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Volumn 7, Issue 10, 2012, Pages

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN BCL 2; PROTEIN KINASE B; PUMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHRL1;

EID: 84867061502     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046885     Document Type: Article
Times cited : (79)

References (90)
  • 1
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • Mochizuki H, Goto K, Mori H, Mizuno Y, (1996) Histochemical detection of apoptosis in Parkinson's disease. J Neurol Sci 137: 120-123.
    • (1996) J Neurol Sci , vol.137 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 2
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
    • Portera-Cailliau C, Hedreen JC, Price DL, Koliatsos VE, (1995) Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J Neurosci 15: 3775-3787.
    • (1995) J Neurosci , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatsos, V.E.4
  • 4
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS, (1997) Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 3: 73-76.
    • (1997) Nat Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3    Masters, J.N.4    Beattie, M.S.5
  • 5
    • 0038205745 scopus 로고    scopus 로고
    • Targeting programmed cell death in neurodegenerative diseases
    • Vila M, Przedborski S, (2003) Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci 4: 365-375.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 365-375
    • Vila, M.1    Przedborski, S.2
  • 6
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    • Brunet A, Datta SR, Greenberg ME, (2001) Transcription-dependent and-independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 11: 297-305.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 7
    • 34347358646 scopus 로고    scopus 로고
    • JNK signalling: a possible target to prevent neurodegeneration
    • Borsello T, Forloni G, (2007) JNK signalling: a possible target to prevent neurodegeneration. Curr Pharm Des 13: 1875-1886.
    • (2007) Curr Pharm Des , vol.13 , pp. 1875-1886
    • Borsello, T.1    Forloni, G.2
  • 8
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • Beurel E, Jope RS, (2006) The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79: 173-189.
    • (2006) Prog Neurobiol , vol.79 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2
  • 9
    • 0033970158 scopus 로고    scopus 로고
    • JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system
    • Mielke K, Herdegen T, (2000) JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system. Prog Neurobiol 61: 45-60.
    • (2000) Prog Neurobiol , vol.61 , pp. 45-60
    • Mielke, K.1    Herdegen, T.2
  • 10
    • 0035089268 scopus 로고    scopus 로고
    • Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death
    • Eilers A, Whitfield J, Shah B, Spadoni C, Desmond H, et al. (2001) Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death. J Neurochem 76: 1439-1454.
    • (2001) J Neurochem , vol.76 , pp. 1439-1454
    • Eilers, A.1    Whitfield, J.2    Shah, B.3    Spadoni, C.4    Desmond, H.5
  • 11
    • 0030780804 scopus 로고    scopus 로고
    • Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    • Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, et al. (1997) Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389: 865-870.
    • (1997) Nature , vol.389 , pp. 865-870
    • Yang, D.D.1    Kuan, C.Y.2    Whitmarsh, A.J.3    Rincon, M.4    Zheng, T.S.5
  • 13
    • 0347479233 scopus 로고    scopus 로고
    • Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad
    • Bhakar AL, Howell JL, Paul CE, Salehi AH, Becker EB, et al. (2003) Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J Neurosci 23: 11373-11381.
    • (2003) J Neurosci , vol.23 , pp. 11373-11381
    • Bhakar, A.L.1    Howell, J.L.2    Paul, C.E.3    Salehi, A.H.4    Becker, E.B.5
  • 14
    • 0034175688 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
    • Hetman M, Cavanaugh JE, Kimelman D, Xia Z, (2000) Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J Neurosci 20: 2567-2574.
    • (2000) J Neurosci , vol.20 , pp. 2567-2574
    • Hetman, M.1    Cavanaugh, J.E.2    Kimelman, D.3    Xia, Z.4
  • 15
  • 16
    • 34547940516 scopus 로고    scopus 로고
    • Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3
    • Eom TY, Roth KA, Jope RS, (2007) Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3. J Biol Chem 282: 22856-22864.
    • (2007) J Biol Chem , vol.282 , pp. 22856-22864
    • Eom, T.Y.1    Roth, K.A.2    Jope, R.S.3
  • 17
    • 7744227096 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
    • Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, et al. (2004) Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 24: 9993-10002.
    • (2004) J Neurosci , vol.24 , pp. 9993-10002
    • Linseman, D.A.1    Butts, B.D.2    Precht, T.A.3    Phelps, R.A.4    Le, S.S.5
  • 18
    • 78049457564 scopus 로고    scopus 로고
    • Differential regulation of AKT, MAPK and GSK3beta during C2-ceramide-induced neuronal death
    • Arboleda G, Cardenas Y, Rodriguez Y, Morales LC, Matheus L, et al. (2010) Differential regulation of AKT, MAPK and GSK3beta during C2-ceramide-induced neuronal death. Neurotoxicology 31: 687-693.
    • (2010) Neurotoxicology , vol.31 , pp. 687-693
    • Arboleda, G.1    Cardenas, Y.2    Rodriguez, Y.3    Morales, L.C.4    Matheus, L.5
  • 19
    • 79952627440 scopus 로고    scopus 로고
    • Akt/GSK3beta signaling is involved in fipronil-induced apoptotic cell death of human neuroblastoma SH-SY5Y cells
    • Lee JE, Kang JS, Ki YW, Lee SH, Lee SJ, et al. (2011) Akt/GSK3beta signaling is involved in fipronil-induced apoptotic cell death of human neuroblastoma SH-SY5Y cells. Toxicol Lett 202: 133-141.
    • (2011) Toxicol Lett , vol.202 , pp. 133-141
    • Lee, J.E.1    Kang, J.S.2    Ki, Y.W.3    Lee, S.H.4    Lee, S.J.5
  • 20
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
    • Crowder RJ, Freeman RS, (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18: 2933-2943.
    • (1998) J Neurosci , vol.18 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 21
    • 0029804116 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase B by insulin and IGF-1
    • Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, et al. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551.
    • (1996) EMBO J , vol.15 , pp. 6541-6551
    • Alessi, D.R.1    Andjelkovic, M.2    Caudwell, B.3    Cron, P.4    Morrice, N.5
  • 22
    • 0031053586 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the serine-threonine protein kinase Akt
    • Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, et al. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665.
    • (1997) Science , vol.275 , pp. 661-665
    • Dudek, H.1    Datta, S.R.2    Franke, T.F.3    Birnbaum, M.J.4    Yao, R.5
  • 23
    • 0031054670 scopus 로고    scopus 로고
    • Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling
    • D'Mello SR, Borodezt K, Soltoff SP, (1997) Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. J Neurosci 17: 1548-1560.
    • (1997) J Neurosci , vol.17 , pp. 1548-1560
    • D'Mello, S.R.1    Borodezt, K.2    Soltoff, S.P.3
  • 24
    • 0030995802 scopus 로고    scopus 로고
    • Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons
    • Deshmukh M, Johnson EM Jr, (1997) Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. Mol Pharmacol 51: 897-906.
    • (1997) Mol Pharmacol , vol.51 , pp. 897-906
    • Deshmukh, M.1    Johnson Jr., E.M.2
  • 25
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • Youle RJ, Strasser A, (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 26
    • 0030797727 scopus 로고    scopus 로고
    • Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
    • Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, et al. (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 139: 205-217.
    • (1997) J Cell Biol , vol.139 , pp. 205-217
    • Miller, T.M.1    Moulder, K.L.2    Knudson, C.M.3    Creedon, D.J.4    Deshmukh, M.5
  • 28
  • 29
    • 0030245811 scopus 로고    scopus 로고
    • BAX is required for neuronal death after trophic factor deprivation and during development
    • Deckwerth TL, Elliott JL, Knudson CM, Johnson EM Jr, Snider WD, et al. (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17: 401-411.
    • (1996) Neuron , vol.17 , pp. 401-411
    • Deckwerth, T.L.1    Elliott, J.L.2    Knudson, C.M.3    Johnson Jr., E.M.4    Snider, W.D.5
  • 30
    • 36348989734 scopus 로고    scopus 로고
    • Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis
    • Steckley D, Karajgikar M, Dale LB, Fuerth B, Swan P, et al. (2007) Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 27: 12989-12999.
    • (2007) J Neurosci , vol.27 , pp. 12989-12999
    • Steckley, D.1    Karajgikar, M.2    Dale, L.B.3    Fuerth, B.4    Swan, P.5
  • 31
    • 34247348628 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons
    • Smith MI, Deshmukh M, (2007) Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell Death Differ 14: 1011-1019.
    • (2007) Cell Death Differ , vol.14 , pp. 1011-1019
    • Smith, M.I.1    Deshmukh, M.2
  • 32
    • 0036479015 scopus 로고    scopus 로고
    • Mitochondrial involvement in the point of no return in neuronal apoptosis
    • Chang LK, Putcha GV, Deshmukh M, Johnson EM Jr, (2002) Mitochondrial involvement in the point of no return in neuronal apoptosis. Biochimie 84: 223-231.
    • (2002) Biochimie , vol.84 , pp. 223-231
    • Chang, L.K.1    Putcha, G.V.2    Deshmukh, M.3    Johnson Jr., E.M.4
  • 33
    • 0030780106 scopus 로고    scopus 로고
    • Movement of Bax from the cytosol to mitochondria during apoptosis
    • Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, et al. (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281-1292.
    • (1997) J Cell Biol , vol.139 , pp. 1281-1292
    • Wolter, K.G.1    Hsu, Y.T.2    Smith, C.L.3    Nechushtan, A.4    Xi, X.G.5
  • 34
    • 0026482631 scopus 로고
    • Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium
    • Franklin JL, Johnson EM Jr, (1992) Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium. Trends Neurosci 15: 501-508.
    • (1992) Trends Neurosci , vol.15 , pp. 501-508
    • Franklin, J.L.1    Johnson Jr., E.M.2
  • 35
    • 0030938816 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells
    • Miller TM, Tansey MG, Johnson EM Jr, Creedon DJ, (1997) Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells. J Biol Chem 272: 9847-9853.
    • (1997) J Biol Chem , vol.272 , pp. 9847-9853
    • Miller, T.M.1    Tansey, M.G.2    Johnson Jr., E.M.3    Creedon, D.J.4
  • 36
    • 50349092257 scopus 로고    scopus 로고
    • All JNKs can kill, but nuclear localization is critical for neuronal death
    • Bjorkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney MJ, et al. (2008) All JNKs can kill, but nuclear localization is critical for neuronal death. J Biol Chem 283: 19704-19713.
    • (2008) J Biol Chem , vol.283 , pp. 19704-19713
    • Bjorkblom, B.1    Vainio, J.C.2    Hongisto, V.3    Herdegen, T.4    Courtney, M.J.5
  • 37
    • 20444394386 scopus 로고    scopus 로고
    • Inhibition of GSK3beta is a common event in neuroprotection by different survival factors
    • Chin PC, Majdzadeh N, D'Mello SR, (2005) Inhibition of GSK3beta is a common event in neuroprotection by different survival factors. Brain Res Mol Brain Res 137: 193-201.
    • (2005) Brain Res Mol Brain Res , vol.137 , pp. 193-201
    • Chin, P.C.1    Majdzadeh, N.2    D'Mello, S.R.3
  • 38
    • 0242410719 scopus 로고    scopus 로고
    • p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    • Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038.
    • (2003) Science , vol.302 , pp. 1036-1038
    • Villunger, A.1    Michalak, E.M.2    Coultas, L.3    Mullauer, F.4    Bock, G.5
  • 39
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3    Tarlinton, D.M.4    Kay, T.W.5
  • 40
    • 0033568860 scopus 로고    scopus 로고
    • Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
    • Cregan SP, MacLaurin JG, Craig CG, Robertson GS, Nicholson DW, et al. (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J Neurosci 19: 7860-7869.
    • (1999) J Neurosci , vol.19 , pp. 7860-7869
    • Cregan, S.P.1    MacLaurin, J.G.2    Craig, C.G.3    Robertson, G.S.4    Nicholson, D.W.5
  • 41
    • 0033931586 scopus 로고    scopus 로고
    • Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons
    • Cregan SP, MacLaurin J, Gendron TF, Callaghan SM, Park DS, et al. (2000) Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons. Gene Ther 7: 1200-1209.
    • (2000) Gene Ther , vol.7 , pp. 1200-1209
    • Cregan, S.P.1    MacLaurin, J.2    Gendron, T.F.3    Callaghan, S.M.4    Park, D.S.5
  • 42
    • 0036323443 scopus 로고    scopus 로고
    • Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
    • Cregan SP, Fortin A, MacLaurin JG, Callaghan SM, Cecconi F, et al. (2002) Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol 158: 507-517.
    • (2002) J Cell Biol , vol.158 , pp. 507-517
    • Cregan, S.P.1    Fortin, A.2    MacLaurin, J.G.3    Callaghan, S.M.4    Cecconi, F.5
  • 43
    • 0029954311 scopus 로고    scopus 로고
    • Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species
    • Schulz JB, Weller M, Klockgether T, (1996) Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J Neurosci 16: 4696-4706.
    • (1996) J Neurosci , vol.16 , pp. 4696-4706
    • Schulz, J.B.1    Weller, M.2    Klockgether, T.3
  • 44
    • 0035851204 scopus 로고    scopus 로고
    • BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
    • Harris CA, Johnson EM Jr, (2001) BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. J Biol Chem 276: 37754-37760.
    • (2001) J Biol Chem , vol.276 , pp. 37754-37760
    • Harris, C.A.1    Johnson Jr., E.M.2
  • 45
    • 35648958679 scopus 로고    scopus 로고
    • dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons
    • Ma C, Ying C, Yuan Z, Song B, Li D, et al. (2007) dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons. J Biol Chem 282: 30901-30909.
    • (2007) J Biol Chem , vol.282 , pp. 30901-30909
    • Ma, C.1    Ying, C.2    Yuan, Z.3    Song, B.4    Li, D.5
  • 46
    • 78650412221 scopus 로고    scopus 로고
    • Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA
    • Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, et al. (2010) Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci 30: 16938-16948.
    • (2010) J Neurosci , vol.30 , pp. 16938-16948
    • Galehdar, Z.1    Swan, P.2    Fuerth, B.3    Callaghan, S.M.4    Park, D.S.5
  • 47
    • 78649743727 scopus 로고    scopus 로고
    • Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition
    • Tuffy LP, Concannon CG, D'Orsi B, King MA, Woods I, et al. (2010) Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition. Mol Cell Biol 30: 5484-5501.
    • (2010) Mol Cell Biol , vol.30 , pp. 5484-5501
    • Tuffy, L.P.1    Concannon, C.G.2    D'Orsi, B.3    King, M.A.4    Woods, I.5
  • 48
    • 77954338545 scopus 로고    scopus 로고
    • Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons
    • Fricker M, Papadia S, Hardingham GE, Tolkovsky AM, (2010) Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. J Neurochem 114: 772-783.
    • (2010) J Neurochem , vol.114 , pp. 772-783
    • Fricker, M.1    Papadia, S.2    Hardingham, G.E.3    Tolkovsky, A.M.4
  • 49
    • 38049097948 scopus 로고    scopus 로고
    • Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice
    • Kieran D, Woods I, Villunger A, Strasser A, Prehn JH, (2007) Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A 104: 20606-20611.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20606-20611
    • Kieran, D.1    Woods, I.2    Villunger, A.3    Strasser, A.4    Prehn, J.H.5
  • 50
    • 33645100728 scopus 로고    scopus 로고
    • The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons
    • Wyttenbach A, Tolkovsky AM, (2006) The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. Journal of Neurochemistry 96: 1213-1226.
    • (2006) Journal of Neurochemistry , vol.96 , pp. 1213-1226
    • Wyttenbach, A.1    Tolkovsky, A.M.2
  • 51
    • 77952305771 scopus 로고    scopus 로고
    • Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma
    • Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, et al. (2010) Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB J 24: 853-861.
    • (2010) FASEB J , vol.24 , pp. 853-861
    • Engel, T.1    Murphy, B.M.2    Hatazaki, S.3    Jimenez-Mateos, E.M.4    Concannon, C.G.5
  • 52
    • 15744383841 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 activity mediates neuronal pentraxin 1 expression and cell death induced by potassium deprivation in cerebellar granule cells
    • Enguita M, Gregorio-Rocasolano N, Abad A, Trullas R, (2005) Glycogen synthase kinase 3 activity mediates neuronal pentraxin 1 expression and cell death induced by potassium deprivation in cerebellar granule cells. Mol Pharmacol 67: 1237-1246.
    • (2005) Mol Pharmacol , vol.67 , pp. 1237-1246
    • Enguita, M.1    Gregorio-Rocasolano, N.2    Abad, A.3    Trullas, R.4
  • 53
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA, (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378: 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 54
    • 0242664588 scopus 로고    scopus 로고
    • Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418
    • Bhat R, Xue Y, Berg S, Hellberg S, Ormo M, et al. (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem 278: 45937-45945.
    • (2003) J Biol Chem , vol.278 , pp. 45937-45945
    • Bhat, R.1    Xue, Y.2    Berg, S.3    Hellberg, S.4    Ormo, M.5
  • 55
    • 0033776383 scopus 로고    scopus 로고
    • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    • Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, et al. (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7: 793-803.
    • (2000) Chem Biol , vol.7 , pp. 793-803
    • Coghlan, M.P.1    Culbert, A.A.2    Cross, D.A.3    Corcoran, S.L.4    Yates, J.W.5
  • 56
    • 0033529638 scopus 로고    scopus 로고
    • Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    • Hetman M, Kanning K, Cavanaugh JE, Xia Z, (1999) Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 274: 22569-22580.
    • (1999) J Biol Chem , vol.274 , pp. 22569-22580
    • Hetman, M.1    Kanning, K.2    Cavanaugh, J.E.3    Xia, Z.4
  • 57
    • 33847014888 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke
    • Zhao H, Sapolsky RM, Steinberg GK, (2006) Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34: 249-270.
    • (2006) Mol Neurobiol , vol.34 , pp. 249-270
    • Zhao, H.1    Sapolsky, R.M.2    Steinberg, G.K.3
  • 58
    • 0034655803 scopus 로고    scopus 로고
    • Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration
    • Namikawa K, Honma M, Abe K, Takeda M, Mansur K, et al. (2000) Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J Neurosci 20: 2875-2886.
    • (2000) J Neurosci , vol.20 , pp. 2875-2886
    • Namikawa, K.1    Honma, M.2    Abe, K.3    Takeda, M.4    Mansur, K.5
  • 59
    • 33845507061 scopus 로고    scopus 로고
    • Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
    • Ries V, Henchcliffe C, Kareva T, Rzhetskaya M, Bland R, et al. (2006) Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc Natl Acad Sci U S A 103: 18757-18762.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18757-18762
    • Ries, V.1    Henchcliffe, C.2    Kareva, T.3    Rzhetskaya, M.4    Bland, R.5
  • 60
    • 0032032404 scopus 로고    scopus 로고
    • Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
    • Eilers A, Whitfield J, Babij C, Rubin LL, Ham J, (1998) Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons. J Neurosci 18: 1713-1724.
    • (1998) J Neurosci , vol.18 , pp. 1713-1724
    • Eilers, A.1    Whitfield, J.2    Babij, C.3    Rubin, L.L.4    Ham, J.5
  • 61
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
    • Grimes CA, Jope RS, (2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65: 391-426.
    • (2001) Prog Neurobiol , vol.65 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 62
    • 0032527879 scopus 로고    scopus 로고
    • Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
    • Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, et al. (1998) Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci 18: 5124-5135.
    • (1998) J Neurosci , vol.18 , pp. 5124-5135
    • Herdegen, T.1    Claret, F.X.2    Kallunki, T.3    Martin-Villalba, A.4    Winter, C.5
  • 63
    • 0032909368 scopus 로고    scopus 로고
    • Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures
    • Mielke K, Brecht S, Dorst A, Herdegen T, (1999) Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures. Neuroscience 91: 471-483.
    • (1999) Neuroscience , vol.91 , pp. 471-483
    • Mielke, K.1    Brecht, S.2    Dorst, A.3    Herdegen, T.4
  • 64
    • 0031972678 scopus 로고    scopus 로고
    • Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
    • Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, et al. (1998) Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J Neurosci 18: 751-762.
    • (1998) J Neurosci , vol.18 , pp. 751-762
    • Watson, A.1    Eilers, A.2    Lallemand, D.3    Kyriakis, J.4    Rubin, L.L.5
  • 65
    • 0035956874 scopus 로고    scopus 로고
    • Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 98: 2837-2842.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2837-2842
    • Vila, M.1    Jackson-Lewis, V.2    Vukosavic, S.3    Djaldetti, R.4    Liberatore, G.5
  • 66
    • 33748261830 scopus 로고    scopus 로고
    • Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
    • Gould TW, Buss RR, Vinsant S, Prevette D, Sun W, et al. (2006) Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci 26: 8774-8786.
    • (2006) J Neurosci , vol.26 , pp. 8774-8786
    • Gould, T.W.1    Buss, R.R.2    Vinsant, S.3    Prevette, D.4    Sun, W.5
  • 68
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, et al. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4
  • 69
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del PL, Gonzalez-Garcia M, Page C, Herrera R, Nunez G, (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278: 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • del, P.L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 70
    • 0036850972 scopus 로고    scopus 로고
    • Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons
    • Linseman DA, Phelps RA, Bouchard RJ, Le SS, Laessig TA, et al. (2002) Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J Neurosci 22: 9287-9297.
    • (2002) J Neurosci , vol.22 , pp. 9287-9297
    • Linseman, D.A.1    Phelps, R.A.2    Bouchard, R.J.3    Le, S.S.4    Laessig, T.A.5
  • 71
    • 0035053624 scopus 로고    scopus 로고
    • Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis
    • Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, et al. (2001) Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron 29: 615-628.
    • (2001) Neuron , vol.29 , pp. 615-628
    • Putcha, G.V.1    Moulder, K.L.2    Golden, J.P.3    Bouillet, P.4    Adams, J.A.5
  • 72
    • 0035049449 scopus 로고    scopus 로고
    • Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
    • Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J, (2001) Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29: 629-643.
    • (2001) Neuron , vol.29 , pp. 629-643
    • Whitfield, J.1    Neame, S.J.2    Paquet, L.3    Bernard, O.4    Ham, J.5
  • 73
    • 34347335739 scopus 로고    scopus 로고
    • Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
    • Coultas L, Terzano S, Thomas T, Voss A, Reid K, et al. (2007) Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. J Cell Sci 120: 2044-2052.
    • (2007) J Cell Sci , vol.120 , pp. 2044-2052
    • Coultas, L.1    Terzano, S.2    Thomas, T.3    Voss, A.4    Reid, K.5
  • 75
    • 36048973184 scopus 로고    scopus 로고
    • Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons
    • Uo T, Kinoshita Y, Morrison RS, (2007) Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci 27: 12198-12210.
    • (2007) J Neurosci , vol.27 , pp. 12198-12210
    • Uo, T.1    Kinoshita, Y.2    Morrison, R.S.3
  • 76
    • 68149108384 scopus 로고    scopus 로고
    • PUMA, a potent killer with or without p53
    • Yu J, Zhang L, (2008) PUMA, a potent killer with or without p53. Oncogene 27Suppl 1: S71-S83.
    • (2008) Oncogene , vol.27
    • Yu, J.1    Zhang, L.2
  • 77
    • 0029745387 scopus 로고    scopus 로고
    • Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons
    • Enokido Y, Araki T, Tanaka K, Aizawa S, Hatanaka H, (1996) Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur J Neurosci 8: 1812-1821.
    • (1996) Eur J Neurosci , vol.8 , pp. 1812-1821
    • Enokido, Y.1    Araki, T.2    Tanaka, K.3    Aizawa, S.4    Hatanaka, H.5
  • 78
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5
  • 79
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • Gilley J, Coffer PJ, Ham J, (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162: 613-622.
    • (2003) J Cell Biol , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 80
    • 33745841375 scopus 로고    scopus 로고
    • FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
    • You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, et al. (2006) FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med 203: 1657-1663.
    • (2006) J Exp Med , vol.203 , pp. 1657-1663
    • You, H.1    Pellegrini, M.2    Tsuchihara, K.3    Yamamoto, K.4    Hacker, G.5
  • 81
    • 0033554699 scopus 로고    scopus 로고
    • L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
    • Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, et al. (1999) L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401: 703-708.
    • (1999) Nature , vol.401 , pp. 703-708
    • Graef, I.A.1    Mermelstein, P.G.2    Stankunas, K.3    Neilson, J.R.4    Deisseroth, K.5
  • 83
    • 53349175016 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells
    • Chung H, Seo S, Moon M, Park S, (2008) Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. Journal of Endocrinology 198: 511-521.
    • (2008) Journal of Endocrinology , vol.198 , pp. 511-521
    • Chung, H.1    Seo, S.2    Moon, M.3    Park, S.4
  • 84
    • 33646775275 scopus 로고    scopus 로고
    • Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress
    • Chong ZZ, Li F, Maiese K, (2006) Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress. Curr Neurovasc Res 3: 107-117.
    • (2006) Curr Neurovasc Res , vol.3 , pp. 107-117
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 86
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, et al. (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14: 927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5
  • 87
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
    • Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, et al. (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127: 1717-1727.
    • (1994) J Cell Biol , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5
  • 88
    • 38749131195 scopus 로고    scopus 로고
    • Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons
    • Mei Y, Yuan Z, Song B, Li D, Ma C, et al. (2008) Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons. Neuroscience 151: 771-779.
    • (2008) Neuroscience , vol.151 , pp. 771-779
    • Mei, Y.1    Yuan, Z.2    Song, B.3    Li, D.4    Ma, C.5
  • 89
    • 65449116159 scopus 로고    scopus 로고
    • Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis
    • Yuan Z, Gong S, Luo J, Zheng Z, Song B, et al. (2009) Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol Cell Biol 29: 2431-2442.
    • (2009) Mol Cell Biol , vol.29 , pp. 2431-2442
    • Yuan, Z.1    Gong, S.2    Luo, J.3    Zheng, Z.4    Song, B.5
  • 90
    • 70350418854 scopus 로고    scopus 로고
    • JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis
    • Cazanave SC, Mott JL, Elmi NA, Bronk SF, Werneburg NW, et al. (2009) JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem 284: 26591-26602.
    • (2009) J Biol Chem , vol.284 , pp. 26591-26602
    • Cazanave, S.C.1    Mott, J.L.2    Elmi, N.A.3    Bronk, S.F.4    Werneburg, N.W.5


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