Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells

Diabetologia

Volumn 51, Issue 8, 2008, Pages 1429-1439

  Martin, D ^a   Allagnat, F ^a   Chaffard, G ^b   Caille, D ^b   Fukuda, M ^c   Regazzi, R ^d   Abderrahmani, A ^d   Waeber, G ^a   Meda, P ^b   Maechler, P ^b   Haefliger, J A ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c TOHOKU UNIVERSITY   (Japan)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Exocytosis; Insulin secretion; RE 1; RE 1 silencing transcription factor; REST; Synaptotagmins; Transgenic mice

Indexed keywords

GLUCOSE; INSULIN; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNAPTOTAGMIN IV; SYNAPTOTAGMIN IX; SYNAPTOTAGMIN VII; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; EXOCYTOSIS; GENE EXPRESSION; GENE TARGETING; GLUCOSE INTOLERANCE; HOMEOSTASIS; INNER CELL MASS; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REPRESSOR GENE; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; CHROMATIN; CONSENSUS SEQUENCE; CYTOSOL; GENE SILENCING; GENES, REPORTER; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MITOCHONDRIAL MEMBRANES; REPRESSOR PROTEINS;

EID: 48149101799     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-0984-1     Document Type: Article

References (45)

1. A Abderrahmani G Niederhauser V Plaisance JA Haefliger R Regazzi G Waeber 2004 Neuronal traits are required for glucose-induced insulin secretion FEBS Lett 565 133 138
2. JA Chong J Tapia-Ramirez S Kim 1995 REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons Cell 80 949 957
3. CJ Schoenherr DJ Anderson 1995 The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes Science 267 1360 1363
4. L Li T Suzuki N Mori P Greengard 1993 Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene Proc Natl Acad Sci USA 90 1460 1464
5. A Bessis N Champtiaux L Chatelin JP Changeux 1997 The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain Proc Natl Acad Sci USA 94 5906 5911
6. IC Wood A Roopra NJ Buckley 1996 Neural specific expression of the m4 muscarinic acetylcholine receptor gene is mediated by a RE1/NRSE-type silencing element J Biol Chem 271 14221 14225
7. AW Bruce IJ Donaldson IC Wood 2004 Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes Proc Natl Acad Sci U S A 101 10458 10463
8. K Kuwahara Y Saito M Takano 2003 NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function Embo J 22 6310 6321
9. A Cheong AJ Bingham J Li 2005 Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation Mol Cell 20 45 52
10. F Atouf P Czernichow R Scharfmann 1997 Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer J Biol Chem 272 1929 1934
11. D Martin T Tawadros L Meylan 2003 Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines J Biol Chem 278 53082 53089
12. A Abderrahmani M Steinmann V Plaisance 2001 The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1) Mol Cell Biol 21 7256 7267
13. PL Herrera J Huarte R Zufferey 1994 Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes Proc Natl Acad Sci U S A 91 12999 13003
14. A Charollais V Serre C Mock F Cogne D Bosco P Meda 1999 Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin Dev Genet 24 13 26
15. F Allagnat D Martin DF Condorelli G Waeber JA Haefliger 2005 Glucose represses connexin36 in insulin-secreting cells J Cell Sci 118 5335 5344
16. S Carobbio H Ishihara S Fernandez-Pascual C Bartley R Martin-Del-Rio P Maechler 2004 Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets Diabetologia 47 266 276
17. A Merglen S Theander B Rubi G Chaffard CB Wollheim P Maechler 2004 Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Endocrinology 145 667 678
18. Q Zhang M Fukuda E Van Bockstaele O Pascual PG Haydon 2004 Synaptotagmin IV regulates glial glutamate release Proc Natl Acad Sci USA 101 9441 9446
19. 2+-dependent exocytosis in PC12 cells J Biol Chem 279 52677 52684
20. A Abderrahmani S Cheviet M Ferdaoussi T Coppola G Waeber R Regazzi 2006 ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis Embo J 25 977 986
21. YJ Liu H Cheng H Drought MJ MacDonald GW Sharp SG Straub 2003 Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH Am J Physiol Endocrinol Metab 285 E380 E389
22. M Gembal P Detimary P Gilon ZY Gao JC Henquin 1993 Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells J Clin Invest 91 871 880
23. CJ Schoenherr AJ Paquette DJ Anderson 1996 Identification of potential target genes for the neuron-restrictive silencer factor Proc Natl Acad Sci USA 93 9881 9886
24. M Fukuda Y Ogata C Saegusa E Kanno K Mikoshiba 2002 Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human Biochem J 365 173 180
25. N Ballas C Grunseich DD Lu JC Speh G Mandel 2005 REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis Cell 121 645 657
26. RD Burgoyne A Morgan 2003 Secretory granule exocytosis Physiol Rev 83 581 632
27. K Sadoul J Lang C Montecucco 1995 SNAP-25 is expressed in islets of Langerhans and is involved in insulin release J Cell Biol 128 1019 1028
28. J Vikman X Ma M Tagaya L Eliasson 2003 Requirement for N-ethylmaleimide-sensitive factor for exocytosis of insulin-containing secretory granules in pancreatic beta-cells Biochem Soc Trans 31 842 847
29. W Zhang A Efanov SN Yang 2000 Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell J Biol Chem 275 41521 41527
30. 2+-dependent insulin exocytosis J Cell Sci 117 3119 3127
31. M Ahras GP Otto SA Tooze 2006 Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells J Cell Biol 173 241 251
32. CT Wang JC Lu J Bai 2003 Different domains of synaptotagmin control the choice between kiss-and-run and full fusion Nature 424 943 947
33. T Tsuboi GA Rutter 2003 Multiple forms of "kiss-and-run" exocytosis revealed by evanescent wave microscopy Curr Biol 13 563 567
34. P Wang MC Chicka A Bhalla DA Richards ER Chapman 2005 Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor Mol Cell Biol 25 8693 8702
35. S Sugita W Han S Butz 2001 Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis Neuron 30 459 473
36. C Monterrat F Grise MN Benassy A Hemar J Lang 2007 The calcium-sensing protein synaptotagmin 7 is expressed on different endosomal compartments in endocrine, neuroendocrine cells or neurons but not on large dense core vesicles Histochem Cell Biol 127 625 632
37. BR Gauthier DL Duhamel M Iezzi 2008 Synaptotagmin VII splice variants a, β, and d are expressed in pancreatic β-cells and regulate insulin exocytosis FASEB J 22 194 206
38. HY Gaisano CG Ostenson L Sheu MB Wheeler S Efendic 2002 Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment Endocrinology 143 4218 4226
39. CG Ostenson H Gaisano L Sheu A Tibell T Bartfai 2006 Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients Diabetes 55 435 440
40. P Rorsman E Renstrom 2003 Insulin granule dynamics in pancreatic beta cells Diabetologia 46 1029 1045
41. TF Westbrook ES Martin MR Schlabach 2005 A genetic screen for candidate tumor suppressors identifies REST Cell 121 837 848
42. M Trajkovski H Mziaut A Altkruger 2004 Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells J Cell Biol 167 1063 1074
43. SJ Otto SR McCorkle J Hover 2007 A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions J Neurosci 27 6729 6739
44. DS Johnson A Mortazavi RM Myers B Wold 2007 Genome-wide mapping of in vivo protein-DNA interactions Science 316 1497 1502
45. AW Bruce A Krejci L Ooi 2006 The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype J Neurochem 98 1828 1840