메뉴 건너뛰기




Volumn 1, Issue 4, 2009, Pages 377-381

Non-human primate immune libraries combined with germline humanization: An (almost) new, and powerful approach for the isolation of therapeutic antibodies

Author keywords

Affinity; Antibody; Epitope; Immune library; Na ve library; Non human primate; Patent; Synthetic library; Tolerance

Indexed keywords

EPITOPE; RECOMBINANT ANTIBODY;

EID: 77649270848     PISSN: 19420862     EISSN: None     Source Type: Journal    
DOI: 10.4161/mabs.1.4.8635     Document Type: Review
Times cited : (26)

References (34)
  • 2
    • 0036861899 scopus 로고    scopus 로고
    • Immunogenicity of therapeutic proteins: Clinical implications and future prospects
    • DOI 10.1016/S0149-2918(02)80075-3
    • Schellekens H. Immunogenicity of therapeutic proteins: clinical implications and future prospects. Clin Ther 2002; 24:1720-1740 (Pubitemid 35440946)
    • (2002) Clinical Therapeutics , vol.24 , Issue.11 , pp. 1720-1740
    • Schellekens, H.1
  • 3
    • 56949104947 scopus 로고    scopus 로고
    • Humanized antibodies
    • Boca Raton, Fla.: CRC Press
    • Harris WJ, Adair JR. Humanized antibodies. In Antibody Therapeutics. Boca Raton, Fla.: CRC Press 1997; 6:85-110.
    • (1997) Antibody Therapeutics , vol.6 , pp. 85-110
    • Harris, W.J.1    Adair, J.R.2
  • 5
    • 0026057989 scopus 로고
    • Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning
    • Persson MA, Caothien RH, Burton DR. Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning. Proc Natl Acad Sci USA 1991; 88:2432-2436
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2432-2436
    • Persson, M.A.1    Caothien, R.H.2    Burton, D.R.3
  • 8
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302:575-581
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 10
    • 2942597518 scopus 로고    scopus 로고
    • A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library
    • DOI 10.1016/j.molimm.2004.03.040, PII S0161589004000987
    • Chassagne S, Laffly E, Drouet E, Herodin F, Lefranc MP, Thullier P. A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library. Mol Immunol 2004; 41:539-546 (Pubitemid 38750199)
    • (2004) Molecular Immunology , vol.41 , Issue.5 , pp. 539-546
    • Chassagne, S.1    Laffly, E.2    Drouet, E.3    Herodin, F.4    Lefranc, M.-P.5    Thullier, P.6
  • 11
    • 23044503900 scopus 로고    scopus 로고
    • Selection of a macaque Fab with framework regions like those in humans, high affinity and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694
    • Laffly E, Danjou L, Condemine F, Vidal D, Drouet E, Lefranc MP, et al. Selection of a macaque Fab with framework regions like those in humans, high affinity and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694. Antimicrob Agents Chemother 2005; 49:3414-3420
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3414-3420
    • Laffly, E.1    Danjou, L.2    Condemine, F.3    Vidal, D.4    Drouet, E.5    Lefranc, M.P.6
  • 12
    • 34547646543 scopus 로고    scopus 로고
    • High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation
    • Pelat T, Hust M, Laffly E, Condemine F, Bottex C, Vidal D, et al. High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation. Antimicrob Agents Chemother 2007; 51:2758-2764
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2758-2764
    • Pelat, T.1    Hust, M.2    Laffly, E.3    Condemine, F.4    Bottex, C.5    Vidal, D.6
  • 13
    • 67849092221 scopus 로고    scopus 로고
    • Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity
    • In Press
    • Pelat T, Hust M, Hale M, Lefranc MP, Dübel S, Thullier P. Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity. BMC Biotech 2009; In Press.
    • (2009) BMC Biotech
    • Pelat, T.1    Hust, M.2    Hale, M.3    Lefranc, M.P.4    Dübel, S.5    Thullier, P.6
  • 14
    • 0025876152 scopus 로고
    • Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system
    • Karlsson R, Michaelsson A, Mattsson L. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J Immunol Methods 1991; 145:229-240
    • (1991) J Immunol Methods , vol.145 , pp. 229-240
    • Karlsson, R.1    Michaelsson, A.2    Mattsson, L.3
  • 15
    • 0030571002 scopus 로고    scopus 로고
    • Analysis of mass transport-limited binding kinetics in evanescent wave biosensors
    • DOI 10.1006/abio.1996.0356
    • Schuck P, Minton AP. Analysis of mass transport-limited binding kinetics in evanescent wave biosensors. Anal Biochem 1996; 240:262-272 (Pubitemid 26304270)
    • (1996) Analytical Biochemistry , vol.240 , Issue.2 , pp. 262-272
    • Schuck, P.1    Minton, A.P.2
  • 16
    • 85017685667 scopus 로고    scopus 로고
    • Selection of recombinant antibodies from antibody gene libraries
    • Hust M, Dubel S, Schirrmann T. Selection of recombinant antibodies from antibody gene libraries. Methods Mol Biol 2007; 408:243-255
    • (2007) Methods Mol Biol , vol.408 , pp. 243-255
    • Hust, M.1    Dubel, S.2    Schirrmann, T.3
  • 17
    • 52449088919 scopus 로고    scopus 로고
    • Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV)
    • Kirsch MI, Hulseweh B, Nacke C, Rulker T, Schirrmann T, Marschall HJ, et al. Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV). BMC Biotechnol 2008; 8:66.
    • (2008) BMC Biotechnol , vol.8 , pp. 66
    • Kirsch, M.I.1    Hulseweh, B.2    Nacke, C.3    Rulker, T.4    Schirrmann, T.5    Marschall, H.J.6
  • 19
    • 2542638729 scopus 로고    scopus 로고
    • Enhancement of anthrax lethal toxin cytotoxicity: A subset of monoclonal antibodies against protective antigen increases lethal toxin-mediated killing of murine macrophages
    • DOI 10.1128/IAI.72.6.3276-3283.2004
    • Mohamed N, Li J, Ferreira CS, Little SF, Friedlander AM, Spitalny GL, et al. Enhancement of anthrax lethal toxin cytotoxicity: a subset of monoclonal antibodies against protective antigen increases lethal toxin-mediated killing of murine macrophages. Infect Immun 2004; 72:3276-3283 (Pubitemid 38697749)
    • (2004) Infection and Immunity , vol.72 , Issue.6 , pp. 3276-3283
    • Mohamed, N.1    Li, J.2    Ferreira, C.S.3    Little, S.F.4    Friedlander, A.M.5    Spitalny, G.L.6    Casey, L.S.7
  • 20
    • 0037154718 scopus 로고    scopus 로고
    • Genetic and immunological comparison of anti-botulinum type a antibodies from immune and non-immune human phage libraries
    • DOI 10.1016/S0264-410X(01)00482-0, PII S0264410X01004820
    • Amersdorfer P, Wong C, Smith T, Chen S, Deshpande S, Sheridan R, et al. Genetic and immunological comparison of anti-botulinum type A antibodies from immune and nonimmune human phage libraries. Vaccine 2002; 20:1640-1648 (Pubitemid 34169806)
    • (2002) Vaccine , vol.20 , Issue.11-12 , pp. 1640-1648
    • Amersdorfer, P.1    Wong, C.2    Smith, T.3    Chen, S.4    Deshpande, S.5    Sheridan, R.6    Marks, J.D.7
  • 21
    • 0042736310 scopus 로고    scopus 로고
    • Allergic asthma and an anti-CD23 mAb (IDEC-152): Results of a phase I, single-dose, dose-escalating clinical trial
    • Rosenwasser LJ, Busse WW, Lizambri RG, Olejnik TA, Totoritis MC. Allergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial. J Allergy Clin Immunol 2003; 112:563-570
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 563-570
    • Rosenwasser, L.J.1    Busse, W.W.2    Lizambri, R.G.3    Olejnik, T.A.4    Totoritis, M.C.5
  • 23
    • 0026722514 scopus 로고
    • Concerted evolution of the primate immunoglobulin alpha-gene through gene conversion
    • Kawamura S, Saitou N, Ueda S. Concerted evolution of the primate immunoglobulin alpha-gene through gene conversion. J Biol Chem 1992; 267:7359-7367
    • (1992) J Biol Chem , vol.267 , pp. 7359-7367
    • Kawamura, S.1    Saitou, N.2    Ueda, S.3
  • 24
    • 0030871401 scopus 로고    scopus 로고
    • Variable region gene segment utilization in Rhesus monkey hybridomas producing human red blood cell-specific antibodies: Predominance of the VH4 family but not VH4-21 (V4-34)
    • DOI 10.1016/S0161-5890(97)00021-7, PII S0161589097000217
    • Andris JS, Miller AB, Abraham SR, Cunningham S, Roubinet F, Blancher A, et al. Variable region gene segment utilization in rhesus monkey hybridomas producing human red blood cell-specific antibodies: predominance of the VH4 family but not VH4-21 (V4-34). Mol Immunol 1997; 34:237-253 (Pubitemid 27293739)
    • (1997) Molecular Immunology , vol.34 , Issue.3 , pp. 237-253
    • Andris, J.S.1    Miller, A.B.2    Abraham, S.R.3    Cunningham, S.4    Roubinet, F.5    Blancher, A.6    Capra, J.D.7
  • 25
    • 0025048735 scopus 로고
    • Evolutionary hypervariability in the hinge region of the immunoglobulin alpha gene
    • Kawamura S, Omoto K, Ueda S. Evolutionary hypervariability in the hinge region of the immunoglobulin alpha gene. J Mol Biol 1990; 215:201-206 (Pubitemid 20329739)
    • (1990) Journal of Molecular Biology , vol.215 , Issue.2 , pp. 201-206
    • Kawamura, S.1    Omoto, K.2    Ueda, S.3
  • 26
    • 0025921606 scopus 로고
    • Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution
    • Meek K, Eversole T, Capra JD. Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution. J Immunol 1991; 146:2434-2438
    • (1991) J Immunol , vol.146 , pp. 2434-2438
    • Meek, K.1    Eversole, T.2    Capra, J.D.3
  • 27
    • 2942550031 scopus 로고    scopus 로고
    • Protocol 9.36: Librairies of nonhuman primate anibody fragments
    • Barbas CF, ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Andris-Widhopf J, Steinberger P, Fuller R, Rader C, Barbas CF. Protocol 9.36: Librairies of nonhuman primate anibody fragments. In: Barbas CF, ed. Phage display: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press 2001; 1.
    • (2001) Phage Display: A Laboratory Manual , pp. 1
    • Andris-Widhopf, J.1    Steinberger, P.2    Fuller, R.3    Rader, C.4    Barbas, C.F.5
  • 29
    • 48449094247 scopus 로고    scopus 로고
    • IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    • Brochet X, Lefranc MP, Giudicelli V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res 2008; 36:503-508
    • (2008) Nucleic Acids Res , vol.36 , pp. 503-508
    • Brochet, X.1    Lefranc, M.P.2    Giudicelli, V.3
  • 31
    • 56949105189 scopus 로고    scopus 로고
    • Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering
    • Pelat T, Bedouelle H, Rees AR, Crennell SJ, Lefranc MP, Thullier P. Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering. J Mol Biol 2008; 384:1400-1407
    • (2008) J Mol Biol , vol.384 , pp. 1400-1407
    • Pelat, T.1    Bedouelle, H.2    Rees, A.R.3    Crennell, S.J.4    Lefranc, M.P.5    Thullier, P.6
  • 33
    • 34547638924 scopus 로고    scopus 로고
    • Recombinant antibodies for human therapy
    • U.S. patent 5,693,780
    • Newman RAN. Hanna N, Raab RW. Recombinant antibodies for human therapy. U.S. patent 5,693,780. 1997.
    • (1997)
    • Newman, R.A.N.1    Hanna, N.2    Raab, R.W.3
  • 34
    • 77953674522 scopus 로고
    • Recombinant antibodies for human therapy
    • European patent 1,266,965 B1
    • Newman RAN, Hanna N, Raab RW. Recombinant antibodies for human therapy. European patent 1,266,965 B1. 1992.
    • (1992)
    • Newman, R.A.N.1    Hanna, N.2    Raab, R.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.