Maternal dietary loads of α-tocopherol depress protein kinase C signaling and synaptic plasticity in rat postnatal developing hippocampus and promote permanent deficits in adult offspring

Journal of Nutritional Biochemistry

Volumn 22, Issue 1, 2011, Pages 60-70

  Betti, Michele ^a   Ambrogini, Patrizia ^a   Minelli, Andrea ^a   Floridi, Alessandro ^b   Lattanzi, Davide ^a   Ciuffoli, Stefano ^a   Bucherelli, Corrado ^c   Prospero, Emilia ^d   Frontini, Andrea ^d   Santarelli, Lory ^d   Baldi, Elisabetta ^c   Benetti, Fernando ^e   Galli, Francesco ^b   Cuppini, Riccardo ^a  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Brain development; Cell signaling; Long term potentiation; Morris water maze; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; NEUROMODULIN; PROTEIN KINASE C;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPUS; LONG TERM MEMORY; MATERNAL NUTRITION; MEMORY DISORDER; NERVE CELL PLASTICITY; NONHUMAN; OVERNUTRITION; POSTNATAL DEVELOPMENT; PROGENY; RAT; SIGNAL TRANSDUCTION; SPATIAL MEMORY; SYNAPTOGENESIS;

ALPHA-TOCOPHEROL; ANIMALS; DIETARY SUPPLEMENTS; DOWN-REGULATION; FEMALE; GAP-43 PROTEIN; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTATION; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MEMBRANE PROTEINS; MEMORY DISORDERS; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; NEURONS; PHOSPHORYLATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN KINASE C; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

RATTUS;

EID: 78649962477     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.11.014     Document Type: Article

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