메뉴 건너뛰기




Volumn 7, Issue 8, 2012, Pages

Transferring the characteristics of naturally occurring and biased antibody repertoires to human antibody libraries by trapping CDRH3 sequences

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

EID: 84866631715     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043471     Document Type: Article
Times cited : (22)

References (42)
  • 1
    • 0027266779 scopus 로고
    • Libraries of peptides and proteins displayed on filamentous phage
    • Smith GP, Scott JK, (1993) Libraries of peptides and proteins displayed on filamentous phage. Methods in enzymology 217: 228-257 Available: http://www.ncbi.nlm.nih.gov/pubmed/7682645. Accessed 2 February 2012.
    • (1993) Methods in Enzymology , vol.217 , pp. 228-257
    • Smith, G.P.1    Scott, J.K.2
  • 2
    • 0031012062 scopus 로고    scopus 로고
    • Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines
    • Georgiou G, Stathopoulos C, Daugherty PS, Nayak AR, Iverson BL, et al. (1997) Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines. Nature biotechnology 15: 29-34 Available: http://www.ncbi.nlm.nih.gov/pubmed/9035102. Accessed 12 October 2011.
    • (1997) Nature Biotechnology , vol.15 , pp. 29-34
    • Georgiou, G.1    Stathopoulos, C.2    Daugherty, P.S.3    Nayak, A.R.4    Iverson, B.L.5
  • 3
    • 0025226085 scopus 로고
    • Phage antibodies: filamentous phage displaying antibody variable domains
    • McCafferty J, Griffiths AD, Winter G, Chiswell DJ, (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348: 552-554 Available: http://www.ncbi.nlm.nih.gov/pubmed/2247164. Accessed 25 July 2011.
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 4
    • 60849117841 scopus 로고    scopus 로고
    • Phage Display Derived Therapeutic Antibodies
    • Thie H, Meyer T, Schirrmann T, Hust M, Dubel S, (2008) Phage Display Derived Therapeutic Antibodies. Current Pharmaceutical Biotechnology 9: 8 Available: http://www.ingentaconnect.com/content/ben/cpb/2008/00000009/00000006/art 00004. Accessed 2 February 2012.
    • (2008) Current Pharmaceutical Biotechnology , vol.9 , pp. 8
    • Thie, H.1    Meyer, T.2    Schirrmann, T.3    Hust, M.4    Dubel, S.5
  • 5
    • 0026317443 scopus 로고
    • By-passing immunization. Human antibodies from V-gene libraries displayed on phage
    • Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD, et al. (1991) By-passing immunization. Human antibodies from V-gene libraries displayed on phage. Journal of molecular biology 222: 581-597 Available: http://www.ncbi.nlm.nih.gov/pubmed/1748994. Accessed 22 February 2012.
    • (1991) Journal of Molecular Biology , vol.222 , pp. 581-597
    • Marks, J.D.1    Hoogenboom, H.R.2    Bonnert, T.P.3    McCafferty, J.4    Griffiths, A.D.5
  • 7
    • 9344223986 scopus 로고    scopus 로고
    • Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
    • Vaughan TJ, Williams AJ, Pritchard K, Osbourn JK, Pope AR, et al. (1996) Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library. Nature biotechnology 14: 309-314 Available: http://www.nature.com/nbt/journal/v14/n3/full/nbt0396-309.html. Accessed 2 August 2012.
    • (1996) Nature Biotechnology , vol.14 , pp. 309-314
    • Vaughan, T.J.1    Williams, A.J.2    Pritchard, K.3    Osbourn, J.K.4    Pope, A.R.5
  • 8
    • 77649270848 scopus 로고    scopus 로고
    • Non-human primate immune libraries combined with germline humanization: an (almost) new, and powerful approach for the isolation of therapeutic antibodies
    • Pelat T, Thullier P, (2009) Non-human primate immune libraries combined with germline humanization: an (almost) new, and powerful approach for the isolation of therapeutic antibodies. mAbs 1: 377-381 Available: http://www.ncbi.nlm.nih.gov/pubmed/20068407. Accessed 2 August 2012.
    • (2009) MAbs , vol.1 , pp. 377-381
    • Pelat, T.1    Thullier, P.2
  • 9
    • 0026563253 scopus 로고
    • Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem
    • Barbas CF, Bain JD, Hoekstra DM, Lerner RA, (1992) Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proceedings of the National Academy of Sciences of the United States of America 89: 4457-4461 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=49101&tool =pmcentrez&rendertype=abstract. Accessed 15 June 2012.
    • (1992) Proceedings of the National Academy of Sciences of the United States of America , vol.89 , pp. 4457-4461
    • Barbas, C.F.1    Bain, J.D.2    Hoekstra, D.M.3    Lerner, R.A.4
  • 10
    • 0029111580 scopus 로고
    • Synthetic human antibodies
    • Barbas CF, (1995) Synthetic human antibodies. Nature Medicine 1: 837-839 Available: http://www.nature.com/nm/journal/v1/n8/full/nm0895-837.html. Accessed 15 June 2012.
    • (1995) Nature Medicine , vol.1 , pp. 837-839
    • Barbas, C.F.1
  • 11
    • 0034635335 scopus 로고    scopus 로고
    • Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
    • Knappik A, Ge L, Honegger A, Pack P, Fischer M, et al. (2000) Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. Journal of molecular biology 296: 57-86 Available: http://www.ncbi.nlm.nih.gov/pubmed/10656818. Accessed 2 August 2012.
    • (2000) Journal of Molecular Biology , vol.296 , pp. 57-86
    • Knappik, A.1    Ge, L.2    Honegger, A.3    Pack, P.4    Fischer, M.5
  • 12
    • 4344714933 scopus 로고    scopus 로고
    • Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition
    • Fellouse FA, Wiesmann C, Sidhu SS, (2004) Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition. Proceedings of the National Academy of Sciences of the United States of America 101: 12467-12472 Available: http://www.pnas.org/cgi/content/abstract/101/34/12467. Accessed 26 August 2011.
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , pp. 12467-12472
    • Fellouse, F.A.1    Wiesmann, C.2    Sidhu, S.S.3
  • 13
    • 39149087988 scopus 로고    scopus 로고
    • The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies
    • Rothe C, Urlinger S, Löhning C, Prassler J, Stark Y, et al. (2008) The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies. Journal of molecular biology 376: 1182-1200 Available: http://www.ncbi.nlm.nih.gov/pubmed/18191144. Accessed 2 August 2012.
    • (2008) Journal of Molecular Biology , vol.376 , pp. 1182-1200
    • Rothe, C.1    Urlinger, S.2    Löhning, C.3    Prassler, J.4    Stark, Y.5
  • 14
    • 0028926814 scopus 로고
    • Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions
    • de Kruif J, Boel E, Logtenberg T, (1995) Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions. Journal of molecular biology 248: 97-105 Available: http://www.sciencedirect.com/science/article/pii/S0022283685702045. Accessed 2 February 2012.
    • (1995) Journal of Molecular Biology , vol.248 , pp. 97-105
    • de Kruif, J.1    Boel, E.2    Logtenberg, T.3
  • 15
    • 55349108554 scopus 로고    scopus 로고
    • Construction of a fully synthetic human scFv antibody library with CDR3 regions randomized by a split-mix-split method and its application
    • Yin C-C, Ren L-L, Zhu L-L, Wang X-B, Zhang Z, et al. (2008) Construction of a fully synthetic human scFv antibody library with CDR3 regions randomized by a split-mix-split method and its application. Journal of biochemistry 144: 591-598 Available: http://www.ncbi.nlm.nih.gov/pubmed/18713799. Accessed 2 August 2012.
    • (2008) Journal of Biochemistry , vol.144 , pp. 591-598
    • Yin, C.-C.1    Ren, L.-L.2    Zhu, L.-L.3    Wang, X.-B.4    Zhang, Z.5
  • 16
    • 80054879629 scopus 로고    scopus 로고
    • Exploiting bias in a non-immune human antibody library to predict antigenicity
    • Ackerman ME, Lai JI, Pastan I, Wittrup KD, (2011) Exploiting bias in a non-immune human antibody library to predict antigenicity. Protein Engineering Design and Selection 24: 845-853 Available: http://www.ncbi.nlm.nih.gov/pubmed/21908549. Accessed 13 September 2011.
    • (2011) Protein Engineering Design and Selection , vol.24 , pp. 845-853
    • Ackerman, M.E.1    Lai, J.I.2    Pastan, I.3    Wittrup, K.D.4
  • 17
    • 0018567632 scopus 로고
    • Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination
    • Perelson AS, Oster GF, (1979) Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. Journal of theoretical biology 81: 645-670 Available: http://www.ncbi.nlm.nih.gov/pubmed/94141. Accessed 2 August 2012.
    • (1979) Journal of Theoretical Biology , vol.81 , pp. 645-670
    • Perelson, A.S.1    Oster, G.F.2
  • 18
    • 13144261717 scopus 로고    scopus 로고
    • Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens
    • Sheets MD, (1998) Efficient construction of a large nonimmune phage antibody library: The production of high-affinity human single-chain antibodies to protein antigens. Proceedings of the National Academy of Sciences 95: 6157-6162 Available: http://www.pnas.org/cgi/content/abstract/95/11/6157. Accessed 2 August 2012.
    • (1998) Proceedings of the National Academy of Sciences , vol.95 , pp. 6157-6162
    • Sheets, M.D.1
  • 19
    • 60749123372 scopus 로고    scopus 로고
    • Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens
    • Lloyd C, Lowe D, Edwards B, Welsh F, Dilks T, et al. (2009) Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens. Protein engineering, design & selection: PEDS 22: 159-168 Available: http://www.ncbi.nlm.nih.gov/pubmed/18974080. Accessed 2 August 2012.
    • (2009) Protein Engineering, Design & Selection: PEDS , vol.22 , pp. 159-168
    • Lloyd, C.1    Lowe, D.2    Edwards, B.3    Welsh, F.4    Dilks, T.5
  • 20
    • 0030930268 scopus 로고    scopus 로고
    • Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries
    • Amersdorfer P, Wong C, Chen S, Smith T, Deshpande S, et al. (1997) Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries. Infection and immunity 65: 3743-3752 Available: http://www.ncbi.nlm.nih.gov/pubmed/9284147. Accessed 2 August 2012.
    • (1997) Infection and Immunity , vol.65 , pp. 3743-3752
    • Amersdorfer, P.1    Wong, C.2    Chen, S.3    Smith, T.4    Deshpande, S.5
  • 21
    • 0035686774 scopus 로고    scopus 로고
    • Construction and selection of the natural immune Fab antibody phage display library from patients with colorectal cancer
    • Wu BP, Xiao B, Wan TM, Zhang YL, Zhang ZS, et al. (2001) Construction and selection of the natural immune Fab antibody phage display library from patients with colorectal cancer. World journal of gastroenterology: WJG 7: 811-815 Available: http://www.ncbi.nlm.nih.gov/pubmed/11854907. Accessed 2 August 2012.
    • (2001) World Journal of Gastroenterology: WJG , vol.7 , pp. 811-815
    • Wu, B.P.1    Xiao, B.2    Wan, T.M.3    Zhang, Y.L.4    Zhang, Z.S.5
  • 22
    • 0025838698 scopus 로고
    • A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals
    • Burton DR, Barbas CF, Persson MA, Koenig S, Chanock RM, et al. (1991) A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proceedings of the National Academy of Sciences of the United States of America 88: 10134-10137 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=52882&tool =pmcentrez&rendertype=abstract. Accessed 15 June 2012.
    • (1991) Proceedings of the National Academy of Sciences of the United States of America , vol.88 , pp. 10134-10137
    • Burton, D.R.1    Barbas, C.F.2    Persson, M.A.3    Koenig, S.4    Chanock, R.M.5
  • 23
    • 33745767275 scopus 로고    scopus 로고
    • Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus
    • Throsby M, Geuijen C, Goudsmit J, Bakker AQ, Korimbocus J, et al. (2006) Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus. Journal of virology 80: 6982-6992 Available: http://www.ncbi.nlm.nih.gov/pubmed/16809304. Accessed 2 August 2012.
    • (2006) Journal of Virology , vol.80 , pp. 6982-6992
    • Throsby, M.1    Geuijen, C.2    Goudsmit, J.3    Bakker, A.Q.4    Korimbocus, J.5
  • 24
    • 33745219391 scopus 로고    scopus 로고
    • Construction and characterization of a pseudo-immune human antibody library using yeast surface display
    • Lee H-W, Lee S-H, Park K-J, Kim J-S, Kwon M-H, et al. (2006) Construction and characterization of a pseudo-immune human antibody library using yeast surface display. Biochemical and biophysical research communications 346: 896-903 Available: http://www.ncbi.nlm.nih.gov/pubmed/16777066. Accessed 2 August 2012.
    • (2006) Biochemical and Biophysical Research Communications , vol.346 , pp. 896-903
    • Lee, H.-W.1    Lee, S.-H.2    Park, K.-J.3    Kim, J.-S.4    Kwon, M.-H.5
  • 25
    • 2942597518 scopus 로고    scopus 로고
    • A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library
    • Chassagne S, Laffly E, Drouet E, Hérodin F, Lefranc M-P, et al. (2004) A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library. Molecular immunology 41: 539-546 Available: http://www.ncbi.nlm.nih.gov/pubmed/15183932. Accessed 2 August 2012.
    • (2004) Molecular Immunology , vol.41 , pp. 539-546
    • Chassagne, S.1    Laffly, E.2    Drouet, E.3    Hérodin, F.4    Lefranc, M.-P.5
  • 26
    • 0037154718 scopus 로고    scopus 로고
    • Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries
    • Amersdorfer P, Wong C, Smith T, Chen S, Deshpande S, et al. (2002) Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries. Vaccine 20: 1640-1648 Available: http://www.ncbi.nlm.nih.gov/pubmed/11858873. Accessed 2 August 2012.
    • (2002) Vaccine , vol.20 , pp. 1640-1648
    • Amersdorfer, P.1    Wong, C.2    Smith, T.3    Chen, S.4    Deshpande, S.5
  • 27
    • 0027212854 scopus 로고
    • Length distribution of CDRH3 in antibodies
    • Wu TT, Johnson G, Kabat EA, (1993) Length distribution of CDRH3 in antibodies. Proteins 16: 1-7 Available: http://www.ncbi.nlm.nih.gov/pubmed/8497480. Accessed 6 February 2012.
    • (1993) Proteins , vol.16 , pp. 1-7
    • Wu, T.T.1    Johnson, G.2    Kabat, E.A.3
  • 28
    • 0037227422 scopus 로고    scopus 로고
    • Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen
    • Collis AVJ, Brouwer AP, Martin ACR, (2003) Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen. Journal of molecular biology 325: 337-354 Available: http://www.ncbi.nlm.nih.gov/pubmed/12488099. Accessed 2 August 2012.
    • (2003) Journal of Molecular Biology , vol.325 , pp. 337-354
    • Collis, A.V.J.1    Brouwer, A.P.2    Martin, A.C.R.3
  • 29
    • 3142613577 scopus 로고    scopus 로고
    • Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor
    • n.d
    • Barrios Y, Jirholt P, Ohlin M, (n.d.) Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor. Journal of molecular recognition: JMR 17: 332-338 Available: http://www.ncbi.nlm.nih.gov/pubmed/15227640. Accessed 20 August 2011.
    • Journal of Molecular Recognition: JMR , vol.17 , pp. 332-338
    • Barrios, Y.1    Jirholt, P.2    Ohlin, M.3
  • 30
    • 0032555214 scopus 로고    scopus 로고
    • A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries
    • Rader C, (1998) A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries. Proceedings of the National Academy of Sciences 95: 8910-8915 Available: http://www.pnas.org/cgi/content/abstract/95/15/8910. Accessed 15 June 2012.
    • (1998) Proceedings of the National Academy of Sciences , vol.95 , pp. 8910-8915
    • Rader, C.1
  • 31
    • 0242551578 scopus 로고    scopus 로고
    • Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures
    • Zemlin M, Klinger M, Link J, Zemlin C, Bauer K, et al. (2003) Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures. Journal of molecular biology 334: 733-749 Available: http://www.ncbi.nlm.nih.gov/pubmed/14636599. Accessed 2 August 2012.
    • (2003) Journal of Molecular Biology , vol.334 , pp. 733-749
    • Zemlin, M.1    Klinger, M.2    Link, J.3    Zemlin, C.4    Bauer, K.5
  • 32
    • 0037225412 scopus 로고    scopus 로고
    • Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display
    • Popkov M, Mage RG, Alexander CB, Thundivalappil S, Barbas CF, et al. (2003) Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display. Journal of molecular biology 325: 325-335 Available: http://www.ncbi.nlm.nih.gov/pubmed/12488098. Accessed 2 February 2012.
    • (2003) Journal of Molecular Biology , vol.325 , pp. 325-335
    • Popkov, M.1    Mage, R.G.2    Alexander, C.B.3    Thundivalappil, S.4    Barbas, C.F.5
  • 33
    • 78649893449 scopus 로고    scopus 로고
    • By-passing in vitro screening-next generation sequencing technologies applied to antibody display and in silico candidate selection
    • Ravn U, Gueneau F, Baerlocher L, Osteras M, Desmurs M, et al. (2010) By-passing in vitro screening-next generation sequencing technologies applied to antibody display and in silico candidate selection. Nucleic acids research 38: e193 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2995085&to ol=pmcentrez&rendertype=abstract. Accessed 21 July 2011.
    • (2010) Nucleic Acids Research , vol.38
    • Ravn, U.1    Gueneau, F.2    Baerlocher, L.3    Osteras, M.4    Desmurs, M.5
  • 34
    • 77956688921 scopus 로고    scopus 로고
    • Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells
    • Reddy ST, Ge X, Miklos AE, Hughes RA, Kang SH, et al. (2010) Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nature biotechnology 28: 965-969 Available: http://www.ncbi.nlm.nih.gov/pubmed/20802495. Accessed 27 June 2011.
    • (2010) Nature Biotechnology , vol.28 , pp. 965-969
    • Reddy, S.T.1    Ge, X.2    Miklos, A.E.3    Hughes, R.A.4    Kang, S.H.5
  • 35
    • 73949116413 scopus 로고    scopus 로고
    • Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
    • Glanville J, Zhai W, Berka J, Telman D, Huerta G, et al. (2009) Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proceedings of the National Academy of Sciences of the United States of America 106: 20216-20221 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2787155&to ol=pmcentrez&rendertype=abstract. Accessed 18 January 2012.
    • (2009) Proceedings of the National Academy of Sciences of the United States of America , vol.106 , pp. 20216-20221
    • Glanville, J.1    Zhai, W.2    Berka, J.3    Telman, D.4    Huerta, G.5
  • 36
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • Jones PT, Dear PH, Foote J, Neuberger MS, Winter G, (1986) Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321: 522-525 Available: http://www.nature.com/nature/journal/v321/n6069/abs/321522a0.html. Accessed 28 March 2012.
    • (1986) Nature , vol.321 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 37
    • 0034607856 scopus 로고    scopus 로고
    • The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies
    • Rader C, Ritter G, Nathan S, Elia M, Gout I, et al. (2000) The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies. The Journal of biological chemistry 275: 13668-13676 Available: http://www.ncbi.nlm.nih.gov/pubmed/10788485. Accessed 15 June 2012.
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 13668-13676
    • Rader, C.1    Ritter, G.2    Nathan, S.3    Elia, M.4    Gout, I.5
  • 38
    • 0034680852 scopus 로고    scopus 로고
    • Generation and Characterization of a Recombinant Human CCR5-specific Antibody. A PHAGE DISPLAY APPROACH FOR RABBIT ANTIBODY HUMANIZATION
    • Steinberger P, (2000) Generation and Characterization of a Recombinant Human CCR5-specific Antibody. A PHAGE DISPLAY APPROACH FOR RABBIT ANTIBODY HUMANIZATION. Journal of Biological Chemistry 275: 36073-36078 Available:http://www.ncbi.nlm.nih.gov/pubmed/10969070. Accessed 4 May 2012.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 36073-36078
    • Steinberger, P.1
  • 39
    • 4544250973 scopus 로고    scopus 로고
    • Crystal structure of a shark single-domain antibody V region in complex with lysozyme
    • Stanfield RL, Dooley H, Flajnik MF, Wilson IA, (2004) Crystal structure of a shark single-domain antibody V region in complex with lysozyme. Science (New York, NY) 305: 1770-1773 Available: http://www.sciencemag.org/content/305/5691/1770.abstract. Accessed 22 August 2011.
    • (2004) Science (New York, NY) , vol.305 , pp. 1770-1773
    • Stanfield, R.L.1    Dooley, H.2    Flajnik, M.F.3    Wilson, I.A.4
  • 40
    • 0029764444 scopus 로고    scopus 로고
    • Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme
    • Desmyter A, Transue TR, Ghahroudi MA, Dao Thi M-H, Poortmans F, et al. (1996) Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme. Nature Structural Biology 3: 803-811 Available: http://www.nature.com/nsmb/journal/v3/n9/abs/nsb0996-803.html. Accessed 22 February 2012.
    • (1996) Nature Structural Biology , vol.3 , pp. 803-811
    • Desmyter, A.1    Transue, T.R.2    Ghahroudi, M.A.3    Dao Thi, M.-H.4    Poortmans, F.5
  • 42
    • 33344476078 scopus 로고    scopus 로고
    • A focused antibody library for improved hapten recognition
    • Persson H, Lantto J, Ohlin M, (2006) A focused antibody library for improved hapten recognition. Journal of molecular biology 357: 607-620 Available: http://www.ncbi.nlm.nih.gov/pubmed/16445941. Accessed 20 December 2011.
    • (2006) Journal of Molecular Biology , vol.357 , pp. 607-620
    • Persson, H.1    Lantto, J.2    Ohlin, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.