GW0742, a selective PPAR-β/δ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury

Journal of Leukocyte Biology

Volumn 88, Issue 2, 2010, Pages 291-301

  Di Paola, Rosanna ^a   Esposito, Emanuela ^a,b   Mazzon, Emanuela ^a   Paterniti, Irene ^b   Galuppo, Maria ^b   Cuzzocrea, Salvatore ^a,b  

^a IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Apoptosis; MPO activity; NF B expression; Nitrosative stress; Proinflammatory cytokines; SAO shock

Indexed keywords

3 NITROTYROSINE; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MYELOPEROXIDASE; PADGEM PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEINASE ACTIVATED RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; HISTOLOGY; INFLAMMATION; ISCHEMIA; MALE; MESENTERIC ARTERY; MORTALITY; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TISSUE INJURY; ANIMAL; APOPTOSIS; BIOSYNTHESIS; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; ENTEROPATHY; METABOLISM; PATHOLOGY; SURVIVAL RATE;

ANIMALIA;

ANIMALS; APOPTOSIS; CYTOKINES; DOWN-REGULATION; INFLAMMATION; INTESTINAL DISEASES; MICE; PPAR DELTA; PPAR-BETA; REPERFUSION INJURY; SURVIVAL RATE; THIAZOLES;

EID: 77956399623     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0110053     Document Type: Article

References (28)

1. Star, R. A. (1998) Treatment of acute renal failure. Kidney Int. 54, 1817-1831.
2. Bonventre, J. V. (1993) Mechanisms of ischemic acute renal failure. Kidney Int. 43, 1160-1178. (Pubitemid 23137105)
3. del Zoppo, G. J., Schmid-Schonbein, G. W., Mori, E., Copeland, B. R., Chang, C. M. (1991) Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22, 1276-1283.
4. Murota, S., Fujita, H., Wakabayashi, Y., Morita, I. (1996) Cell adhesion molecule mediates endothelial cell injury caused by activated neutrophils. Keio J. Med. 45, 207-211, discussion 211-212.
5. Weiss, S. J. (1989) Tissue destruction by neutrophils. N. Engl. J. Med. 320, 365-376.
6. Bjork, J., Hedqvist, P., Arfors, K. E. (1982) Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes. Inflammation 6, 189-200. (Pubitemid 12027026)
7. Berger, J., Moller, D. E. (2002) The mechanisms of action of PPARs. Annu. Rev. Med. 53, 409-435.
8. Higashiyama, H., Billin, A. N., Okamoto, Y., Kinoshita, M., Asano, S. (2007) Expression profiling of peroxisome proliferator-activated receptor-δ (PPAR-δ) in mouse tissues using tissue microarray. Histochem. Cell Biol. 127, 485-494.
9. Rival, Y., Beneteau, N., Taillandier, T., Pezet, M., Dupont-Passelaigue, E., Patoiseau, J. F., Junquero, D., Colpaert, F. C., Delhon, A. (2002) PPARα and PPARδ activators inhibit cytokine-induced nuclear translocation of NF-κB and expression of VCAM-1 in EAhy926 endothelial cells. Eur. J. Pharmacol. 435, 143-151.
10. Ding, G., Cheng, L., Qin, Q., Frontin, S., Yang, Q. (2006) PPARδ modulates lipopolysaccharide-induced TNFα inflammation signaling in cultured cardiomyocytes. J. Mol. Cell. Cardiol. 40, 821-828.
11. Fujise, T., Iwakiri, R., Wu, B., Amemori, S., Kakimoto, T., Yokoyama, F., Sakata, Y., Tsunada, S., Fujimoto, K. (2006) Apoptotic pathway in the rat small intestinal mucosa is different between fasting and ischemia-reperfusion. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G110-G116.
12. Itoh, H., Yagi, M., Fushida, S., Tani, T., Hashimoto, T., Shimizu, K., Miwa, K. (2000) Activation of immediate early gene, c-fos, and c-jun in the rat small intestine after ischemia/reperfusion. Transplantation 69, 598-604. (Pubitemid 30129595)
13. Zou, L., Attuwaybi, B., Kone, B. C. (2003) Effects of NF-κ B inhibition on mesenteric ischemia-reperfusion injury. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G713-G721.
14. Ghosh, S., Karin, M. (2002) Missing pieces in the NF-κB puzzle. Cell 109 (Suppl.), S81-S96.
15. Grotz, M. R., Deitch, E. A., Ding, J., Xu, D., Huang, Q., Regel, G. (1999) Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann. Surg. 229, 478-486.
16. De Plaen, I. G., Tan, X. D., Chang, H., Wang, L., Remick, D. G., Hsueh, W. (2000) Lipopolysaccharide activates nuclear factor κB in rat intestine: role of endogenous platelet-activating factor and tumor necrosis factor. Br. J. Pharmacol. 129, 307-314.
17. Arndt, H., Kubes, P., Granger, D. N. (1991) Involvement of neutrophils in ischemia-reperfusion injury in the small intestine. Klin. Wochenschr. 69, 1056-1060.
18. Eppihimer, M. J., Granger, D. N. (1997) Ischemia/reperfusion-induced leukocyte-endothelial interactions in postcapillary venules. Shock 8, 16-25.
19. Granger, D. N. (1997) Cell adhesion and migration. II. Leukocyte-endothelial cell adhesion in the digestive system. Am. J. Physiol. 273, G982-G986.
20. Koike, K., Moore, F. A., Moore, E. E., Read, R. A., Carl, V. S., Banerjee, A. (1993) Gut ischemia mediates lung injury by a xanthine oxidase-dependent neutrophil mechanism. J. Surg. Res. 54, 469-473.
21. Grisham, M. B., Benoit, J. N., Granger, D. N. (1990) Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol. 186, 729-742. (Pubitemid 20280020)
22. Duilio, C., Ambrosio, G., Kuppusamy, P., DiPaula, A., Becker, L. C., Zweier, J. L. (2001) Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol. 280, H2649-H2657.
23. Beckman, J. S. (1996) Oxidative damage and tyrosine nitration from peroxynitrite. Chem. Res. Toxicol. 9, 836-844.
24. Erdelyi, K., Bakondi, E., Gergely, P., Szabo, C., Virag, L. (2005) Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase- 1 activation: focus on cell death and transcriptional regulation. Cell. Mol. Life Sci. 62, 751-759.
25. Giovannelli, L., Cozzi, A., Guarnieri, I., Dolara, P., Moroni, F. (2002) Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly-(ADP-ribose) polymerase inhibitors. J. Cereb. Blood Flow Metab. 22, 697-704.
26. Mandir, A. S., Poitras, M. F., Berliner, A. R., Herring, W. J., Guastella, D. B., Feldman, A., Poirier, G. G., Wang, Z. Q., Dawson, T. M., Dawson, V. L. (2000) NMDA but not non-NMDA excitotoxicity is mediated by poly(ADP-ribose) polymerase. J. Neurosci. 20, 8005-8011.
27. Ikeda, H., Suzuki, Y., Suzuki, M., Koike, M., Tamura, J., Tong, J., Nomura, M., Itoh, G. (1998) Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 42, 530-537. (Pubitemid 28186571)
28. Pinkoski, M. J., Brunner, T., Green, D. R., Lin, T. (2000) Fas and Fas ligand in gut and liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278, G354-G366.