메뉴 건너뛰기




Volumn 49, Issue 1, 2010, Pages 1-12

Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells

Author keywords

Chemoprevention; Inositol hexaphosphate; Phytic acid; Prostate cancer

Indexed keywords

ANDROGEN; BIOLOGICAL RESPONSE MODIFIER; CASPASE 3; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHYTIC ACID; PROTEIN KINASE B; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE;

EID: 74249091558     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20560     Document Type: Article
Times cited : (26)

References (37)
  • 3
    • 0031867690 scopus 로고    scopus 로고
    • Diet, nutrition, and prostate cancer
    • Clinton SK, Giovannucci E. Diet, nutrition, and prostate cancer. Annu Rev Nutr 1998;18:413-440.
    • (1998) Annu Rev Nutr , vol.18 , pp. 413-440
    • Clinton, S.K.1    Giovannucci, E.2
  • 4
    • 12344285031 scopus 로고    scopus 로고
    • Macronutrients, fatty acids, cholesterol and prostate cancer risk
    • Bidoli E, Talamini R, Bosetti C, et al. Macronutrients, fatty acids, cholesterol and prostate cancer risk. Ann Oncol 2005;16:152-157.
    • (2005) Ann Oncol , vol.16 , pp. 152-157
    • Bidoli, E.1    Talamini, R.2    Bosetti, C.3
  • 5
    • 22944459874 scopus 로고    scopus 로고
    • Prostate cancer and inositol hexaphosphate: Efficacy and mechanisms
    • Singh RP, Agarwal R. Prostate cancer and inositol hexaphosphate: Efficacy and mechanisms. Anticancer Res 2005;25: 2891-2903.
    • (2005) Anticancer Res , vol.25 , pp. 2891-2903
    • Singh, R.P.1    Agarwal, R.2
  • 6
    • 0034492496 scopus 로고    scopus 로고
    • Role of diet modification in cancer prevention
    • Abdulla M, Gruber P. Role of diet modification in cancer prevention. Biofactors 2000;12:45-51.
    • (2000) Biofactors , vol.12 , pp. 45-51
    • Abdulla, M.1    Gruber, P.2
  • 7
    • 32944481144 scopus 로고    scopus 로고
    • Chemoprevention of prostate cancer
    • Klein EA. Chemoprevention of prostate cancer. Annu Rev Med 2006;57:49-63.
    • (2006) Annu Rev Med , vol.57 , pp. 49-63
    • Klein, E.A.1
  • 8
    • 33751081567 scopus 로고    scopus 로고
    • Mechanisms of action of novel agents for prostate cancer chemoprevention
    • Singh RP, Agarwal R. Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocr Relat Cancer 2006;13:751-778.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 751-778
    • Singh, R.P.1    Agarwal, R.2
  • 9
    • 34547657069 scopus 로고    scopus 로고
    • Chemoprevention of prostate cancer: Agents and study designs
    • Thompson IM. Chemoprevention of prostate cancer: Agents and study designs. J Urol 2007;178:S9-S13.
    • (2007) J Urol , vol.178
    • Thompson, I.M.1
  • 10
    • 0035102946 scopus 로고    scopus 로고
    • Rice-bran products: Phytonutrients with potential applications in preventive and clinical medicine
    • Jariwalla RJ. Rice-bran products: Phytonutrients with potential applications in preventive and clinical medicine. Drugs Exp Clin Res 2001;27:17-26.
    • (2001) Drugs Exp Clin Res , vol.27 , pp. 17-26
    • Jariwalla, R.J.1
  • 12
    • 0242526048 scopus 로고    scopus 로고
    • Cancer inhibition by inositol hexaphosphate (IP6) and inositol: From laboratory to clinic
    • Vucenik I, Shamsuddin AM. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: From laboratory to clinic. J Nutr 2003;133:3778S-3784S.
    • (2003) J Nutr , vol.133
    • Vucenik, I.1    Shamsuddin, A.M.2
  • 13
    • 33750846875 scopus 로고    scopus 로고
    • Protection against cancer by dietary IP6 and inositol
    • Vucenik I, Shamsuddin AM. Protection against cancer by dietary IP6 and inositol. Nutr Cancer 2006;55:109-125.
    • (2006) Nutr Cancer , vol.55 , pp. 109-125
    • Vucenik, I.1    Shamsuddin, A.M.2
  • 14
    • 0023936256 scopus 로고
    • Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate
    • Shamsuddin AM, Elsayed AM, Ullah A. Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate. Carcinogenesis 1988;9:577-580.
    • (1988) Carcinogenesis , vol.9 , pp. 577-580
    • Shamsuddin, A.M.1    Elsayed, A.M.2    Ullah, A.3
  • 15
    • 0024517059 scopus 로고
    • Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5 months after induction by azoxymethane
    • Shamsuddin AM, Ullah A. Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5 months after induction by azoxymethane. Carcinogenesis 1989;10:625-626.
    • (1989) Carcinogenesis , vol.10 , pp. 625-626
    • Shamsuddin, A.M.1    Ullah, A.2
  • 16
    • 0029122135 scopus 로고
    • Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells
    • Shamsuddin AM, Yang GY. Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Carcinogenesis 1995;16:1975-1979.
    • (1995) Carcinogenesis , vol.16 , pp. 1975-1979
    • Shamsuddin, A.M.1    Yang, G.Y.2
  • 17
    • 6944232245 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells
    • Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia 2004;6:646-659.
    • (2004) Neoplasia , vol.6 , pp. 646-659
    • Agarwal, C.1    Dhanalakshmi, S.2    Singh, R.P.3    Agarwal, R.4
  • 18
    • 0037360095 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: Modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
    • Singh RP, Agarwal C, Agarwal R. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: Modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis 2003;24:555-563.
    • (2003) Carcinogenesis , vol.24 , pp. 555-563
    • Singh, R.P.1    Agarwal, C.2    Agarwal, R.3
  • 19
    • 0034526276 scopus 로고    scopus 로고
    • Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells
    • Zi X, Singh RP, Agarwal R. Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis 2000;21:2225-2235.
    • (2000) Carcinogenesis , vol.21 , pp. 2225-2235
    • Zi, X.1    Singh, R.P.2    Agarwal, R.3
  • 20
    • 0345305275 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits constitutive activation of NF-kappa B in androgen-independent human prostate carcinoma DU145 cells
    • Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits constitutive activation of NF-kappa B in androgen-independent human prostate carcinoma DU145 cells. Anticancer Res 2003;23:3855-3861.
    • (2003) Anticancer Res , vol.23 , pp. 3855-3861
    • Agarwal, C.1    Dhanalakshmi, S.2    Singh, R.P.3    Agarwal, R.4
  • 21
    • 1642453720 scopus 로고    scopus 로고
    • In vivo suppression of hormonerefractory prostate cancer growth by inositol hexaphosphate: Induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor
    • Singh RP, Sharma G, Mallikarjuna GU, Dhanalakshmi S, Agarwal C, Agarwal R. In vivo suppression of hormonerefractory prostate cancer growth by inositol hexaphosphate: Induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clin Cancer Res 2004;10:244-250.
    • (2004) Clin Cancer Res , vol.10 , pp. 244-250
    • Singh, R.P.1    Sharma, G.2    Mallikarjuna, G.U.3    Dhanalakshmi, S.4    Agarwal, C.5    Agarwal, R.6
  • 22
    • 3142745596 scopus 로고    scopus 로고
    • Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells
    • Sharma G, Singh RP, Agarwal R. Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. Int J Oncol 2003;23:1413-1418.
    • (2003) Int J Oncol , vol.23 , pp. 1413-1418
    • Sharma, G.1    Singh, R.P.2    Agarwal, R.3
  • 23
    • 49649098564 scopus 로고    scopus 로고
    • Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice
    • Raina K, Rajamanickam S, Singh RP, Agarwal R. Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice. Clin Cancer Res 2008;14:3177-3184.
    • (2008) Clin Cancer Res , vol.14 , pp. 3177-3184
    • Raina, K.1    Rajamanickam, S.2    Singh, R.P.3    Agarwal, R.4
  • 25
    • 0034668148 scopus 로고    scopus 로고
    • Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents
    • Agarwal R. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem Pharmacol 2000;60:1051-1059.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1051-1059
    • Agarwal, R.1
  • 26
    • 1842471336 scopus 로고    scopus 로고
    • Signaling through the epidermal growth factor receptor during the development of malignancy
    • Grandis JR, Sok JC. Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther 2004;102:37-46.
    • (2004) Pharmacol Ther , vol.102 , pp. 37-46
    • Grandis, J.R.1    Sok, J.C.2
  • 27
    • 33745112128 scopus 로고    scopus 로고
    • Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells
    • Singh RP, Dhanalakshmi S, Mohan S, Agarwal C, Agarwal R. Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells. Mol Cancer Ther 2006;5:1145-1153.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1145-1153
    • Singh, R.P.1    Dhanalakshmi, S.2    Mohan, S.3    Agarwal, C.4    Agarwal, R.5
  • 28
    • 33845332401 scopus 로고    scopus 로고
    • Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines
    • Sharrard RM, Maitland NJ. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines. Cell Signal 2007;19:129-138.
    • (2007) Cell Signal , vol.19 , pp. 129-138
    • Sharrard, R.M.1    Maitland, N.J.2
  • 29
    • 0024869513 scopus 로고
    • AP1, a composite transcription factor implicated in abnormal growth control
    • Imler JL, Wasylyk B. AP1, a composite transcription factor implicated in abnormal growth control. Prog Growth Factor Res 1989;1:69-77.
    • (1989) Prog Growth Factor Res , vol.1 , pp. 69-77
    • Imler, J.L.1    Wasylyk, B.2
  • 30
    • 0038732463 scopus 로고    scopus 로고
    • Phytic acid (IP6), novel broad spectrum antineoplastic agent: A systematic review
    • Fox CH, Eberl M. Phytic acid (IP6), novel broad spectrum antineoplastic agent: A systematic review. Complement Ther Med 2002;10:229-234.
    • (2002) Complement Ther Med , vol.10 , pp. 229-234
    • Fox, C.H.1    Eberl, M.2
  • 31
    • 0025021262 scopus 로고
    • Antioxidant functions of phytic acid
    • Graf E, Eaton JW. Antioxidant functions of phytic acid. Free Radic Biol Med 1990;8:61-69.
    • (1990) Free Radic Biol Med , vol.8 , pp. 61-69
    • Graf, E.1    Eaton, J.W.2
  • 32
    • 0032080609 scopus 로고    scopus 로고
    • A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells
    • Zi X, Grasso AW, Kung HJ, Agarwal R. A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res 1998;58:1920-1929.
    • (1998) Cancer Res , vol.58 , pp. 1920-1929
    • Zi, X.1    Grasso, A.W.2    Kung, H.J.3    Agarwal, R.4
  • 33
    • 28544444712 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor as a therapeutic target in cancer
    • Miller BS, Yee D. Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res 2005;65:10123-10127.
    • (2005) Cancer Res , vol.65 , pp. 10123-10127
    • Miller, B.S.1    Yee, D.2
  • 34
    • 40349091247 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factors, insulin resistance, and neoplasia
    • Pollack MN. Insulin, insulin-like growth factors, insulin resistance, and neoplasia. Am J Clin Nutr 2007;86:s820-s822.
    • (2007) Am J Clin Nutr , vol.86
    • Pollack, M.N.1
  • 35
    • 34248572839 scopus 로고    scopus 로고
    • MAP kinases and the control of nuclear events
    • Turjanski AG, Vaqué JP, Gutkind JS. MAP kinases and the control of nuclear events. Oncogene 2007;26:3240-3243.
    • (2007) Oncogene , vol.26 , pp. 3240-3243
    • Turjanski, A.G.1    Vaqué, J.P.2    Gutkind, J.S.3
  • 36
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007;26:3100-3112.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 37
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J.Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-869.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.