Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by α-tocopherol and MEK inhibition

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 13079-13091

  Kondo, Kazunari ^a   Obitsu, Saemi ^a   Ohta, Sayaka ^a   Matsunami, Katsuyoshi ^b   Otsuka, Hideaki ^b   Teshima, Reiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; APOPTOSIS; APOPTOSIS-INDUCING FACTORS; APOPTOTIC; CALPAINS; CASPASE-3; CASPASE-INDEPENDENT; CYTOCHROME C; DNA DAMAGES; ELEOSTEARIC ACID; ISOQUINOLINES; MITOCHONDRIAL MEMBRANE POTENTIAL; NEURONAL CELL; OVER-EXPRESSION; PARP-INHIBITOR; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOLIPASE A2; PHOSPHORYLATED HISTONE; POLY(ADP-RIBOSE) POLYMERASE; POLY(ADP-RIBOSE)-POLYMERASE 1 (PARP-1); SMALL INTERFERING RNA; SUPEROXIDE PRODUCTION; THERAPEUTIC TARGETS; TRACE AMOUNTS; TRIENOIC FATTY ACIDS;

ACIDS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURE; CELL MEMBRANES; CHEMICAL ACTIVATION; FATTY ACIDS; MITOCHONDRIA; OXYGEN; PHOSPHORYLATION; PROTEINS; RNA;

CELL DEATH;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA TOCOPHEROL; APOPTOSIS INDUCING FACTOR; CALPASTATIN; CASPASE; CASPASE 3; CYTOCHROME C; DNA; FATTY ACID DERIVATIVE; HISTONE H2AX; ISOQUINOLINE DERIVATIVE; METHYLNITRONITROSOGUANIDINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE A2 INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; SMALL INTERFERING RNA; STEARIC ACID DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SUPEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL NUCLEUS; ENZYME INHIBITORS; HUMANS; LINOLENIC ACIDS; MAP KINASE KINASE KINASES; MICE; NEURONS; PC12 CELLS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; RATS;

EID: 77951241220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.044206     Document Type: Article

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