Nanomolar vitamin e α-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection

Journal of Neurochemistry

Volumn 112, Issue 5, 2010, Pages 1249-1260

  Khanna, Savita ^a   Parinandi, Narasimham L ^b   Kotha, Sainath R ^b   Roy, Sashwati ^a   Rink, Cameron ^a   Bibus, Douglas ^c   Sen, Chandan K ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

tocotrienol; Glutamate; Neurotoxicity; Vitamin E

Indexed keywords

ALPHA TOCOTRIENOL; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONIC ACID; ARACHIDONYLTRIFLUOROMETHYLKETONE; DOCOSAHEXAENOIC ACID; EGTAZIC ACID; ETHER PHOSPHOLIPID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUTAMIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; POLYUNSATURATED FATTY ACID; SERINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBSTRATE; MOUSE; NERVE CELL NECROSIS; NEUROPHARMACOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; CALCIUM; CELL DEATH; CELL LINE, TRANSFORMED; CELL SIZE; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG INTERACTIONS; EGTAZIC ACID; ENZYME ACTIVATION; ENZYME INHIBITORS; FATTY ACIDS; GLUTAMIC ACID; HIPPOCAMPUS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHOLIPASES A2; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS; TRANSFECTION; VITAMIN E;

EID: 75949103949     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06550.x     Document Type: Article

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