Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Martin, David ^a   Allagnat, Florent ^a   Gesina, Emilie ^b   Caille, Dorothee ^c   Gjinovci, Asllan ^c   Waeber, Gerard ^a   Meda, Paolo ^c   Haefliger, Jacques Antoine ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b EPFL   (Switzerland)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; RE1 SILENCING TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CDK5R2 GENE; CELL LOSS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; EXOCYTOSIS; EXPERIMENTAL MOUSE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCATION; GENE SILENCING; GENE TARGETING; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC TRANSDUCTION; GJD2 GENE; HYPERGLYCEMIA; INSULIN RELEASE; IRS2 GENE; MALE; MAPK8IP1 GENE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN BINDING; PROTEIN MOTIF; PTPRN GENE; RAT; REGULATOR GENE; REST GENE; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; CONSENSUS SEQUENCE; DIABETES MELLITUS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HOMEOSTASIS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PANCREAS; RATS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; RNA INTERFERENCE;

MUS; MUS MUSCULUS;

EID: 84866692345     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045844     Document Type: Article

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