ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity

Journal of Neurochemistry

Volumn 114, Issue 2, 2010, Pages 452-461

  He, Kai ^a   Aizenman, Elias ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

cortical neuron; extracellular signal regulated kinase 1 2; mitochondria; neurotoxicity; Ras; zinc

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; ADENINE NUCLEOTIDE; BONGKREKIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 3; RAS PROTEIN; ZINC;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEATH; BRAIN NERVE CELL; CELL DEATH; CELL VIABILITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FETUS; GENE EXPRESSION; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CHLORIDES; ENZYME ACTIVATION; ETS-DOMAIN PROTEIN ELK-1; EXTRACELLULAR SPACE; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RAS PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; ZINC; ZINC COMPOUNDS;

RATTUS;

EID: 77953837000     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06762.x     Document Type: Article

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