Molecular characterization of murine humoral immune response to botulinum neurotoxin type A binding domain as assessed by using phage antibody libraries

Infection and Immunity

Volumn 65, Issue 9, 1997, Pages 3743-3752

  Amersdorfer, Peter ^a   Wong, Cindy ^a   Chen, Steven ^a   Smith, Theresa ^b   Deshpande, Sharad ^c   Sheridan, Robert ^c   Finnern, Ricarda ^a,d   Marks, James D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A;

ANTIBODY PRODUCTION; ARTICLE; BACTERIOPHAGE; BINDING SITE; DNA LIBRARY; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOPROPHYLAXIS; INTERNALIZATION; MOLECULAR GENETICS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL;

EID: 0030930268     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.9.3743-3752.1997     Document Type: Article

References (52)

1. Arnon, S. S. 1993. Clinical trial of human botulism immune globulin, p. 477-482. In B. R. DasGupta (ed), Botulinum and tetanus neurotoxins: neurotransmission and biomedical aspects. Plenum, New York, N.Y.
2. Arnon, S. S. 1992. Infant botulism. In R. D. Feigen and J. D. Cherry (ed.), Textbook of pediatric infectious diseases, 3rd ed. Saunders, Philadelphia, Pa.
3. Atassi, M. Z., B. Z. Dolimbek, M. Hayakari, J. L. Middlebrook, B. Whitney, and M. Oshima. 1996. Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species. J. Protein Chem. 15:691-699.
4. 125I-labeled botulinum neurotoxins with nerve terminals. I. Ultrastructural autoradiographic localization and quantitation of distinct membrane acceptors for types A and B on motor nerves. J. Cell Biol. 103:521-534.
5. Black, R. E., and R. A. Gunn. 1980. Hypersensitive reactions associated with botulinum antitoxin. Am. J. Med. 69:567-570.
6. Breitling, F., S. Dubel, T. Seehaus, I. Klewinghaus, and M. Little. 1991. A surface expression vector for antibody screening. Gene 104:147-153.
7. Cathala, G., J. Savouret, B. Mendez, B. L. Wesr, M. Karin, J. A. Martial, and J. D. Baxter. 1983. A method for isolation of intact, transcriptionally active ribonucleic acid. DNA 2:329.
8. Chen, F., G. M. Kuziemko, P. Amersdorfer, C. Wong, J. D. Marks, and R. C. Stevens. 1997. Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms. Infect. Immun. 65:1626-1630.
9. Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196:901-917.
10. Clackson, T., H. R. Hoogenboom, A. D. Griffiths, and G. Winter. 1991. Making antibody fragments using phage display libraries. Nature 352:624-628.
11. Clayton, M. A., J. M. Clayton, D. R. Brown, and J. L. Middlebrook. 1995. Protective vaccination with a recombinant fragment of Clostridium botulinum neurotoxin serotype A expressed from a synthetic gene in Escherichia coli. Infect. Immun. 63:2738-2742.
12. Daniels-Holgate, P. U., and J. O. Dolly. 1996. Productive and non-productive binding of botulinum neurotoxin A to motor nerve endings are distinguished by its heavy chain. J. Neurosci. Res. 44:263-271.
13. De Bellis, D., and I. Schwartz. 1990. Regulated expression of foreign genes fused to lac: control by glucose levels in growth medium. Nucleic Acids Res. 18:1311.
14. Deshpande, S. S., R. E. Sheridan, and M. Adler. 1995. A study of zinc-dependent metalloendopeptidase inhibitors as pharmacological antagonists in botulinum neurotoxin poisoning. Toxicon 33:551-557.
15. Dowell, V. R. J. 1984. Botulism and tetanus: selected epidemiologic and microbiologic aspects. Rev. Infect. Dis. 6(Suppl. 1):S202-S207.
16. Dower, W. J., J. F. Miller, and C. W. Ragsdale. 1988. High efficiency transformation of E. coli by high voltage electroporation. Nucleic Acids Res. 16:6127-6145.
17. Emanuel, P., T. O'Brien, J. Burans, B. R. DasGupta, J. J. Valdes, and M. Eldefrawi. 1996. Directing antigen specificity towards botulinum neurotoxin with combinatorial phage display libraries. J. Immunol. Methods 193:189-197.
18. Foote, J., and C. Milstein. 1991. Kinetic maturation of an immune response. Nature 352:530-532.
19. Gibson, T. J. 1984. Studies on the Epstein-Barr virus genome. University of Cambridge, Cambridge, United Kingdom.
20. Gussow, D., and T. Clackson. 1989. Direct clone characterization from plaques and colonies by the polymerase chain reaction. Nucleic Acids Res. 17:4000.
21. Hatheway, C. H., J. D. Snyder, J. E. Seals, T. A. Edell, and G. E. Lewis. 1984. Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A. B. and E. J. Infect. Dis. 150:407-412.
22. Hawkins, R. E., S. J. Russell, and G. Winter. 1992. Selection of phage antibodies by binding affinity: mimicking affinity maturation. J. Mol. Biol. 226:889-896.
23. Hildebrand, G. E., C. Lamanna, and R. J. Heckly. 1961. Distribution and particle size of type A botulinum toxin in body fluids of intravenously injected rabbits. Proc. Soc. Exp. Biol. Med. 107:284-289.
24. Hochuli, E., W. Bannwarth, H. Dobeli, R. Gentz, and D. Stuber. 1988. Genetic approach to facilitate purification of recombinant proteins with a novel metal chelate adsorbent. Bio/Technology. 6:1321-1325.
25. Hoogenboom, H. R., A. D. Griffiths, K. S. Johnson, D. J. Chiswell, P. Hudson, and G. Winter. 1991. Multi-subunit proteins on the surface of filamentous phase: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res. 19:4133-4137.
26. Huston, J. S., A. J. T. George, G. P. Adams, W. F. Stafford, F. Jamar, M.-S. Tai, J. E. McCartney, H. Oppermann, B. T. Heelan, A. M. Peters, L. L. Houston, M. A. Bookman, E. J. Wolf, and L. M. Weiner. 1996. Single-chain Fv radioimmunotargeting. Q. J. Nucl. Med. 40:320.
27. Huston, J. S., D. Levinson, H. M. Mudgett, M. S. Tai, J. Novotny, M. N. Margolies, R. J. Ridge, R. E. Bruccoleri, E. Haber, R. Crea, and H. Oppermann. 1988. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 85:5879-5883.
28. Jankovic, J., and M. Hallet. 1994. Therapy with botulinum toxin. Marcel Dekker, New York, N.Y.
29. Johnsson, B., S. Löfås, and G. Lindqvist. 1991. Immobilization of proteins to a carboxymethyldextran modified gold surface for BIAcore in surface plasmon resonance. Anal. Biochem. 198:258-277.
30. Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of proteins of immunological interest. U.S. Department of Health and Human Services, U.S. Government Printing Office, Bethesda, Md.
31. Karlsson, R., A. Michaelsson, and L. Mattsson. 1991. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Methods 145:229-240.
32. Lang, A. B., S. J. Cryz, U. Schurch, M. T. Ganss, and U. Bruderer. 1993. Immunotherapy with human monoclonal antibodies: fragment A specificity of polyclonal and monoclonal antibodies is crucial for full protection against tetanus toxin. J. Immunol. 151:466-473.
33. LaPenotiere, H. F., M. A. Clayton, and J. L. Middlebrook. 1995. Expression of a large, nontoxic fragment of botulinum neurotoxin serotype A and its use as an immunogen. Toxicon 33:1383-1386.
34. Marks, C., and J. D. Marks. 1996. Phage libraries: a new route to clinically useful antibodies. N. Engl. J. Med. 335:731-733.
35. Marks, J. U., H. R. Hoogenboom, T. P. Bonnert, J. McCafferty, A. D. Griffiths, and G. Winter. 1991. By-passing immunization: human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222:581-597.
36. Marks, J. D., M. Tristrem, A. Karpas, and G. Winter. 1991. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur. J. Immunol. 21:985-991.
37. McCafferty, J., A. D. Griffiths, G. Winter, and D. J. Chiswell. 1990. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348:552-554.
38. Middlebrook, J. E., and J. E. Brown. 1995. Immunodiagnosis and immunotherapy of tetanus and botulinum neurotoxins. Curr. Top. Microbiol. Immunol. 195:89-122.
39. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
40. Montecucco, C. 1986. How do tetanus and botulinum toxins bind to neuronal membranes? Trends Biochem. Sci. 11:314-317.
41. Moore, P. 1995. Handbook of botulinum toxin treatment. Blackwell Science, Oxford, United Kingdom.
42. Munro, S., and H. R. B. Pelham. 1986. An Hsp-like protein in the ER: identity with the 78kd glucose regulated protein and immunoglobulin heavy chain binding protein. Cell 46:291-300.
43. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
44. Schier, R., R. F. Balint, A. McCall, G. Apell, J. W. Larrick, and J. D. Marks. 1996. Identification of functional and structural amino acid residues by parsimonious mutagenesis. Gene 169:147-155.
45. Schier, R., J. Bye, G. Apell, A. McCall, G. P. Adams, M. Malmqvist, L. M. Weiner, and J. D. Marks. 1996. Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv usine affinity-driven selection. J. Mol. Biol. 255:28-43.
46. Schier, R., J. D. Marks, E. J. Wolf, G. Apell, C. Wong, J. E. McCartney, M. A. Bookman, J. S. Huston, L. L. Houston, L. M. Weiner, and G. P. Adams. 1995. In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology 1: 73-81.
47. Schier, R., A. McCall, G. P. Adams, K. Marshall, M. Yim, H. Merritt, R. S. Crawford, L. M. Weiner, C. Marks, and J. D. Marks. 1996. Isolation of high affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody combining site. J. Mol. Biol. 263:551-567.
48. 47a. Sheridan, R., T. Smith, and S. Deshpande. Unpublished data.
49. Tacket, C. O., W. X. Shandera, J. M. Mann, N. T. Hargrett, and P. A. Blake. 1984. Equine antitoxin use and other factors that predict outcome in type A foodborne botulism. Am. J. Med. 76:794-798.
50. Tomlinson, I. M., G. Walter, P. T. Jones, P. H. Dear, E. L. Sonnhammer, and G. Winter. 1996. The imprint of somatic hypermutation on the repertoire of human germline V genes. J. Mol. Biol. 256:813-817.
51. Weber, J. T., H. C. Goodpasture, H. Alexander, S. B. Werner, C. L. Hatheway, and R. V. Tauxe. 1993. Wound botulism in a patient with a tooth abscess: case report and review. Clin. Infect. Dis. 16:635-639.
52. Williams, R. S., C.-K. Tse, J. O. Dolly, P. Hambleton, and J. Melling. 1983. Radioiodination of botulinum neurotoxin type A with retention of biological activity and its binding to brain synaptosomes. Eur. J. Biochem. 131:437-445.