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Volumn 83, Issue 2, 2009, Pages 405-415

Human cardiac gap-junction coupling: Effects of antiarrhythmic peptide AAP10

Author keywords

AAP10; Antiarrhythmic peptide; Dual whole cell voltage clamp; Gap junctions; Human cardiomyocytes

Indexed keywords

AAP 10; ANTIARRHYTHMIC PEPTIDE; ANTIARRHYTHMIC PEPTIDE AAP 10; CARBON DIOXIDE; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; LUCIFER YELLOW; UNCLASSIFIED DRUG;

EID: 67650266546     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp028     Document Type: Article
Times cited : (36)

References (47)
  • 1
    • 33744457045 scopus 로고    scopus 로고
    • Structural and functional coupling of cardiac myocytes and fibroblasts
    • Camelliti P, Green CR, Kohl P. Structural and functional coupling of cardiac myocytes and fibroblasts. Adv. Cardiol. 2006;42:132-149.
    • (2006) Adv. Cardiol , vol.42 , pp. 132-149
    • Camelliti, P.1    Green, C.R.2    Kohl, P.3
  • 2
    • 0035040155 scopus 로고    scopus 로고
    • Late ventricular arrhythmias during acute regional ischemia in the isolated blood perfused pig heart. Role of electrical cellular coupling
    • de Groot JR, Wilms-Schopman FJ, Opthof T, Remme CA, Coronel R. Late ventricular arrhythmias during acute regional ischemia in the isolated blood perfused pig heart. Role of electrical cellular coupling. Cardiovasc. Res. 2001;50:362-372.
    • (2001) Cardiovasc. Res , vol.50 , pp. 362-372
    • de Groot, J.R.1    Wilms-Schopman, F.J.2    Opthof, T.3    Remme, C.A.4    Coronel, R.5
  • 3
    • 0028784358 scopus 로고
    • The Ib phase of ventricular arrhythmias in ischemic in situ porcine heart is related to changes in cell-to-cell electrical coupling. Experimental Cardiology Group, University of North Carolina
    • Smith WT IV, Fleet WF, Johnson TA, Engle CL, Cascio WE. The Ib phase of ventricular arrhythmias in ischemic in situ porcine heart is related to changes in cell-to-cell electrical coupling. Experimental Cardiology Group, University of North Carolina. Circulation 1995;92:3051-3060.
    • (1995) Circulation , vol.92 , pp. 3051-3060
    • Smith, W.I.1    Fleet, W.F.2    Johnson, T.A.3    Engle, C.L.4    Cascio, W.E.5
  • 4
    • 0027958859 scopus 로고
    • A new synthetic antiarrhythmic peptide reduces dispersion of epicardial activation recovery interval and diminishes alterations of epicardial activation patterns induced by regional ischemia
    • Dhein S, Manicone N, Müller A, Gerwin R, Ziskoven U, Irankhahi A et al. A new synthetic antiarrhythmic peptide reduces dispersion of epicardial activation recovery interval and diminishes alterations of epicardial activation patterns induced by regional ischemia. Naunyn-Schmiedebergs Arch. Pharmacol. 1994;350:174-184.
    • (1994) Naunyn-Schmiedebergs Arch. Pharmacol , vol.350 , pp. 174-184
    • Dhein, S.1    Manicone, N.2    Müller, A.3    Gerwin, R.4    Ziskoven, U.5    Irankhahi, A.6
  • 5
    • 0032408651 scopus 로고    scopus 로고
    • Spatial structure determination of antiarrhythmic peptide using nuclear magnetic resonance spectroscopy
    • Grover R, Dhein S. Spatial structure determination of antiarrhythmic peptide using nuclear magnetic resonance spectroscopy. Peptides 1998; 19:1725-1729.
    • (1998) Peptides , vol.19 , pp. 1725-1729
    • Grover, R.1    Dhein, S.2
  • 6
    • 0036634865 scopus 로고    scopus 로고
    • Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation
    • Weng S, Lauven M, Schaefer T, Polontchouk L, Grover R, Dhein S. Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation. FASEBJ. 2002;16:1114-1116.
    • (2002) FASEBJ , vol.16 , pp. 1114-1116
    • Weng, S.1    Lauven, M.2    Schaefer, T.3    Polontchouk, L.4    Grover, R.5    Dhein, S.6
  • 7
    • 0038662776 scopus 로고    scopus 로고
    • ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs
    • Xing D, Kjoølbe AL, Nielsen MS, Petersen JS, Harlow KW, Holstein-Rathlou NH et al. ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs. J. Cardiovasc. Electrophysiol. 2003;14:510-520.
    • (2003) J. Cardiovasc. Electrophysiol , vol.14 , pp. 510-520
    • Xing, D.1    Kjoølbe, A.L.2    Nielsen, M.S.3    Petersen, J.S.4    Harlow, K.W.5    Holstein-Rathlou, N.H.6
  • 9
    • 0034968994 scopus 로고    scopus 로고
    • Structure-activity relationships of novel peptides related to the antiarrhythmic peptide AAP10 which reduce the dispersion of epicardial action potential duration
    • Grover R, Dhein S. Structure-activity relationships of novel peptides related to the antiarrhythmic peptide AAP10 which reduce the dispersion of epicardial action potential duration. Peptides 2001;22:1011-1021.
    • (2001) Peptides , vol.22 , pp. 1011-1021
    • Grover, R.1    Dhein, S.2
  • 10
    • 0036872337 scopus 로고    scopus 로고
    • Anti-arrhythmic peptide N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly-OH reduces dispersion of action potential duration during ischemia/reperfusion in rabbit hearts
    • Kjoølbye AL, Holstein-Rathlou NH, Petersen JS. Anti-arrhythmic peptide N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly-OH reduces dispersion of action potential duration during ischemia/reperfusion in rabbit hearts. J. Cardiovasc. Pharmacol. 2002;40:770-779.
    • (2002) J. Cardiovasc. Pharmacol , vol.40 , pp. 770-779
    • Kjoølbye, A.L.1    Holstein-Rathlou, N.H.2    Petersen, J.S.3
  • 11
    • 0042889320 scopus 로고    scopus 로고
    • Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): In vivo and in vitro studies
    • Kjoølbye AL, Knudsen CB, Jepsen T, Larsen BD, Petersen JS. Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): in vivo and in vitro studies. J. Pharmacol. Exp. Ther. 2003;306:1191-1199.
    • (2003) J. Pharmacol. Exp. Ther , vol.306 , pp. 1191-1199
    • Kjoølbye, A.L.1    Knudsen, C.B.2    Jepsen, T.3    Larsen, B.D.4    Petersen, J.S.5
  • 12
    • 33744521144 scopus 로고    scopus 로고
    • Identification of ischemia-regulated phos- phorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123)
    • Axelsen LN, Stahlhut M, Mohammed S, Larsen BD, Nielsen MS, Holstein-Rathlou NH et al. Identification of ischemia-regulated phos- phorylation sites in connexin43: a possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J. Mol. Cell. Cardiol. 2006;40: 790-798.
    • (2006) J. Mol. Cell. Cardiol , vol.40 , pp. 790-798
    • Axelsen, L.N.1    Stahlhut, M.2    Mohammed, S.3    Larsen, B.D.4    Nielsen, M.S.5    Holstein-Rathlou, N.H.6
  • 13
    • 33644823558 scopus 로고    scopus 로고
    • The anti- arrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43
    • Clarke TC, Thomas D, Petersen JS, Evans WH, Martin PE. The anti- arrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. Br. J. Pharmacol. 2006;147:486-495.
    • (2006) Br. J. Pharmacol , vol.147 , pp. 486-495
    • Clarke, T.C.1    Thomas, D.2    Petersen, J.S.3    Evans, W.H.4    Martin, P.E.5
  • 15
    • 48449084798 scopus 로고    scopus 로고
    • Neonatal rat cardiomyocytes show characteristics of non-homotypic gap junction channels
    • Schulte JS, Scheffler A, Rojas-Gomez D, Mohr FW, Dhein S. Neonatal rat cardiomyocytes show characteristics of non-homotypic gap junction channels. Cell Commun. Adhes. 2008;15:13-25.
    • (2008) Cell Commun. Adhes , vol.15 , pp. 13-25
    • Schulte, J.S.1    Scheffler, A.2    Rojas-Gomez, D.3    Mohr, F.W.4    Dhein, S.5
  • 16
    • 67650214424 scopus 로고    scopus 로고
    • Recording gap junction currents
    • Dhein S, Mohr FW, Delmar M eds, Heidelberg, Germany: Springer-Verlag;
    • Rastan AJ, Dhein S. Recording gap junction currents. In: Dhein S, Mohr FW, Delmar M eds., Practical Methods in Cardiovascular Research. Heidelberg, Germany: Springer-Verlag; 2005. p397-416.
    • (2005) Practical Methods in Cardiovascular Research , pp. 397-416
    • Rastan, A.J.1    Dhein, S.2
  • 17
    • 0032899775 scopus 로고    scopus 로고
    • Switched single-electrode voltage-clamp amplifiers allow precise measurement of gap junction conductance
    • Müller A, Lauven M, Berkels R, Dhein S, Polder HR, Klaus W. Switched single-electrode voltage-clamp amplifiers allow precise measurement of gap junction conductance. Am. J. Physiol. 1999;276:C980-C987.
    • (1999) Am. J. Physiol , vol.276
    • Müller, A.1    Lauven, M.2    Berkels, R.3    Dhein, S.4    Polder, H.R.5    Klaus, W.6
  • 18
    • 0025775356 scopus 로고
    • Low access resistance perforated patch recordings using amphotericin B
    • Rae J, Cooper K, Gates P, Watsky M. Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Methods 1991;37: 15-26.
    • (1991) J. Neurosci. Methods , vol.37 , pp. 15-26
    • Rae, J.1    Cooper, K.2    Gates, P.3    Watsky, M.4
  • 19
    • 0019365945 scopus 로고
    • Equilibrium properties of a voltage dependent junctional conductance
    • Spray DC, Harris AL, Bennett MVL. Equilibrium properties of a voltage dependent junctional conductance. J. Gen. Physiol. 1981;77:77-93.
    • (1981) J. Gen. Physiol , vol.77 , pp. 77-93
    • Spray, D.C.1    Harris, A.L.2    Bennett, M.V.L.3
  • 20
    • 0029878244 scopus 로고    scopus 로고
    • Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions
    • Kwak BR, Jongsma HJ. Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions. Mol. Cell. Biochem. 1996;157:93-99.
    • (1996) Mol. Cell. Biochem , vol.157 , pp. 93-99
    • Kwak, B.R.1    Jongsma, H.J.2
  • 22
    • 0029838641 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes
    • Doble BW, Chen Y, Bosc DG, Litchfield DW, Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ. Res.1996; 79:647-658.]
    • (1996) Circ. Res , vol.79 , pp. 647-658
    • Doble, B.W.1    Chen, Y.2    Bosc, D.G.3    Litchfield, D.W.4    Kardami, E.5
  • 24
    • 0023161934 scopus 로고
    • Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea pig
    • Noma A, Tsuboi N. Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea pig. J. Physiol. (Lond) 1987;382:193-211.
    • (1987) J. Physiol. (Lond) , vol.382 , pp. 193-211
    • Noma, A.1    Tsuboi, N.2
  • 25
    • 0027172696 scopus 로고
    • A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: The carboxy tail length
    • Liu S, Taffet S, Stoner L, Delmar M, Vallano ML, Jalife J. A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxy tail length. Biophys. J. 1993;64: 1422-1433.
    • (1993) Biophys. J , vol.64 , pp. 1422-1433
    • Liu, S.1    Taffet, S.2    Stoner, L.3    Delmar, M.4    Vallano, M.L.5    Jalife, J.6
  • 26
    • 0030050142 scopus 로고    scopus 로고
    • Intramolecular interactions mediate pH regulation of connexin 43 channels
    • Morley GE, Taffet SM, Delmar M. Intramolecular interactions mediate pH regulation of connexin 43 channels. Biophys. J. 1996;70:1294-1302.
    • (1996) Biophys. J , vol.70 , pp. 1294-1302
    • Morley, G.E.1    Taffet, S.M.2    Delmar, M.3
  • 27
    • 0028284598 scopus 로고
    • Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43
    • Ek JF, Delmar M, Perzova R, Taffet SM. Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43. Circ. Res. 1994;74:1058-1064.
    • (1994) Circ. Res , vol.74 , pp. 1058-1064
    • Ek, J.F.1    Delmar, M.2    Perzova, R.3    Taffet, S.M.4
  • 28
    • 0028845193 scopus 로고
    • pH sensitivity of the cardiac gap junction proteins, connexin 45 and 43
    • Hermans MMP, Kortekaas P, Jongsma HJ, Rook MB. pH sensitivity of the cardiac gap junction proteins, connexin 45 and 43. Pflǘs Arch. 1995; 431:138-140.
    • (1995) Pflǘs Arch , vol.431 , pp. 138-140
    • Hermans, M.M.P.1    Kortekaas, P.2    Jongsma, H.J.3    Rook, M.B.4
  • 30
    • 33645115754 scopus 로고    scopus 로고
    • c-Src: Bridging the gap between phosphorylation- and acidification-induced gap junction channel closure
    • p
    • Lau AF. c-Src: bridging the gap between phosphorylation- and acidification-induced gap junction channel closure. Sci. STKE 2005;291: e33. p.
    • (2005) Sci. STKE , vol.291
    • Lau, A.F.1
  • 32
    • 54249150370 scopus 로고    scopus 로고
    • Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: Electrophysiologi- cal and molecular findings
    • Jozwiak J, Dhein S. Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiologi- cal and molecular findings. Naunyn Schmiedebergs Arch. Pharmacol. 2008;378:459-470.
    • (2008) Naunyn Schmiedebergs Arch. Pharmacol , vol.378 , pp. 459-470
    • Jozwiak, J.1    Dhein, S.2
  • 33
    • 0347418930 scopus 로고    scopus 로고
    • Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction. Evidence supporting a novel target for anti-arrhythmic therapy
    • Eloff BC, Gilat E, Wan X, Rosenbaum DS. Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction. Evidence supporting a novel target for anti-arrhythmic therapy. Circulation 2003;108: 3157-3163.
    • (2003) Circulation , vol.108 , pp. 3157-3163
    • Eloff, B.C.1    Gilat, E.2    Wan, X.3    Rosenbaum, D.S.4
  • 34
    • 38149068097 scopus 로고    scopus 로고
    • Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans
    • Kjolbye AL, Dikshteyn M, Eloff BC, Deschênes I, Rosenbaum DS. Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans. Am. J. Physiol. 2008; 294:H41-H49.
    • (2008) Am. J. Physiol , vol.294
    • Kjolbye, A.L.1    Dikshteyn, M.2    Eloff, B.C.3    Deschênes, I.4    Rosenbaum, D.S.5
  • 35
    • 33846471716 scopus 로고    scopus 로고
    • Model- dependent effects of the gap junction conduction-enhancing anti- arrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs
    • Shiroshita-Takeshita A, Sakabe M, Haugan K, Hennan JK, Nattel S. Model- dependent effects of the gap junction conduction-enhancing anti- arrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs. Circulation 2007;115:310-318.
    • (2007) Circulation , vol.115 , pp. 310-318
    • Shiroshita-Takeshita, A.1    Sakabe, M.2    Haugan, K.3    Hennan, J.K.4    Nattel, S.5
  • 37
    • 33645007430 scopus 로고    scopus 로고
    • Rotigaptide (ZP123) reverts established atrial conduction velocity slowing
    • Haugan K, Kjolbye AL, Hennan JK, Petersen JS. Rotigaptide (ZP123) reverts established atrial conduction velocity slowing. Cell Commun. Adhes. 2005;12:271-278.
    • (2005) Cell Commun. Adhes , vol.12 , pp. 271-278
    • Haugan, K.1    Kjolbye, A.L.2    Hennan, J.K.3    Petersen, J.S.4
  • 38
    • 0029119513 scopus 로고
    • TPA increases conductance but decreases permeability in neonatal rat cardiomyocytes gap junction channels
    • Kwak BR, van Veen TAB, Analbers LJS, Jongsma HJ. TPA increases conductance but decreases permeability in neonatal rat cardiomyocytes gap junction channels. Exp. Cell Res. 1995;220:456-463.
    • (1995) Exp. Cell Res , vol.220 , pp. 456-463
    • Kwak, B.R.1    van Veen, T.A.B.2    Analbers, L.J.S.3    Jongsma, H.J.4
  • 39
    • 0242302359 scopus 로고    scopus 로고
    • A method to determine the relative cAMP permeability of connexin channels
    • Bedner P, Niessen H, Odermatt B, Willecke K, Harz H. A method to determine the relative cAMP permeability of connexin channels. Exp. Cell Res. 291:25-35. 200.
    • Exp. Cell Res , vol.291 , Issue.25-35 , pp. 200
    • Bedner, P.1    Niessen, H.2    Odermatt, B.3    Willecke, K.4    Harz, H.5
  • 40
    • 0037454041 scopus 로고    scopus 로고
    • Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice
    • Kanno S, Kovacs A, Yamada KA, Saffitz JE. Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J. Am. Coll. Cardiol. 2003;41:681-686.
    • (2003) J. Am. Coll. Cardiol , vol.41 , pp. 681-686
    • Kanno, S.1    Kovacs, A.2    Yamada, K.A.3    Saffitz, J.E.4
  • 41
    • 0033771821 scopus 로고    scopus 로고
    • Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myo- cytes
    • Yasui K, Kada K, Hojo M, Lee JK, Kamiya K, Toyama J et al. Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myo- cytes. Cardiovasc. Res. 2000;48:68-76.
    • (2000) Cardiovasc. Res , vol.48 , pp. 68-76
    • Yasui, K.1    Kada, K.2    Hojo, M.3    Lee, J.K.4    Kamiya, K.5    Toyama, J.6
  • 42
    • 0014014672 scopus 로고
    • Permeability of membrane junctions
    • Loewenstein WR. Permeability of membrane junctions. NY Acad. Sci. 1966;137:441-472.
    • (1966) NY Acad. Sci , vol.137 , pp. 441-472
    • Loewenstein, W.R.1
  • 44
    • 0028900935 scopus 로고
    • Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepa-toma (SKHep1) cells
    • Moreno AP, Laing JG, Beyer EC, Spray DC. Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepa-toma (SKHep1) cells. Am. J. Physiol. 1995;268:C356-C365.
    • (1995) Am. J. Physiol , vol.268
    • Moreno, A.P.1    Laing, J.G.2    Beyer, E.C.3    Spray, D.C.4
  • 45
    • 0029095038 scopus 로고
    • Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40
    • Beblo DA, Wang HZ, Beyer BC, Westphale EM, Veenstra RD. Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40. Circ. Res. 1995;77:813-822.
    • (1995) Circ. Res , vol.77 , pp. 813-822
    • Beblo, D.A.1    Wang, H.Z.2    Beyer, B.C.3    Westphale, E.M.4    Veenstra, R.D.5
  • 46
    • 10244257651 scopus 로고
    • Expression of dog connexin 40 and 45 in paired Xenopus oocytes
    • Kanno Y, Kataoka K, Shiba Y, Shibata Y, Shimazu T, eds, Amsterdam, Holland: Elsevier Science Publishers;
    • Ebihara L. Expression of dog connexin 40 and 45 in paired Xenopus oocytes. In: Kanno Y, Kataoka K, Shiba Y, Shibata Y, Shimazu T, eds., Intercellular Communication through Gap Junctions Progress in Cell Research. Vol. 4. Amsterdam, Holland: Elsevier Science Publishers; 1995. p395-398.
    • (1995) Intercellular Communication through Gap Junctions Progress in Cell Research , vol.4 , pp. 395-398
    • Ebihara, L.1
  • 47
    • 0036128134 scopus 로고    scopus 로고
    • Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts
    • Polontchouk LO, Valiunas V, Haefliger JA, Eppenberger HM, Weingart R. Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts. Pflugers Arch. 2002;443:676-689.
    • (2002) Pflugers Arch , vol.443 , pp. 676-689
    • Polontchouk, L.O.1    Valiunas, V.2    Haefliger, J.A.3    Eppenberger, H.M.4    Weingart, R.5


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