Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 48, 2009, Pages 20216-20221

  Glanville, Jacob ^a   Zhai, Wenwu ^a   Berka, Jan ^a   Telman, Dilduz ^a   Huerta, Gabriella ^a   Mehta, Gautam R ^a   Ni, Irene ^a   Mei, Li ^a   Sundar, Purnima D ^a   Day, Giles M R ^a   Cox, David ^a   Rajpal, Arvind ^a   Pons, Jaume ^a  

^a PFIZER INC   (United States)

Author keywords

CDRs; HMM; Phage display; Pyrosequencing

Indexed keywords

HUMAN IMMUNOGLOBULIN;

ACCURACY; AMPLICON; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ARTICLE; COMBINATORIAL LIBRARY; COMPLEMENTARITY DETERMINING REGION; GERM LINE; HEAVY CHAIN; LIGHT CHAIN; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PYROSEQUENCING;

ANTIBODY DIVERSITY; GENE LIBRARY; HUMANS; IMMUNOGLOBULIN M; SEQUENCE ANALYSIS, DNA;

EID: 73949116413     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909775106     Document Type: Article

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