Delayed apoptosis of human monocytes exposed to immune complexes is reversed by Oxaprozin: Role of the Akt/1KB kinase/nuclear factor KB pathway

British Journal of Pharmacology

Volumn 157, Issue 2, 2009, Pages 294-306

  Ottonello, Luciano ^a,b   Bertolotto, Maria ^a,b   Montecucco, Fabrizio ^a,b   Bianchi, Giordano ^a,b   Dallegri, Franco ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Akt; Apoptosis; IKK; Immune complexes; Monocytes; NF KB; NSAIDS; Oxaprozin

Indexed keywords

ACETYLSALICYLIC ACID; CASPASE 3; I KAPPA B KINASE; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE; NAPROXEN; OXAPROZIN; PROTEIN KINASE B; X LINKED INHIBITOR OF APOPTOSIS; NONSTEROID ANTIINFLAMMATORY AGENT; PROPIONIC ACID DERIVATIVE;

ANTIGEN ANTIBODY COMPLEX; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MONOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GEL MOBILITY SHIFT ASSAY; IN VITRO STUDY; METABOLISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGEN-ANTIBODY COMPLEX; APOPTOSIS; CASPASE 3; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; I-KAPPA B KINASE; MONOCYTES; NF-KAPPA B; PROPIONIC ACIDS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 68549088862     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00162.x     Document Type: Article

References (67)

1. Abramson SB, Weaver AL (2005). Current state of therapy for pain and inflammation. Arthritis Res Ther 7 (Suppl. 4): S1-S6. (Pubitemid 41646248)
2. Arend WP, Gabay C (2004). Cytokines In the rheumatic diseases. Rheum Dis Clin North Am 30 (1): 41-67, v-vi.
3. Bhatt NY, Kelley TW, Khramtsov VV, Wang Y, Lam GK, Clanton TL et al (2002). Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes. J Immunol 169 (11): 6427-6434. (Pubitemid 36903492)
4. Blanchi G, Montecucco F, Bertolotto M, Dallegri F, Ottonello L (2007). Immune complexes induce monocyte survival through defined intracellular pathways. Ann N Y Acad Sci. 1095: 209-219. (Pubitemid 47092453)
5. Bratton DL, Hamid Q, Boguniewicz M, Doherty DE, Kailey JM, Leung DY (1995). Granulocyte macrophage colony-stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis. J. Clin Invest 95 (1): 211-218.
6. Chaturvedi MM, LaPushin R, Aggarwal BB (1994). Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response. J Biol Chem 269 (20): 14575-14583. (Pubitemid 24194015)
7. Cheng JQ, Lindsley CW, Cheng GZ, Yang H, Nicosia SV (2005). The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 24 (50): 7482-7492. (Pubitemid 41637988)
8. Chiabrando C, Castelli MG, Cozzi E, Fanelli R, Campoleoni A, Balotta C et al (1989). Antiinflammatory action of salicylates: aspirin is not a prodrug for salicylate against rat carrageenin pleurisy. Eur J Pharmacol 159 (3): 257-264. (Pubitemid 19032158)
9. Cho M, Gwak J, Park S, Won J, Kim DE, Yea SS et al (2005). Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB. FEBS Lett 579 (20): 4213-4218. (Pubitemid 41121964)
10. Cook AD, Visvanathan K (2004). Molecular targets in immunemediated diseases: focus on rheumatoid arthritis. Expert Opin Ther Targets 8 (5): 375-390. (Pubitemid 39359645)
11. Dankberg F, Persidsky MD (1976). A test of granulocyte membrane integrity and phagocytic function. Cryobiology 13 (4): 430-432.
12. Davies N (1998). Clinical pharmacokinetics of Oxaprozin. Clin Pharmacokinet 35: 425-436.
13. Duffield JS (2003). The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci. (Lond) 104 (1): 27-38.
14. Eisele G, Schwedhelm E, Schleifer B, Tsikas D, Boger RH (2004). Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanism. J. Cardiovasc Pliarmacol 43 (4): 514521. (Pubitemid 39090017)
15. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998). Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/ paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101 (4): 890-898. (Pubitemid 28096086)
16. Fahy RJ, Doseff AI, Wewers MD (1999). Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1. J Immunol 163 (4): 1755-1762.
17. Feldmann M, Maini RN (2003). Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 9 (10): 1245-1250. (Pubitemid 37466197)
18. Fernandez N, Renedo M, Garcia-Rodriguez C, Sanchez Crespo M (2002). Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES. J Immunol 169 (6): 33213328. (Pubitemid 35013181)
19. FIrestein GS (2003). Evolving concepts of rheumatoid arthritis. Nature 423 (6937): 356-361.
20. Firestein GS (2006). Inhibiting inflammation in rheumatoid arthritis. N Engl J Med 354 (1): 80-82.
21. Firestein GS, Alvaro-Gracia JM, Maki R (1990). Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 144 (9): 3347-3353.
22. Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A et al. (1988). Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med 168 (5): 1573-1586. (Pubitemid 19023248)
23. Funk CD (2001). Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294 (5548): 1871-1875.
24. Gong JH, Ratkay LG, Waterfield JD, Clark-Lewis I (1997). An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J Exp Med 186 (1): 131-137.
25. Gordon S (1999). Development and distribution of mononuclear phagocytes. In: Gallin, J, Snyderman, R (eds). Inflammation: Principles and Clincal Correlates, 3rd edn. Lippincott Williams & Wilkins: Philadelphia, pp. 35-48.
26. Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T et al. (1998). Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur f Pharmacol 347 (1): 87-94. (Pubitemid 28238090)
27. Kazmi SM, Plante RK, Visconti V, Taylor GR, Zhou L, Lau CY (1995). Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase. J. Cell Biochem 57 (2): 299-310.
28. Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC et al (1999). Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem 274 (37): 26393-26398. (Pubitemid 129520072)
29. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR (2000). Macrophages in rheumatoid arthritis. Arthritis Res 2 (3): 189-202.
30. Kopp E, Ghosh S (1994). Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265 (5174): 956-959. (Pubitemid 2115182)
31. Kurowski M, Thabe H (1989). The transynovial distribution of Oxaprozin. Agents Actions 27: 458-460.
32. Ia Sala A, Gadina M, Kelsall BL (2005). G(i)-protein-dependent Inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK. J Immunol 175 (5): 2994-2999. (Pubitemid 41170517)
33. Lavagno L, Gunella G, Bardelli C, Spina S, Fresu LG, Viano I et al. (2004). Anti-inflammatory drugs and tumor necrosis factor-alpha production from monocytes: role of transcription factor NF-kappa B and implication for rheumatoid arthritis therapy. Eur J Pharmacol 501 (1-3): 199-208. (Pubitemid 39298953)
34. Lee R, Collins T (2001). Nuclear factor-kappaB and cell survival: IAPs call for support. Circ Res 88 (3): 262-264. (Pubitemid 32173747)
35. Li Q Verma IM (2002). NF-kappaB regulation in the immune system. Nat Rev Immunol 2 (10): 725-734.
36. Liew FY, Mclnnes IB (2002). The role of innate mediators in inflammatory response. Mol. Immunol 38 (12-13): 887-890. (Pubitemid 34496946)
37. Liu H, Pope RM (2003). The role of apoptosis in rheumatoid arthritis. Curr Opin Pharmacol 3 (3): 317-322.
38. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL et al. (1998). Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 187 (4): 601-608. (Pubitemid 28093362)
39. Makarov SS (2001). NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 3 (4): 200-206.
40. Marone R, Cmiljanovic V, Giese B, Wymann MP (2008). Targeting phosphoinositide 3-kinase: moving towards therapy. Biochim Biophys Acta 1784 (1): 159-185.
41. Marsh CB, Pomerantz RP, Parker JM, Winnard AV, Mazzaferri EL Jr, Kelley TM et al (1999). Regulation of monocyte survival in vitro by deposited IgG: role of macrophage colony-stimulating factor. J Immunol 162 (10): 6217-6225.
42. Mulherin D, Fitzgerald O, Bresnihan B (1996). Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 39 (1): 115-124. (Pubitemid 26036386)
43. Ottonello L, Bertolotto M, Montecucco F, Dapino P, Dallegri F (2005). Dexamethasone-induced apoptosis of human monocytes exposed to immune complexes. Intervention of CD95- and XIAP-dependent pathways. Int J Immunopathol Pharmacol 18 (3): 403-415. (Pubitemid 41532357)
44. Ottonello L, Frumento G, Arduino N, Bertolotto M, Dapino P, Mancinl M et al (2002). Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflammatory cytokines. Role of oxidants, Bax and caspase-3. J Leukoc Biol 72 (1): 125-132.
45. Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD (1999). Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells Is inhibited by ibuprofen. Oncogene 18 (51): 7389-7394.
46. Pollard L, Choy EH, Scott DL (2005). The consequences of rheumatoid arthritis: quality of life measures in the individual patient. Clin Exp Rheumatol 23 (5 Suppl. 39): S43-S52. (Pubitemid 46657510)
47. Pope RM (2002). Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol 2 (7): 527-535. (Pubitemid 37328744)
48. Rainsford K, Omar H, Ashraf A, Hewson A, Bunning R, Rishiraj R et al (2002). Recent pharmacodynamic and pharmacokinetic findings on Oxaprozin. Inflammopharmacology 10: 185-239.
49. Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW et al (2001). Structural basis for the inhibition of caspase-3 by XIAP. Cell 104 (5): 791-800. (Pubitemid 32241028)
50. van Roon JA, van Vuuren AJ, Wijngaarden S, Jacobs KM, Bijlsma JW, Lafeber FP et al. (2003). Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fcgamma receptor I-directed immunotoxin. Arthritis Rheum 48 (5): 12291238. (Pubitemid 36554522)
51. Savill J, Dransfield I, Gregory C, Haslett C (2002). A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2 (12): 965-975. (Pubitemid 37323217)
52. Scheuren N, Bang H, Munster T, Brune K, Pahl A (1998). Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol 123 (4): 645-652. (Pubitemid 128515013)
53. Scott DL, Smith C, Kingsley G (2005). What are the consequences of early rheumatoid arthritis for the individual? Best Pract Res Clin Rheumatol 19 (1): 117-136. (Pubitemid 40003944)
54. Solbach W, Moll H, Rollinghoff M (1991). Lymphocytes play the music but the macrophage calls the tune. Immunol Today 12 (1): 4-6.
55. Stuhlmeier KM, Li H, Kao JJ (1999). Ibuprofen: new explanation for an old phenomenon. Biochem Pharmacol 57 (3): 313-320. (Pubitemid 29056210)
56. Tak PP, Firestein GS (2001). NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107 (1): 7-11.
57. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB (2004). Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23 (57): 9247-9258. (Pubitemid 40069695)
58. Tang ED, Inohara N, Wang CY, Nunez G, Guan KL (2003). Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected], J Biol Chem 278 (40): 38566-38570. (Pubitemid 37221752)
59. Todd P, Brogden R (1986). Oxaprozin: a preliminary review of its pharmacodynamic and phamacokinetic properties and therapeutic effects. Drugs 32: 291-312. (Pubitemid 16028713)
60. Vane JR, Botting RM (1998). Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med 104 (3A): 2S-8S; discussion 21S-22S.
61. Viatour P, Merville MP, Bours V, Chariot A (2005). Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 30 (1): 43-52. (Pubitemid 40093740)
62. van Vuuren AJ, van Roon JA, Walraven V, Stuij I, Harmsen MC, McLaughlin PM et al (2006). CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model. J Immunol 176 (10): 5833-5838.
63. Xu WD, Firestein GS, Taetle R, Kaushansky K, Zvaifler NJ (1989). Cytokines in chronic inflammatory arthritis. II. Granulocytemacrophage colony-stimulating factor in rheumatoid synovial effusions. J Clin Invest 83 (3): 876-882. (Pubitemid 19080619)
64. Xu XJ, Reichner JS, Mastrofrancesco B, Henry WLJr, Albina, JE (2008). Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFNbeta production. J Immunol 180 (4): 2125-2131.
65. Yamamoto Y, Yin MJ, Lin KM, Gaynor RB (1999). Sulindac inhibits activation of the NF-kappaB pathway. J Biol Chem 274 (38): 2730727314. (Pubitemid 129520262)
66. Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S (2002). Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells. J Pharmacol Exp Ther 302 (1): 18-25. (Pubitemid 34680416)
67. YIn MJ, Yamamoto Y, Gaynor RB (1998). The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinasebeta. Nature 396 (6706): 77-80. (Pubitemid 28520452)