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Volumn 10, Issue 41, 2012, Pages 8216-8235

Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - Development of potential agents for the treatment of Alzheimer's disease

(8) Linning, Philipp a Haussmann, Ute b Beyer, Isaak a Weidlich, Sebastian a Schieb, Heinke b Wiltfang, Jens b Klafki, Hans Wolfgang b Knölker, Hans Joachim a

a DRESDEN UNIVERSITY OF TECHNOLOGY (Germany)

b UNIVERSITY OF DUISBURG ESSEN (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; BUILDING BLOCKES; INHIBITORY EFFECT; MEMBRANE ANCHORS; OPTIMISATIONS; PHARMACOPHORES; SYSTEMATIC VARIATION; TRIPARTITE STRUCTURES;

OPTIMIZATION;

PHARMACODYNAMICS;

ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; ENZYME INHIBITOR; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; IC 50; SYNTHESIS;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE;

EID: 84867266792 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c2ob26103k Document Type: Article

Times cited : (12)

References (46)

1
- 34249697099
- R. Brookmeyer E. Johnson K. Ziegler-Graham H. M. Arrighi Alzheimer's Dementia 2007 3 186
- (2007) Alzheimer's Dementia , vol.3 , pp. 186
- Brookmeyer, R.¹ Johnson, E.² Ziegler-Graham, K.³ Arrighi, H.M.⁴

2
- 0025899041
- J. Hardy D. Allsop Trends Pharmacol. Sci. 1991 12 383
- (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383
- Hardy, J.¹ Allsop, D.²

3
- 13944276825
- R. E. Tanzi L. Bertram Cell 2005 120 545
- (2005) Cell , vol.120 , pp. 545
- Tanzi, R.E.¹ Bertram, L.²

4
- 0033382226
- I. Hussain D. Powell D. R. Howlett D. G. Tew T. D. Meek C. Chapman I. S. Gloger K. E. Murphy C. D. Southan D. M. Ryan T. S. Smith D. L. Simmons F. S. Walsh C. Dingwall G. Christie Mol. Cell. Neurosci. 1999 14 419
- (1999) Mol. Cell. Neurosci. , vol.14 , pp. 419
- Hussain, I.¹ Powell, D.² Howlett, D.R.³ Tew, D.G.⁴ Meek, T.D.⁵ Chapman, C.⁶ Gloger, I.S.⁷ Murphy, K.E.⁸ Southan, C.D.⁹ Ryan, D.M.¹⁰ Smith, T.S.¹¹ Simmons, D.L.¹² Walsh, F.S.¹³ Dingwall, C.¹⁴ Christie, G.¹⁵

5
- 0033518251
- S. Sinha J. P. Anderson R. Barbour G. S. Basi R. Caccavello D. Davis M. Doan H. F. Dovey N. Frigon J. Hong K. Jacobson-Croak N. Jewett P. Keim J. Knops I. Lieberburg M. Power H. Tan G. Tatsuno J. Tung D. Schenk P. Seubert S. M. Suomensaari S. Wang D. Walker J. Zhao L. McConlogue V. John Nature 1999 402 537
- (1999) Nature , vol.402 , pp. 537
- Sinha, S.¹ Anderson, J.P.² Barbour, R.³ Basi, G.S.⁴ Caccavello, R.⁵ Davis, D.⁶ Doan, M.⁷ Dovey, H.F.⁸ Frigon, N.⁹ Hong, J.¹⁰ Jacobson-Croak, K.¹¹ Jewett, N.¹² Keim, P.¹³ Knops, J.¹⁴ Lieberburg, I.¹⁵ Power, M.¹⁶ Tan, H.¹⁷ Tatsuno, G.¹⁸ Tung, J.¹⁹ Schenk, D.²⁰ more..

6
- 0033595706
- R. Vassar B. D. Bennett S. Babu-Khan S. Kahn E. A. Mendiaz P. Denis D. B. Teplow S. Ross P. Amarante R. Loeloff Y. Luo S. Fisher J. Fuller S. Edenson J. Lile M. A. Jarosinski A. L. Biere E. Curran T. Burgess J.-C. Louis F. Collins J. Treanor G. Rogers M. Citron Science 1999 286 735
- (1999) Science , vol.286 , pp. 735
- Vassar, R.¹ Bennett, B.D.² Babu-Khan, S.³ Kahn, S.⁴ Mendiaz, E.A.⁵ Denis, P.⁶ Teplow, D.B.⁷ Ross, S.⁸ Amarante, P.⁹ Loeloff, R.¹⁰ Luo, Y.¹¹ Fisher, S.¹² Fuller, J.¹³ Edenson, S.¹⁴ Lile, J.¹⁵ Jarosinski, M.A.¹⁶ Biere, A.L.¹⁷ Curran, E.¹⁸ Burgess, T.¹⁹ Louis, J.-C.²⁰ more..

7
- 0033518264
- R. Yan M. J. Bienkowski M. E. Shuck H. Miao N. C. Stratman W. R. Mathews A. E. Buhlk Nature 1999 402 533
- (1999) Nature , vol.402 , pp. 533
- Yan, R.¹ Bienkowski, M.J.² Shuck, M.E.³ Miao, H.⁴ Stratman, N.C.⁵ Mathews, W.R.⁶ Buhlk, A.E.⁷

8
- 0034652309
- For a review, see
- X. Lin G. Koelsch S. Wu D. Downs A. Dashti J. Tang Proc. Natl. Acad. Sci. U. S. A. 2000 97 1456
- (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 1456
- Lin, X.¹ Koelsch, G.² Wu, S.³ Downs, D.⁴ Dashti, A.⁵ Tang, J.⁶

9
- 70350455062
- R. Vassar D. M. Kovacs R. Yan P. C. Wong J. Neurosci. 2009 29 12787
- (2009) J. Neurosci. , vol.29 , pp. 12787
- Vassar, R.¹ Kovacs, D.M.² Yan, R.³ Wong, P.C.⁴

10
- 33847662852
- C. Haass D. J. Selkoe Nat. Rev. Mol. Cell Biol. 2007 8 101
- (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101
- Haass, C.¹ Selkoe, D.J.²

11
- 84655162702
- A. K. Ghosh M. Brindisi J. Tang J. Neurochem. 2011 120 71
- (2011) J. Neurochem. , vol.120 , pp. 71
- Ghosh, A.K.¹ Brindisi, M.² Tang, J.³

12
- 4644229581
- J. Cumming U. Iserloh M. Kennedy Curr. Opin. Drug Discovery Dev. 2004 7 536
- (2004) Curr. Opin. Drug Discovery Dev. , vol.7 , pp. 536
- Cumming, J.¹ Iserloh, U.² Kennedy, M.³

13
- 0142092495
- V. John J. P. Beck M. J. Bienkowski S. Sinha R. L. Heinrikson J. Med. Chem. 2003 46 4625
- (2003) J. Med. Chem. , vol.46 , pp. 4625
- John, V.¹ Beck, J.P.² Bienkowski, M.J.³ Sinha, S.⁴ Heinrikson, R.L.⁵

14
- 84891578105
- Wiley, Hoboken (NJ)
- V. John, BACE - Lead Target for Orchestrated Therapy of Alzheimer's Disease, Wiley, Hoboken (NJ), 2010
- (2010) BACE - Lead Target for Orchestrated Therapy of Alzheimer's Disease
- John, V.¹

15
- 84055217616
- T. H. Al-Tel M. H. Semreen R. A. Al-Qawasmeh M. F. Schmidt R. El-Awadi M. Ardah R. Zaarour S. N. Rao O. El-Agnaf J. Med. Chem. 2011 54 8373
- (2011) J. Med. Chem. , vol.54 , pp. 8373
- Al-Tel, T.H.¹ Semreen, M.H.² Al-Qawasmeh, R.A.³ Schmidt, M.F.⁴ El-Awadi, R.⁵ Ardah, M.⁶ Zaarour, R.⁷ Rao, S.N.⁸ El-Agnaf, O.⁹

16
- 74049133619
- L. Rajendran H.-J. Knölker K. Simons Nat. Rev. Drug Discovery 2010 9 29
- (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 29
- Rajendran, L.¹ Knölker, H.-J.² Simons, K.³

17
- 84866291339
- B. Dislich S. F. Lichtenthaler Front. Physiol. 2012 3 8
- (2012) Front. Physiol. , vol.3 , pp. 8
- Dislich, B.¹ Lichtenthaler, S.F.²

18
- 34248574864
- L. Zou Z. Wang L. Shen G. B. Bao T. Wang J. H. Kang G. Pei Cell Res. 2007 17 389
- (2007) Cell Res. , vol.17 , pp. 389
- Zou, L.¹ Wang, Z.² Shen, L.³ Bao, G.B.⁴ Wang, T.⁵ Kang, J.H.⁶ Pei, G.⁷

19
- 0030949124
- K. Simons E. Ikonen Nature 1997 387 569
- (1997) Nature , vol.387 , pp. 569
- Simons, K.¹ Ikonen, E.²

20
- 74849118341
- D. Lingwood K. Simons Science 2010 327 46
- (2010) Science , vol.327 , pp. 46
- Lingwood, D.¹ Simons, K.²

21
- 0035928732
- D. R. Riddell G. Christie I. Hussain C. Dingwall Curr. Biol. 2001 11 1288
- (2001) Curr. Biol. , vol.11 , pp. 1288
- Riddell, D.R.¹ Christie, G.² Hussain, I.³ Dingwall, C.⁴

22
- 0037421206
- R. Ehehalt P. Keller C. Haass C. Thiele K. Simons J. Cell Biol. 2003 160 113
- (2003) J. Cell Biol. , vol.160 , pp. 113
- Ehehalt, R.¹ Keller, P.² Haass, C.³ Thiele, C.⁴ Simons, K.⁵

23
- 33645299023
- J. M. Cordy N. M. Hooper A. J. Turner Mol. Membr. Biol. 2006 23 111
- (2006) Mol. Membr. Biol. , vol.23 , pp. 111
- Cordy, J.M.¹ Hooper, N.M.² Turner, A.J.³

24
- 84874757201
- WO 05/097199,; PCT/EP2005/003740, 2005
- T. Braxmeier, T. Friedrichson, W. Froehner, G. Jennings, M. Munick, G. Schlechtingen, C. Schroeder, H.-J. Knölker, K. Simons, M. Zerial and T. Kurzchalia, International Patent, WO 05/097199, 2005; PCT/EP2005/003740, 2005
- (2005) International Patent
- Braxmeier, T.¹ Friedrichson, T.² Froehner, W.³ Jennings, G.⁴ Munick, M.⁵ Schlechtingen, G.⁶ Schroeder, C.⁷ Knölker, H.-J.⁸ Simons, K.⁹ Zerial, M.¹⁰ Kurzchalia, T.¹¹

25
- 42549148456
- L. Rajendran A. Schneider G. Schlechtingen S. Weidlich J. Ries T. Braxmeier P. Schwille J. B. Schulz C. Schroeder M. Simons G. Jennings H.-J. Knölker K. Simons Science 2008 320 520
- (2008) Science , vol.320 , pp. 520
- Rajendran, L.¹ Schneider, A.² Schlechtingen, G.³ Weidlich, S.⁴ Ries, J.⁵ Braxmeier, T.⁶ Schwille, P.⁷ Schulz, J.B.⁸ Schroeder, C.⁹ Simons, M.¹⁰ Jennings, G.¹¹ Knölker, H.-J.¹² Simons, K.¹³

26
- 78651278930
- H. Schieb S. Weidlich G. Schlechtingen P. Linning G. Jennings M. Gruner J. Wiltfang H.-W. Klafki H.-J. Knölker Chem.-Eur. J. 2010 16 14412
- (2010) Chem.-Eur. J. , vol.16 , pp. 14412
- Schieb, H.¹ Weidlich, S.² Schlechtingen, G.³ Linning, P.⁴ Jennings, G.⁵ Gruner, M.⁶ Wiltfang, J.⁷ Klafki, H.-W.⁸ Knölker, H.-J.⁹

27
- 0037122704
- J. S. Tung D. L. Davis J. P. Anderson D. E. Walker S. Mamo N. Jewett R. K. Hom S. Sinha E. D. Thorsett V. John J. Med. Chem. 2002 45 259
- (2002) J. Med. Chem. , vol.45 , pp. 259
- Tung, J.S.¹ Davis, D.L.² Anderson, J.P.³ Walker, D.E.⁴ Mamo, S.⁵ Jewett, N.⁶ Hom, R.K.⁷ Sinha, S.⁸ Thorsett, E.D.⁹ John, V.¹⁰

28
- 0029789935
- K. Tasaki J. Am. Chem. Soc. 1996 118 8459
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 8459
- Tasaki, K.¹

29
- 84867281737
- WO 03/045378
- V. John, International Patent, WO 03/045378, 2003
- (2003) International Patent
- John, V.¹

30
- 84867268256
- WO 03/059346
- A. Dietrich, O. Nimz, U. Rester, W. Fecke, M. Haemmerle and F. Baier, International Patent, WO 03/059346, 2003
- (2003) International Patent
- Dietrich, A.¹ Nimz, O.² Rester, U.³ Fecke, W.⁴ Haemmerle, M.⁵ Baier, F.⁶

31
- 34548510854
- E. W. Baxter K. A. Conway L. Kennis F. Bischoff M. H. Mercken H. L. De Winter C. H. Reynolds B. A. Tounge C. Luo M. K. Scott Y. Huang M. Braeken S. M. A. Pieters D. J. C. Berthelot S. Masure W. D. Bruinzeel A. D. Jordan M. H. Parker R. E. Boyd J. Qu R. S. Alexander D. E. Brenneman A. B. Reitz J. Med. Chem. 2007 50 4261
- (2007) J. Med. Chem. , vol.50 , pp. 4261
- Baxter, E.W.¹ Conway, K.A.² Kennis, L.³ Bischoff, F.⁴ Mercken, M.H.⁵ De Winter, H.L.⁶ Reynolds, C.H.⁷ Tounge, B.A.⁸ Luo, C.⁹ Scott, M.K.¹⁰ Huang, Y.¹¹ Braeken, M.¹² Pieters, S.M.A.¹³ Berthelot, D.J.C.¹⁴ Masure, S.¹⁵ Bruinzeel, W.D.¹⁶ Jordan, A.D.¹⁷ Parker, M.H.¹⁸ Boyd, R.E.¹⁹ Qu, J.²⁰ more..

32
- 54549115053
- J. C. Barrow S. R. Stauffer K. E. Rittle P. L. Ngo Z. Yang H. G. Selnick S. L. Graham S. Munshi G. B. McGaughey M. K. Holloway A. J. Simon E. A. Price S. Sankaranarayanan D. Colussi K. Tugusheva M.-T. Lai A. S. Espeseth M. Xu Q. Huang A. Wolfe B. Pietrak P. Zuck D. A. Levorse D. Hazuda J. P. Vacca J. Med. Chem. 2008 51 6259
- (2008) J. Med. Chem. , vol.51 , pp. 6259
- Barrow, J.C.¹ Stauffer, S.R.² Rittle, K.E.³ Ngo, P.L.⁴ Yang, Z.⁵ Selnick, H.G.⁶ Graham, S.L.⁷ Munshi, S.⁸ McGaughey, G.B.⁹ Holloway, M.K.¹⁰ Simon, A.J.¹¹ Price, E.A.¹² Sankaranarayanan, S.¹³ Colussi, D.¹⁴ Tugusheva, K.¹⁵ Lai, M.-T.¹⁶ Espeseth, A.S.¹⁷ Xu, M.¹⁸ Huang, Q.¹⁹ Wolfe, A.²⁰ more..

33
- 33746795392
- N. Sawada T. Itoh N. Yasuda Tetrahedron Lett. 2006 47 6595
- (2006) Tetrahedron Lett. , vol.47 , pp. 6595
- Sawada, N.¹ Itoh, T.² Yasuda, N.³

34
- 78651391986
- D. K. H. Ho L. Chan A. Hooper P. E. Brennan Tetrahedron Lett. 2011 52 820
- (2011) Tetrahedron Lett. , vol.52 , pp. 820
- Ho, D.K.H.¹ Chan, L.² Hooper, A.³ Brennan, P.E.⁴

35
- 0035819345
- O. Brümmer T. Z. Hoffman D.-W. Chen K. D. Janda Chem. Commun. 2001 19
- (2001) Chem. Commun. , pp. 19
- Brümmer, O.¹ Hoffman, T.Z.² Chen, D.-W.³ Janda, K.D.⁴

36
- 24944550164
- L. A. Thompson J. J. Bronson F. C. Zusi Curr. Pharm. Des. 2005 11 3383
- (2005) Curr. Pharm. Des. , vol.11 , pp. 3383
- Thompson, L.A.¹ Bronson, J.J.² Zusi, F.C.³

37
- 69849115359
- D. Frattarelli M. Schiavo A. Facchetti M. A. Ratner T. J. Marks J. Am. Chem. Soc. 2009 131 12595
- (2009) J. Am. Chem. Soc. , vol.131 , pp. 12595
- Frattarelli, D.¹ Schiavo, M.² Facchetti, A.³ Ratner, M.A.⁴ Marks, T.J.⁵

38
- 0141570892
- H. Alkhathlan Tetrahedron 2003 59 8163 8170
- (2003) Tetrahedron , vol.59 , pp. 8163-8170
- Alkhathlan, H.¹

39
- 33645877967
- D. F. Taber D. A. Gerstenhaber X. Zhao Tetrahedron Lett. 2006 47 3065
- (2006) Tetrahedron Lett. , vol.47 , pp. 3065
- Taber, D.F.¹ Gerstenhaber, D.A.² Zhao, X.³

40
- 0035974358
- R. Jackson Tetrahedron Lett. 2001 42 5163
- (2001) Tetrahedron Lett. , vol.42 , pp. 5163
- Jackson, R.¹

41
- 77949281474
- H. Lee M. Suzuki J. Cui S. A. Kozmin J. Org. Chem. 2010 75 1756
- (2010) J. Org. Chem. , vol.75 , pp. 1756
- Lee, H.¹ Suzuki, M.² Cui, J.³ Kozmin, S.A.⁴

42
- 40149109539
- A. Fürstner A. Korte Chem.-Asian J. 2008 3 310
- (2008) Chem.-Asian J. , vol.3 , pp. 310
- Fürstner, A.¹ Korte, A.²

43
- 85066897001
- A. J. Fatiadi Synthesis 1976 65
- (1976) Synthesis , pp. 65
- Fatiadi, A.J.¹

44
- 84986947049
- H.-J. Knölker J. Prakt. Chem. 1995 337 75
- (1995) J. Prakt. Chem. , vol.337 , pp. 75
- Knölker, H.-J.¹

45
- 77951864540
- G. R. Fulmer A. J. M. Miller N. H. Sherden H. E. Gottlieb A. Nudelman B. M. Stoltz J. E. Bercaw K. I. Goldberg Organometallics 2010 29 2176
- (2010) Organometallics , vol.29 , pp. 2176
- Fulmer, G.R.¹ Miller, A.J.M.² Sherden, N.H.³ Gottlieb, H.E.⁴ Nudelman, A.⁵ Stoltz, B.M.⁶ Bercaw, J.E.⁷ Goldberg, K.I.⁸

46
- 77954359268
- L. M. Munter A. Botev L. Richter P. W. Hildebrand V. Althoff C. Weise D. Kaden G. Multhaup J. Biol. Chem. 2010 285 21636
- (2010) J. Biol. Chem. , vol.285 , pp. 21636
- Munter, L.M.¹ Botev, A.² Richter, L.³ Hildebrand, P.W.⁴ Althoff, V.⁵ Weise, C.⁶ Kaden, D.⁷ Multhaup, G.⁸

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