786758 scopus 로고    scopus 로고
    • The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells
    • Allen W.L., McLean E.G., Boyer J., McCulla A., Wilson P.M., Coyle V., et al. The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol. Cancer Ther. 6 (2007) 128-137
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 128-137
    • Allen, W.L.1    McLean, E.G.2    Boyer, J.3    McCulla, A.4    Wilson, P.M.5    Coyle, V.6
  • 26
    • 0029075055 scopus 로고
    • Quinoxaline chemistry: Part 4. 2-(R)-anilinoquinoxalines as non classic antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity
    • Loriga M., Fiore M., Sanna P., and Paglietti G. Quinoxaline chemistry: Part 4. 2-(R)-anilinoquinoxalines as non classic antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity. Il Farmaco 50 (1995) 289-301
    • (1995) Il Farmaco , vol.50 , pp. 289-301
    • Loriga, M.1    Fiore, M.2    Sanna, P.3    Paglietti, G.4
  • 27
    • 0031424452 scopus 로고    scopus 로고
    • Quinoxaline chemistry: Part 8. 2-[Anilino]-3-[Carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity
    • Loriga M., Moro P., Sanna P., and Paglietti G. Quinoxaline chemistry: Part 8. 2-[Anilino]-3-[Carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity. Il Farmaco 52 (1997) 531-537
    • (1997) Il Farmaco , vol.52 , pp. 531-537
    • Loriga, M.1    Moro, P.2    Sanna, P.3    Paglietti, G.4
  • 28
    • 0041967063 scopus 로고    scopus 로고
    • Quinoxaline chemistry: Part 15. 4-[2-Quinoxalylmethylenimino]benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaluation of antifolate and anticancer activities
    • Loriga M., Piras S., Paglietti G., Costi M.P., and Venturelli A. Quinoxaline chemistry: Part 15. 4-[2-Quinoxalylmethylenimino]benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaluation of antifolate and anticancer activities. Il Farmaco 58 (2003) 51-61
    • (2003) Il Farmaco , vol.58 , pp. 51-61
    • Loriga, M.1    Piras, S.2    Paglietti, G.3    Costi, M.P.4    Venturelli, A.5
  • 29
    • 1342281021 scopus 로고    scopus 로고
    • Quinoxaline chemistry: Part 17. 4[3,6(7)disubstituted-2-quinoxalinyl-oxy]phenylacetate and phenylacetylglutamate analogues of methotrexate. Synthesis and evaluation of in vitro anticancer activity
    • Piras S., Loriga M., and Paglietti G. Quinoxaline chemistry: Part 17. 4[3,6(7)disubstituted-2-quinoxalinyl-oxy]phenylacetate and phenylacetylglutamate analogues of methotrexate. Synthesis and evaluation of in vitro anticancer activity. Farmaco 59 (2004) 185-194
    • (2004) Farmaco , vol.59 , pp. 185-194
    • Piras, S.1    Loriga, M.2    Paglietti, G.3
  • 31
    • 0026752490 scopus 로고
    • Mitochondrial defects in cis-diamminedichloroplatinum(II)-resistant human ovarian carcinoma cells
    • Andrews P.A., and Albright K.D. Mitochondrial defects in cis-diamminedichloroplatinum(II)-resistant human ovarian carcinoma cells. Cancer Res. 52 (1992) 1895-1901
    • (1992) Cancer Res. , vol.52 , pp. 1895-1901
    • Andrews, P.A.1    Albright, K.D.2
  • 33
    • 0024454325 scopus 로고
    • Quantification of cells cultured on 96-well plates
    • Kueng W., Siber E., and Eppenberger U. Quantification of cells cultured on 96-well plates. Anal. Biochem. 182 (1989) 16-19
    • (1989) Anal. Biochem. , vol.182 , pp. 16-19
    • Kueng, W.1    Siber, E.2    Eppenberger, U.3
  • 34
    • 33645672106 scopus 로고    scopus 로고
    • -ΔΔCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts
    • -ΔΔCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn. Mol. Pathol. 15 (2006) 56-61
    • (2006) Diagn. Mol. Pathol. , vol.15 , pp. 56-61
    • Arocho, A.1    Chen, B.2    Ladanyi, M.3    Pan, Q.4
  • 36
    • 0017851175 scopus 로고
    • Determination of di- and polyamines by high-performance liquid-chromatographic separation of their 5-dimethylaminonaphtalene-1-sulfonyl derivatives
    • Seiler N.B., Knodgen B., and Eisenbess F. Determination of di- and polyamines by high-performance liquid-chromatographic separation of their 5-dimethylaminonaphtalene-1-sulfonyl derivatives. J. Chromatogr. 145 (1978) 29-39
    • (1978) J. Chromatogr. , vol.145 , pp. 29-39
    • Seiler, N.B.1    Knodgen, B.2    Eisenbess, F.3
  • 37
    • 33847014053 scopus 로고    scopus 로고
    • Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
    • Marzano C., Gandin V., Folda A., Scutari G., Bindoli A., and Rigobello M.P. Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells. Free Radic. Biol. Med. 42 (2007) 872-881
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 872-881
    • Marzano, C.1    Gandin, V.2    Folda, A.3    Scutari, G.4    Bindoli, A.5    Rigobello, M.P.6
  • 38
    • 0023930781 scopus 로고
    • Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues
    • Tagliaferri P., Katsaros D., Clair T., Ally S., Tortora G., Neckers L., et al. Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues. Cancer Res. 48 (1988) 1642-1650
    • (1988) Cancer Res. , vol.48 , pp. 1642-1650
    • Tagliaferri, P.1    Katsaros, D.2    Clair, T.3    Ally, S.4    Tortora, G.5    Neckers, L.6
  • 39
    • 0037341359 scopus 로고    scopus 로고
    • Antisense protein kinase A RIα acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy
    • Cho Y.S., and Cho-Chung Y.S. Antisense protein kinase A RIα acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy. Clin. Cancer Res. 9 (2003) 1171-1178
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1171-1178
    • Cho, Y.S.1    Cho-Chung, Y.S.2
  • 40
    • 0023838919 scopus 로고
    • Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells
    • Scanlon K.J., and Kashani-Sabet M. Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 650-653
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 650-653
    • Scanlon, K.J.1    Kashani-Sabet, M.2
  • 43
    • 3042553345 scopus 로고    scopus 로고
    • Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells
    • Kee K., Vujcic S., Merali S., Diegelman P., Kisiel N., Powell C.T., et al. Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells. J. Biol. Chem. 279 (2004) 27050-27058
    • (2004) J. Biol. Chem. , vol.279 , pp. 27050-27058
    • Kee, K.1    Vujcic, S.2    Merali, S.3    Diegelman, P.4    Kisiel, N.5    Powell, C.T.6
  • 44
    • 0027450179 scopus 로고
    • Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis
    • Shappell N.W., Fogel-Petrovic M.F., and Porter C.W. Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis. FEBS Lett. 321 (1993) 179-183
    • (1993) FEBS Lett. , vol.321 , pp. 179-183
    • Shappell, N.W.1    Fogel-Petrovic, M.F.2    Porter, C.W.3
  • 45
    • 0025281643 scopus 로고
    • Effects of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes
    • Basu H.S., Schwietert H.C., Feuerstein B.G., and Marton L.J. Effects of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes. Biochem. J. 269 (1990) 329-334
    • (1990) Biochem. J. , vol.269 , pp. 329-334
    • Basu, H.S.1    Schwietert, H.C.2    Feuerstein, B.G.3    Marton, L.J.4
  • 46
    • 0024416719 scopus 로고
    • Correlation between the effects of polyamine analogues on DNA conformation and cell growth
    • Basu S., Feuerstein B.G., Dennis F.D., Lubich W.P., Bergeron R.J., Samejima K., et al. Correlation between the effects of polyamine analogues on DNA conformation and cell growth. Cancer Res. 49 (1989) 5591-5597
    • (1989) Cancer Res. , vol.49 , pp. 5591-5597
    • Basu, S.1    Feuerstein, B.G.2    Dennis, F.D.3    Lubich, W.P.4    Bergeron, R.J.5    Samejima, K.6
  • 47
    • 0034327355 scopus 로고    scopus 로고
    • Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison
    • Gao H., Yamasaki E.F., Chan K.K., Shen L.L., and Snapka R.M. Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison. Cancer Res. 60 (2000) 5937-5940
    • (2000) Cancer Res. , vol.60 , pp. 5937-5940
    • Gao, H.1    Yamasaki, E.F.2    Chan, K.K.3    Shen, L.L.4    Snapka, R.M.5
  • 49
    • 0033213831 scopus 로고    scopus 로고
    • Topoisomerase II is nonfunctional in polyamine-depleted cells
    • Alm K., Berntsson P., and Oredsson S.M. Topoisomerase II is nonfunctional in polyamine-depleted cells. J. Cell. Biochem. 75 (1999) 46-55
    • (1999) J. Cell. Biochem. , vol.75 , pp. 46-55
    • Alm, K.1    Berntsson, P.2    Oredsson, S.M.3
  • 50
    • 4444295545 scopus 로고    scopus 로고
    • Polyamine catabolism in platinum drug action: interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase
    • Hector S., Porter C.W., Kramer D.L., Clark K., Prey J., et al. Polyamine catabolism in platinum drug action: interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase. Mol. Cancer Ther. 3 (2004) 813-822
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 813-822
    • Hector, S.1    Porter, C.W.2    Kramer, D.L.3    Clark, K.4    Prey, J.5
  • 51
    • 33947320115 scopus 로고    scopus 로고
    • Platinum drug effects on the expression of gene in polyamine pathway: time-course and concentration-effect analysis based on Affymetrix gene expression profiling of A2780 ovarian carcinoma cells
    • Varma R., Hector S., Greco W.R., Clark K., Hawthorn L., Porter C., et al. Platinum drug effects on the expression of gene in polyamine pathway: time-course and concentration-effect analysis based on Affymetrix gene expression profiling of A2780 ovarian carcinoma cells. Cancer Chemother. Pharmacol. 59 (2007) 711-723
    • (2007) Cancer Chemother. Pharmacol. , vol.59 , pp. 711-723
    • Varma, R.1    Hector, S.2    Greco, W.R.3    Clark, K.4    Hawthorn, L.5    Porter, C.6
  • 52
    • 33645070534 scopus 로고    scopus 로고
    • Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer
    • Boyer J., Allen W.L., McLean E.G., Wilson P.M., McCulla A., Moore S., et al. Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 66 (2006) 2765-2777
    • (2006) Cancer Res. , vol.66 , pp. 2765-2777
    • Boyer, J.1    Allen, W.L.2    McLean, E.G.3    Wilson, P.M.4    McCulla, A.5    Moore, S.6
  • 54
    • 0028342611 scopus 로고
    • Anti-mitochondrial effects of bisethyl polyamines in mammalian cells
    • Snyder R.D., Beach D.C., and Loudy D.E. Anti-mitochondrial effects of bisethyl polyamines in mammalian cells. Anticancer Res. 14 (1994) 347-356
    • (1994) Anticancer Res. , vol.14 , pp. 347-356
    • Snyder, R.D.1    Beach, D.C.2    Loudy, D.E.3
  • 55
    • 70349621130 scopus 로고    scopus 로고
    • The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer
    • Dredge K., Kink J.A., Johnson R.M., Bytheway I., and Marton L.J. The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer. Cancer Chemother. Pharmacol. 65 (2009) 191-195
    • (2009) Cancer Chemother. Pharmacol. , vol.65 , pp. 191-195
    • Dredge, K.1    Kink, J.A.2    Johnson, R.M.3    Bytheway, I.4    Marton, L.J.5


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