A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 3, 2009, Pages 732-739

  Gould, Neal S ^a   White, Carl W ^a,b   Day, Brian J ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROETHYL ETHYL SULFIDE; GLUTATHIONE; METALLOPORPHYRIN; MUSTARD GAS DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG INJURY; MITOCHONDRIAL RESPIRATION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

ANTIOXIDANTS; CELL SURVIVAL; EPITHELIAL CELLS; HUMANS; LUNG INJURY; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MUSTARD GAS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 62449195493     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.145037     Document Type: Article

References (37)

1. Blanc PD (1999) The legacy of war gas. Am J Med 6:689-690.
2. Brimfield AA, Mancebo AM, Mason RP, Jiang JJ, Siraki AG, and Novak MJ (2009) Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport, systems. Toxicol Appl Pharmacol 234:128-134.
3. Brookes P and Lawley P (1961) The reaction of mono- and di-functional alkylating agents with nucleic acids. J Biochem 80:496-503.
4. Chatterjee D, Mukherjee S, Smith MG, and Das SK (2003) Signal transduction events in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol 17:114-121.
5. Darzynkiewicz Z, Staiano-Coico L, and Melamed MR (1981) Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation. Proc Natl Acad Sci U S A 78:2383-2387.
6. Das SK, Mukherjee S, Smith MG, and Chatterjee D (2003) Prophylactic protection by N-acetylcysteine against the pulmonary injury induced by 2-chloroethyl ethyl sidfide, a mustard analogue. J Biochem Mol Toxicol 17:177-184.
7. Day BJ (2004) Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov Today 9:557-566.
8. Day BJ (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal 10:355-370.
9. Dillman JF 3rd, Phillips CS, Dorsch LM, Croxton MD, Hege AI, Sylvester AJ, Moran TS, and Sciuto AM (2005) Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure. Chem Res Toxicol 18:28-34.
10. Drose S and Brandt U (2008) The mechanism of mitochondrial superoxide production by the cytochrome bcl complex. J Biol Chem 31:21649-21654.
11. Elsayed NM, Omaye ST, Klain GJ, Inase JL, Dahlberg ET, Wheeler CR, and Korte DW Jr (1989) Response of mouse brain to a single subcutaneous injection of the monofunctional sulfur mustard, butyl 2-chloroethyl sulfide. Toxicology 58:11-20.
12. Elsayed NM, Omaye ST, Klain GJ, and Korte DW Jr (1992) Free radical-mediated lung response to the monofunctional sulfur mustard butyl 2-chloroethyl sulfide after subcutaneous injection. Toxicology 72:153-165.
13. Fridovich I (1978) The biology of oxygen radicals. Science 201:875-880.
14. Gautam A, Vijayaraghavan R, Sharma M, and Ganesan K (2006) Comparative toxicity studies of sulfur mustard (2,2′-dichloro diethyl sulfide) and monofunctional sulfur mustard (2-chloroethyl ethyl sulfide), administered through various routes in mice. J Med CBR Def 4:1-21.
15. Ghanei M and Harandi AA (2007) Long term consequences from exposure to sulfur mustard: a review. Inhal Toxicol 19:451-456.
16. Gray PJ (1995) Sulphur mustards inhibit binding of transcription factor AP2 in vitro. Nucleic Acids Res 23:4378-4382.
17. Han S, Espinoza LA, Liao H, Boulares AH, and Smulson ME (2004) Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard ana log 2-chloroethyl ethyl sulphide (CEES) in Jurkat T cells and normal human lymphocytes. Br J Pharmacol 141:795-802.
18. Hoesel LM, Flierl MA, Niederbichler AD, Rittirsch D, McClintock SD, Reuben JS, Pianko MJ, Stone W, Yang H, Smith M, et al. (2008) Abihty of antioxidant liposomes to prevent acute and progressive pulmonary injury. Antioxid Redox Signal 10:978-981.
19. Jafari M (2007) Dose- and time-dependent effects of sulfur mustard on antioxidant system in liver and brain of rat. Toxicology 231:30-39.
20. Kehe K and Szinicz L (2005) Medical aspects of sulphur mustard poisoning. Toxicology 214:198-209.
21. Kim YB, Lee YS, Choi DS, Cha SH, and Sok DE (1996) Change in glutathione -transferase and glyceraldehyde-3-phosphate dehydrogenase activities in the organs of mice treated with 2-chloroethyl ethyl sulfide or its oxidation products. Food Chem Toxicol 34:259-265.
22. Korkmaz A, Yaren H, Topal T, and Oter S (2006) Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Arch Toxicol 80:662-670.
23. Lawley PD and Brookes P (1967) Interstrand cross-linking of DNA by difunctional alkylating agents. J Mol Biol 25:143-160.
24. McClintock SD, Hoesel LM, Das SK, Till GO, Neff T, Kunkel RG, Smith MG, and Ward PA (2006) Attenuation of half sidfur mustard gas-induced acute lung injury in rats. J Appl Toxicol 26:126-131.
25. McClintock SD, Till GO, Smith MG, and Ward PA (2002) Protection from half-mustard-gas-induced acute lung injury in the rat. J Appl Toxicol 22:257-262.
26. + levels in human leukocytes. Toxicol Lett 39:109-122.
27. Milano J and Day BJ (2000) A catalytic antioxidant metalloporphyrin blocks hydrogen peroxide-induced mitochondrial DNA damage. Nucleic Acids Res 28:968-973.
28. Mukhopadhyay S, Rajaratnam V, Mukherjee S, Smith M, and Das SK (2006) Modulation of the expression of superoxide dismutase gene in lung injury by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol 20:142-149.
29. Munro NB, Watson AP, Ambrose KR, and Griffin GD (1990) Treating exposure to chemical warfare agents: implications for health care providers and community emergency planning. Environ Health Perspect 89:205-215.
30. Papirmeister B, Gross CL, Meier HL, Petrali JP, and Johnson JB (1985) Molecular basis for mustard-induced vesication. Fundam Appl Toxicol 5:S134-S149.
31. Paromov V, Qui M, Yang H, Smith M, and Stone WL (2008) The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue. BMC Cell Biol 9:33.
32. Qui M, Paromov VM, Yang H, Smith M, and Stone WL (2006) Inhibition of inducible Nitric Oxide Synthase by a mustard gas analog in murine macrophages. BMC Cell Biol 7:39.
33. Rahman I, Kode A, and Biswas SK (2006) Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1:3159-3165.
34. Ray R, Keyser B, Benton B, Daher A, Simbulan-Rosenthal CM, and Rosenthal DS (2008) Sulfur mustard induces apoptosis in cultured normal airway epithelial cells: evidence of a dominant caspase-8-mediated pathway and differential cellular responses. Drug Chem Toxicol 31:137-148.
35. Sourdeval M, Lemaire C, Deniaud A, Taysse L, Daulon S, Breton P, Brenner C, Boisvieux-Ulrich E, and Marano F (2006) Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis 11:1545-1559.
36. Tietze F (1969) Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 27:502-522.
37. Watson AP and Griffin GD (1992) Toxicity of vesicant agents scheduled for destruction by the Chemical Stockpile Disposal Program. Environ Health Perspect 98:259-280.