Structural bases for the chemical regulation of Connexin43 channels

Cardiovascular Research

Volumn 62, Issue 2, 2004, Pages 268-275

  Delmar, Mario ^a   Coombs, Wanda ^a   Sorgen, Paul ^b   Duffy, Heather S ^c   Taffet, Steven M ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Connexin; Cx43; Gap junction regulation; Gap junctions

Indexed keywords

AMINO ACID; ANTIBODY; CONNEXIN 43; GAP JUNCTION PROTEIN;

CARBOXY TERMINAL SEQUENCE; CELL COMMUNICATION; CHANNEL GATING; CYTOPLASM; DIFFUSION; ENZYME LINKED IMMUNOSORBENT ASSAY; GAP JUNCTION; HUMAN; HYPOTHESIS; KINETICS; MOLECULAR INTERACTION; MOLECULE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTUM CHEMISTRY; REVIEW; SCREENING; SEDIMENTATION; STOICHIOMETRY; SURFACE PLASMON RESONANCE; TIME;

ANIMALS; CELL COMMUNICATION; CELL MEMBRANE PERMEABILITY; CONNEXIN 43; GAP JUNCTIONS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MYOCARDIUM; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 1942470893     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2003.12.030     Document Type: Review

References (39)

1. Lampe P.D., Lau A.F. Regulation of gap junctions by phosphorylation of connexins. Arch. Biochem. Biophys. 384:2000;205-215.
2. Giepmans B.N., Verlaan I., Hengeveld T.et al. Gap junction protein connexin-43 interacts directly with microtubules. Curr. Biol. 11:2001;1364-1368.
3. Toyofuku T., Yabuki M., Otsu K., Kuzuya T., Hori M., Tada M. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J. Biol. Chem. 273:1998;12725-12731.
4. Gutstein D.E., Morley G.E., Tamaddon H.et al. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of Connexin43. Circ. Res. 88:2001;333-339.
5. Lo C.W., Wessels A. Cx43 gap junctions in cardiac development. Trends Cardiovasc. Med. 8:1998;264-269.
6. Harris A.L. Emerging issues of connexin channels: biophysics fills the gap. Q. Rev. Biophys. 34:2001;325-472.
7. Liu S., Taffet S., Stoner L., Delmar M., Vallano M.L., Jalife J. A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length. Biophys. J. 64:1993;1422-1433.
8. Morley G.E., Taffet S.M., Delmar M. Intramolecular interactions mediate pH regulation of Cx43 channels. Biophys. J. 70:1996;1294-1302.
9. Armstrong C.M., Bezanilla F. Inactivation of the sodium current: II. Gating current experiments. J. Gen. Physiol. 70:1977;567-590.
10. Zagotta W.N., Hoshi T., Aldrich R.W. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science. 250:1990;568-571.
11. Homma N., Alvarado J.L., Coombs W.et al. A particle-receptor model for the insulin-induced closure of Connexin43 channels. Circ. Res. 83:1998;27-32.
12. Zhou L., Kasperek E.M., Nicholson B.J. Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J. Cell Biol. 144:1999;1033-1045.
13. Stergiopoulos K., Alvarado J.L., Mastroianni M., Ek-Vitorin J.F., Taffet S.M., Delmar M. Hetero-domain interactions as a mechanism for the regulation of connexin channels. Circ. Res. 84:1999;1144-1155.
14. Gu H., Ek-Vitorin J.F., Taffet S.M., Delmar M. Coexpression of connexins 40 and 43 enhances the pH sensitivity of gap junctions: a model for synergistic interactions among connexins. Circ. Res. 86:2000;e98-e103.
15. Moreno A.P., Chanson M., Anumonwo J.et al. Role of the carboxyl terminal of Connexin43 in transjunctional fast voltage gating. Circ. Res. 90:2002;450-457.
16. Anumonwo J.M.B., Taffet S.M., Gu H., Chanson M., Moreno A.P., Delmar M. The carboxyl terminal domain regulates the unitary conductance and voltage dependence of Connexin40 gap junction channels. Circ. Res. 88:2001;666-673.
17. Kukar T., Eckenrode S., Gu Y.et al. Protein microarrays to detect protein-protein interactions using red and green fluorescent proteins. Anal. Biochem. 306:2002;50-54.
18. Lueking A., Horn M., Eickhoff H., Bussow K., Lehrach H., Walter G. Protein microarrays for gene expression and antibody screening. Anal. Biochem. 270:1999;103-111.
19. Duffy H.S., Sorgen P.L., Girvin M.E.et al. pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains. J. Biol. Chem. 277:2002;36706-36714.
20. Salamon Z., Brown M.F., Tollin G. Plasmon resonance spectroscopy: probing molecular interactions within membranes. Trends Biochem. Sci. 24:1999;213-219.
21. MacLeod T.J., Kwon M., Filipenko N.R., Waisman D.M. Phospholipid- associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. J. Biol. Chem. 278:2003;25577-25584.
22. Duffy H.S., Delmar M., Coombs W.C.et al. Functional demonstration of connexin-protein binding using surface plasmon resonance. J. Cell Adhes. Commun. 8:2001;225-229.
23. Sorgen P.L., Bubb M.R., McCormick K.A., Edison A.S., Cain B.D. Formation of the b subunit dimer is necessary for interaction with F1-ATPase. Biochemistry. 37:1998;923-932.
24. Wu D., Chen A., Johnson C.S. Jr. An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulse. J. Magn. Reson., Ser. A. 115:1995;260-264.
25. Macomber R.S. A complete introduction to modern NMR spectroscopy. 1998;Wiley, New York.
26. Unwin P.N., Zampighi G. Structure of the junction between communicating cells. Nature. 283:1980;545-549.
27. Unwin P.N., Ennis P.D. Two configurations of a channel-forming membrane protein. Nature. 307:1984;609-613.
28. Makowski L. Structural domains in gap junctions: implications for the control of intercellular communication. Bennett M.V.L., Spray D.C. Gap junctions. 1985;5-12 Cold Spring Harbor Laboratory, New York.
29. Tibbitts T.T., Caspar D.L., Phillips W.C., Goodenough D.A. Diffraction diagnosis of protein folding in gap junction connexons. Biophys. J. 57:1990;1025-1036.
30. Unger V.M., Kumar N.M., Gilula N.B., Yeager M. Three-dimensional structure of a recombinant gap junction membrane channel. Science. 283:1999;1176-1180.
31. Skerrett I.M., Aronowitz J., Shin J.H.et al. Identification of amino acid residues lining the pore of a gap junction channel. J. Cell Biol. 159:2002;349-360.
32. Sorgen P.L., Duffy H.S., Cahill S.M.et al. Sequence-specific resonance assignment of the carboxyl terminal domain of Connexin43. J. Biomol. NMR. 23:2002;245-246.
33. Safferling M., Tichelaar W., Kummerle G.et al. First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers. Biochemistry. 20(40):2001;13948-13953.
34. Galvan D.L., Mignery G.A. Carboxyl-terminal sequences critical for inositol 1,4,5-trisphosphate receptor subunit assembly. J. Biol. Chem. 277:2002;48248-48260.
35. Matulef K., Zagotta W. Multimerization of the ligand binding domains of cyclic nucleotide-gated channels. Neuron. 36:2002;93-103.
36. Giepmans B.N., Hengeveld T., Postma F.R., Moolenaar W.H. Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. J. Biol. Chem. 276:2001;8544-8549.
37. Schubert A.L., Schubert W., Spray D.C., Lisanti M.P. Connexin family members target to lipid raft domains and interact with caveolin-1. Biochemistry. 41:2002;5754-5764.
38. Ai Z., Fischer A., Spray D.C., Brown A.M.C., Fishman G.I. Wnt-1 regulation of Connexin43 in cardiac myocytes. J. Clin. Invest. 105:2001;161-171.
39. Xu X., Li W.E., Huang G.Y.et al. Modulation of mouse neural crest cell motility by N-cadherin and Connexin43 junctions. J. Cell Biol. 154:2001;217-230.