α-tocopherol at nanomolar concentration protects pc12 cells from hydrogen peroxide-induced death and modulates protein kinase activities

International Journal of Molecular Sciences

Volumn 13, Issue 9, 2012, Pages 11543-11568

  Zakharova, Irina O ^a   Sokolova, Tatyana V ^a   Bayunova, Liubov V ^a   Vlasova, Yulia A ^a   Rychkova, Maria P ^a   Avrova, Natalia F ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

tocopherol; Akt; Anti apoptotic compound; Mek erk signaling pathway; Oxidative stress; Pc12 cells; Physiological concentrations

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA TOCOPHEROL; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C; ANTIOXIDANT; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOBLOTTING; INHIBITION KINETICS; NERVE CELL NECROSIS; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN INDUCTION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; PC12 CELL LINE; TUMOR CELL LINE; WISTAR RAT;

ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYDROGEN PEROXIDE; NEURONS; OXIDATIVE STRESS; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR;

EID: 84866936369     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms130911543     Document Type: Article

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