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Volumn 20, Issue 4, 2009, Pages 333-336

PPARδ in humans: Genetic and pharmacological evidence for a significant metabolic function

Author keywords

Free fatty acids; Hyperlipoproteinaemia; LDL; VLDL

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ATORVASTATIN; MBX 8025; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; UNCLASSIFIED DRUG; FATTY ACID; LOW DENSITY LIPOPROTEIN; THIAZOLE DERIVATIVE; VERY LOW DENSITY LIPOPROTEIN;

EID: 68449095060     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32832dd4b1     Document Type: Review
Times cited : (35)

References (23)
  • 1
    • 0037135623 scopus 로고    scopus 로고
    • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    • Muoio DM, MacLean PS, Lang DB, et al. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. J Biol Chem 2002; 277:26089-26097.
    • (2002) J Biol Chem , vol.277 , pp. 26089-26097
    • Muoio, D.M.1    MacLean, P.S.2    Lang, D.B.3
  • 2
    • 33644645013 scopus 로고    scopus 로고
    • PPAR delta: A dagger in the heart of the metabolic syndrome
    • Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest 2006; 116:590-597.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 3
    • 48449094498 scopus 로고    scopus 로고
    • AMPK and PPARdelta agonists are exercise mimetics
    • Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell 2008; 134:405-415.
    • (2008) Cell , vol.134 , pp. 405-415
    • Narkar, V.A.1    Downes, M.2    Yu, R.T.3
  • 4
    • 0037192764 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes postconfluent cell proliferation in vascular smooth muscle cells
    • Zhang J, Fu M, Zhu X, et al. Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes postconfluent cell proliferation in vascular smooth muscle cells. J Biol Chem 2002; 277:11505-11512.
    • (2002) J Biol Chem , vol.277 , pp. 11505-11512
    • Zhang, J.1    Fu, M.2    Zhu, X.3
  • 5
    • 33846577833 scopus 로고    scopus 로고
    • Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis
    • Piqueras L, Reynolds AR, Hodivala-Dilke KM, et al. Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. Arterioscler Thromb Vasc Biol 2007; 27:63-69.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 63-69
    • Piqueras, L.1    Reynolds, A.R.2    Hodivala-Dilke, K.M.3
  • 6
    • 0037387593 scopus 로고    scopus 로고
    • Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men
    • Skogsberg J, Kannisto K, Cassel TN, et al. Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men. Arterioscler Thromb Vasc Biol 2003; 23:637-643.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 637-643
    • Skogsberg, J.1    Kannisto, K.2    Cassel, T.N.3
  • 7
    • 0348134971 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
    • Skogsberg J, McMahon AD, Karpe F, et al. Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. J Intern Med 2003; 254:597-604.
    • (2003) J Intern Med , vol.254 , pp. 597-604
    • Skogsberg, J.1    McMahon, A.D.2    Karpe, F.3
  • 8
    • 33745819570 scopus 로고    scopus 로고
    • Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women
    • Aberle J, Hopfer I, Beil FU, Seedorf U. Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women. Int J Med Sci 2006; 3:108-111.
    • (2006) Int J Med Sci , vol.3 , pp. 108-111
    • Aberle, J.1    Hopfer, I.2    Beil, F.U.3    Seedorf, U.4
  • 9
    • 0842334063 scopus 로고    scopus 로고
    • Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
    • Chen S, Tsybouleva N, Ballantyne CM, et al. Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenetics 2004; 14:61-71.
    • (2004) Pharmacogenetics , vol.14 , pp. 61-71
    • Chen, S.1    Tsybouleva, N.2    Ballantyne, C.M.3
  • 10
    • 27644501387 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in nondiabetic controls
    • Gouni-Berthold I, Giannakidou E, Faust M, et al. The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in nondiabetic controls. Atherosclerosis 2005; 183:336-341.
    • (2005) Atherosclerosis , vol.183 , pp. 336-341
    • Gouni-Berthold, I.1    Giannakidou, E.2    Faust, M.3
  • 11
    • 1442301053 scopus 로고    scopus 로고
    • Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity
    • Shin HD, Park BL, Kim LH, et al. Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Diabetes 2004; 53:847-851.
    • (2004) Diabetes , vol.53 , pp. 847-851
    • Shin, H.D.1    Park, B.L.2    Kim, L.H.3
  • 12
    • 33751251346 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects
    • Hu C, Jia W, Fang Q, et al. Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects. Diabet Med 2006; 23:1307-1312.
    • (2006) Diabet Med , vol.23 , pp. 1307-1312
    • Hu, C.1    Jia, W.2    Fang, Q.3
  • 13
    • 51249089430 scopus 로고    scopus 로고
    • Interaction between calpain 5, peroxisome proliferator-activated receptor-gamma and peroxisome proliferator-activated receptor-delta genes: A polygenic approach to obesity
    • Saez ME, Grilo A, Moron FJ, et al. Interaction between calpain 5, peroxisome proliferator-activated receptor-gamma and peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity. Cardiovasc Diabetol 2008; 7:23.
    • (2008) Cardiovasc Diabetol , vol.7 , pp. 23
    • Saez, M.E.1    Grilo, A.2    Moron, F.J.3
  • 14
    • 34247844401 scopus 로고    scopus 로고
    • Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people
    • Grarup N, Albrechtsen A, Ek J, et al. Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people. Diabetologia 2007; 50:1201-1208.
    • (2007) Diabetologia , vol.50 , pp. 1201-1208
    • Grarup, N.1    Albrechtsen, A.2    Ek, J.3
  • 15
    • 33644688988 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
    • Vanttinen M, Nuutila P, Kuulasmaa T, et al. Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake. Diabetes 2005; 54:3587-3591.
    • (2005) Diabetes , vol.54 , pp. 3587-3591
    • Vanttinen, M.1    Nuutila, P.2    Kuulasmaa, T.3
  • 16
    • 34250797341 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: The HERITAGE Family Study
    • Hautala AJ, Leon AS, Skinner JS, et al. Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family Study. Am J Physiol Heart Circ Physiol 2007; 292:H2498-H2505.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Hautala, A.J.1    Leon, A.S.2    Skinner, J.S.3
  • 17
    • 42049105146 scopus 로고    scopus 로고
    • Variations in PPARD determine the change in body composition during lifestyle intervention: A whole-body magnetic resonance study
    • Thamer C, Machann J, Stefan N, et al. Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study. J Clin Endocrinol Metab 2008; 93:1497-1500.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1497-1500
    • Thamer, C.1    Machann, J.2    Stefan, N.3
  • 18
    • 34249852535 scopus 로고    scopus 로고
    • Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    • Stefan N, Thamer C, Staiger H, et al. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab 2007; 92:1827-1833.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1827-1833
    • Stefan, N.1    Thamer, C.2    Staiger, H.3
  • 19
    • 33847256899 scopus 로고    scopus 로고
    • Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta-87T>C polymorphism and dietary fat in French-Canadians
    • Robitaille J, Gaudet D, Perusse L, Vohl MC. Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta-87T>C polymorphism and dietary fat in French-Canadians. Int J Obes (Lond) 2007; 31:411-417.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 411-417
    • Robitaille, J.1    Gaudet, D.2    Perusse, L.3    Vohl, M.C.4
  • 20
    • 33846443997 scopus 로고    scopus 로고
    • Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist
    • Sprecher DL, Massien C, Pearce G, et al. Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arterioscler Thromb Vasc Biol 2007; 27:359-365.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 359-365
    • Sprecher, D.L.1    Massien, C.2    Pearce, G.3
  • 21
    • 39649101196 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    • Riserus U, Sprecher D, Johnson T, et al. Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes 2008; 57:332-339.
    • (2008) Diabetes , vol.57 , pp. 332-339
    • Riserus, U.1    Sprecher, D.2    Johnson, T.3
  • 22
    • 4043147798 scopus 로고    scopus 로고
    • Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins
    • Brand MD, Affourtit C, Esteves TC, et al. Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 2004; 37:755-767.
    • (2004) Free Radic Biol Med , vol.37 , pp. 755-767
    • Brand, M.D.1    Affourtit, C.2    Esteves, T.C.3
  • 23
    • 0027946529 scopus 로고
    • Impaired free fatty acid utilization by skeletal muscle in noninsulin-dependent diabetes mellitus
    • Kelley DE, Simoneau JA. Impaired free fatty acid utilization by skeletal muscle in noninsulin-dependent diabetes mellitus. J Clin Invest 1994; 94:2349-2356.
    • (1994) J Clin Invest , vol.94 , pp. 2349-2356
    • Kelley, D.E.1    Simoneau, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.