Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton

Sub-Cellular Biochemistry

Volumn 59, Issue , 2012, Pages 177-215

  Zhang, Li ^a   Mao, Yuntao S ^b   Janmey, Paul A ^c   Yin, Helen L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Actin Cytoskeleton; Phosphatidylinositol 4 phosphate 5 kinase (PIP5K); PIP2

Indexed keywords

1-PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; CALCIUM; ISOENZYME; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOTRANSFERASE; PROTEIN BINDING;

ACTIN FILAMENT; ALTERNATIVE RNA SPLICING; ANIMAL; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; EUKARYOTIC CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

ACTIN CYTOSKELETON; ALTERNATIVE SPLICING; ANIMALS; CALCIUM; EUKARYOTIC CELLS; GENE EXPRESSION REGULATION; HUMANS; ISOENZYMES; MEMBRANE MICRODOMAINS; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

EID: 84867143408     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-007-3015-1_6     Document Type: Article

References (212)

1. Adachi, R, Takeuchi, K, Suzuki, K (2002) Antisense oligonucleotide to cofilin enhances respiratory burst and phagocytosis in opsonized zymosan-stimulated mouse macrophage j774. 1 cells 277: pp. 45566-45571
2. Agranoff, BW, Murthy, P, Seguin, EB (1983) Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets. J Biol Chem 258: pp. 2076-2078
3. Anderson, RA, Marchesi, VT (1985) Regulation of the association of membrane skeletal protein 4. 1 with glycophorin by a polyphosphoinositide 318: pp. 295-298
4. Aoyagi, K, Sugaya, T, Umeda, M, Yamamoto, S, Terakawa, S, Takahashi, M (2005) The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters. J Biol Chem 280: pp. 17346-17352
5. Arioka, M, Nakashima, S, Shibasaki, Y, Kitamoto, K (2004) Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase [gamma]. Biochem Biophys Res Commun 319: pp. 456-463
6. Arora, PD, Chan, MWC, Anderson, RA, Janmey, PA, McCulloch, CA (2005) Separate functions of gelsolin mediate sequential steps of collagen phagocytosis. Mol Biol Cell 16: pp. 5175-5190
7. Audhya, A, Emr, SD (2002) Stt4 pi 4-kinase localizes to the plasma membrane and functions in the pkc1-mediated map kinase cascade. Dev Cell 2: pp. 593-605
8. Audhya, A, Emr, SD (2003) Regulation of pi4,5p2 synthesis by nuclear-cytoplasmic shuttling of the mss4 lipid kinase. EMBO J 22: pp. 4223-4236
9. Bairstow, SF, Ling, K, Anderson, RA (2005) Phosphatidylinositol phosphate kinase type i{gamma} directly associates with and regulates shp-1 tyrosine phosphatase. J Biol Chem 280: pp. 23884-23891
10. Bakolitsa, C, Cohen, DM, Bankston, LA, Bobkov, AA, Cadwell, GW, Jennings, L, Critchley, DR, Craig, SW, Liddington, RC (2004) Structural basis for vinculin activation at sites of cell adhesion. Nature 430: pp. 583-586
11. Balla, T (2009) Green light to illuminate signal transduction events. Trends Cell Biol 19: pp. 575-586
12. Balla T, Varnai P (2002) Visualizing cellular phosphoinositide pools with gfp-fused protein-modules. Sci STKE 2002:PL3
13. Balla T, Varnai P (2009) Visualization of cellular phosphoinositide pools with gfp-fused protein-domains. Curr Protoc Cell Biol Chapter 24:Unit 24 4
14. Barret, C, Roy, C, Montcourrier, P, Mangeat, P, Niggli, V (2000) Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (pip(2)) binding site in the nh(2)-terminal domain of ezrin correlates with its altered cellular distribution. J Cell Biol 151: pp. 1067-1080
15. Berridge, MJ (1983) Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem J 212: pp. 849-858
16. Bolomini-Vittori, M, Montresor, A, Giagulli, C, Staunton, D, Rossi, B, Martinello, M, Constantin, G, Laudanna, C (2009) Regulation of conformer-specific activation of the integrin lfa-1 by a chemokine-triggered rho signaling module. Nat Immunol 10: pp. 185-194
17. Botelho, RJ, Teruel, M, Dierckman, R, Anderson, R, Wells, A, York, JD, Meyer, T, Grinstein, S (2000) Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol 151: pp. 1353-1368
18. Brown, FD, Rozelle, AL, Yin, HL, Balla, T, Donaldson, JG (2001) Phosphatidylinositol 4,5-bisphosphate and arf6-regulated membrane traffic. J Cell Biol 154: pp. 1007-1017
19. Brown, DA, Hughes, SA, Marsh, SJ, Tinker, A (2007) Regulation of m(kv7. 2/7.3) channels in neurons by pip(2) and products of pip(2) hydrolysis: significance for receptor-mediated inhibition. 582: pp. 917-925
20. Burn, P, Rotman, A, Meyer, RK, Burger, MM (1985) Diacylglycerol in large alpha-actinin/actin complexes and in the cytoskeleton of activated platelets. Nature 314: pp. 469-472
21. Catimel, B, Schieber, C, Condron, M, Patsiouras, H, Connolly, L, Catimel, J, Nice, EC, Burgess, AW, Holmes, AB (2008) The pi(3,5)p2 and pi(4,5)p2 interactomes. J Proteome Res 7: pp. 5295-5313
22. Chandrasekar, I, Stradal, TEB, Holt, MR, Entschladen, F, Jockusch, BM, Ziegler, WH (2005) Vinculin acts as a sensor in lipid regulation of adhesion-site turnover. J Cell Sci 118: pp. 1461-1472
23. Chang, LC, Huang, TH, Chang, CS, Tsai, YR, Lin, RH, Lee, PW, Hsu, MF, Huang, LJ, Wang, JP (2011) Signaling mechanisms of inhibition of phospholipase d activation by chs-111 in formyl peptide-stimulated neutrophils. Biochem Pharmacol 81: pp. 269-278
24. Chao, WT, Ashcroft, F, Daquinag, AC, Vadakkan, T, Wei, Z, Zhang, P, Dickinson, ME, Kunz, J (2010a) Type i phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol 30: pp. 4463-4479
25. Chao, WT, Daquinag, AC, Ashcroft, F, Kunz, J (2010b) Type i pipk-alpha regulates directed cell migration by modulating rac1 plasma membrane targeting and activation. J Cell Biol 190: pp. 247-262
26. Chen, MZ, Zhu, X, Sun, HQ, Mao, YS, Wei, Y, Yamamoto, M, Yin, HL (2009) Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a syk-dependent manner. J Biol Chem 284: pp. 23743-23753
27. Chichili, GR, Westmuckett, AD, Rodgers, W (2009) T cell signal regulation by the actin cytoskeleton. J Biol Chem 285: pp. 14737-14746
28. Cho, H, Kim, YA, Yoon, J-Y, Lee, D, Kim, JH, Lee, SH, Ho, W-K (2005) Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of gq-mediated ion channel regulation in atrial myocytes. PNAS 102: pp. 15241-15246
29. Chong, LD, Traynor-Kaplan, A, Bokoch, GM, Schwartz, MA (1994) The small gtp-binding protein rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79: pp. 507-513
30. Christian, DA, Tian, A, Ellenbroek, WG, Levental, I, Rajagopal, K, Janmey, PA, Liu, AJ, Baumgart, T, Discher, DE (2009) Spotted vesicles, striped micelles and janus assemblies induced by ligand binding. Nat Mater 8: pp. 843-849
31. Ciano-Oliveira, CD, Sirokmany, G, Szaszi, K, Arthur, WT, Masszi, A, Peterson, M, Rotstein, OD, Kapus, A (2003) Hyperosmotic stress activates rho: differential involvement in rho kinase-dependent mlc phosphorylation and nkcc activation. Am J Physiol Cell Physiol 285: pp. C555
32. Clarke, JH, Wang, M, Irvine, RF (2010) Localization, regulation and function of type ii phosphatidylinositol 5-phosphate 4-kinases. Adv Enzyme Regul 50: pp. 12-18
33. Coon, BG, Mukherjee, D, Hanna, CB, Riese, DJ, Lowe, M, Aguilar, RC (2009) Lowe syndrome patient fibroblasts display ocrl1-specific cell migration defects that cannot be rescued by the homologous inpp5b phosphatase. Hum Mol Genet 18: pp. 4478-4491
34. Coppolino, MG, Dierckman, R, Loijens, J, Collins, RF, Pouladi, M, Jongstra-Bilen, J, Schreiber, AD, Trimble, WS, Anderson, R, Grinstein, S(2002) Inhibition of phosphatidylinositol-4-phosphate 5-kinase ialpha impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem 277: pp. 43849-43857
35. Corbett-Nelson, EF, Mason, D, Marshall, JG, Collette, Y, Grinstein, S (2006) Signaling-dependent immobilization of acylated proteins in the inner monolayer of the plasma membrane. J Cell Biol 174: pp. 255-265
36. Cremona, O, Camilli, P (2001) Phosphoinositides in membrane traffic at the synapse. J Cell Sci 114: pp. 1041-1052
37. Cremona, O, Paolo, G, Wenk, MR, Luthi, A, Kim, WT, Takei, K, Daniell, L, Nemoto, Y, Shears, SB, Flavell, RA, McCormick, DA, Camilli, P(1999) Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 99: pp. 179-188
38. Das, ND, Yoshioka, T, Samuelson, D, Shichi, H (1987) Immunohistochemical localization of phosphatidylinositol-4,5-bisphosphate in the rat lens. Ophthalmic Res 19: pp. 57-60
39. Paolo, G, Camilli, P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443: pp. 651-657
40. Paolo, G, Pellegrini, L, Letinic, K, Cestra, G, Zoncu, R, Voronov, S, Chang, S, Guo, J, Wenk, MR, Camilli, P (2002) Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the ferm domain of talin. Nature 420: pp. 85-89
41. Paolo, G, Moskowitz, HS, Gipson, K, Wenk, MR, Voronov, S, Obayashi, M, Flavell, R, Fitzsimonds, RM, Ryan, TA, Camilli, P (2004) Impaired ptdins(4,5)p2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 431: pp. 415-422
42. Divecha, N, Irvine, RF (1995) Phospholipid signaling. Cell 80: pp. 269-278
43. Doughman, RL, Firestone, AJ, Wojtasiak, ML, Bunce, MW, Anderson, RA (2003) Membrane ruffling requires coordination between type ialpha phosphatidylinositol phosphate kinase and rac signaling. J Biol Chem 278: pp. 23036-23045
44. Dubash, AD, Menold, MM, Samson, T, Boulter, E, Garcia-Mata, R, Doughman, R, Burridge, K (2009) Focal adhesions: new angles on an old structure. Int Rev Cell Mol Biol 277: pp. 1-65
45. Sayegh, TY, Arora, PD, Ling, K, Laschinger, C, Janmey, PA, Anderson, RA, McCulloch, CA (2007) Phosphatidylinositol-4,5 bisphosphate produced by pip5kigamma regulates gelsolin, actin assembly, and adhesion strength of n-cadherin junctions. Mol Biol Cell 18: pp. 3026-3038
46. Elliott, PR, Goult, BT, Kopp, PM, Bate, N, Grossmann, JG, Roberts, GC, Critchley, DR, Barsukov, IL (2010) The structure of the talin head reveals a novel extended conformation of the ferm domain. Structure 18: pp. 1289-1299
47. Elvers, M, Pozgaj, R, Pleines, I, May, F, Kuijpers, MJ, Heemskerk, JM, Nieswandt, B (2010) Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase cgamma2. J Thromb Haemost 8: pp. 1353-1363
48. Erwig, L-P, McPhilips, KA, Wynes, MW, Ivetic, A, Ridley, AJ, Henson, PM (2006) Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by rho gtpases and ezrin-radixin-moesin (erm) proteins. Proc Natl Acad Sci 103: pp. 12825-12830
49. Fairn, GD, Ogata, K, Botelho, RJ, Stahl, PD, Anderson, RA, Camilli, P, Meyer, T, Wodak, S, Grinstein, S (2009) An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol 187: pp. 701-714
50. Fehon, RG, McClatchey, AI, Bretscher, A (2010) Organizing the cell cortex: the role of erm proteins. Nat Rev Mol Cell Biol 11: pp. 276-287
51. Finkelstein, M, Etkovitz, N, Breitbart, H (2010) Role and regulation of sperm gelsolin prior to fertilization. J Biol Chem 285: pp. 39702-39709
52. Flannagan, RS, Grinstein, S (2010) The application of fluorescent probes for the analysis of lipid dynamics during phagocytosis. Methods Mol Biol 591: pp. 121-134
53. Fujita, A, Cheng, J, Tauchi-Sato, K, Takenawa, T, Fujimoto, T (2009) A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique. Proc Natl Acad Sci U S A 106: pp. 9256-9261
54. Funaki, M, DiFransico, L, Janmey, PA (2006) Pi 4,5-p2 stimulates glucose transport activity of glut4 in the plasma membrane of 3t3-l1 adipocytes. Biochim Biophys Acta (BBA) Mol Cell Res 1763: pp. 5-p2
55. Funakoshi Y, Hasegawa H, Kanaho Y (2011) Regulation of pip5k activity by arf6 and its physiological significance. J Cell Physiol 226:888–895
56. Gascard, P, Tran, D, Sauvage, M, Sulpice, JC, Fukami, K, Takenawa, T, Claret, M, Giraud, F (1991) Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. Biochim Biophys Acta 1069: pp. 27-36
57. Gilmore AP, Burridge K (1996) Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature 381:531–535
58. Giudici, M-L, Emson, PC, Irvine, RF (2004) A novel neuronal-specific splice variant of type i phosphatidylinositol 4-phosphate 5-kinase isoform gamma. Biochem J 379: pp. 489-496
59. Goksoy, E, Ma, Y-Q, Wang, X, Kong, X, Perera, D, Plow, EF, Qin, J (2008) Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell 31: pp. 124-133
60. Golebiewska, U, Nyako, M, Woturski, W, Zaitseva, I, McLaughlin, S (2008) Diffusion coefficient of fluorescent phosphatidylinositol 4,5-bisphosphate in the plasma membrane of cells. Mol Biol Cell 19: pp. 1663-1669
61. Golub, T, Caroni, P (2005) Pi(4,5)p2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility. J Cell Biol 169: pp. 151-165
62. Gong, L-W, Paolo, G, Diaz, E, Cestra, G, Diaz, M-E, Lindau, M, Camilli, P, Toomre, D (2005) Phosphatidylinositol phosphate kinase type i{gamma} regulates dynamics of large dense-core vesicle fusion. PNAS 102: pp. 5204-5209
63. Gorbatyuk, VY, Nosworthy, NJ, Robson, SA, Bains, NPS, Maciejewski, MW, Remedios, CG, King, GF (2006) Mapping the phosphoinositide-binding site on chick cofilin explains how pip2 regulates the cofilin-actin interaction. Mol Cell 24: pp. 511-522
64. Grinstein, S (2010) Imaging signal transduction during phagocytosis: phospholipids, surface charge, and electrostatic interactions. Am J Physiol Cell Physiol 299: pp. C876
65. Groves, E, Dart, AE, Covarelli, V, Caron, E (2008) Molecular mechanisms of phagocytic uptake in mammalian cells. Cell Mol Life Sci 65: pp. 1957-1976
66. Haeffner, EW (1993) Transient temporal relationship between 1-oleoyl-2-acetyl-sn-glycerol (oag)-activated synthesis and hydrolysis of polyphosphoinositides: desensitization of phospholipase c and the inositol lipid kinases upon long-term treatment of ascites cells by exogenous oag. J Lipid Mediat 7: pp. 239-252
67. Halstead, JR, Rheenen, J, Mireille, HJ, Meeuws, S, Mohammed, S, D’Santos, CS, Albert, J, Jalink, K, Divecha, N (2006) A role for ptdins(4,5)p2 and pip5k[alpha] in regulating stress-induced apoptosis. Curr Biol 16: pp. 1850-1856
68. Halstead, JR, Savaskan, NE, Bout, I, Horck, F, Hajdo-Milasinovic, A, Snell, M, Keune, WJ, Klooster, JP, Hordijk, PL, Divecha, N (2010) Rac controls pip5k localisation and ptdins(4,5)p synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci 123: pp. 3535-3546
69. Hammond, GR, Schiavo, G, Irvine, RF (2009) Immunocytochemical techniques reveal multiple, distinct cellular pools of ptdins4p and ptdins(4,5)p(2). Biochem J 422: pp. 23-35
70. Hao, JJ, Liu, Y, Kruhlak, M, Debell, KE, Rellahan, BL, Shaw, S (2009) Phospholipase c-mediated hydrolysis of pip2 releases erm proteins from lymphocyte membrane. J Cell Biol 184: pp. 451-462
71. Hartwig, JH, Bokoch, GM, Carpenter, CL, Janmey, PA, Taylor, LA, Toker, A, Stossel, TP (1995) Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82: pp. 643-653
72. Heldwein, EE, Macia, E, Wang, J, Yin, HL, Kirchhausen, T, Harrison, SC (2004) Crystal structure of the clathrin adaptor protein 1 core. PNAS 101: pp. 14108-14113
73. Heo, WD, Inoue, T, Park, WS, Kim, ML, Park, BO, Wandless, TJ, Meyer, T (2006) Pi(3,4,5)p3 and pi(4,5)p2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314: pp. 1458-1461
74. Hirose, K, Kadowaki, S, Tanabe, M, Takeshima, H, Iino, M (1999) Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex ca2+ mobilization patterns. Science 284: pp. 1527-1530
75. Honda, A, Nogami, M, Yokozeki, T, Yamazaki, M, Nakamura, H, Watanabe, H, Kawamoto, K, Nakayama, K, Morris, AJ, Frohman, MA, Kanaho, Y (1999) Phosphatidylinositol 4-phosphate 5-kinase [alpha] is a downstream effector of the small g protein arf6 in membrane ruffle formation. Cell 99: pp. 521-532
76. Huang, S, Lifshitz, L, Patki-Kamath, V, Tuft, R, Fogarty, K, Czech, MP (2004) Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol 24: pp. 9102-9123
77. Hughes, S, Marsh, SJ, Tinker, A, Brown, DA (2007) Pip(2)-dependent inhibition of m-type (kv7. 2/7.3) potassium channels: direct on-line assessment of pip(2) depletion by gq-coupled receptors in single living neurons. 455: pp. 115-124
78. Ishihara, H, Shibasaki, Y, Kizuki, N, Katagiri, H, Yazaki, Y, Asano, T, Oka, Y (1996) Cloning of cdnas encoding two isoforms of 68-kda type i phosphatidylinositol4-phosphate 5-kinase. J Biol Chem 271: pp. 23611-23614
79. Ishihara, H, Shibasaki, Y, Kizuki, N, Wada, T, Yazaki, Y, Asano, T, Oka, Y (1998) Type i phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem 273: pp. 8741-8748
80. Ito, S, Werth, DK, Richert, ND, Pastan, I (1983) Vinculin phosphorylation by the src kinase. Interaction of vinculin with phospholipid vesicles. J Biol Chem 258: pp. 14626-14631
81. Itoh, T, Ishihara, H, Shibasaki, Y, Oka, Y, Takenawa, T (2000) Autophosphorylation of type i phosphatidylinositol phosphate kinase regulates its lipid kinase activity. J Biol Chem 275: pp. 19389-19394
82. Janetopoulos, C, Devreotes, P (2006) Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol 174: pp. 485-490
83. Janmey, PA, Stossel, TP (1987) Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature 325: pp. 362-364
84. Janmey PA, Bucki R, Yin HL (2009) Phosphoinositides and actin cytoskeletal rearrangement. In: Bradshaw T, Dennis E (eds) The handbook of cell signaling, 2nd edn. Elsevier, New York
85. Jarquin-Pardo, M, Fitzpatrick, A, Galiano, FJ, First, EA, Davis, JN (2007) Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-ibeta for phosphatidylinositol-4-phosphate. J Cell Biochem 100: pp. 112-128
86. Johnson, RP, Niggli, V, Durrer, P, Craig, SW (1998) A conserved motif in the tail domain of vinculin mediates association with and insertion into acidic phospholipid bilayers. Biochemistry 37: pp. 10211-10222
87. Johnson, CM, Chichili, GR, Rodgers, W (2008) Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatases. J Biol Chem 283: pp. 29920-29928
88. Kagan, JC, Medzhitov, R (2006) Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling. Cell 125: pp. 943-955
89. Kalwa, H, Michel, T (2010) The marcks protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem 286: pp. 2320-2330
90. Kalwa, H, Michel, T (2011) The marcks protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem 286: pp. 2320-2330
91. Kisseleva, M, Feng, Y, Ward, M, Song, C, Anderson, RA, Longmore, GD (2005) The lim protein ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of pipki{alpha}. Mol Cell Biol 25: pp. 3956-3966
92. Klein, RM, Spofford, LS, Abel, EV, Ortiz, A, Aplin, AE (2008) B-raf regulation of rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol Biol Cell 19: pp. 498-508
93. Kobayashi, T, Takematsu, H, Yamaji, T, Hiramoto, S, Kozutsumi, Y (2005) Disturbance of sphingolipid biosynthesis abrogates the signaling of mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast. J Biol Chem 280: pp. 18087-18094
94. Komaba, S, Coluccio, LM (2010) Localization of myosin 1b to actin protrusions requires phosphoinositide binding. J Biol Chem 285: pp. 27686-27693
95. Krauss, M, Haucke, V (2007) Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling. EMBO Rep 8: pp. 241-246
96. Kunz, J, Wilson, MP, Kisseleva, M, Hurley, JH, Majerus, PW, Anderson, RA (2000) The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 5: pp. 1-11
97. Kunz, J, Fuelling, A, Kolbe, L, Anderson, RA (2002) Stereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue. J Biol Chem 277: pp. 5611-5619
98. Kwiatkowska, K (2010) One lipid, multiple functions: how various pools of pi(4,5)p(2) are created in the plasma membrane. Cell Mol Life Sci 67: pp. 3927-3946
99. Lacalle, RA, Peregil, RM, Albar, JP, Merino, E, Martinez, AC, Merida, I, Manes, S (2007) Type i phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement. J Cell Biol 179: pp. 1539-1553
100. Lassing, I, Lindberg, U (1985) Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature 314: pp. 472-474
101. Laux, T, Fukami, K, Thelen, M, Golub, T, Frey, D, Caroni, P (2000) Gap43, marcks, and cap23 modulate pi(4,5)p2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol 149: pp. 1455-1472
102. Lee, SY, Voronov, S, Letinic, K, Nairn, AC, Paolo, G, Camilli, P (2005) Regulation of the interaction between pipki{gamma} and talin by proline-directed protein kinases. J Cell Biol 168: pp. 789-799
103. Lee, SY, Kim, B, Yoon, S, Kim, YJ, Liu, T, Woo, JH, Chwae, Y-J, Jou, I (2010) Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses. Exp Mol Med 42: pp. 662-673
104. Levental, I, Cebers, A, Janmey, PA (2008a) Combined electrostatics and hydrogen bonding determine intermolecular interactions between polyphosphoinositides. J Am Chem Soc 130: pp. 9025-9030
105. Levental, I, Janmey, PA, Cebers, A (2008b) Electrostatic contribution to the surface pressure of charged monolayers containing polyphosphoinositides. Biophys J 95: pp. 1199-1205
106. Levental, I, Byfield, FJ, Chowdhury, P, Gai, F, Baumgart, T, Janmey, PA (2009a) Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles. Biochem J 424: pp. 163-167
107. Levental, I, Christian, DA, Wang, YH, Madara, JJ, Discher, DE, Janmey, PA (2009b) Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (pip2)- and cholesterol-containing monolayers. Biochemistry 48: pp. 8241-8248
108. Leyman, S, Sidani, M, Ritsma, L, Waterschoot, D, Eddy, R, Dewitte, D, Debeir, O, Decaestecker, C, Vandekerckhove, J, Rheenen, J, Ampe, C, Condeelis, J, Troys, M (2009) Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering. Mol Biol Cell 20: pp. 4509-4523
109. Liepina, I, Czaplewski, C, Janmey, P, Liwo, A (2003) Molecular dynamics study of a gelsolin-derived peptide binding to a lipid bilayer containing phosphatidylinositol 4,5-bisphosphate. Biopolymers 71: pp. 49-70
110. Ling, K, Doughman, RL, Firestone, AJ, Bunce, MW, Anderson, RA (2002) Type i[gamma] phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420: pp. 89-93
111. Ling, K, Doughman, RL, Iyer, VV, Firestone, AJ, Bairstow, SF, Mosher, DF, Schaller, MD, Anderson, RA (2003) Tyrosine phosphorylation of type i{gamma} phosphatidylinositol phosphate kinase by src regulates an integrin-talin switch. J Cell Biol 163: pp. 1339-1349
112. Ling, K, Bairstow, SF, Carbonara, C, Turbin, DA, Huntsman, DG, Anderson, RA (2007) Type igamma phosphatidylinositol phosphate kinase modulates adherens junction and e-cadherin trafficking via a direct interaction with mu 1b adaptin. J Cell Biol 176: pp. 343-353
113. Liu, Y, Bankaitis, VA (2010) Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res 49: pp. 201-217
114. Logan, MR, Mandato, CA (2006) Regulation of the actin cytoskeleton by pip2 in cytokinesis. Biol Cell 98: pp. 377-388
115. Loijens, JC, Anderson, RA (1996) Type i phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J Biol Chem 271: pp. 32937-32943
116. Lokuta, MA, Senetar, MA, Bennin, DA, Nuzzi, PA, Chan, KT, Ott, VL, Huttenlocher, A (2007) Type igamma pip kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Mol Biol Cell 18: pp. 5069-5080
117. Lorenz, CD, Faraudo, J, Travesset, A (2008) Hydrogen bonding and binding of polybasic residues with negatively charged mixed lipid monolayers. Langmuir 24: pp. 1654-1658
118. Ludwig, A, Otto, GP, Riento, K, Hams, E, Fallon, PG, Nichols, BJ (2010) Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol 191: pp. 771-781
119. Mace, EM, Zhang, J, Siminovitch, KA, Takei, F (2010) Elucidation of the integrin lfa-1-mediated signaling pathway of actin polarization in natural killer cells. Blood 116: pp. 1272-1279
120. Malm, B, Larsson, H, Lindberg, U (1983) The profilin–actin complex: further characterization of profilin and studies on the stability of the complex. J Muscle Res Cell Motil 4: pp. 569-588
121. Manes, S, Fuentes, G, Peregil, RM, Rojas, AM, Lacalle, RA (2010) An isoform-specific pdz-binding motif targets type i pip5 kinase beta to the uropod and controls polarization of neutrophil-like hl60 cells. FASEB J 24: pp. 3381-3392
122. Mao, YS, Yin, HL (2007) Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch 455: pp. 5-18
123. Mao, Y, Balkin, DM, Zoncu, R, Erdmann, KS, Tomasini, L, Hu, F, Jin, MM, Hodsdon, ME, Camilli, P (2009a) A ph domain within ocrl bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J 28: pp. 1831-1842
124. Mao, YS, Yamaga, M, Zhu, X, Wei, Y, Sun, HQ, Wang, J, Yun, M, Wang, Y, Paolo, G, Bennett, M, Mellman, I, Abrams, CS, Camilli, P, Lu, CY, Yin, HL (2009b) Essential and unique roles of pip5k-gamma and -alpha in fcgamma receptor-mediated phagocytosis. J Cell Biol 184: pp. 281-296
125. Martin, TFJ (2001) Pi(4,5)p2 regulation of surface membrane traffic. Curr Opin Cell Biol 13: pp. 493-499
126. Martin-Belmonte, F, Gassama, A, Datta, A, Rescher, U, Gerke, V, Mostov, K (2007) Pten-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through cdc42. Cell 128: pp. 383-397
127. McCrea, HJ, Camilli, P (2009) Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda) 24: pp. 8-16
128. McLaughlin, S, Murray, D (2005) Plasma membrane phosphoinositide organization by protein electrostatics. Nature 438: pp. 605-611
129. McLaughlin, S, Wang, J, Gambhir, A, Murray, D (2002) Pip2 and proteins: interactions, organization, and information flow. Annu Rev Biophys Biomol Struct 31: pp. 151-175
130. Meira, M, Masson, R, Stagljar, I, Lienhard, S, Maurer, F, Boulay, A, Hynes, NE (2009) Memo is a cofilin-interacting protein that influences plc{gamma}1 and cofilin activities, and is essential for maintaining directionality during erbb2-induced tumor-cell migration. J Cell Sci 122: pp. 787-797
131. Mejillano, M, Yamamoto, M, Rozelle, AL, Sun, H-Q, Wang, X, Yin, HL (2001) Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases. J Biol Chem 276: pp. 1865-1872
132. Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L (2011) Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflugers Arch 461:387–397
133. Micucci, F, Capuano, C, Marchetti, E, Piccoli, M, Frati, L, Santoni, A, Galandrini, R (2008) Pi5ki-dependent signals are critical regulators of the cytolytic secretory pathway. Blood 111: pp. 4165-4172
134. Milosevic, I, Sorensen, JB, Lang, T, Krauss, M, Nagy, G, Haucke, V, Jahn, R, Neher, E (2005) Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci 25: pp. 2557-2565
135. Morone, N, Fujiwara, T, Murase, K, Kasai, RS, Ike, H, Yuasa, S, Usukura, J, Kusumi, A (2006) Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. J Cell Biol 174: pp. 851-862
136. Morris, JB, Huynh, H, Vasilevski, O, Woodcock, EA (2006) Alpha1-adrenergic receptor signaling is localized to caveolae in neonatal rat cardiomyocytes. J Mol Cell Cardiol 41: pp. 17-25
137. Nakano-Kobayashi, A, Yamazaki, M, Unoki, T, Hongu, T, Murata, C, Taguchi, R, Katada, T, Frohman, MA, Yokozeki, T, Kanaho, Y (2007) Role of activation of pip5kgamma661 by ap-2 complex in synaptic vesicle endocytosis. EMBO J 26: pp. 1105-1116
138. Nelson, CD, Kovacs, JJ, Nobles, KN, Whalen, EJ, Lefkowitz, RJ (2008) Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. J Biol Chem 283: pp. 21093-21101
139. Niggli, V, Dimitrov, DP, Brunner, J, Burger, MM (1986) Interaction of the cytoskeletal component vinculin with bilayer structures analyzed with a photoactivatable phospholipid. J Biol Chem 261: pp. 6912-6918
140. Padron, D, Wang, YJ, Yamamoto, M, Yin, H, Roth, MG (2003) Phosphatidylinositol phosphate 5-kinase ibeta recruits ap-2 to the plasma membrane and regulates rates of constitutive endocytosis. J Cell Biol 162: pp. 693-701
141. Pan, W, Choi, SC, Wang, H, Qin, Y, Volpicelli-Daley, L, Swan, L, Lucast, L, Khoo, C, Zhang, X, Li, L, Abrams, CS, Sokol, SY, Wu, D (2008) Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates lrp6 phosphorylation. Science 321: pp. 1350-1353
142. Papayannopoulos, V, Co, C, Prehoda, KE, Snapper, S, Taunton, J, Lim, WA (2005) A polybasic motif allows n-wasp to act as a sensor of pip(2) density. Mol Cell 17: pp. 181-191
143. Park, SJ, Itoh, T, Takenawa, T (2001) Phosphatidylinositol 4-phosphate 5-kinase type i is regulated through phosphorylation response by extracellular stimuli. J Biol Chem 276: pp. 4781-4787
144. Parsons, JT, Horwitz, AR, Schwartz, MA (2010) Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol 11: pp. 633-643
145. Pearson, MA, Reczek, D, Bretscher, A, Karplus, PA (2000) Structure of the erm protein moesin reveals the ferm domain fold masked by an extended actin binding tail domain. Cell 101: pp. 259-270
146. Pike, LJ, Miller, JM (1998) Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J Biol Chem 273: pp. 22298-22304
147. Powner, DJ, Payne, RM, Pettitt, TR, Giudici, ML, Irvine, RF, Wakelam, MJO (2005) Phospholipase d2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase i{gamma}b. J Cell Sci 118: pp. 2975-2986
148. Quinn, K, Behe, P, Tinker, A (2008) Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby. J Physiol 586: pp. 2855-2871
149. Rao, VD, Misra, S, Boronenkov, IV, Anderson, RA, Hurley, JH (1998) Structure of type ii[beta] phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94: pp. 829-839
150. Raucher, D, Stauffer, T, Chen, W, Shen, K, Guo, S, York, JD, Sheetz, MP, Meyer, T (2000) Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100: pp. 221-228
151. Redfern, DA, Gericke, A (2004) Domain formation in phosphatidylinositol monophosphate/phosphatidylcholine mixed vesicles. Biophys J 86: pp. 2980-2992
152. Redfern, DA, Gericke, A (2005) Ph-dependent domain formation in phosphatidylinositol polyphosphate/phosphatidylcholine mixed vesicles. J Lipid Res 46: pp. 504-515
153. Ren, XD, Bokoch, GM, Traynor-Kaplan, A, Jenkins, GH, Anderson, RA, Schwartz, MA (1996) Physical association of the small gtpase rho with a 68-kda phosphatidylinositol 4-phosphate 5-kinase in swiss 3t3 cells. Mol Biol Cell 7: pp. 435-442
154. Rozelle, AL, Machesky, LM, Yamamoto, M, Driessens, MHE, Insall, RH, Roth, MG, Luby-Phelps, K, Marriott, G, Hall, A, Yin, HL (2000) Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through wasp-arp2/3. Curr Biol 10: pp. 311-320
155. Rumenapp, U, Schmidt, M, Olesch, S, Ott, S, Eichel-Streiber, CV, Jakobs, KH (1998) Tyrosine-phosphorylation-dependent and rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels. Biochem J 334: pp. 625-631
156. Russo, C, Gao, Y, Mancini, P, Vanni, C, Porotto, M, Falasca, M, Torrisi, MR, Zheng, Y, Eva, A (2001) Modulation of oncogenic dbl activity by phosphoinositol phosphate binding to pleckstrin homology domain. J Biol Chem 276: pp. 19524-19531
157. Saarikangas, J, Zhao, H, Lappalainen, P (2010) Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol Rev 90: pp. 259-289
158. Saito, K, Tolias, KF, Saci, A, Koon, HB, Humphries, LA, Scharenberg, A, Rawlings, DJ, Kinet, J-P, Carpenter, CL (2003) Btk regulates ptdins-4,5-p2 synthesis: importance for calcium signaling and pi3k activity. Immunity 19: pp. 5-p2
159. Sanchez-Madrid, F, Serrador, JM (2009) Bringing up the rear: defining the roles of the uropod. Nat Rev Mol Cell Biol 10: pp. 353-359
160. Sasaki, J, Sasaki, T, Yamazaki, M, Matsuoka, K, Taya, C, Shitara, H, Takasuga, S, Nishio, M, Mizuno, K, Wada, T, Miyazaki, H, Watanabe, H, Iizuka, R, Kubo, S, Murata, S, Chiba, T, Maehama, T, Hamada, K, Kishimoto, H, Frohman, MA, Tanaka, K, Penninger, JM, Yonekawa, H, Suzuki, A, Kanaho, Y (2005) Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type i {alpha}. J Exp Med 201: pp. 859-870
161. Saunders, RM, Holt, MR, Jennings, L, Sutton, DH, Barsukov, IL, Bobkov, A, Liddington, RC, Adamson, EA, Dunn, GA, Critchley, DR (2006) Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol 85: pp. 487-500
162. Schill, NJ, Anderson, RA (2009) Two novel phosphatidylinositol-4-phosphate 5-kinase type igamma splice variants expressed in human cells display distinctive cellular targeting. Biochem J 422: pp. 473-482
163. Scott, CC, Dobson, W, Botelho, RJ, Coady-Osberg, N, Chavrier, P, Knecht, DA, Heath, C, Stahl, P, Grinstein, S (2005) Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. J Cell Biol 169: pp. 139-149
164. Shaw, AS (2006) Lipid rafts: now you see them, now you don’t. Nat Immunol 7: pp. 1139-1142
165. Sheetz, MP, Sable, JE, Dobereiner, HG (2006) Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. Annu Rev Biophys Biomol Struct 35: pp. 417-434
166. Stace, C, Manifava, M, Delon, C, Coadwell, J, Cockcroft, S, Ktistakis, NT (2008) Pa binding of phosphatidylinositol 4-phosphate 5-kinase. Adv Enzyme Regul 48: pp. 55-72
167. Strochlic, TI, Viaud, J, Rennefahrt, UEE, Anastassiadis, T, Peterson, JR (2010) Phosphoinositides are essential coactivators for p21-activated kinase 1. Mol Cell 40: pp. 493-500
168. Suchy, SF, Nussbaum, RL (2002) The deficiency of pip2 5-phosphatase in lowe syndrome affects actin polymerization. Am J Hum Genet 71: pp. 1420-1427
169. Suh, B-C, Inoue, T, Meyer, T, Hille, B (2006) Rapid chemically induced changes of ptdins(4,5)p2 gate kcnq ion channels. Science 314: pp. 1454-1457
170. Suh, BC, Leal, K, Hille, B (2010) Modulation of high-voltage activated ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron 67: pp. 224-238
171. Sun Y, Dandekar RD, Mao YS, Yin HL, Wulfing C (2011) Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization. PLoS One 6:e27227
172. Sun, Y, Ling, K, Wagoner, MP, Anderson, RA (2007) Type i gamma phosphatidylinositol phosphate kinase is required for egf-stimulated directional cell migration. J Cell Biol 178: pp. 297-308
173. Sun Y, Turbin D, Ling K, Thapa N, Leung S, Huntsman D, Anderson R (2010) Type i gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer. Breast Cancer Res 12:R6
174. Szentpetery, Z, Balla, A, Kim, Y, Lemmon, M, Balla, T (2009) Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol 10: pp. 67
175. Szymanska, E, Sobota, A, Czurylo, E, Kwiatkowska, K (2008) Expression of pi(4,5)p2-binding proteins lowers the pi(4,5)p2level and inhibits fcgammariia-mediated cell spreading and phagocytosis. Eur J Immunol 38: pp. 260-272
176. Szymanska, E, Korzeniowski, M, Raynal, P, Sobota, A, Kwiatkowska, K (2009) Contribution of pip-5 kinase i[alpha] to raft-based fc[gamma]riia signaling. Exp Cell Res 315: pp. 981-995
177. Toker, A, Cantley, LC (1997) Signalling through the lipid products of phosphoinositide-3-oh kinase. Nature 387: pp. 673-676
178. Tolias, K, Carpenter, CL (2000) In vitro interaction of phosphoinositide-4-phosphate 5-kinases with rac. Methods Enzymol 325: pp. 190-200
179. Tolias, KF, Cantley, LC, Carpenter, CL (1995) Rho family gtpases bind to phosphoinositide kinases. J Biol Chem 270: pp. 17656-17659
180. Tomas, A, Yermen, B, Regazzi, R, Pessin, JE, Halban, PA (2010) Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate. Traffic 11: pp. 123-137
181. Tong, J, Nguyen, L, Vidal, A, Simon, SA, Skene, JH, McIntosh, TJ (2008) Role of gap-43 in sequestering phosphatidylinositol 4,5-bisphosphate to raft bilayers. Biophys J 94: pp. 125-133
182. Tran, D, Gascard, P, Berthon, B, Fukami, K, Takenawa, T, Giraud, F, Claret, M (1993) Cellular distribution of polyphosphoinositides in rat hepatocytes. Cell Signal 5: pp. 565-581
183. Bout, I, Divecha, N (2009) Pip5k-driven ptdins(4,5)p2 synthesis: regulation and cellular functions. J Cell Sci 122: pp. 3837-3850
184. Rheenen, J, Achame, EM, Janssen, H, Calafat, J, Jalink, K (2005) Pip2 signaling in lipid domains: a critical re-evaluation. EMBO J 24: pp. 1664-1673
185. Rheenen, J, Song, X, Roosmalen, W, Cammer, M, Chen, X, Desmarais, V, Yip, SC, Backer, JM, Eddy, RJ, Condeelis, JS (2007) Egf-induced pip2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol 179: pp. 1247-1259
186. Varnai, P, Lin, X, Lee, S, Tuymetova, G, Bondeva, T, Spat, A, Rhee, S, Hajnoczky, G, Balla, T (2002) Inositol lipid binding and membrane localization of isolated pleckstrin homology (ph) domains. Studies on the ph domains of phospholipase c delta 1 and p130. J Biol Chem 277: pp. 27412-27422
187. Varnai, P, Thyagarajan, B, Rohacs, T, Balla, T (2006) Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J Cell Biol 175: pp. 377-382
188. Vasudevan, L, Jeromin, A, Volpicelli-Daley, L, Camilli, P, Holowka, D, Baird, B (2009) The beta- and gamma-isoforms of type i pip5k regulate distinct stages of ca2+ signaling in mast cells. J Cell Sci 122: pp. 2567-2574
189. Volpicelli-Daley, LA, Lucast, L, Gong, LW, Liu, L, Sasaki, J, Sasaki, T, Abrams, CS, Kanaho, Y, Camilli, P (2010) Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem 285: pp. 28708-28714
190. Voronov, SV, Frere, SG, Giovedi, S, Pollina, EA, Borel, C, Zhang, H, Schmidt, C, Akeson, EC, Wenk, MR, Cimasoni, L, Arancio, O, Davisson, MT, Antonarakis, SE, Gardiner, K, Camilli, P, Paolo, G (2008) Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of down’s syndrome. Proc Natl Acad Sci U S A 105: pp. 9415-9420
191. Wang F (2009) The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol 1:a002980
192. Wang, YJ, Wang, J, Sun, HQ, Martinez, M, Sun, YX, Macia, E, Kirchhausen, T, Albanesi, JP, Roth, MG, Yin, HL (2003) Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor ap-1 complexes to the golgi. Cell 114: pp. 299-310
193. Wang, Y, Li, W, Wang, J, Xu, K, Dong, P, Luo, X, Yin, H (2004) Critical role of pip5ki{gamma}87 in insp3-mediated ca(2+) signaling. J Cell Biol 167: pp. 1005-1010
194. Wang, L, Li, G, Sugita, S (2005) A central kinase domain of type i phosphatidylinositol phosphate kinases is sufficient to prime exocytosis: isoform specificity and its underlying mechanism. J Biol Chem 280: pp. 16522-16527
195. Wang, Y, Lian, L, Golden, JA, Morrisey, EE, Abrams, CS (2007) Pip5ki gamma is required for cardiovascular and neuronal development. Proc Natl Acad Sci U S A 104: pp. 11748-11753
196. Wang, Y, Chen, X, Lian, L, Tang, T, Stalker, TJ, Sasaki, T, Brass, LF, Choi, JK, Hartwig, JH, Abrams, CS (2008a) Loss of pip5kibeta demonstrates that pip5ki isoform-specific pip2 synthesis is required for ip3 formation. Proc Natl Acad Sci U S A 105: pp. 14064-14069
197. Wang, Y, Litvinov, RI, Chen, X, Bach, TL, Lian, L, Petrich, BG, Monkley, SJ, Critchley, DR, Sasaki, T, Birnbaum, MJ, Weisel, JW, Hartwig, J, Abrams, CS (2008b) Loss of pip5kigamma, unlike other pip5ki isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest 118: pp. 812-819
198. Weekes J, Barry ST, Critchley DR (1996) Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites. Biochem J 314(Pt 3):827–832
199. Weernink, PAO, Meletiadis, K, Hommeltenberg, S, Hinz, M, Ishihara, H, Schmidt, M, Jakobs, KH (2004) Activation of type i phosphatidylinositol 4-phosphate 5-kinase isoforms by the rho gtpases, rhoa, rac1, and cdc42. J Biol Chem 279: pp. 7840-7849
200. Wenk, MR, Pellegrini, L, Klenchin, VA, Paolo, G, Chang, S, Daniell, L, Arioka, M, Martin, TF, Camilli, P (2001) Pip kinase i[gamma] is the major pi(4,5)p2 synthesizing enzyme at the synapse. Neuron 32: pp. 79-88
201. Wernimont, SA, Legate, KR, Simonson, WT, Fassler, R, Huttenlocher, A (2010) Pipki gamma 90 negatively regulates lfa-1-mediated adhesion and activation in antigen-induced cd4 + t cells. J Immunol 185: pp. 4714-4723
202. Wong, K-W, Isberg, RR (2003) Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the rac1 requirement for {beta}1 integrin-mediated bacterial uptake. J Exp Med 198: pp. 603-614
203. Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD (2009) Phosphatidylinositol 4-phosphate 5-kinase 1 alpha mediates extracellular calcium-induced keratinocyte differentiation. Mol Biol Cell 20:1695–1704
204. Xu, W, Wang, P, Petri, B, Zhang, Y, Tang, W, Sun, L, Kress, H, Mann, T, Shi, Y, Kubes, P, Wu, D (2010) Integrin-induced pip5k1c kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity 33: pp. 340-350
205. Yamaguchi, H, Yoshida, S, Muroi, E, Kawamura, M, Kouchi, Z, Nakamura, Y, Sakai, R, Fukami, K (2010) Phosphatidylinositol 4,5-bisphosphate and pip5-kinase ialpha are required for invadopodia formation in human breast cancer cells. Cancer Sci 101: pp. 1632-1638
206. Yamamoto, M, Hilgemann, DH, Feng, S, Bito, H, Ishihara, H, Shibasaki, Y, Yin, HL (2001) Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in cv1 cells. J Cell Biol 152: pp. 867-876
207. Yamamoto, M, Chen, MZ, Wang, YJ, Sun, HQ, Wei, Y, Martinez, M, Yin, HL (2006) Hypertonic stress increases phosphatidylinositol 4,5-bisphosphate levels by activating pip5kibeta. J Biol Chem 281: pp. 32630-32638
208. Yang, SA, Carpenter, CL, Abrams, CS (2004) Rho and rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets. J Biol Chem 279: pp. 42331-42336
209. Yeo DS, Chan R, Brown G, Ying L, Sutejo R, Aitken J, Tan BH, Wenk MR, Sugrue RJ (2009) Evidence that selective changes in the lipid composition of raft-membranes occur during respiratory syncytial virus infection. Virology 86:168–182
210. Yin, HL, Janmey, PA (2003) Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol 65: pp. 761-789
211. Zhao, H, Hakala, M, Lappalainen, P (2010) Adf/cofilin binds phosphoinositides in a multivalent manner to act as a pip(2)-density sensor. Biophys J 98: pp. 2327-2336
212. Zoncu, R, Perera, RM, Sebastian, R, Nakatsu, F, Chen, H, Balla, T, Ayala, G, Toomre, D, Camilli, PV (2007) Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A 104: pp. 3793-3798