The connexin43 carboxyl terminus and cardiac gap junction organization

Biochimica et Biophysica Acta - Biomembranes

Volumn 1818, Issue 8, 2012, Pages 1831-1843

  Palatinus, Joseph A ^a   Rhett, J Matthew ^a   Gourdie, Robert G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Carboxyl terminus; Connexin 43; Gap junction; Intercalated disk; ZO 1

Indexed keywords

CONNEXIN 43; PROTEIN ZO1;

CARBOXY TERMINAL SEQUENCE; CELL COMMUNICATION; CELL FUNCTION; CELL INTERACTION; CELL SIZE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONGESTIVE CARDIOMYOPATHY; EXCITATION CONTRACTION COUPLING; GAP JUNCTION; HEART ARRHYTHMIA; HEART CONDUCTION; HEART LEFT VENTRICLE OVERLOAD; HEART VENTRICLE REMODELING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION; SUDDEN DEATH;

ADULT; AMINO ACID SEQUENCE; ANIMALS; ARRHYTHMIAS, CARDIAC; CONNEXIN 43; DEATH, SUDDEN, CARDIAC; GAP JUNCTIONS; HEART VENTRICLES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOCARDIUM; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; TIGHT JUNCTIONS;

EID: 84861635757     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.08.006     Document Type: Review

References (196)

1. D.A. Goodenough, J.A. Goliger, and D.L. Paul Connexins, connexons, and intercellular communication Annu. Rev. Biochem. 65 1996 475 502
2. J.C. Herve, N. Bourmeyster, D. Sarrouilhe, and H.S. Duffy Gap junctional complexes: from partners to functions Prog. Biophys. Mol. Biol. 94 2007 29 65
3. R. Bruzzone, T.W. White, and D.L. Paul Connections with connexins: the molecular basis of direct intercellular signaling Eur. J. Biochem. 238 1996 1 27
4. K. Willecke, J. Eiberger, J. Degen, D. Eckardt, A. Romualdi, M. Guldenagel, U. Deutsch, and G. Sohl Structural and functional diversity of connexin genes in the mouse and human genome Biol. Chem. 383 2002 725 737
5. L.S. Musil, and D.A. Goodenough Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques J. Cell Biol. 115 1991 1357 1374
6. D.W. Laird Life cycle of connexins in health and disease Biochem. J. 394 2006 527 543
7. G.E. Sosinsky, and B.J. Nicholson Structural organization of gap junction channels Biochim. Biophys. Acta 1711 2005 99 125
8. W.A. Paznekas, B. Karczeski, S. Vermeer, R.B. Lowry, M. Delatycki, F. Laurence, P.A. Koivisto, L. Van Maldergem, S.A. Boyadjiev, J.N. Bodurtha, and E.W. Jabs GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype Hum. Mutat. 30 2009 724 733
9. N.J. Severs, S.R. Coppen, E. Dupont, H. Yeh, Y. Ko, and T. Matsushita Gap junction alterations in human cardiac disease Cardiovasc. Res. 62 2004 368 377
10. L. Miquerol, L. Dupays, M. Theveniau-Ruissy, S. Alcolea, T. Jarry-Guichard, P. Abran, and D. Gros Gap junctional connexins in the developing mouse cardiac conduction system Novartis Found. Symp. 250 2003 80 98 discussion 98-109, 276-109.
11. A.F. Bruce, S. Rothery, E. Dupont, and N.J. Severs Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1 Cardiovasc. Res. 77 2008 757 765
12. N.J. Severs, A.F. Bruce, E. Dupont, and S. Rothery Remodelling of gap junctions and connexin expression in diseased myocardium Cardiovasc. Res. 80 2008 9 19
13. A.L. Wit, Remodeling of cardiac gap junctions: the relationship to the genesis of ventricular tachycardia. 34 Suppl (2001) 77-83.
14. S.B. Danik, F. Liu, J. Zhang, H.J. Suk, G.E. Morley, G.I. Fishman, and D.E. Gutstein Modulation of cardiac gap junction expression and arrhythmic susceptibility Circ. Res. 95 2004 1035 1041
15. D.E. Gutstein, G.E. Morley, D. Vaidya, F. Liu, F.L. Chen, H. Stuhlmann, and G.I. Fishman Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction Circulation 104 2001 1194 1199
16. Saffitz Je Gap junctions: functional effects of molecular structure and tissue distribution Adv. Exp. Med. Biol. 430 1997 291 301
17. S. Poelzing, and D.S. Rosenbaum Altered connexin43 expression produces arrhythmia substrate in heart failure Am. J. Physiol. Heart Circ. Physiol. 287 2004 H1762 H1770
18. J. Yao, W. Hussain, P. Patel, N.S. Peters, P.A. Boyden, and A.L. Wit remodeling of gap junctional channel function in epicardial border zone of healing canine infarct Circ. Res. 92 2003 437 443
19. J.R. de Groot, and R. Coronel Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis Cardiovasc. Res. 62 2004 323 334
20. S. Rohr Role of gap junctions in the propagation of the cardiac action potential Cardiovasc. Res. 62 2004 309 322
21. S. Dhein, A. Hagen, J. Jozwiak, A. Dietze, J. Garbade, M. Barten, M. Kostelka, and F.W. Mohr Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides Naunyn Schmiedebergs Arch. Pharmacol. 381 2010 221 234
22. M. Delmar The intercalated disk as a single functional unit Heart Rhythm 1 2004 12 13
23. N.J. Severs Gap junction shape and orientation at the cardiac intercalated disk Circ. Res. 65 1989 1458 1462
24. J.A. Palatinus, and R.G. Gourdie Xin and the art of intercalated disk maintenance Am. J. Physiol. Heart Circ. Physiol. 293 2007 H2626 H2628
25. J.A. Palatinus, J.M. Rhett, and R.G. Gourdie Translational lessons from scarless healing of cutaneous wounds and regenerative repair of the myocardium J. Mol. Cell. Cardiol. 48 2010 550 557
26. M.S. Forbes, and N. Sperelakis Intercalated discs of mammalian heart: a review of structure and function Tissue Cell 17 1985 605 648
27. F.S. Sjostrand, and E. Andersson Electron microscopy of the intercalated discs of cardiac muscle tissue Experientia 10 1954 369 370
28. Da Meddoff, and E. Page Extensions of the cardiac plasma membrane from the intercalated disk of one cell into the transverse tubules of the adjacent cell J. Ultrastruct. Res. 24 1968 508 521
29. J.E. Saffitz, L.M. Davis, B.J. Darrow, H.L. Kanter, J.G. Laing, and E.C. Beyer The molecular basis of anisotropy: role of gap junctions J. Cardiovasc. Electrophysiol. 6 1995 498 510
30. R.H. Hoyt, M.L. Cohen, and J.E. Saffitz Distribution and three-dimensional structure of intercellular junctions in canine myocardium Circ. Res. 64 1989 563 574
31. J.E. Saffitz, R.B. Schuessler, and K.A. Yamada Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias Cardiovasc. Res. 42 1999 309 317
32. R.A. Luke, E.C. Beyer, R.F. Hoyt, and J.E. Saffitz Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43 Circ. Res. 65 1989 1450 1457
33. C.R. Green, and N.J. Severs Gap junction connexon configuration in rapidly frozen myocardium and isolated intercalated disks J. Cell Biol. 99 1984 453 463
34. N.J. Severs, R.G. Gourdie, E. Harfst, N.S. Peters, and C.R. Green Intercellular junctions and the application of microscopical techniques: the cardiac gap junction as a case model J. Microsc. 169 1993 299 328
35. D. Gros, J.P. Mocquard, C.E. Challice, and J. Schrevel Formation and growth of gap junctions in mouse myocardium during ontogenesis: a freeze-cleave study J. Cell Sci. 30 1978 45 61
36. Y. Shibata, K. Nakata, and E. Page Ultrastructural changes during development of gap junctions in rabbit left ventricular myocardial cells J. Ultrastruct. Res. 71 1980 258 271
37. D.L. Paul Molecular cloning of cDNA for rat liver gap junction protein J. Cell Biol. 103 1986 123 134
38. E.C. Beyer, D.L. Paul, and D.A. Goodenough Connexin43: a protein from rat heart homologous to a goap junction protein from liver J. Cell Biol. 105 1987 2621 2629
39. E.C. Beyer, J. Kistler, D.L. Paul, and D.A. Goodenough Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues J. Cell Biol. 108 1989 595 605
40. C. Fromaget, A. el Aoumari, and D. Gros Distribution pattern of connexin 43, a gap junctional protein, during the differentiation of mouse heart myocytes Differentiation 51 1992 9 20
41. R.G. Gourdie, C.R. Green, and N.J. Severs Gap junction distribution in adult mammalian myocardium revealed by an anti-peptide antibody and laser scanning confocal microscopy J. Cell Sci. 99 1991 41 55
42. R.G. Gourdie, C.R. Green, N.J. Severs, and R.P. Thompson Three-dimensional reconstruction of gap junction arrangement in developing and adult rat hearts Trans. Roy Microsc. Soc. 1 1990 417 420
43. N.S. Peters, N.J. Severs, S.M. Rothery, C. Lincoln, M.H. Yacoub, and C.R. Green Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium [see comments] Circulation 90 1994 713 725
44. Rr Kaprielian, M. Gunning, E. Dupont, Mn Sheppard, Sm Rothery, R. Underwood, Dj Pennell, K. Fox, J. Pepper, Pa Poolewilson, and Nj Severs Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle Circulation 97 1998 651 660
45. R.G. Gourdie, E. Harfst, N.J. Severs, and C.R. Green Cardiac gap junctions in rat ventricle: localization using site-directed antibodies and laser scanning confocal microscopy Cardioscience 1 1990 75 82
46. C.R. Green, N.S. Peters, R.G. Gourdie, S. Rothery, and N.J. Severs Validation of immunohistochemical quantification in confocal scanning laser microscopy: a comparative assessment of gap junction size with confocal and ultrastructural techniques J. Histochem. Cytochem. 41 1993 1339 1349
47. R.G. Gourdie, C.R. Green, N.J. Severs, and R.P. Thompson Immunolabelling patterns of gap junction connexins in the developing and mature rat heart Anat. Embryol. (Berl) 185 1992 363 378
48. M.S. Spach, and P.C. Dolber Relating extracellular potentials and their derivates to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age Circ. Res. 58 1986 356 371
49. W.H. Litchenberg, L.W. Norman, A.K. Holwell, K.L. Martin, K.W. Hewett, and R.G. Gourdie The rate and anisotropy of impulse propagation in the postnatal terminal crest are correlated with remodeling of Cx43 gap junction pattern Cardiovasc. Res. 45 2000 379 387
50. M.S. Spach, J.F. Heidlage, P.C. Dolber, and R.C. Barr Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth Circ. Res. 86 2000 302 311
51. J.H. Smith, C.R. Green, N.S. Peters, S. Rothery, and N.J. Severs Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy Am. J. Pathol. 139 1991 801 821
52. R.A. Luke, and J.E. Saffitz Remodeling of ventricular conduction pathways in healed canine infarct border zones J. Clin. Invest. 87 1991 1594 1602
53. M.S. Spach, J.F. Heidlage, P.C. Dolber, and R.C. Barr Changes in anisotropic conduction caused by remodeling cell size and the cellular distribution of gap junctions and Na(+) channels J. Electrocardiol. 34 Suppl 2001 69 76
54. S. Poelzing, and D.S. Rosenbaum Nature, significance, and mechanisms of electrical heterogeneities in ventricle Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 280 2004 1010 1017
55. A.L. Wit, and H.S. Duffy Drug development for treatment of cardiac arrhythmias: targeting the gap junctions Am. J. Physiol. Heart Circ. Physiol. 294 2008 H16 H18
56. C. Cabo, J. Yao, P.A. Boyden, S. Chen, W. Hussain, H.S. Duffy, E.J. Ciaccio, N.S. Peters, and A.L. Wit Heterogeneous gap junction remodeling in reentrant circuits in the epicardial border zone of the healing canine infarct Cardiovasc. Res. 72 2006 241 249
57. V.S. Kasi, H.D. Xiao, L.L. Shang, S. Iravanian, J. Langberg, E.A. Witham, Z. Jiao, C.J. Gallego, K.E. Bernstein, and S.C. Dudley Jr. Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation Am. J. Physiol. Heart Circ. Physiol. 293 2007 H182 H192
58. N.S. Peters, J. Coromilas, N.J. Severs, and A.L. Wit Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia Circulation 95 1997 988 996
59. A.G. Kleber, and Y. Rudy Basic mechanisms of cardiac impulse propagation and associated arrhythmias Physiol. Rev. 84 2004 431 488
60. T. Matsushita, M. Oyamada, K. Fujimoto, Y. Yasuda, S. Masuda, Y. Wada, T. Oka, and T. Takamatsu Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts Circ. Res. 85 1999 1046 1055
61. B.D. Angst, L.U. Khan, N.J. Severs, K. Whitely, S. Rothery, R.P. Thompson, A.I. Magee, and R.G. Gourdie Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium Circ. Res. 80 1997 88 94
62. S.B. Geisler, K.J. Green, L.L. Isom, S. Meshinchi, J.R. Martens, M. Delmar, and M.W. Russell Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes J. Biomed. Biotechnol. 2010 2010 624719
63. A. Hirschy, F. Schatzmann, E. Ehler, and J.C. Perriard Establishment of cardiac cytoarchitecture in the developing mouse heart Dev. Biol. 289 2006 430 441
64. K. Maass, J. Shibayama, S.E. Chase, K. Willecke, and M. Delmar C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques Circ. Res. 101 2007 1283 1291
65. P.L. Sorgen, H.S. Duffy, P. Sahoo, W. Coombs, M. Delmar, and D.C. Spray Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1 J. Biol. Chem. 279 2004 54695 54701
66. B.N. Giepmans Gap junctions and connexin-interacting proteins Cardiovasc. Res. 62 2004 233 245
67. P.L. Sorgen, H.S. Duffy, D.C. Spray, and M. Delmar pH-dependent dimerization of the carboxyl terminal domain of Cx43 Biophys. J. 87 2004 574 581
68. N. Homma, J.L. Alvarado, W. Coombs, K. Stergiopoulos, S.M. Taffet, A.F. Lau, and M. Delmar A particle-receptor model for the insulin-induced closure of connexin43 channels Circ. Res. 83 1998 27 32
69. G.E. Morley, S.M. Taffet, and M. Delmar Intramolecular interactions mediate pH regulation of connexin43 channels Biophys. J. 70 1996 1294 1302
70. V. Verma, B.D. Larsen, W. Coombs, X. Lin, G. Spagnol, P.L. Sorgen, S.M. Taffet, and M. Delmar Novel pharmacophores of connexin43 based on the RXP series of Cx43-binding peptides Circ. Res. 105 2009 176 184
71. R. Ponsaerts, E. De Vuyst, M. Retamal, C. D'Hondt, D. Vermeire, N. Wang, H. De Smedt, P. Zimmermann, B. Himpens, J. Vereecke, L. Leybaert, and G. Bultynck Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity FASEB J. 24 2010 4378 4395
72. T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes J. Biol. Chem. 273 1998 12725 12731
73. B.N. Giepmans, and W.H. Moolenaar The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein Curr. Biol. 8 1998 931 934
74. D. Segretain, C. Fiorini, X. Decrouy, N. Defamie, J.R. Prat, and G. Pointis A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway Biochimie 86 2004 241 244
75. P.A. Nielsen, A. Baruch, V.I. Shestopalov, B.N. Giepmans, I. Dunia, E.L. Benedetti, and N.M. Kumar Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1) Mol. Biol. Cell 14 2003 2470 2481
76. Y. Jinn, and N. Inase Connexin43, E-cadherin, {beta}-catenin and ZO-1 expression, and aberrant methylation of the connexin43 gene in NSCLC Anticancer Res. 30 2010 2271 2278
77. R.J. Barker, R.L. Price, and R.G. Gourdie Increased co-localization of connexin43 and ZO-1 in dissociated adult myocytes Cell Commun. Adhes. 8 2001 205 208
78. B.N. Giepmans, I. Verlaan, and W.H. Moolenaar Connexin-43 interactions with ZO-1 and alpha- and beta-tubulin Cell Commun. Adhes. 8 2001 219 223
79. Barker R.J., Gang C., Jourdan J., Zhang Y., Price R.L., Bond J., Harris B.S., Hewett K.W., G. R.G., Connexin and ZO1 interactions during gap junction remodeling, Einthoven 2002: 100 Years of Electrocardiography, (2002) 161-165.
80. B.R. Stevenson, J.D. Siliciano, M.S. Mooseker, and D.A. Goodenough Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia J. Cell Biol. 103 1986 755 766
81. J.M. Anderson Cell signalling: MAGUK magic Curr. Biol. 6 1996 382 384
82. A. Hartsock, and W.J. Nelson Adherens and tight junctions: structure, function and connections to the actin cytoskeleton Biochim. Biophys. Acta 1778 2008 660 669
83. A.S. Fanning, M.F. Lye, J.M. Anderson, and A. Lavie Domain swapping within PDZ2 is responsible for dimerization of ZO proteins J. Biol. Chem. 282 2007 37710 37716
84. F. Xiao, J. Weng, K. Fan, and W. Wang Detailed regulatory mechanism of the interaction between ZO-1 PDZ2 and connexin43 revealed by MD simulations PLoS One 6 2011 e21527
85. P.J. Kausalya, M. Reichert, and W. Hunziker Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells FEBS Lett. 505 2001 92 96
86. J.G. Laing, B.C. Chou, and T.H. Steinberg ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells J. Cell Sci. 118 2005 2167 2176
87. P.A. Nielsen, D.L. Beahm, B.N. Giepmans, A. Baruch, J.E. Hall, and N.M. Kumar Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1 J. Biol. Chem. 277 2002 38272 38283
88. C.E. Flores, X. Li, M.V. Bennett, J.I. Nagy, and A.E. Pereda Interaction between connexin35 and zonula occludens-1 and its potential role in the regulation of electrical synapses Proc. Natl. Acad. Sci. U.S.A. 105 2008 12545 12550
89. C. Jin, A.F. Lau, and K.D. Martyn Identification of connexin-interacting proteins: application of the yeast two-hybrid screen Methods 20 2000 219 231
90. D. Singh, J.L. Solan, S.M. Taffet, R. Javier, and P.D. Lampe Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner J. Biol. Chem. 280 2005 30416 30421
91. A.S. Fanning, T.Y. Ma, and J.M. Anderson Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1 FASEB J. 16 2002 1835 1837
92. R.J. Barker, R.L. Price, and R.G. Gourdie Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions Circ. Res. 90 2002 317 324
93. R.J. Barker, and R.G. Gourdie W.C. De Mello, Connexin Interacting Proteins, Gap junctional Communication in Health and Disease 2nd Edition 2003 Kluwer 25 53
94. H. Girao, and P. Pereira The proteasome regulates the interaction between Cx43 and ZO-1 J. Cell. Biochem. 102 2007 719 728
95. J.M. Rhett, J. Jourdan, and R.G. Gourdie Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1 Mol. Biol. Cell 22 2011 1516 1528
96. V. Akoyev, and D.J. Takemoto ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43 Cell. Signal. 19 2007 958 967
97. T. Toyofuku, Y. Akamatsu, H. Zhang, T. Kuzuya, M. Tada, and M. Hori c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes J. Biol. Chem. 276 2001 1780 1788
98. J. Gilleron, C. Fiorini, D. Carette, C. Avondet, M.M. Falk, D. Segretain, and G. Pointis Molecular reorganization of Cx43, ZO-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen J. Cell Sci. 121 2008 4069 4078
99. M. Derangeon, N. Bourmeyster, I. Plaisance, C. Pinet-Charvet, Q. Chen, F. Duthe, M.R. Popoff, D. Sarrouilhe, and J.C. Herve RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes J. Biol. Chem. 283 2008 30754 30765
100. A.W. Hunter, J. Jourdan, and R.G. Gourdie Fusion of GFP to the carboxyl terminus of connexin43 increases gap junction size in HeLa cells Cell Commun. Adhes. 10 2003 211 214
101. A.W. Hunter, R.J. Barker, C. Zhu, and R.G. Gourdie Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion Mol. Biol. Cell 16 2005 5686 5698
102. A.W. Hunter, and R.G. Gourdie The second PDZ domain of zonula occludens-1 is dispensable for targeting to connexin 43 gap junctions Cell Commun. Adhes. 15 2008 55 63
103. S.M. Baker, N. Kim, A.M. Gumpert, D. Segretain, and M.M. Falk Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation FEBS Lett. 582 2008 4039 4046
104. N.J. Severs, K.S. Shovel, A.M. Slade, T. Powell, V.W. Twist, and C.R. Green Fate of gap junctions in isolated adult mammalian cardiomyocytes Circ. Res. 65 1989 22 42
105. D.S. Crow, E.C. Beyer, D.L. Paul, S.S. Kobe, and A.F. Lau Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts Mol. Cell. Biol. 10 1990 1754 1763
106. A.J. Filson, R. Azarnia, E.C. Beyer, W.R. Loewenstein, and J.S. Brugge Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication Cell Growth Differ. 1 1990 661 668
107. R. Lin, B.J. Warn-Cramer, W.E. Kurata, and A.F. Lau v-Src-mediated phosphorylation of connexin43 on tyrosine disrupts gap junctional communication in mammalian cells Cell Commun. Adhes. 8 2001 265 269
108. T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Tada, and M. Hori Functional role of c-Src in gap junctions of the cardiomyopathic heart Circ. Res. 85 1999 672 681
109. F. Kieken, N. Mutsaers, E. Dolmatova, K. Virgil, A.L. Wit, A. Kellezi, B.J. Hirst-Jensen, H.S. Duffy, and P.L. Sorgen Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction Circ. Res. 104 2009 1103 1112
110. J. Gilleron, D. Carette, C. Fiorini, J. Dompierre, E. Macia, J.P. Denizot, D. Segretain, and G. Pointis The large GTPase dynamin2: a new player in connexin 43 gap junction endocytosis, recycling and degradation Int. J. Biochem. Cell Biol. 43 2011 1208 1217
111. L. van Zeijl, B. Ponsioen, B.N. Giepmans, A. Ariaens, F.R. Postma, P. Varnai, T. Balla, N. Divecha, K. Jalink, and W.H. Moolenaar Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate J. Cell Biol. 177 2007 881 891
112. M. Piehl, C. Lehmann, A. Gumpert, J.P. Denizot, D. Segretain, and M.M. Falk Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process Mol. Biol. Cell 18 2007 337 347
113. H.S. Duffy, A.W. Ashton, P. O'Donnell, W. Coombs, S.M. Taffet, M. Delmar, and D.C. Spray Regulation of connexin43 protein complexes by intracellular acidification Circ. Res. 94 2004 215 222
114. A. Hunter, and R. Gourdie Mictotubules and actin differentially influence remodeling of connexin43 gap junctions FASEB J. 22 2008 800 804
115. C. Zhu, R.J. Barker, A.W. Hunter, Y. Zhang, J. Jourdan, and R.G. Gourdie Quantitative analysis of ZO-1 colocalization with Cx43 gap junction plaques in cultures of rat neonatal cardiomyocytes Microsc. Microanal. 11 2005 244 248
116. U. Lauf, B.N. Giepmans, P. Lopez, S. Braconnot, S.C. Chen, and M.M. Falk Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells Proc. Natl. Acad. Sci. U.S.A. 99 2002 10446 10451
117. G. Gaietta, T.J. Deerinck, S.R. Adams, J. Bouwer, O. Tour, D.W. Laird, G.E. Sosinsky, R.Y. Tsien, and M.H. Ellisman Multicolor and electron microscopic imaging of connexin trafficking Science 296 2002 503 507
118. B.K. Lim, D. Xiong, A. Dorner, T.J. Youn, A. Yung, T.I. Liu, Y. Gu, N.D. Dalton, A.T. Wright, S.M. Evans, J. Chen, K.L. Peterson, A.D. McCulloch, T. Yajima, and K.U. Knowlton Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart J. Clin. Invest. 118 2008 2758 2770
119. K. Grikscheit, N. Thomas, A.F. Bruce, S. Rothery, J. Chan, N.J. Severs, and E. Dupont Coexpression of connexin 45 with connexin 43 decreases gap junction size Cell Commun. Adhes. 15 2008 185 193
120. J.A. Palatinus, M.P. O'Quinn, R.J. Barker, B.S. Harris, J. Jourdan, and R.G. Gourdie ZO-1 determines adherens and gap junction localization at intercalated disks Am. J. Physiol. Heart Circ. Physiol. 300 2010 H583 H594
121. K. Maass, S.E. Chase, X. Lin, and M. Delmar Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction Cardiovasc. Res. 84 2009 361 367
122. C.G. Fonseca, C.R. Green, and L.F. Nicholson Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy Brain Res. 929 2002 105 116
123. J.G. Laing, J.E. Saffitz, T.H. Steinberg, and K.A. Yamada Diminished zonula occludens-1 expression in the failing human heart Cardiovasc. Pathol. 16 2007 159 164
124. S. Kostin Zonula occludens-1 and connexin 43 expression in the failing human heart J. Cell. Mol. Med. 11 2007 892 895
125. C. Sasano, H. Honjo, Y. Takagishi, M. Uzzaman, L. Emdad, A. Shimizu, Y. Murata, K. Kamiya, and I. Kodama Internalization and dephosphorylation of connexin43 in hypertrophied right ventricles of rats with pulmonary hypertension Circ. J. 71 2007 382 389
126. H. Jin, E.R. Chemaly, A. Lee, C. Kho, L. Hadri, R.J. Hajjar, and F.G. Akar Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy FASEB J. 24 2009 451 463
127. S.M. Goldfine, B. Walcott, P.R. Brink, N.M. Magid, and J.S. Borer Myocardial connexin43 expression in left ventricular hypertrophy resulting from aortic regurgitation Cardiovasc. Pathol. 8 1999 1 6
128. J. Benes, L. Kazdova, Z. Drahota, J. Houstek, D. Medrikova, J. Kopecky, N. Kovarova, M. Vrbacky, D. Sedmera, H. Strnad, M. Kolar, J. Petrak, O. Benada, P. Skaroupkova, L. Cervenka, and V. Melenovsky Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Clin. Sci. (Lond.) 121 2011 29 41
129. J.E. Saffitz, K.G. Green, W.J. Kraft, K.B. Schechtman, and K.A. Yamada Effects of diminished expression of connexin43 on gap junction number and size in ventricular myocardium Am. J. Physiol. Heart Circ. Physiol. 278 2000 H1662 H1670
130. L. Chen, Ge Goings, J. Upshaw-Earley, and E. Page Cardiac gap junctions and gap junction-associated vesicles: ultrastructural comparison of in situ negative staining with conventional positive staining Circ. Res. 64 1989 501 514
131. M.J. Legato Cellular mechanisms of normal growth in the mammalian heart. I. Qualitative and quantitative features of ventricular architecture in the dog from birth to five months of age Circ. Res. United States 44 1979 250 262
132. C. Muhlfeld, and J. Richter High-pressure freezing and freeze substitution of rat myocardium for immunogold labeling of connexin 43 Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 288 2006 1059 1067
133. T. Matsuda, Y. Fujio, T. Nariai, T. Ito, M. Yamane, T. Takatani, K. Takahashi, and J. Azuma N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes J. Mol. Cell. Cardiol. 40 2006 495 502
134. H.W. de Jonge, D.H. Dekkers, A.B. Houtsmuller, H.S. Sharma, and J.M. Lamers Differential signaling and hypertrophic responses in cyclically stretched vs endothelin-1 stimulated neonatal rat cardiomyocytes Cell Biochem. Biophys. 47 2007 21 32
135. T. Matsuda, K. Takahashi, T. Nariai, T. Ito, T. Takatani, Y. Fujio, and J. Azuma N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes Biochem. Biophys. Res. Commun. 326 2005 228 232
136. A. Salameh, A. Wustmann, S. Karl, K. Blanke, D. Apel, D. Rojas-Gomez, H. Franke, F.W. Mohr, J. Janousek, and S. Dhein Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43 Circ. Res. 2010
137. K. Yamada, K.G. Green, A.M. Samarel, and J.E. Saffitz Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch Circ. Res. 97 2005 346 353
138. S.M. Gopalan, C. Flaim, S.N. Bhatia, M. Hoshijima, R. Knoell, K.R. Chien, J.H. Omens, and A.D. McCulloch Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers Biotechnol. Bioeng. 81 2003 578 587
139. C.M. Hertig, S. Butz, S. Koch, M. Eppenberger-Eberhardt, R. Kemler, and H.M. Eppenberger N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes J. Cell Sci. 109 Pt 1 1996 11 20
140. J. Li, M.D. Levin, Y. Xiong, N. Petrenko, V.V. Patel, and G.L. Radice N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility J. Mol. Cell. Cardiol. 44 2008 597 606
141. B.N. Giepmans, I. Verlaan, T. Hengeveld, H. Janssen, J. Calafat, M.M. Falk, and W.H. Moolenaar Gap junction protein connexin-43 interacts directly with microtubules Curr. Biol. 11 2001 1364 1368
142. R.M. Shaw, A.J. Fay, M.A. Puthenveedu, M. von Zastrow, Y.N. Jan, and L.Y. Jan Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions Cell 128 2007 547 560
143. C.J. Wei, R. Francis, X. Xu, and C.W. Lo Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells J. Biol. Chem. 280 2005 19925 19936
144. J.W. Smyth, T.T. Hong, D. Gao, J.M. Vogan, B.C. Jensen, T.S. Fong, P.C. Simpson, D.Y. Stainier, N.C. Chi, and R.M. Shaw Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium J. Clin. Invest. 120 2010 266 279
145. P. Dai, T. Nakagami, H. Tanaka, T. Hitomi, and T. Takamatsu Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules Mol. Biol. Cell 18 2007 2264 2273
146. R. Bauer, C. Lehmann, J. Martini, F. Eckardt, and M. Hoch Gap junction channel protein innexin 2 is essential for epithelial morphogenesis in the Drosophila embryo Mol. Biol. Cell 15 2004 2992 3004
147. F.G. Akar, D.D. Spragg, R.S. Tunin, D.A. Kass, and G.F. Tomaselli Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy Circ. Res. 95 2004 717 725
148. F.G. Akar, R.D. Nass, S. Hahn, E. Cingolani, M. Shah, G.G. Hesketh, D. DiSilvestre, R.S. Tunin, D.A. Kass, and G.F. Tomaselli Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure Am. J. Physiol. Heart Circ. Physiol. 293 2007 H1223 H1230
149. G.G. Hesketh, M.H. Shah, V.L. Halperin, C.A. Cooke, F.G. Akar, T.E. Yen, D.A. Kass, C.E. Machamer, J.E. Van Eyk, and G.F. Tomaselli Ultrastructure and regulation of lateralized connexin43 in the failing heart Circ. Res. 2010
150. A. Nygren, M.L. Olson, K.Y. Chen, T. Emmett, G. Kargacin, and Y. Shimoni Propagation of the cardiac impulse in the diabetic rat heart: reduced conduction reserve J. Physiol. 580 2007 543 560
151. S. Kostin, S. Dammer, S. Hein, W.P. Klovekorn, E.P. Bauer, and J. Schaper Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis Cardiovasc. Res. 62 2004 426 436
152. R. Sepp, Nj Severs, and Rg Gourdie Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy Heart 76 1996 412 417
153. M. Uzzaman, H. Honjo, Y. Takagishi, L. Emdad, A.I. Magee, N.J. Severs, and I. Kodama Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension Circ. Res. 86 2000 871 878
154. K. Gehmlich, P. Syrris, E. Peskett, A. Evans, E. Ehler, A. Asimaki, A. Anastasakis, A. Tsatsopoulou, A.I. Vouliotis, C. Stefanadis, J.E. Saffitz, N. Protonotarios, and W.J. McKenna Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations Cardiovasc. Res. 90 2011 77 87
155. M.C. Bolling, and M.F. Jonkman Skin and heart: une liaison dangereuse Exp. Dermatol. 18 2009 658 668
156. J. Li, and G.L. Radice A new perspective on intercalated disc organization: implications for heart disease Dermatol. Res. Pract. 2010 2010 207835
157. R. Lombardi, and A.J. Marian Arrhythmogenic right ventricular cardiomyopathy is a disease of cardiac stem cells Curr. Opin. Cardiol. 2010
158. J. Saffitz, E., Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling, Heart rhythm: the official journal of the Heart Rhythm Society, 6 (2009) S62-S65.
159. L.M. Fidler, G.J. Wilson, F. Liu, X. Cui, S.W. Scherer, G.P. Taylor, and R.M. Hamilton Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations J. Cell. Mol. Med. 13 2009 4219 4228
160. E.M. Oxford, H. Musa, K. Maass, W. Coombs, S.M. Taffet, and M. Delmar Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells Circ. Res. 101 2007 703 711
161. J.E. Saffitz Dependence of electrical coupling on mechanical coupling in cardiac myocytes: insights gained from cardiomyopathies caused by defects in cell-cell connections Ann. N. Y. Acad. Sci. 1047 2005 336 344
162. X. Ai, and S.M. Pogwizd Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A Circ. Res. 96 2005 54 63
163. P.D. Lampe, and A.F. Lau Regulation of gap junctions by phosphorylation of connexins Arch. Biochem. Biophys. 384 2000 205 215
164. J.L. Solan, M.D. Fry, E.M. TenBroek, and P.D. Lampe Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation J. Cell Sci. 116 2003 2203 2211
165. N. Kalcheva, J. Qu, N. Sandeep, L. Garcia, J. Zhang, Z. Wang, P.D. Lampe, S.O. Suadicani, D.C. Spray, and G.I. Fishman Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia Proc. Natl. Acad. Sci. U.S.A. 104 2007 20512 20516
166. E.M. TenBroek, P.D. Lampe, J.L. Solan, J.K. Reynhout, and R.G. Johnson Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP J. Cell Biol. 155 2001 1307 1318
167. J. Qu, F.M. Volpicelli, L.I. Garcia, N. Sandeep, J. Zhang, L. Marquez-Rosado, P.D. Lampe, and G.I. Fishman Gap junction remodeling and spironolactone-dependent reverse remodeling in the hypertrophied heart Circ. Res. 104 2009 365 371
168. B.F. Remo, J. Qu, F.M. Volpicelli, S. Giovannone, D. Shin, J. Lader, F.Y. Liu, J. Zhang, D.S. Lent, G.E. Morley, and G.I. Fishman Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias Circ. Res. 108 2011 1459 1466
169. J. Chen, L. Pan, Z. Wei, Y. Zhao, and M. Zhang Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites EMBO J. 27 2008 2113 2123
170. J.F. Ek-Vitorin, T.J. King, N.S. Heyman, P.D. Lampe, and J.M. Burt Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation Circ. Res. 98 2006 1498 1505
171. W. Srisakuldee, M.M. Jeyaraman, B.E. Nickel, S. Tanguy, Z.S. Jiang, and E. Kardami Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state Cardiovasc. Res. 83 2009 672 681
172. J. Jozwiak, and S. Dhein Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings Naunyn Schmiedebergs Arch. Pharmacol. 378 2008 459 470
173. M.P. O'Quinn, J.A. Palatinus, B.S. Harris, K.W. Hewett, and R.G. Gourdie A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury Circ. Res. 108 2011 704 715
174. M.L. Lindsey, G.P. Escobar, R. Mukherjee, D.K. Goshorn, N.J. Sheats, J.A. Bruce, I.M. Mains, J.K. Hendrick, K.W. Hewett, R.G. Gourdie, L.M. Matrisian, and F.G. Spinale Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction Circulation 113 2006 2919 2928
175. J.A. Palatinus, J.M. Rhett, and R.G. Gourdie Enhanced PKCepsilon mediated phosphorylation of connexin43 at serine 368 by a carboxyl-terminal mimetic peptide is dependent on injury Channels (Austin) 5 2011 236 240
176. R.Y. Huang, J.G. Laing, E.M. Kanter, V.M. Berthoud, M. Bao, H.W. Rohrs, R.R. Townsend, and K.A. Yamada Identification of CaMKII phosphorylation sites in connexin43 by high-resolution mass spectrometry J. Proteome Res. 10 2011 1098 1109
177. A.F. Lau, W.E. Kurata, M.Y. Kanemitsu, L.W. Loo, B.J. Warn-Cramer, W. Eckhart, and P.D. Lampe Regulation of connexin43 function by activated tyrosine protein kinases J. Bioenerg. Biomembr. 28 1996 359 368
178. S. Sirnes, A. Kjenseth, E. Leithe, and E. Rivedal Interplay between PKC and the MAP kinase pathway in connexin43 phosphorylation and inhibition of gap junction intercellular communication Biochem. Biophys. Res. Commun. 382 2009 41 45
179. B.J. Warn-Cramer, P.D. Lampe, W.E. Kurata, M.Y. Kanemitsu, L.W. Loo, W. Eckhart, and A.F. Lau Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein J. Biol. Chem. 271 1996 3779 3786
180. Z. Lan, W.E. Kurata, K.D. Martyn, C. Jin, and A.F. Lau Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation Biochemistry 44 2005 2385 2396
181. B.W. Doble, X. Dang, P. Ping, R.R. Fandrich, B.E. Nickel, Y. Jin, P.A. Cattini, and E. Kardami Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes J. Cell Sci. 117 2004 507 514
182. B.N. Giepmans, T. Hengeveld, F.R. Postma, and W.H. Moolenaar Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication J. Biol. Chem. 276 2001 8544 8549
183. J.L. Solan, and P.D. Lampe Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways Cell Commun. Adhes. 15 2008 75 84
184. Kanemitsu My, Loo Lwm, S. Simon, Af Lau, and W. Eckhart Tyrosine phosphorylation of connexin 43 by V-Src is mediated by Sh2 and Sh3 domain interactions J. Biol. Chem. 272 1997 22824 22831
185. K. Leykauf, M. Salek, J. Bomke, M. Frech, W.D. Lehmann, M. Durst, and A. Alonso Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process J. Cell Sci. 119 2006 3634 3642
186. C.D. Cooper, and P.D. Lampe Casein kinase 1 regulates connexin-43 gap junction assembly J. Biol. Chem. 277 2002 44962 44968
187. J.L. Solan, and P.D. Lampe Key connexin 43 phosphorylation events regulate the gap junction life cycle J. Membr. Biol. 217 2007 35 41
188. J.L. Solan, L. Marquez-Rosado, P.L. Sorgen, P.J. Thornton, P.R. Gafken, and P.D. Lampe Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC J. Cell Biol. 179 2007 1301 1309
189. P.D. Lampe, E.M. TenBroek, J.M. Burt, W.E. Kurata, R.G. Johnson, and A.F. Lau Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication J. Cell Biol. 149 2000 1503 1512
190. K. Yogo, T. Ogawa, M. Akiyama, N. Ishida-Kitagawa, H. Sasada, E. Sato, and T. Takeya PKA implicated in the phosphorylation of Cx43 induced by stimulation with FSH in rat granulosa cells J. Reprod. Dev. 52 2006 321 328
191. Saez Jc, Nairn Ac, Czernik Aj, Fishman Gi, Spray Dc, Hertzberg El, and Phosphorylation Of Connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions J. Mol. Cell. Cardiol. 29 1997 2131 2145
192. D.J. Park, T.A. Freitas, C.J. Wallick, C.V. Guyette, and B.J. Warn-Cramer Molecular dynamics and in vitro analysis of connexin43: a new 14-3-3 mode-1 interacting protein Protein Sci. 15 2006 2344 2355
193. C.T. Fu, J.F. Bechberger, M.A. Ozog, B. Perbal, and C.C. Naus CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression J. Biol. Chem. 279 2004 36943 36950
194. L. Liu, Y. Li, J. Lin, Q. Liang, X. Sheng, J. Wu, R. Huang, and S. Liu Connexin43 interacts with caveolin-3 in the heart Mol. Biol. Rep. 37 2009 1685 1691
195. S. Langlois, K.N. Cowan, Q. Shao, B.J. Cowan, and D.W. Laird Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes Mol. Biol. Cell 19 2008 912 928
196. E. Butkevich, S. Hulsmann, D. Wenzel, T. Shirao, R. Duden, and I. Majoul Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton Curr. Biol. 14 2004 650 658