Exploiting bias in a non-immune human antibody library to predict antigenicity

Protein Engineering, Design and Selection

Volumn 24, Issue 11, 2011, Pages 845-853

  Ackerman, Margaret E ^a,b   Lai, Jennifer I ^c   Pastan, Ira ^d   Wittrup, K Dane ^c  

^a DARTMOUTH COLLEGE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c USA   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

antibody; antibody fragment; antigenicity; immune library; immunogenicity; protein library; protein selection; scFv

Indexed keywords

ANTIBODY FRAGMENT; ANTIGENICITY; IMMUNE LIBRARY; IMMUNOGENICITY; PROTEIN LIBRARY; SCFV;

ANTIGENS; CLONING; LIBRARIES;

ANTIBODIES;

ALBUMIN; ANTIGEN; IMMUNOGLOBULIN G; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; ORTHOLOGY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN VARIANT;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN ENGINEERING; SINGLE-CHAIN ANTIBODIES;

EID: 80054879629     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr046     Document Type: Article

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