메뉴 건너뛰기




Volumn 7, Issue 9, 2012, Pages

Inhibition of Doxorubicin-Induced Senescence by PPARδ Activation Agonists in Cardiac Muscle Cells: Cooperation between PPARδ and Bcl6

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PROTEIN BCL 6; PROTEIN KINASE B; SMALL INTERFERING RNA;

EID: 84866637965     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046126     Document Type: Article
Times cited : (29)

References (62)
  • 1
    • 49249105457 scopus 로고    scopus 로고
    • Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma
    • Hershman DL, McBride RB, Eisenberger A, Tsai WY, Grann VR, et al. (2008) Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. J Clin Oncol 26: 3159-3165.
    • (2008) J Clin Oncol , vol.26 , pp. 3159-3165
    • Hershman, D.L.1    McBride, R.B.2    Eisenberger, A.3    Tsai, W.Y.4    Grann, V.R.5
  • 2
    • 0035266475 scopus 로고    scopus 로고
    • Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis Cancer Res 60: 1789-1792
    • Auner HW, Tinchon C, Linkesch W, Halwachs-Baumann G, Sill H, (2001) Correspondence re: O. J. Arola, et al., (2000) Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis Cancer Res 60: 1789-1792. Cancer Res 61: 2335-2336.
    • (2001) Cancer Res , vol.61 , pp. 2335-2336
    • Auner, H.W.1    Tinchon, C.2    Linkesch, W.3    Halwachs-Baumann, G.4    Sill, H.5    Arola, O.J.6
  • 3
    • 40549128682 scopus 로고    scopus 로고
    • Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
    • Maejima Y, Adachi S, Ito H, Hirao K, Isobe M, (2008) Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell 7: 125-136.
    • (2008) Aging Cell , vol.7 , pp. 125-136
    • Maejima, Y.1    Adachi, S.2    Ito, H.3    Hirao, K.4    Isobe, M.5
  • 4
    • 72249121009 scopus 로고    scopus 로고
    • Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2
    • Spallarossa P, Altieri P, Aloi C, Garibaldi S, Barisione C, et al. (2009) Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2. Am J Physiol Heart Circ Physiol 297: H2169-H2181.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Spallarossa, P.1    Altieri, P.2    Aloi, C.3    Garibaldi, S.4    Barisione, C.5
  • 5
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS, (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 6
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12: 3008-3019.
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    van Aelst, L.4    Serrano, M.5
  • 7
    • 25444486937 scopus 로고    scopus 로고
    • Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1
    • Vigneron A, Roninson IB, Gamelin E, Coqueret O, (2005) Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. Cancer Res 65: 8927-8935.
    • (2005) Cancer Res , vol.65 , pp. 8927-8935
    • Vigneron, A.1    Roninson, I.B.2    Gamelin, E.3    Coqueret, O.4
  • 8
    • 78650917095 scopus 로고    scopus 로고
    • p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells
    • Spallarossa P, Altieri P, Barisione C, Passalacqua M, Aloi C, et al. (2010) p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells. PLoS One 5: e15583.
    • (2010) PLoS One , vol.5
    • Spallarossa, P.1    Altieri, P.2    Barisione, C.3    Passalacqua, M.4    Aloi, C.5
  • 9
    • 31344453935 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase
    • Spallarossa P, Altieri P, Garibaldi S, Ghigliotti G, Barisione C, et al. (2006) Matrix metalloproteinase-2 and-9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase. Cardiovasc Res 69: 736-745.
    • (2006) Cardiovasc Res , vol.69 , pp. 736-745
    • Spallarossa, P.1    Altieri, P.2    Garibaldi, S.3    Ghigliotti, G.4    Barisione, C.5
  • 10
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs Annu
    • Berger J, Moller DE (2002) The mechanisms of action of PPARs Annu. Rev. Med. 53,409-435.
    • (2002) Rev. Med. , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 11
    • 68449095060 scopus 로고    scopus 로고
    • PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function
    • Karpe F, Ehrenborg EE, (2009) PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function. Curr Opin Lipidol 20: 333-336.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 333-336
    • Karpe, F.1    Ehrenborg, E.E.2
  • 12
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, Yu RT, Ham J, et al. (2003) Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113: 159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5
  • 13
    • 77956399623 scopus 로고    scopus 로고
    • GW0742,a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury
    • Di Paola R, Esposito E, Mazzon E, Paterniti I, Galuppo M, et al. (2010) GW0742,a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. J Leukoc Biol 88: 291-301.
    • (2010) J Leukoc Biol , vol.88 , pp. 291-301
    • Di Paola, R.1    Esposito, E.2    Mazzon, E.3    Paterniti, I.4    Galuppo, M.5
  • 14
    • 33744519163 scopus 로고    scopus 로고
    • PPARδ modulates lipopolysaccharide-induced TNFα inflammation signaling in cultured cardiomyocytes J Mol Cell Cardiol
    • Ding G, Cheng L, Qin Q, Frontin S, Yang Q, (2006) PPARδ modulates lipopolysaccharide-induced TNFα inflammation signaling in cultured cardiomyocytes J Mol Cell Cardiol. 40: 821-828.
    • (2006) , vol.40 , pp. 821-828
    • Ding, G.1    Cheng, L.2    Qin, Q.3    Frontin, S.4    Yang, Q.5
  • 15
    • 38549127422 scopus 로고    scopus 로고
    • Suppression of pro-inflammatory adhesion molecules by PPAR-δ in human vascular endothelial cells Arterioscler Thromb Vasc Biol
    • Fan Y, Wang Y, Tang Z, Zhang H, Qin X, et al. (2008) Suppression of pro-inflammatory adhesion molecules by PPAR-δ in human vascular endothelial cells Arterioscler Thromb Vasc Biol. 28: 315-321.
    • (2008) , vol.28 , pp. 315-321
    • Fan, Y.1    Wang, Y.2    Tang, Z.3    Zhang, H.4    Qin, X.5
  • 16
    • 0142116239 scopus 로고    scopus 로고
    • Transcriptional repression of atherogenic inflammation: modulation by PPARdelta
    • Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, et al. (2003) Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science 302: 453-457.
    • (2003) Science , vol.302 , pp. 453-457
    • Lee, C.H.1    Chawla, A.2    Urbiztondo, N.3    Liao, D.4    Boisvert, W.A.5
  • 17
    • 41949123156 scopus 로고    scopus 로고
    • PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
    • Takata Y, Liu J, Yin F, Collins AR, Lyon CJ, et al. (2008) PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci U S A 105: 4277-4282.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4277-4282
    • Takata, Y.1    Liu, J.2    Yin, F.3    Collins, A.R.4    Lyon, C.J.5
  • 18
    • 13544262333 scopus 로고    scopus 로고
    • BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production
    • Yu RY, Wang X, Pixley FJ, Yu JJ, Dent AL, et al. (2005) BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105: 1777-17784.
    • (2005) Blood , vol.105 , pp. 1777-17784
    • Yu, R.Y.1    Wang, X.2    Pixley, F.J.3    Yu, J.J.4    Dent, A.L.5
  • 19
    • 71049185095 scopus 로고    scopus 로고
    • The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cells
    • Glauser DA, Schlegel W, (2009) The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cells. J Recept Signal Transduct Res 29: 293-308.
    • (2009) J Recept Signal Transduct Res , vol.29 , pp. 293-308
    • Glauser, D.A.1    Schlegel, W.2
  • 21
    • 33846623798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
    • Brown JD, Plutzky J, (2007) Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 115: 518-33.
    • (2007) Circulation , vol.115 , pp. 518-533
    • Brown, J.D.1    Plutzky, J.2
  • 23
    • 0037087737 scopus 로고    scopus 로고
    • A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF-p53 signaling Genes Dev
    • Shvarts A, Brummelkamp TR, Scheeren F, Koh E, Daley GQ, et al. (2002) A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF-p53 signaling Genes Dev. 16: 681-816.
    • (2002) , vol.16 , pp. 681-816
    • Shvarts, A.1    Brummelkamp, T.R.2    Scheeren, F.3    Koh, E.4    Daley, G.Q.5
  • 24
    • 79953027322 scopus 로고    scopus 로고
    • Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells
    • Kim HJ, Ham SA, Paek KS, Hwang JS, Jung SY, et al. (2011) Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells. Biochem Biophys Res Commun 406: 564-569.
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 564-569
    • Kim, H.J.1    Ham, S.A.2    Paek, K.S.3    Hwang, J.S.4    Jung, S.Y.5
  • 25
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • Karlseder J, Smogorzewska A, de Lange T, (2002) Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449.
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    de Lange, T.3
  • 26
    • 30744460411 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis
    • Pesant M, Sueur S, Dutartre P, Tallandier M, Grimaldi PA, et al. (2006) Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovasc Res 69: 440-449.
    • (2006) Cardiovasc Res , vol.69 , pp. 440-449
    • Pesant, M.1    Sueur, S.2    Dutartre, P.3    Tallandier, M.4    Grimaldi, P.A.5
  • 27
    • 0142020927 scopus 로고    scopus 로고
    • PPARs as therapeutic targets: reverse cardiology?
    • Plutzky J, (2003) PPARs as therapeutic targets: reverse cardiology? Science 302: 406-407.
    • (2003) Science , vol.302 , pp. 406-407
    • Plutzky, J.1
  • 28
    • 33748489928 scopus 로고    scopus 로고
    • BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells
    • Kharroubi I, Lee CH, Hekerman P, Darville MI, Evans RM, et al. (2006) BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells. Diabetologia 49: 2350-2358.
    • (2006) Diabetologia , vol.49 , pp. 2350-2358
    • Kharroubi, I.1    Lee, C.H.2    Hekerman, P.3    Darville, M.I.4    Evans, R.M.5
  • 29
    • 77957348621 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    • Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, et al. (2010) Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol 177: 1834-1847.
    • (2010) Am J Pathol , vol.177 , pp. 1834-1847
    • Zingarelli, B.1    Piraino, G.2    Hake, P.W.3    O'Connor, M.4    Denenberg, A.5
  • 30
    • 70349111436 scopus 로고    scopus 로고
    • Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation
    • Bishop-Bailey D, Bystrom J, (2009) Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation. Pharmacol Ther 124: 141-50.
    • (2009) Pharmacol Ther , vol.124 , pp. 141-150
    • Bishop-Bailey, D.1    Bystrom, J.2
  • 31
    • 0242361641 scopus 로고    scopus 로고
    • Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis
    • Minamino T, Yoshida T, Tateno K, Miyauchi H, Zou Y, et al. (2003) Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation. 108: 2264-2269.
    • (2003) Circulation , vol.108 , pp. 2264-2269
    • Minamino, T.1    Yoshida, T.2    Tateno, K.3    Miyauchi, H.4    Zou, Y.5
  • 32
    • 77952105389 scopus 로고    scopus 로고
    • J. Inflammatory networks during cellular senescence: causes and consequences
    • Campisi
    • Freund A, Orjalo AV, Desprez PY, (2010) Campisi (2010) J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 16: 238-46.
    • (2010) Trends Mol Med , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3
  • 34
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R,et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133: 1019-1031.
    • Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1    Michaloglou, C.2    Vredeveld, L.C.3    Douma, S.4    van Doorn, R.5
  • 35
    • 33846049673 scopus 로고    scopus 로고
    • Telomere length, risk of coronary disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested casecontrolstudy
    • Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, et al. (2007) Telomere length, risk of coronary disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested casecontrolstudy. Lancet 369: 107-114.
    • (2007) Lancet , vol.369 , pp. 107-114
    • Brouilette, S.W.1    Moore, J.S.2    McMahon, A.D.3    Thompson, J.R.4    Ford, I.5
  • 36
    • 80051470205 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin
    • He T, Smith LA, Lu T, Joyner MJ, Katusic ZS, (2011) Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin. Hypertension 58: 287-294.
    • (2011) Hypertension , vol.58 , pp. 287-294
    • He, T.1    Smith, L.A.2    Lu, T.3    Joyner, M.J.4    Katusic, Z.S.5
  • 37
    • 84876478717 scopus 로고    scopus 로고
    • Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: Involvement of the MAPK, NF-κB and AP-1 signaling pathways
    • Dec 4 [Epub ahead of print]
    • Kim JY, Park HJ, Um SH, Sohn EH, Kim BO, et al. (2011) Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: Involvement of the MAPK, NF-κB and AP-1 signaling pathways. Vascul Pharmacol. Dec 4 [Epub ahead of print].
    • (2011) Vascul Pharmacol
    • Kim, J.Y.1    Park, H.J.2    Um, S.H.3    Sohn, E.H.4    Kim, B.O.5
  • 38
    • 60149093582 scopus 로고    scopus 로고
    • Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival Int J Biol Sci
    • Thornton TM, Rincon M, (2009) Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival Int J Biol Sci. 5: 44-52.
    • (2009) , vol.5 , pp. 44-52
    • Thornton, T.M.1    Rincon, M.2
  • 39
  • 40
    • 73949096812 scopus 로고    scopus 로고
    • Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane
    • Spallarossa P, Altieri P, Pronzato P, Aloi C, Ghigliotti G,et al. Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. J Pharmacol Exp Ther. 2010 Jan 332(1): 87-96.
    • J Pharmacol Exp Ther. , vol.332 , Issue.1 , pp. 87-96
    • Spallarossa, P.1    Altieri, P.2    Pronzato, P.3    Aloi, C.4    Ghigliotti, G.5
  • 41
    • 77955088393 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta agonists attenuated the C-reactive protein-induced pro-inflammation in cardiomyocytes and H9c2 cardiomyoblasts
    • Liang YJ, Chen CY, Juang SJ, Lai LP, Shyu KG, et al. (2010) Peroxisome proliferator-activated receptor delta agonists attenuated the C-reactive protein-induced pro-inflammation in cardiomyocytes and H9c2 cardiomyoblasts. Eur J Pharmacol 643: 84-92.
    • (2010) Eur J Pharmacol , vol.643 , pp. 84-92
    • Liang, Y.J.1    Chen, C.Y.2    Juang, S.J.3    Lai, L.P.4    Shyu, K.G.5
  • 42
    • 42449113843 scopus 로고    scopus 로고
    • In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats
    • Yue TL, Nerurkar SS, Bao W, Jucker BM, Sarov-Blat L, et al. (2008) In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats. J Pharmacol Exp Ther 325: 466-474.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 466-474
    • Yue, T.L.1    Nerurkar, S.S.2    Bao, W.3    Jucker, B.M.4    Sarov-Blat, L.5
  • 43
    • 0033552811 scopus 로고    scopus 로고
    • The proto-oncogene Bcl6 inhibits apoptotic cell death in differentiation-induced mouse myogenic cells
    • Kumagai T, Miki T, Kikuchi M, Fukuda T, Miyasaka N, et al. (1999) The proto-oncogene Bcl6 inhibits apoptotic cell death in differentiation-induced mouse myogenic cells. Oncogene 18: 467-475.
    • (1999) Oncogene , vol.18 , pp. 467-475
    • Kumagai, T.1    Miki, T.2    Kikuchi, M.3    Fukuda, T.4    Miyasaka, N.5
  • 44
    • 18344389897 scopus 로고    scopus 로고
    • The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis
    • Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, et al. (2002) The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc Natl Acad Sci USA 99: 2860-2865.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2860-2865
    • Baron, B.W.1    Anastasi, J.2    Thirman, M.J.3    Furukawa, Y.4    Fears, S.5
  • 45
  • 46
    • 33846925649 scopus 로고    scopus 로고
    • Cardiomyocyte apoptosis in the right auricle of patients with ostium secundum atrial septal defect diseases
    • Gong J, Qian L, Kong X, Yang R, Zhou L, et al. (2007) Cardiomyocyte apoptosis in the right auricle of patients with ostium secundum atrial septal defect diseases. Life Sci 80: 1143-1151.
    • (2007) Life Sci , vol.80 , pp. 1143-1151
    • Gong, J.1    Qian, L.2    Kong, X.3    Yang, R.4    Zhou, L.5
  • 47
    • 0033552949 scopus 로고    scopus 로고
    • Adenovirus-mediated high expression of BCL-6 in CV-1 cells induces apoptotic cell death accompanied by down regulation of BCL-2 and BCL-X
    • Yamochi T, Kaneita Y, Akiyama T, Mori S, Moriyama M, (1999) Adenovirus-mediated high expression of BCL-6 in CV-1 cells induces apoptotic cell death accompanied by down regulation of BCL-2 and BCL-X. Oncogene 18: 487-494.
    • (1999) Oncogene , vol.18 , pp. 487-494
    • Yamochi, T.1    Kaneita, Y.2    Akiyama, T.3    Mori, S.4    Moriyama, M.5
  • 48
    • 0033539126 scopus 로고    scopus 로고
    • Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci
    • Albagli O, Lantoine D, Quief S, Quignon F, Englert C, et al. (1999) Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene 18: 5063-5075.
    • (1999) Oncogene , vol.18 , pp. 5063-5075
    • Albagli, O.1    Lantoine, D.2    Quief, S.3    Quignon, F.4    Englert, C.5
  • 50
    • 13844256366 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes
    • Planavila A, Rodríguez-Calvo R, Jové M, Michalik L, Wahli W, et al. (2005) Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc Res 65: 832-841.
    • (2005) Cardiovasc Res , vol.65 , pp. 832-841
    • Planavila, A.1    Rodríguez-Calvo, R.2    Jové, M.3    Michalik, L.4    Wahli, W.5
  • 51
    • 72049131347 scopus 로고    scopus 로고
    • Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis
    • Frias MA, Lang U, Gerber-Wicht C, James RW, (2010) Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res 85: 118-126.
    • (2010) Cardiovasc Res , vol.85 , pp. 118-126
    • Frias, M.A.1    Lang, U.2    Gerber-Wicht, C.3    James, R.W.4
  • 52
    • 33947507392 scopus 로고    scopus 로고
    • Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties
    • Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, et al. (2007) Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res 100: 536-544.
    • (2007) Circ Res , vol.100 , pp. 536-544
    • Chen, X.1    Wilson, R.M.2    Kubo, H.3    Berretta, R.M.4    Harris, D.M.5
  • 53
    • 56349128620 scopus 로고    scopus 로고
    • Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes
    • Konorev EA, Vanamala S, Kalyanaraman B, (2008) Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes. Free Radic Biol Med 45: 1723-1728.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1723-1728
    • Konorev, E.A.1    Vanamala, S.2    Kalyanaraman, B.3
  • 54
    • 74949138296 scopus 로고    scopus 로고
    • Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function
    • De Angelis A, Piegari E, Cappetta D, Marino L, Filippelli A, et al. (2010) Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation 121: 276-292.
    • (2010) Circulation , vol.121 , pp. 276-292
    • de Angelis, A.1    Piegari, E.2    Cappetta, D.3    Marino, L.4    Filippelli, A.5
  • 55
    • 0041530268 scopus 로고    scopus 로고
    • Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors
    • Antos CL, McKinsey TA, Dreitz M, Hollingsworth LM, Zhang CL, et al. (2003) Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors. J Biol Chem 278: 28930-28937.
    • (2003) J Biol Chem , vol.278 , pp. 28930-28937
    • Antos, C.L.1    McKinsey, T.A.2    Dreitz, M.3    Hollingsworth, L.M.4    Zhang, C.L.5
  • 56
    • 34548586975 scopus 로고    scopus 로고
    • Reduced migration, altered matrix and enhanced TGF beta1 signaling are signatures of mouse keratinocytes lacking Sdc1
    • Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, et al. (2007) Reduced migration, altered matrix and enhanced TGF beta1 signaling are signatures of mouse keratinocytes lacking Sdc1. J Cell Sci 120: 2851-2863.
    • (2007) J Cell Sci , vol.120 , pp. 2851-2863
    • Stepp, M.A.1    Liu, Y.2    Pal-Ghosh, S.3    Jurjus, R.A.4    Tadvalkar, G.5
  • 57
    • 68549088862 scopus 로고    scopus 로고
    • Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway
    • Ottonello L, Bertolotto M, Montecucco F, Bianchi G, Dallegri F, (2009) Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol 157: 294-306.
    • (2009) Br J Pharmacol , vol.157 , pp. 294-306
    • Ottonello, L.1    Bertolotto, M.2    Montecucco, F.3    Bianchi, G.4    Dallegri, F.5
  • 58
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in Vivo
    • Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in Vivo. Proc Natl Acad Sci USA 92: 363-9367.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3    Acosta, M.4    Scott, G.5
  • 59
    • 0042206639 scopus 로고    scopus 로고
    • Association o increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging
    • Gerland LM, Peyrol S, Lallemand C, Branche R, Magaud JP, et al. (2003) Association o increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging. Exp Gerontol 38: 887-895.
    • (2003) Exp Gerontol , vol.38 , pp. 887-895
    • Gerland, L.M.1    Peyrol, S.2    Lallemand, C.3    Branche, R.4    Magaud, J.P.5
  • 60
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mossmann T, (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 65: 55-63.
    • (1983) J Immunol Meth , vol.65 , pp. 55-63
    • Mossmann, T.1
  • 62
    • 0033813153 scopus 로고    scopus 로고
    • Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss
    • Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, et al. (2000) Caspase-Dependent Apoptosis Induced by Telomere Cleavage and TRF2 Loss. Neoplasia 2: 339-345.
    • (2000) Neoplasia , vol.2 , pp. 339-345
    • Multani, A.S.1    Ozen, M.2    Narayan, S.3    Kumar, V.4    Chandra, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.