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Volumn 45, Issue 1, 2010, Pages 37-46

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

Author keywords

Astrocytes; Connexins; Excitotoxicity; Neuro inflammation; Neuroprotection

Indexed keywords

CONNEXIN 43; CYTOKINE; GAP JUNCTION PROTEIN; INTERLEUKIN 1BETA; N METHYL DEXTRO ASPARTIC ACID; TUMOR NECROSIS FACTOR ALPHA; FLUORESCENT DYE; N METHYLASPARTIC ACID;

EID: 77955091332     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2010.05.007     Document Type: Article
Times cited : (149)

References (62)
  • 1
    • 0042536473 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    • Arundine M., Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003, 34:325-337.
    • (2003) Cell Calcium , vol.34 , pp. 325-337
    • Arundine, M.1    Tymianski, M.2
  • 4
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    • Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism. Prog. Neurobiol. 2005, 76:77-98.
    • (2005) Prog. Neurobiol. , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 9
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity
    • Choi D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 1987, 7:369-379.
    • (1987) J. Neurosci. , vol.7 , pp. 369-379
    • Choi, D.W.1
  • 11
    • 0026091649 scopus 로고
    • Gap junctions between cultured astrocytes: Immunocytochemical, molecular, and electrophysiological analysis
    • Dermietzel R., Hertberg E.L., Kessler J.A., Spray D.C. Gap junctions between cultured astrocytes: Immunocytochemical, molecular, and electrophysiological analysis. J. Neurosci. 1991, 11:1421-1432.
    • (1991) J. Neurosci. , vol.11 , pp. 1421-1432
    • Dermietzel, R.1    Hertberg, E.L.2    Kessler, J.A.3    Spray, D.C.4
  • 12
    • 33745528139 scopus 로고    scopus 로고
    • The gap junction cellular internet: Connexin HCs enter the signalling limelight
    • Evans W.H., De Vuyst E., Leybaert L. The gap junction cellular internet: Connexin HCs enter the signalling limelight. Biochem. J. 2006, 397:1-14.
    • (2006) Biochem. J. , vol.397 , pp. 1-14
    • Evans, W.H.1    De Vuyst, E.2    Leybaert, L.3
  • 15
    • 70450197469 scopus 로고    scopus 로고
    • Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments
    • Froger N., Orellana J.A., Cohen-Salmon M., Ezan P., Amigou E., Sáez J.C., Giaume C. Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. J. Neurochem. 2009, 111:1383-1397.
    • (2009) J. Neurochem. , vol.111 , pp. 1383-1397
    • Froger, N.1    Orellana, J.A.2    Cohen-Salmon, M.3    Ezan, P.4    Amigou, E.5    Sáez, J.C.6    Giaume, C.7
  • 16
    • 77952426247 scopus 로고    scopus 로고
    • Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system
    • Giaume C., Theis M. Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system. Brain Res. Rev. 2009, 63:160-176.
    • (2009) Brain Res. Rev. , vol.63 , pp. 160-176
    • Giaume, C.1    Theis, M.2
  • 17
    • 0026020817 scopus 로고
    • Gap junctions in cultured astrocytes: Single-channel currents and characterization of channel-forming protein
    • Giaume C., Fromaget C., El Aoumari A., Cordier J., Glowinski J., Gros D. Gap junctions in cultured astrocytes: Single-channel currents and characterization of channel-forming protein. Neuron 1991, 6:133-143.
    • (1991) Neuron , vol.6 , pp. 133-143
    • Giaume, C.1    Fromaget, C.2    El Aoumari, A.3    Cordier, J.4    Glowinski, J.5    Gros, D.6
  • 19
    • 34249082403 scopus 로고    scopus 로고
    • Connexin channel permeability to cytoplasmic molecules
    • Harris A.L. Connexin channel permeability to cytoplasmic molecules. Prog. Biophys. Mol. Biol. 2007, 94:120-143.
    • (2007) Prog. Biophys. Mol. Biol. , vol.94 , pp. 120-143
    • Harris, A.L.1
  • 20
    • 33751572168 scopus 로고    scopus 로고
    • Pannexin 1 is expressed by neurons and glia but does not form functional gap junctions
    • Huang Y., Grinspan J.B., Abrams C.K., Scherer S.S. Pannexin 1 is expressed by neurons and glia but does not form functional gap junctions. Glia 2007, 55:46-56.
    • (2007) Glia , vol.55 , pp. 46-56
    • Huang, Y.1    Grinspan, J.B.2    Abrams, C.K.3    Scherer, S.S.4
  • 21
    • 0035372340 scopus 로고    scopus 로고
    • An in vitro model for the study of microglia-induced neurodegeneration: Involvement of nitric oxide and tumor necrosis factor-alpha
    • Hemmer K., Fransen L., Vanderstichele H., Vanmechelen E., Heuschling P. An in vitro model for the study of microglia-induced neurodegeneration: Involvement of nitric oxide and tumor necrosis factor-alpha. Neurochem. Int. 2001, 38:557-565.
    • (2001) Neurochem. Int. , vol.38 , pp. 557-565
    • Hemmer, K.1    Fransen, L.2    Vanderstichele, H.3    Vanmechelen, E.4    Heuschling, P.5
  • 22
    • 66149173401 scopus 로고    scopus 로고
    • Pannexin 1: The molecular substrate of astrocyte "hemichannels"
    • Iglesias R., Dahl G., Qiu F., Spray D.C., Scemes E. Pannexin 1: The molecular substrate of astrocyte "hemichannels". J. Neurosci. 2009, 27:7092-7097.
    • (2009) J. Neurosci. , vol.27 , pp. 7092-7097
    • Iglesias, R.1    Dahl, G.2    Qiu, F.3    Spray, D.C.4    Scemes, E.5
  • 23
    • 48249146963 scopus 로고    scopus 로고
    • Glial connexins and gap junctions in CNS inflammation and disease
    • Kielian T. Glial connexins and gap junctions in CNS inflammation and disease. J. Neurochem. 2008, 106:1000-1016.
    • (2008) J. Neurochem. , vol.106 , pp. 1000-1016
    • Kielian, T.1
  • 24
    • 0034788643 scopus 로고    scopus 로고
    • Pathways of neuron-astrocyte interactions and their possible role in neuroprotection
    • Kirchhoff F., Dringen R., Giaume C. Pathways of neuron-astrocyte interactions and their possible role in neuroprotection. Eur. Arch. Psychiatry Clin. Neurosci. 2001, 251:159-169.
    • (2001) Eur. Arch. Psychiatry Clin. Neurosci. , vol.251 , pp. 159-169
    • Kirchhoff, F.1    Dringen, R.2    Giaume, C.3
  • 25
    • 51349116146 scopus 로고    scopus 로고
    • Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes
    • Koulakoff A., Ezan P., Giaume C. Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes. Glia 2008, 56:1299-1311.
    • (2008) Glia , vol.56 , pp. 1299-1311
    • Koulakoff, A.1    Ezan, P.2    Giaume, C.3
  • 26
    • 0032850167 scopus 로고    scopus 로고
    • Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity
    • Maus M., Marin P., Israel M., Glowinski J., Premont J. Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity. Eur. J. Neurosci. 1999, 11:3215-3224.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 3215-3224
    • Maus, M.1    Marin, P.2    Israel, M.3    Glowinski, J.4    Premont, J.5
  • 27
    • 33645827104 scopus 로고    scopus 로고
    • Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: Potentiation by beta-amyloid
    • Même W., Calvo C.F., Froger N., Ezan P., Amigou E., Koulakoff A., Giaume C. Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: Potentiation by beta-amyloid. FASEB J. 2006, 20:494-496.
    • (2006) FASEB J. , vol.20 , pp. 494-496
    • Même, W.1    Calvo, C.F.2    Froger, N.3    Ezan, P.4    Amigou, E.5    Koulakoff, A.6    Giaume, C.7
  • 28
    • 33847696120 scopus 로고    scopus 로고
    • Dual-regulation of astrocyte gap junction hemichannels by growth factors and a pro-inflammatory cytokine via the mitogen-activated protein kinase cascade
    • Morita M., Saruta C., Kozuka N., Okubo Y., Itakura M., Takahashi M., Kudo Y. Dual-regulation of astrocyte gap junction hemichannels by growth factors and a pro-inflammatory cytokine via the mitogen-activated protein kinase cascade. Glia 2007, 55:508-515.
    • (2007) Glia , vol.55 , pp. 508-515
    • Morita, M.1    Saruta, C.2    Kozuka, N.3    Okubo, Y.4    Itakura, M.5    Takahashi, M.6    Kudo, Y.7
  • 29
    • 1642377170 scopus 로고    scopus 로고
    • Gap junctions and neurological disorders of the central nervous system
    • Nakase T., Naus C.C. Gap junctions and neurological disorders of the central nervous system. Biochim. Biophys. Acta 2004, 1662:149-158.
    • (2004) Biochim. Biophys. Acta , vol.1662 , pp. 149-158
    • Nakase, T.1    Naus, C.C.2
  • 30
    • 0042122377 scopus 로고    scopus 로고
    • Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia
    • Nakase T., Fushiki S., Naus C.C. Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. Stroke 2003, 34:1987-1993.
    • (2003) Stroke , vol.34 , pp. 1987-1993
    • Nakase, T.1    Fushiki, S.2    Naus, C.C.3
  • 31
    • 2442707974 scopus 로고    scopus 로고
    • Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes
    • Nakase T., Sohl G., Theis M., Willecke K., Naus C.C. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. Am. J. Pathol. 2004, 164:2067-2075.
    • (2004) Am. J. Pathol. , vol.164 , pp. 2067-2075
    • Nakase, T.1    Sohl, G.2    Theis, M.3    Willecke, K.4    Naus, C.C.5
  • 33
    • 0141463763 scopus 로고    scopus 로고
    • Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system
    • Oprica M., Eriksson C., Schultzberg M. Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system. J. Cell. Mol. Med. 2003, 7:127-140.
    • (2003) J. Cell. Mol. Med. , vol.7 , pp. 127-140
    • Oprica, M.1    Eriksson, C.2    Schultzberg, M.3
  • 34
    • 75849165091 scopus 로고    scopus 로고
    • Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    • Orellana J.A., Hernández D.E., Ezan P., Velarde V., Bennett M.V., Giaume C., Sáez J.C. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia 2009, 58:329-343.
    • (2009) Glia , vol.58 , pp. 329-343
    • Orellana, J.A.1    Hernández, D.E.2    Ezan, P.3    Velarde, V.4    Bennett, M.V.5    Giaume, C.6    Sáez, J.C.7
  • 36
    • 0036159649 scopus 로고    scopus 로고
    • Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures
    • Ozog M.A., Siushansian R., Naus C.C. Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures. J. Neuropathol. Exp. Neurol. 2002, 61:132-141.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 132-141
    • Ozog, M.A.1    Siushansian, R.2    Naus, C.C.3
  • 38
    • 0037791780 scopus 로고    scopus 로고
    • Interleukin-1 in the brain: Mechanisms of action in acute neurodegeneration
    • Patel H.C., Boutin H., Allan S.M. Interleukin-1 in the brain: Mechanisms of action in acute neurodegeneration. Ann. NY Acad. Sci. 2003, 992:39-47.
    • (2003) Ann. NY Acad. Sci. , vol.992 , pp. 39-47
    • Patel, H.C.1    Boutin, H.2    Allan, S.M.3
  • 39
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 40
    • 33750473352 scopus 로고    scopus 로고
    • Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    • Pelegrin P., Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 2006, 25:5071-5082.
    • (2006) EMBO J. , vol.25 , pp. 5071-5082
    • Pelegrin, P.1    Surprenant, A.2
  • 42
    • 36549084087 scopus 로고    scopus 로고
    • Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins
    • Peñuela S., Bhalla R., Gong X.Q., Cowan K.N., Celetti S.J., Cowan B.J., Bai D., Shao Q., Laird D.W. Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J. Cell Sci. 2007, 120:3772-3783.
    • (2007) J. Cell Sci. , vol.120 , pp. 3772-3783
    • Peñuela, S.1    Bhalla, R.2    Gong, X.Q.3    Cowan, K.N.4    Celetti, S.J.5    Cowan, B.J.6    Bai, D.7    Shao, Q.8    Laird, D.W.9
  • 44
    • 33645238079 scopus 로고    scopus 로고
    • S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents
    • Retamal M.A., Cortés C.J., Reuss L., Bennett M.V., Sáez J.C. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:4475-4480.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 4475-4480
    • Retamal, M.A.1    Cortés, C.J.2    Reuss, L.3    Bennett, M.V.4    Sáez, J.C.5
  • 45
    • 37249015389 scopus 로고    scopus 로고
    • Cx43 hemi- and full channels in astrocytes are oppositely regulated by pro-inflammatory cytokines released from activated microglia
    • Retamal M.A., Froger N., Ezan P., Sáez P.J., Sáez J.C., Giaume C. Cx43 hemi- and full channels in astrocytes are oppositely regulated by pro-inflammatory cytokines released from activated microglia. J. Neurosci. 2007, 27:13781-13792.
    • (2007) J. Neurosci. , vol.27 , pp. 13781-13792
    • Retamal, M.A.1    Froger, N.2    Ezan, P.3    Sáez, P.J.4    Sáez, J.C.5    Giaume, C.6
  • 46
    • 70349425672 scopus 로고    scopus 로고
    • Astrocytic dysfunction: Insights on the role in neurodegeneration
    • Rossi D., Volterra A. Astrocytic dysfunction: Insights on the role in neurodegeneration. Brain Res. Bull. 2009, 80:224-232.
    • (2009) Brain Res. Bull. , vol.80 , pp. 224-232
    • Rossi, D.1    Volterra, A.2
  • 47
    • 0034717542 scopus 로고    scopus 로고
    • Activity-dependent neuronal control of gap-junctional communication in astrocytes
    • Rouach N., Glowinski J., Giaume C. Activity-dependent neuronal control of gap-junctional communication in astrocytes. J. Cell Biol. 2000, 149:1513-1526.
    • (2000) J. Cell Biol. , vol.149 , pp. 1513-1526
    • Rouach, N.1    Glowinski, J.2    Giaume, C.3
  • 51
    • 62549143109 scopus 로고    scopus 로고
    • Connexins, pannexins, innexins: Novel roles of "hemi-channels"
    • Scemes E., Spray D.C., Meda P. Connexins, pannexins, innexins: Novel roles of "hemi-channels". Pflugers Arch. 2009, 457:1207-1226.
    • (2009) Pflugers Arch. , vol.457 , pp. 1207-1226
    • Scemes, E.1    Spray, D.C.2    Meda, P.3
  • 53
    • 33750300467 scopus 로고    scopus 로고
    • Functional connexin "hemichannels": A critical appraisal
    • Spray D.C., Ye Z.C., Ransom B.R. Functional connexin "hemichannels": A critical appraisal. Glia 2006, 54:758-773.
    • (2006) Glia , vol.54 , pp. 758-773
    • Spray, D.C.1    Ye, Z.C.2    Ransom, B.R.3
  • 54
    • 34247496802 scopus 로고    scopus 로고
    • Divergent roles for tumor necrosis factor-a in the brain
    • Sriram K., O'Callaghan J.P. Divergent roles for tumor necrosis factor-a in the brain. J. Neuroimmune Pharmacol. 2007, 2:140-153.
    • (2007) J. Neuroimmune Pharmacol. , vol.2 , pp. 140-153
    • Sriram, K.1    O'Callaghan, J.P.2
  • 56
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • Takeuchi H., Jin S., Wang J., Zhang G., Kawanokuchi J., Kuno R., Sonobe Y., Mizuno T., Suzumura A. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 2006, 281:21362-21368.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 57
    • 0345561544 scopus 로고    scopus 로고
    • Tumor necrosis factor induced Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
    • Tamatani M., Che Y.H., Matsuzaki H., Ogawa H., Miyake S., Mizuno T., Tohyama M. Tumor necrosis factor induced Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J. Biol. Chem. 1999, 274:8531-8538.
    • (1999) J. Biol. Chem. , vol.274 , pp. 8531-8538
    • Tamatani, M.1    Che, Y.H.2    Matsuzaki, H.3    Ogawa, H.4    Miyake, S.5    Mizuno, T.6    Tohyama, M.7
  • 58
    • 15944387795 scopus 로고    scopus 로고
    • Emerging complexities in identity and function of glial connexins
    • Theis M., Söhl G., Willecke K. Emerging complexities in identity and function of glial connexins. Trend Neurosci. 2005, 28:188-195.
    • (2005) Trend Neurosci. , vol.28 , pp. 188-195
    • Theis, M.1    Söhl, G.2    Willecke, K.3
  • 59
    • 60849101949 scopus 로고    scopus 로고
    • Connexin and pannexin hemichannels of neurons and astrocytes
    • Thompson R.J., MacVicar B.A. Connexin and pannexin hemichannels of neurons and astrocytes. Channels (Austin) 2008, 2:81-86.
    • (2008) Channels (Austin) , vol.2 , pp. 81-86
    • Thompson, R.J.1    MacVicar, B.A.2
  • 60
    • 33646584876 scopus 로고    scopus 로고
    • Ischemia opens neuronal gap junction hemichannels
    • Thompson R.J., Zhou N., MacVicar B.A. Ischemia opens neuronal gap junction hemichannels. Science 2006, 312:924-927.
    • (2006) Science , vol.312 , pp. 924-927
    • Thompson, R.J.1    Zhou, N.2    MacVicar, B.A.3
  • 61
    • 23044435896 scopus 로고    scopus 로고
    • Astrocytes, from brain glue to communication elements: The revolution continues
    • Volterra A., Meldolesi J. Astrocytes, from brain glue to communication elements: The revolution continues. Nat. Rev. Neurosci. 2005, 6:626-640.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 626-640
    • Volterra, A.1    Meldolesi, J.2


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