A polybasic motif allows N-WASP to act as a sensor of PIP2 density

Molecular Cell

Volumn 17, Issue 2, 2005, Pages 181-191

  Papayannopoulos, Venizelos ^a   Co, Carl ^a   Prehoda, Kenneth E ^c   Snapper, Scott ^b   Taunton, Jack ^a   Lim, Wendell A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN MOTIF; RAT;

ACTINS; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CDC42 GTP-BINDING PROTEIN; CELLS, CULTURED; CYTOPLASMIC VESICLES; FIBROBLASTS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN BINDING; RATS; RECOMBINANT FUSION PROTEINS; SECOND MESSENGER SYSTEMS; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

EID: 12344337525     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.11.054     Document Type: Article

References (45)

1. Benesch S., Lommel S., Steffen A., Stradal T.E., Scaplehorn N., Way M., Wehland J., Rottner K. Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. J. Biol. Chem. 277:2002;37771-37776
2. Botelho R.J., Teruel M., Dierckman R., Anderson R., Wells A., York J.D., Meyer T., Grinstein S. Localized biphasic changes in phosphatidylinositol-4,5- bisphosphate at sites of phagocytosis. J. Cell Biol. 151:2000;1353-1368
3. Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296:2002;1655-1657
4. Carpenter C.L., Duckworth B.C., Auger K.R., Cohen B., Schaffhausen B.S., Cantley L.C. Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem. 265:1990;19704-19711
5. Czech M.P. PIP2 and PIP3. complex roles at the cell surface Cell. 100:2000;603-606
6. Egile C., Loisel T.P., Laurent V., Li R., Pantaloni D., Sansonetti P.J., Carlier M.F. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J. Cell Biol. 146:1999;1319-1332
7. Ferrell J.E. Jr., Machleder E.M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science. 280:1998;895-898
8. Fruman D.A., Rameh L.E., Cantley L.C. Phosphoinositide binding domains. embracing 3-phosphate Cell. 97:1999;817-820
9. Higgs H.N., Pollard T.D. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J. Cell Biol. 150:2000;1311-1320
10. Higgs H.N., Pollard T.D. Regulation of actin filament network formation through ARP2/3 complex. activation by a diverse array of proteins Annu. Rev. Biochem. 70:2001;649-676
11. Hillier B.J., Christopherson K.S., Prehoda K.E., Bredt D.S., Lim W.A. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science. 284:1999;812-815
12. Ho H.Y., Rohatgi R., Lebensohn A.M., Le M., Li J., Gygi S.P., Kirschner M.W. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 118:2004;203-216
13. Hoffman G.R., Nassar N., Cerione R.A. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell. 100:2000;345-356
14. Hurley J.H., Meyer T. Subcellular targeting by membrane lipids. Curr. Opin. Cell Biol. 13:2001;146-152
15. Kavran J.M., Klein D.E., Lee A., Falasca M., Isakoff S.J., Skolnik E.Y., Lemmon M.A. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J. Biol. Chem. 273:1998;30497-30508
16. Kim A.S., Kakalis L.T., Abdul-Manan N., Liu G.A., Rosen M.K. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature. 404:2000;151-158
17. Koshland D.E. Jr., Goldbeter A., Stock J.B. Amplification and adaptation in regulatory and sensory systems. Science. 217:1982;220-225
18. Lemmon M.A. Phosphoinositide recognition domains. Traffic. 4:2003;201-213
19. Lemmon M.A., Ferguson K.M. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350:2000;1-18
20. Machesky L.M., Mullins R.D., Higgs H.N., Kaiser D.A., Blanchoin L., May R.C., Hall M.E., Pollard T.D. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc. Natl. Acad. Sci. USA. 96:1999;3739-3744
21. MacLean-Fletcher S., Pollard T.D. Mechanism of action of cytochalasin B on actin. Cell. 20:1980;329-341
22. Marshall J.G., Booth J.W., Stambolic V., Mak T., Balla T., Schreiber A.D., Meyer T., Grinstein S. Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J. Cell Biol. 153:2001;1369-1380
23. Martin T.F. PI(4,5)P(2) regulation of surface membrane traffic. Curr. Opin. Cell Biol. 13:2001;493-499
24. Mayer A., Scheglmann D., Dove S., Glatz A., Wickner W., Haas A. Phosphatidylinositol 4,5-bisphosphate regulates two steps of homotypic vacuole fusion. Mol. Biol. Cell. 11:2000;807-817
25. McLaughlin S., Wang J., Gambhir A., Murray D. PIP(2) and proteins. interactions, organization, and information flow Annu. Rev. Biophys. Biomol. Struct. 31:2002;151-175
26. Pardee J.D., Spudich J.A. Purification of muscle actin. Methods Cell Biol. 24:1982;271-289
27. Perutz M.F. Hemoglobin structure and respiratory transport. Sci. Am. 239:1978;92-125
28. Pike L.J., Miller J.M. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273:1998;22298-22304
29. Prehoda K.E., Scott J.A., Mullins R.D., Lim W.A. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science. 290:2000;801-806
30. Rohatgi R., Ma L., Miki H., Lopez M., Kirchhausen T., Takenawa T., Kirschner M.W. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97:1999;221-231
31. Rohatgi R., Ho H.Y., Kirschner M.W. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J. Cell Biol. 150:2000;1299-1310
32. Rozelle A.L., Machesky L.M., Yamamoto M., Driessens M.H., Insall R.H., Roth M.G., Luby-Phelps K., Marriott G., Hall A., Yin H.L. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr. Biol. 10:2000;311-320
33. Sandhoff R., Brugger B., Jeckel D., Lehmann W.D., Wieland F.T. Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. J. Lipid Res. 40:1999;126-132
34. Sato T.K., Overduin M., Emr S.D. Location, location, location. membrane targeting directed by PX domains Science. 294:2001;1881-1885
35. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572
36. Simonsen A., Wurmser A.E., Emr S.D., Stenmark H. The role of phosphoinositides in membrane transport. Curr. Opin. Cell Biol. 13:2001;485-492
37. Snapper S.B., Takeshima F., Anton I., Liu C.H., Thomas S.M., Nguyen D., Dudley D., Fraser H., Purich D., Lopez-Ilasaca M., et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat. Cell Biol. 3:2001;897-904
38. Taunton J. Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr. Opin. Cell Biol. 13:2001;85-91
39. Taunton J., Rowning B.A., Coughlin M.L., Wu M., Moon R.T., Mitchison T.J., Larabell C.A. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J. Cell Biol. 148:2000;519-530
40. Wang J., Arbuzova A., Hangyas-Mihalyne G., McLaughlin S. The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 276:2001;5012-5019
41. Wang J., Gambhir A., Hangyas-Mihalyne G., Murray D., Golebiewska U., McLaughlin S. Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions. J. Biol. Chem. 277:2002;34401-34412
42. Wang T., Pentyala S., Rebecchi M.J., Scarlata S. Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Biochemistry. 38:1999;1517-1524
43. Welch M.D., Mullins R.D. Cellular control of actin nucleation. Annu. Rev. Cell Dev. Biol. 18:2002;247-288
44. Xu C., Watras J., Loew L.M. Kinetic analysis of receptor-activated phosphoinositide turnover. J. Cell Biol. 161:2003;779-791
45. Yin H.L., Janmey P.A. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65:2003;761-789